Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serologically defined colon cancer antigen 8 homolog

Gene

Sdccag8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the establishment of cell polarity and epithelial lumen formation. May play a role in ciliogenesis.1 Publication

GO - Biological processi

  • centrosome organization Source: InterPro
  • establishment of cell polarity Source: UniProtKB
  • microtubule organizing center organization Source: MGI
  • neuron migration Source: MGI
  • tube formation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Serologically defined colon cancer antigen 8 homolog
Alternative name(s):
Centrosomal colon cancer autoantigen protein
Short name:
mCCCAP
Gene namesi
Name:Sdccag8
Synonyms:Cccap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1924066. Sdccag8.

Subcellular locationi

GO - Cellular componenti

  • cell-cell junction Source: MGI
  • centriolar satellite Source: MGI
  • centriole Source: UniProtKB
  • centrosome Source: MGI
  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

In renal epithelial cells gene knockdown results in the formation of spheroids with architectural defects characterized by disturbed localization of beta-catenin (CTNNB1) at the basolateral membrane, fewer tight junctions and an irregular lumen.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717Serologically defined colon cancer antigen 8 homologPRO_0000076311Add
BLAST

Proteomic databases

EPDiQ80UF4.
MaxQBiQ80UF4.
PaxDbiQ80UF4.
PRIDEiQ80UF4.

PTM databases

PhosphoSiteiQ80UF4.

Expressioni

Tissue specificityi

Expressed in liver, kidney, spleen, brain, heart and muscle. Expressed in photoreceptor cells of the retina.2 Publications

Gene expression databases

BgeeiQ80UF4.
CleanExiMM_SDCCAG8.
ExpressionAtlasiQ80UF4. baseline and differential.
GenevisibleiQ80UF4. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with OFD1; the interaction is direct (By similarity). Interacts with FAM161A (By similarity).By similarity

Protein-protein interaction databases

BioGridi218334. 24 interactions.
IntActiQ80UF4. 25 interactions.
STRINGi10090.ENSMUSP00000027785.

Structurei

3D structure databases

ProteinModelPortaliQ80UF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni216 – 717502Sufficient for homodimerizationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili129 – 16840Sequence analysisAdd
BLAST
Coiled coili221 – 27858Sequence analysisAdd
BLAST
Coiled coili352 – 590239Sequence analysisAdd
BLAST
Coiled coili622 – 71291Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi352 – 536185Glu-richAdd
BLAST
Compositional biasi509 – 58173Gln-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGC5. Eukaryota.
ENOG410XQMR. LUCA.
GeneTreeiENSGT00730000111198.
HOGENOMiHOG000133059.
HOVERGENiHBG056806.
InParanoidiQ80UF4.
KOiK16488.
OMAiILSQNIA.
OrthoDBiEOG7W6WK8.
PhylomeDBiQ80UF4.
TreeFamiTF325472.

Family and domain databases

InterProiIPR031887. SDCCAG8.
[Graphical view]
PANTHERiPTHR34343. PTHR34343. 1 hit.
PfamiPF15964. CCCAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSPGNSTL EDSLGQYQRS LRERANRSIH QLKCALREVD VTVEEDALDP
60 70 80 90 100
STSINVENED TGVAWHELQH SHAVNQLKAL LRQQTNKENE TSPPRRRKLS
110 120 130 140 150
PSRPSECDDG SMPTMHNLVP IINDQSQYIH HLEAEVKFCK DELSGMKNRV
160 170 180 190 200
QVVVLENERL QQELKSQRPE ETLREQTFLD ASGNMQNSWI MTREDSRVDE
210 220 230 240 250
AAKRPFSHGD AETGKTASTG DANKWKLELE RLKLTYEAKT DLLESQLMLL
260 270 280 290 300
RKDLAEYQKT CEDLKERLKH KESLLAASAS SRVGGLCLKC AQHEAVLSQT
310 320 330 340 350
HSNVHIQTIE RLTKERDDLM SVLVSVRSSL AEAQKRETSA YEQVKHAVQM
360 370 380 390 400
TEEANFEKTK ALIQCEQLKS ELERQTERLE KELASQQEKR AVEKEMIKKE
410 420 430 440 450
VAREREDAES KMLILSQNIA KLEAQVEKVT REKTAAVSHL EEIQNHVASQ
460 470 480 490 500
EMDVTKVCGE MRFQLNKTKM EKDEVEKEHR EYKAKSHKDL EMKVQEIEKL
510 520 530 540 550
RLELSESEQH VEQEQQKAAR ARQECLRVTE LLGEAERQLH LTRLEKDSIQ
560 570 580 590 600
QSFSNEAKAQ ALQAQQREQE LTQKIQQMET QHDKTESEQY LLLTSQNTFL
610 620 630 640 650
TKLKEECCLL AKKLEKVSLK SRSQIVRLSQ EKRYLCDKLE KLQKRNDELE
660 670 680 690 700
EQCIQHGRVH ETMKERLRQL DKHGQATAQQ LVQLLNKQNQ LLLERQNLSE
710
EVARLRAQLP SMPQSDC
Length:717
Mass (Da):82,979
Last modified:June 1, 2003 - v1
Checksum:iC9F69DBFB3DCD59D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250729 mRNA. Translation: AAO27828.1.
AK132316 mRNA. Translation: BAE21100.1.
AK133622 mRNA. Translation: BAE21753.1.
CCDSiCCDS35798.1.
RefSeqiNP_084032.1. NM_029756.3.
UniGeneiMm.171399.

Genome annotation databases

EnsembliENSMUST00000027785; ENSMUSP00000027785; ENSMUSG00000026504.
GeneIDi76816.
KEGGimmu:76816.
UCSCiuc007duj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250729 mRNA. Translation: AAO27828.1.
AK132316 mRNA. Translation: BAE21100.1.
AK133622 mRNA. Translation: BAE21753.1.
CCDSiCCDS35798.1.
RefSeqiNP_084032.1. NM_029756.3.
UniGeneiMm.171399.

3D structure databases

ProteinModelPortaliQ80UF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218334. 24 interactions.
IntActiQ80UF4. 25 interactions.
STRINGi10090.ENSMUSP00000027785.

PTM databases

PhosphoSiteiQ80UF4.

Proteomic databases

EPDiQ80UF4.
MaxQBiQ80UF4.
PaxDbiQ80UF4.
PRIDEiQ80UF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027785; ENSMUSP00000027785; ENSMUSG00000026504.
GeneIDi76816.
KEGGimmu:76816.
UCSCiuc007duj.2. mouse.

Organism-specific databases

CTDi10806.
MGIiMGI:1924066. Sdccag8.

Phylogenomic databases

eggNOGiENOG410IGC5. Eukaryota.
ENOG410XQMR. LUCA.
GeneTreeiENSGT00730000111198.
HOGENOMiHOG000133059.
HOVERGENiHBG056806.
InParanoidiQ80UF4.
KOiK16488.
OMAiILSQNIA.
OrthoDBiEOG7W6WK8.
PhylomeDBiQ80UF4.
TreeFamiTF325472.

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.

Miscellaneous databases

ChiTaRSiSdccag8. mouse.
NextBioi345883.
PROiQ80UF4.
SOURCEiSearch...

Gene expression databases

BgeeiQ80UF4.
CleanExiMM_SDCCAG8.
ExpressionAtlasiQ80UF4. baseline and differential.
GenevisibleiQ80UF4. MM.

Family and domain databases

InterProiIPR031887. SDCCAG8.
[Graphical view]
PANTHERiPTHR34343. PTHR34343. 1 hit.
PfamiPF15964. CCCAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the novel centrosome-associated protein CCCAP."
    Kenedy A.A., Cohen K.J., Loveys D.A., Kato G.J., Dang C.V.
    Gene 303:35-46(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head and Pituitary.
  3. "Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy."
    Otto E.A., Hurd T.W., Airik R., Chaki M., Zhou W., Stoetzel C., Patil S.B., Levy S., Ghosh A.K., Murga-Zamalloa C.A., van Reeuwijk J., Letteboer S.J., Sang L., Giles R.H., Liu Q., Coene K.L., Estrada-Cuzcano A., Collin R.W.
    , McLaughlin H.M., Held S., Kasanuki J.M., Ramaswami G., Conte J., Lopez I., Washburn J., Macdonald J., Hu J., Yamashita Y., Maher E.R., Guay-Woodford L.M., Neumann H.P., Obermuller N., Koenekoop R.K., Bergmann C., Bei X., Lewis R.A., Katsanis N., Lopes V., Williams D.S., Lyons R.H., Dang C.V., Brito D.A., Dias M.B., Zhang X., Cavalcoli J.D., Nurnberg G., Nurnberg P., Pierce E.A., Jackson P.K., Antignac C., Saunier S., Roepman R., Dollfus H., Khanna H., Hildebrandt F.
    Nat. Genet. 42:840-850(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSDCG8_MOUSE
AccessioniPrimary (citable) accession number: Q80UF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: April 13, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.