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Q80UA9

- INSI2_RAT

UniProt

Q80UA9 - INSI2_RAT

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Protein
Insulin-induced gene 2 protein
Gene
Insig2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR By similarity.

GO - Molecular functioni

  1. transcription factor binding Source: RGD
Complete GO annotation...

GO - Biological processi

  1. SREBP signaling pathway Source: Ensembl
  2. cholesterol biosynthetic process Source: Ensembl
  3. cranial suture morphogenesis Source: Ensembl
  4. inner ear morphogenesis Source: Ensembl
  5. middle ear morphogenesis Source: Ensembl
  6. negative regulation of fatty acid biosynthetic process Source: Ensembl
  7. negative regulation of steroid biosynthetic process Source: Ensembl
  8. palate development Source: Ensembl
  9. response to fatty acid Source: RGD
  10. response to insulin Source: RGD
  11. response to lipid Source: RGD
  12. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Enzyme and pathway databases

ReactomeiREACT_198603. Regulation of cholesterol biosynthesis by SREBP (SREBF).

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-induced gene 2 protein
Short name:
INSIG-2
Gene namesi
Name:Insig2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi631417. Insig2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Reviewed prediction
Add
BLAST
Transmembranei71 – 9121Helical; Reviewed prediction
Add
BLAST
Transmembranei131 – 14818Helical; Reviewed prediction
Add
BLAST
Transmembranei154 – 17421Helical; Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. SREBP-SCAP-Insig complex Source: Ensembl
  2. endoplasmic reticulum Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Insulin-induced gene 2 protein
PRO_0000286801Add
BLAST

Proteomic databases

PRIDEiQ80UA9.

PTM databases

PhosphoSiteiQ80UA9.

Expressioni

Gene expression databases

GenevestigatoriQ80UA9.

Interactioni

Subunit structurei

Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003391.

Family & Domainsi

Sequence similaritiesi

Belongs to the INSIG family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263628.
GeneTreeiENSGT00580000081600.
HOGENOMiHOG000253021.
HOVERGENiHBG058958.
InParanoidiQ80UA9.
OMAiHRFKREW.
OrthoDBiEOG7RNK13.
PhylomeDBiQ80UA9.
TreeFamiTF331013.

Family and domain databases

InterProiIPR025929. INSIG_fam.
[Graphical view]
PfamiPF07281. INSIG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80UA9-1 [UniParc]FASTAAdd to Basket

« Hide

MAEGETESPR PKKRGPYISS VTSQSVNVVI RGVVLFFIGV FLALVLNLLQ    50
IQRNVTLFPP DVITSIFSSA WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK 100
FKREWSSVMR CVAVFVGINH ASAKVDFDNN FQFSLTLAAL SVGLWWTFDR 150
SRSGFGLGVG IAFLATVVTQ LLVYNGVYQY TSPDFLYVRS WLPCIFFAGG 200
ITMGNIGRQL AMYECKVIAE KSHQE 225
Length:225
Mass (Da):24,968
Last modified:June 1, 2003 - v1
Checksum:i534E933526CB2195
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY152392 mRNA. Translation: AAN78347.1.
BC085682 mRNA. Translation: AAH85682.1.
RefSeqiNP_835192.1. NM_178091.4.
XP_006249729.1. XM_006249667.1.
XP_006249730.1. XM_006249668.1.
XP_006249731.1. XM_006249669.1.
UniGeneiRn.16736.
Rn.217040.

Genome annotation databases

EnsembliENSRNOT00000003391; ENSRNOP00000003391; ENSRNOG00000002478.
GeneIDi288985.
KEGGirno:288985.
UCSCiRGD:631417. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY152392 mRNA. Translation: AAN78347.1 .
BC085682 mRNA. Translation: AAH85682.1 .
RefSeqi NP_835192.1. NM_178091.4.
XP_006249729.1. XM_006249667.1.
XP_006249730.1. XM_006249668.1.
XP_006249731.1. XM_006249669.1.
UniGenei Rn.16736.
Rn.217040.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000003391.

PTM databases

PhosphoSitei Q80UA9.

Proteomic databases

PRIDEi Q80UA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000003391 ; ENSRNOP00000003391 ; ENSRNOG00000002478 .
GeneIDi 288985.
KEGGi rno:288985.
UCSCi RGD:631417. rat.

Organism-specific databases

CTDi 51141.
RGDi 631417. Insig2.

Phylogenomic databases

eggNOGi NOG263628.
GeneTreei ENSGT00580000081600.
HOGENOMi HOG000253021.
HOVERGENi HBG058958.
InParanoidi Q80UA9.
OMAi HRFKREW.
OrthoDBi EOG7RNK13.
PhylomeDBi Q80UA9.
TreeFami TF331013.

Enzyme and pathway databases

Reactomei REACT_198603. Regulation of cholesterol biosynthesis by SREBP (SREBF).

Miscellaneous databases

NextBioi 629044.
PROi Q80UA9.

Gene expression databases

Genevestigatori Q80UA9.

Family and domain databases

InterProi IPR025929. INSIG_fam.
[Graphical view ]
Pfami PF07281. INSIG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis."
    Yabe D., Komuro R., Liang G., Goldstein J.L., Brown M.S.
    Proc. Natl. Acad. Sci. U.S.A. 100:3155-3160(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiINSI2_RAT
AccessioniPrimary (citable) accession number: Q80UA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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