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Protein

Probable G-protein coupled receptor 139

Gene

Gpr139

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Seems to act through a G(q/11)-mediated pathway.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI
  • neuropeptide receptor activity Source: MGI
  • protein dimerization activity Source: MGI

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 139
Alternative name(s):
G(q)-coupled orphan receptor GPRg1
G-protein-coupled receptor PGR3
Gene namesi
Name:Gpr139
Synonyms:Gm495, Gprg1, Pgr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2685341. Gpr139.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence analysisAdd
BLAST
Transmembranei22 – 4221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini43 – 5715CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9416ExtracellularSequence analysisAdd
BLAST
Transmembranei95 – 11521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini116 – 14025CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini162 – 17312ExtracellularSequence analysisAdd
BLAST
Transmembranei174 – 19421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini195 – 22026CytoplasmicSequence analysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini242 – 26019ExtracellularSequence analysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini282 – 34564CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Probable G-protein coupled receptor 139PRO_0000069616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ80UC8.
PRIDEiQ80UC8.

Expressioni

Tissue specificityi

Expressed almost exclusively in the brain. Abundantly expressed in the ventrolateral region of caudate putamen, the habenular nucleus, the zona incerta, and the medial mammillary nucleus.1 Publication

Gene expression databases

BgeeiQ80UC8.
CleanExiMM_GPR139.

Interactioni

GO - Molecular functioni

  • protein dimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081700.

Structurei

3D structure databases

ProteinModelPortaliQ80UC8.
SMRiQ80UC8. Positions 9-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG081564.
InParanoidiQ80UC8.
KOiK08428.
OMAiRIAGNIC.
OrthoDBiEOG7XSTDW.
PhylomeDBiQ80UC8.
TreeFamiTF334275.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHTHAHLAA NSSACGLGFV PVVYYSFLLC LGLPANILTV IILSQLVARR
60 70 80 90 100
QKSSYNYLLA LAAADILVLF FIVFVDFLLE DFILTMQMPL IPDKIIEVLE
110 120 130 140 150
FSSIHTSIWI TVPLTVDRYI AVCHPLKYHT VSYPARTRKV ILSVYITCFL
160 170 180 190 200
TSIPYYWWPN IWTEDYISTS MHHVLVWIHC FTVYLVPCSI FFILNSIIVY
210 220 230 240 250
KLRRKSNFRL RGYSTGKTTA ILFTITSIFA TLWAPRIIMI LYHLYGAPIQ
260 270 280 290 300
NPWLVHIMLD VANMLALLNT AINFFLYCFI SKRFRTMAAA TLKALFKCQK
310 320 330 340
QPVQFYTNHN FSITSSPWIS PANSHCIKML VYQYDKHGKP IKVSP
Length:345
Mass (Da):39,758
Last modified:January 10, 2006 - v2
Checksum:i764D568B29EB6036
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196532 mRNA. Translation: BAD97443.1.
BC125496 mRNA. Translation: AAI25497.1.
BC125498 mRNA. Translation: AAI25499.1.
AY255548 mRNA. Translation: AAO85060.1.
CCDSiCCDS21778.1.
RefSeqiNP_001019309.1. NM_001024138.1.
UniGeneiMm.300632.

Genome annotation databases

EnsembliENSMUST00000084650; ENSMUSP00000081700; ENSMUSG00000066197.
GeneIDi209776.
KEGGimmu:209776.
UCSCiuc009jky.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196532 mRNA. Translation: BAD97443.1.
BC125496 mRNA. Translation: AAI25497.1.
BC125498 mRNA. Translation: AAI25499.1.
AY255548 mRNA. Translation: AAO85060.1.
CCDSiCCDS21778.1.
RefSeqiNP_001019309.1. NM_001024138.1.
UniGeneiMm.300632.

3D structure databases

ProteinModelPortaliQ80UC8.
SMRiQ80UC8. Positions 9-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081700.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ80UC8.
PRIDEiQ80UC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084650; ENSMUSP00000081700; ENSMUSG00000066197.
GeneIDi209776.
KEGGimmu:209776.
UCSCiuc009jky.1. mouse.

Organism-specific databases

CTDi124274.
MGIiMGI:2685341. Gpr139.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG081564.
InParanoidiQ80UC8.
KOiK08428.
OMAiRIAGNIC.
OrthoDBiEOG7XSTDW.
PhylomeDBiQ80UC8.
TreeFamiTF334275.

Miscellaneous databases

PROiQ80UC8.
SOURCEiSearch...

Gene expression databases

BgeeiQ80UC8.
CleanExiMM_GPR139.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system."
    Matsuo A., Matsumoto S., Nagano M., Masumoto K.H., Takasaki J., Matsumoto M., Kobori M., Katoh M., Shigeyoshi Y.
    Biochem. Biophys. Res. Commun. 331:363-369(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 218-271.

Entry informationi

Entry nameiGP139_MOUSE
AccessioniPrimary (citable) accession number: Q80UC8
Secondary accession number(s): Q059X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: July 6, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.