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Protein

Probable G-protein coupled receptor 62

Gene

Gpr62

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 62
Gene namesi
Name:Gpr62
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3525078. Gpr62.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717ExtracellularSequence analysisAdd
BLAST
Transmembranei18 – 3821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini39 – 5315CytoplasmicSequence analysisAdd
BLAST
Transmembranei54 – 7421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini75 – 8915ExtracellularSequence analysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini111 – 12818CytoplasmicSequence analysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini150 – 17627ExtracellularSequence analysisAdd
BLAST
Transmembranei177 – 19721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini198 – 23437CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini256 – 26813ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 35869CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Probable G-protein coupled receptor 62PRO_0000305584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ80UC6.
PRIDEiQ80UC6.

Expressioni

Gene expression databases

BgeeiQ80UC6.
CleanExiMM_GPR62.
GenevisibleiQ80UC6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129055.

Structurei

3D structure databases

ProteinModelPortaliQ80UC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi235 – 28147Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000110969.
HOVERGENiHBG051816.
InParanoidiQ80UC6.
KOiK08415.
OMAiVGQFAAC.
OrthoDBiEOG7WT42Z.
PhylomeDBiQ80UC6.
TreeFamiTF332667.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANGSGLSVT ELAGSVGFIL AVLVEVGAVL GNGTLLVVVL RTPDLQDAFY
60 70 80 90 100
LAHLCVVDLL AAASIMPLGL LAAPPGLGTV PLDPSSCRAA RFLSAALLPA
110 120 130 140 150
CTLGVAALGL ARYRLIVHPL RPGARPAPAL VLTAVWSAAA LLGALSLLGP
160 170 180 190 200
PPAPPPAPAR CSVLAGGLGP FRPLWAMLAF ALPALLLLAA YGSIFLVARR
210 220 230 240 250
AALRPPRGTR PRSDSLDSRL SFLPPLRPRL LGGKAALAPA LAVGQFAACW
260 270 280 290 300
LPYGCACLAP AARAAAAEAT VTWVAYSAFA AHPFLYGLLQ RPVRLALGRL
310 320 330 340 350
TRRALPRAPK ACTSQAWHLQ TLLRRLQELR KDPVLGPSEA PEQARELARQ

TPSVSEAT
Length:358
Mass (Da):37,148
Last modified:October 2, 2007 - v2
Checksum:i6FC222684565B5D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151729 Genomic DNA. No translation available.
AK016613 mRNA. Translation: BAC25490.1.
AY255551 mRNA. Translation: AAO85063.1.
CCDSiCCDS52909.1.
RefSeqiNP_001153124.1. NM_001159652.1.
XP_006511830.1. XM_006511767.2.
UniGeneiMm.482905.

Genome annotation databases

EnsembliENSMUST00000164834; ENSMUSP00000129055; ENSMUSG00000091735.
GeneIDi436090.
KEGGimmu:436090.
UCSCiuc012gzw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151729 Genomic DNA. No translation available.
AK016613 mRNA. Translation: BAC25490.1.
AY255551 mRNA. Translation: AAO85063.1.
CCDSiCCDS52909.1.
RefSeqiNP_001153124.1. NM_001159652.1.
XP_006511830.1. XM_006511767.2.
UniGeneiMm.482905.

3D structure databases

ProteinModelPortaliQ80UC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129055.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ80UC6.
PRIDEiQ80UC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164834; ENSMUSP00000129055; ENSMUSG00000091735.
GeneIDi436090.
KEGGimmu:436090.
UCSCiuc012gzw.1. mouse.

Organism-specific databases

CTDi118442.
MGIiMGI:3525078. Gpr62.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000110969.
HOVERGENiHBG051816.
InParanoidiQ80UC6.
KOiK08415.
OMAiVGQFAAC.
OrthoDBiEOG7WT42Z.
PhylomeDBiQ80UC6.
TreeFamiTF332667.

Miscellaneous databases

NextBioi410554.
PROiQ80UC6.
SOURCEiSearch...

Gene expression databases

BgeeiQ80UC6.
CleanExiMM_GPR62.
GenevisibleiQ80UC6. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-120.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 271-358.
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiGPR62_MOUSE
AccessioniPrimary (citable) accession number: Q80UC6
Secondary accession number(s): Q8CEQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 11, 2015
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.