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Protein

G-protein coupled receptor 62

Gene

Gpr62

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28912303). Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity).By similarity1 Publication

GO - Molecular functioni

  • arrestin family protein binding Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • identical protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 62
Gene namesi
Name:Gpr62
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:3525078 Gpr62

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17ExtracellularSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini39 – 53CytoplasmicSequence analysisAdd BLAST15
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 89ExtracellularSequence analysisAdd BLAST15
Transmembranei90 – 110Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini111 – 128CytoplasmicSequence analysisAdd BLAST18
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 176ExtracellularSequence analysisAdd BLAST27
Transmembranei177 – 197Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini198 – 234CytoplasmicSequence analysisAdd BLAST37
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 268ExtracellularSequence analysisAdd BLAST13
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 358CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Deficient mice show any abnormality in growth and behavior. Both male and female are fertile.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi111A → D: No effect on constitutive activity; No effect on protein level; Does not affect homooligomerization. 1 Publication1
Mutagenesisi232 – 237GGKAAL → KKAAKT: Stong decreases on constitutive activity; No effect on protein level; Does not affect homooligomerization. 1 Publication6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003055841 – 358G-protein coupled receptor 62Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ80UC6
PRIDEiQ80UC6

PTM databases

iPTMnetiQ80UC6
PhosphoSitePlusiQ80UC6
SwissPalmiQ80UC6

Expressioni

Tissue specificityi

Expressed in the brain and testes. Expressed widely, in the brain, including the cerebral cortex, cerebellum, hippocampus,thalamus and pituitary gland. In the testes, expressed specificaly in the germ cells.1 Publication

Developmental stagei

Expression in the testes starts 25 days after birth and continues thereafter.1 Publication

Gene expression databases

BgeeiENSMUSG00000091735
CleanExiMM_GPR62
GenevisibleiQ80UC6 MM

Interactioni

Subunit structurei

Homodimer (PubMed:28912303). Forms heterodimer with MTNR1B (By similarity). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR62 in the endosomal compartment (By similarity).By similarity1 Publication

GO - Molecular functioni

  • arrestin family protein binding Source: UniProtKB
  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129055

Structurei

3D structure databases

ProteinModelPortaliQ80UC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi235 – 281Ala-richAdd BLAST47

Domaini

Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity.1 Publication

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00730000110969
HOVERGENiHBG051816
InParanoidiQ80UC6
KOiK08415
OMAiVGQFAAC
OrthoDBiEOG091G0TJJ
PhylomeDBiQ80UC6
TreeFamiTF332667

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q80UC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANGSGLSVT ELAGSVGFIL AVLVEVGAVL GNGTLLVVVL RTPDLQDAFY
60 70 80 90 100
LAHLCVVDLL AAASIMPLGL LAAPPGLGTV PLDPSSCRAA RFLSAALLPA
110 120 130 140 150
CTLGVAALGL ARYRLIVHPL RPGARPAPAL VLTAVWSAAA LLGALSLLGP
160 170 180 190 200
PPAPPPAPAR CSVLAGGLGP FRPLWAMLAF ALPALLLLAA YGSIFLVARR
210 220 230 240 250
AALRPPRGTR PRSDSLDSRL SFLPPLRPRL LGGKAALAPA LAVGQFAACW
260 270 280 290 300
LPYGCACLAP AARAAAAEAT VTWVAYSAFA AHPFLYGLLQ RPVRLALGRL
310 320 330 340 350
TRRALPRAPK ACTSQAWHLQ TLLRRLQELR KDPVLGPSEA PEQARELARQ

TPSVSEAT
Length:358
Mass (Da):37,148
Last modified:October 2, 2007 - v2
Checksum:i6FC222684565B5D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151729 Genomic DNA No translation available.
AK016613 mRNA Translation: BAC25490.1
AY255551 mRNA Translation: AAO85063.1
CCDSiCCDS52909.1
RefSeqiNP_001153124.1, NM_001159652.1
XP_006511830.1, XM_006511767.3
UniGeneiMm.482905

Genome annotation databases

EnsembliENSMUST00000164834; ENSMUSP00000129055; ENSMUSG00000091735
GeneIDi436090
KEGGimmu:436090
UCSCiuc012gzw.1 mouse

Entry informationi

Entry nameiGPR62_MOUSE
AccessioniPrimary (citable) accession number: Q80UC6
Secondary accession number(s): Q8CEQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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