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Q80U93

- NU214_MOUSE

UniProt

Q80U93 - NU214_MOUSE

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Protein
Nuclear pore complex protein Nup214
Gene
Nup214, Kiaa0023
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex By similarity.

GO - Molecular functioni

  1. nucleocytoplasmic transporter activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. mRNA export from nucleus Source: MGI
  2. protein export from nucleus Source: Ensembl
  3. protein import into nucleus Source: MGI
  4. regulation of cell cycle Source: MGI
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_198691. HuR stabilizes mRNA.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup214
Alternative name(s):
214 kDa nucleoporin
Nucleoporin Nup214
Gene namesi
Name:Nup214
Synonyms:Kiaa0023
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1095411. Nup214.

Subcellular locationi

Nucleusnuclear pore complex By similarity
Note: Cytoplasmic filaments By similarity.

GO - Cellular componenti

  1. nuclear pore Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 20852084Nuclear pore complex protein Nup214
PRO_0000345014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine By similarity
Modified residuei430 – 4301Phosphoserine By similarity
Modified residuei433 – 4331Phosphoserine By similarity
Modified residuei437 – 4371Phosphothreonine By similarity
Modified residuei645 – 6451Phosphoserine By similarity
Modified residuei651 – 6511Phosphoserine By similarity
Modified residuei660 – 6601Phosphoserine By similarity
Modified residuei672 – 6721Phosphoserine By similarity
Modified residuei930 – 9301Phosphoserine1 Publication
Modified residuei960 – 9601Phosphoserine By similarity
Modified residuei964 – 9641Phosphoserine By similarity
Modified residuei979 – 9791Phosphoserine By similarity
Modified residuei1029 – 10291Phosphoserine By similarity
Modified residuei1051 – 10511Phosphoserine By similarity
Modified residuei1139 – 11391Phosphoserine1 Publication
Modified residuei1156 – 11561Phosphothreonine By similarity
Modified residuei1162 – 11621Phosphothreonine By similarity
Modified residuei1187 – 11871Phosphoserine By similarity
Modified residuei1324 – 13241Phosphothreonine By similarity
Modified residuei1980 – 19801Phosphoserine By similarity

Post-translational modificationi

Probably glycosylated as it reacts with wheat germ agglutinin (WGA) By similarity.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ80U93.
PaxDbiQ80U93.
PRIDEiQ80U93.

PTM databases

PhosphoSiteiQ80U93.

Expressioni

Gene expression databases

ArrayExpressiQ80U93.
BgeeiQ80U93.
GenevestigatoriQ80U93.

Interactioni

Subunit structurei

Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5 By similarity.

Protein-protein interaction databases

BioGridi230673. 11 interactions.
IntActiQ80U93. 8 interactions.
STRINGi10090.ENSMUSP00000066492.

Structurei

3D structure databases

ProteinModelPortaliQ80U93.
SMRiQ80U93. Positions 1-433.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 9353Blade 1 By similarity
Add
BLAST
Repeati94 – 15057Blade 2 By similarity
Add
BLAST
Repeati151 – 19343Blade 3 By similarity
Add
BLAST
Repeati194 – 23946Blade 4 By similarity
Add
BLAST
Repeati240 – 30364Blade 5 By similarity
Add
BLAST
Repeati304 – 35956Blade 6 By similarity
Add
BLAST
Repeati360 – 40445Blade 7 By similarity
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 404364Seven-bladed beta propeller By similarity
Add
BLAST
Regioni479 – 2071159311 X 5 AA approximate repeats
Add
BLAST
Regioni734 – 76229Leucine-zipper 1
Add
BLAST
Regioni855 – 87622Leucine-zipper 2
Add
BLAST
Regioni1421 – 207965918 X 4 AA approximate repeats
Add
BLAST
Regioni1439 – 208064211 X 3 AA approximate repeats
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili674 – 1217544 By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1221 – 2085865Pro/Ser/Thr-rich
Add
BLAST

Domaini

Contains FG repeats.
The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B By similarity.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000111045.
HOGENOMiHOG000113878.
HOVERGENiHBG052683.
InParanoidiQ80U93.
KOiK14317.
OMAiNERNRDS.
OrthoDBiEOG7V765H.
PhylomeDBiQ80U93.
TreeFamiTF323517.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80U93-1 [UniParc]FASTAAdd to Basket

« Hide

MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS VLTISNKYGM     50
LFAGGTNGLN VFPTKSLLIQ NKPGDDPNKI VDTIQGLNVP MKFPVHHLAL 100
SCDSLTLSAC MMSSEYGSII AFFDVRTFSN QAKPLKRPFT YHKVSNDASG 150
MVNDMKWNPT VPSMVAVCLA DGSISVLQVT DVVKVCATLP PSTGVTCVCW 200
SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP VRVLDVLWIG 250
TYVFTIVYAG ADGTLETCPD VVMALLPKKE EKHPEIFVNF MEPCYSSCTE 300
RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQNDQTNWES WLLEDSSRAE 350
LPVTDKSDDS LPMGVAIDYT NEVEVTINEE KTLPPAPVLL LLSTDGVLCP 400
FYMINQNPGV RSLIKTLELI STEGERQPKS SGSFPGTPSS PQAPQNLDAP 450
ATASSPLPPV SAAPTSTFPM PSAAGSPSVF SFGPSSFKSS ASVTGEPPLY 500
PTGSDSSRAA PGSGTSTFSF APPSKGSLAS TPAVAPVATS AAPFTFGFKP 550
TLESTPMSST PNTGMKPSFP PSASSVKVNL NEKFTAVASS APVHSSTSTP 600
SVLPFSSSPK PTASGPLSHP TPLPASSSSM PLKSSVSPSP AAGRSTQTAP 650
SSAPSTGQKS PRVNPPVPKS GSSQAKALQP PVTEKQRPQW KDSDPVLAGI 700
GEEIAHFQKE LEELKARTAK ACLQVGTSEE MKMLRTESDD LHTFLFEIRE 750
TTESLHGDIS TLKTTLLEGF AGVEEAREQH GRNHDSGYLH LLYKRPLDPK 800
SEAQLQEIRR LHQYVKFAVQ DVNDVLDLEW DRHLEQKKRQ RRLIVPERET 850
LFNTLANNRE IINQQRKRLN QLVDSLQQLR LYNHTAPWSL PSALSTQSNS 900
HSFDSDLECL LKTTIESHTK PSPRVPGKLS PAKQAQLRNF LAKRKTPPVR 950
STAPASLSRS AFLSQRYYED LDEGSSASSV AQPLEGEDAR PTCTSVAQPL 1000
EGEDAQPICK EEEAVVPVPR HAPVVRTPSI QPSLLPQSMP FAKPHLIHSS 1050
SPAVMSSAVS TSATKVIPQG ADSTMLATKT VKHGAPGPSH TVAAPQAAAA 1100
AALRRQMASQ APAMSTLTES TLKTVPQVVN VQELRSNPSP PSAAMGSAVQ 1150
HSAAKTPHAV LTPVANSQAK QGSLINSFKP SGPTAASCQL SSGDKAVGQG 1200
TAKTESAATS TPSAAGQLNK PFSFASPGTF TFGTITPTPS SSFTATPGAG 1250
PPTKEPTQLE AFSFGGGGKP FSEAIPGNSP ATGATSAPST SVTAASLEDS 1300
APSSSKPAAP PETTVSSASS KLETPPSKLG ELLFPSSLAG ETLGSFSGLR 1350
VGQAEDSTKP VSKASSTNLA GAQPAKPSGV SFPNTSVLGK PVEPAVTSSV 1400
SPAPAAPASA LNVSTSSSSA TVFGSVPLTS AGPPGLISFG GAALASSKAS 1450
FSFGNQQTSS STASSATPTS TSVAPSLPAS FPTLSFGGLL SSPSASSLPV 1500
SSGKSTEEAA PPAVPDKSDS SEVSATTPSL PVQPQSTQAS LQTSDPVKKE 1550
PVLVQTTDSS PSRPASSASF VASTESMPVT LGAPDSKIEA VSPASTFAGP 1600
GQAAVATAVL PGAGSAATEA SGTPTTSTVS SSSPTSATET AVFGTATSGS 1650
SVFTQPPAAS SSSAFSQLSS NTATAPSATP VFGQVAASIT STAAATPQAS 1700
SSGFGSPAFG ASAPGVFGQT AFGQTPAFGQ ATSSPASGFS FSQPGFSSVP 1750
AFGQSVSSTP ASTSANVFGA TSSTSSPGSF SFGQASTNTG GTLFGQNNPP 1800
AFGQSPGFGQ GSSVFGGTSA TTSTAAPSGF SFCQASGFGS SNTGSVFGQA 1850
ANTGGSVFGQ SSTSSGGVFG SGNATRGGGF FSGLGGKPSQ DAANKNPFSS 1900
AGGGFGSTAA PNTSNLFGNS GAKTFGGFGS SSFGEQKPAG TFSSGGGSVA 1950
SQGFGFSTPN KTGGFGAAPV FGSPPTFGGS PGFGGVPAFG SAPAFTSPLG 2000
STGGKVFGEG TAAASAGGFG FGSSGNTASF GTLASQNAPT FGSLSQQTSG 2050
FGTPSSGFAG FGSGTGAFTF GSSNSSVQGF GGWRS 2085
Length:2,085
Mass (Da):212,979
Last modified:July 22, 2008 - v2
Checksum:iC9998CC8BC27EE4A
GO

Sequence cautioni

The sequence BAC65471.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1973 – 19731S → G in BAC65471. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122189 mRNA. Translation: BAC65471.1. Different initiation.
AL928893 Genomic DNA. Translation: CAM26045.1.
CCDSiCCDS38098.1.
RefSeqiNP_758472.2. NM_172268.2.
UniGeneiMm.289686.

Genome annotation databases

EnsembliENSMUST00000065398; ENSMUSP00000066492; ENSMUSG00000001855.
GeneIDi227720.
KEGGimmu:227720.
UCSCiuc008jeh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122189 mRNA. Translation: BAC65471.1 . Different initiation.
AL928893 Genomic DNA. Translation: CAM26045.1 .
CCDSi CCDS38098.1.
RefSeqi NP_758472.2. NM_172268.2.
UniGenei Mm.289686.

3D structure databases

ProteinModelPortali Q80U93.
SMRi Q80U93. Positions 1-433.
ModBasei Search...

Protein-protein interaction databases

BioGridi 230673. 11 interactions.
IntActi Q80U93. 8 interactions.
STRINGi 10090.ENSMUSP00000066492.

PTM databases

PhosphoSitei Q80U93.

Proteomic databases

MaxQBi Q80U93.
PaxDbi Q80U93.
PRIDEi Q80U93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065398 ; ENSMUSP00000066492 ; ENSMUSG00000001855 .
GeneIDi 227720.
KEGGi mmu:227720.
UCSCi uc008jeh.1. mouse.

Organism-specific databases

CTDi 8021.
MGIi MGI:1095411. Nup214.
Rougei Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000111045.
HOGENOMi HOG000113878.
HOVERGENi HBG052683.
InParanoidi Q80U93.
KOi K14317.
OMAi NERNRDS.
OrthoDBi EOG7V765H.
PhylomeDBi Q80U93.
TreeFami TF323517.

Enzyme and pathway databases

Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_198691. HuR stabilizes mRNA.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

Miscellaneous databases

ChiTaRSi NUP214. mouse.
NextBioi 378784.
PROi Q80U93.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80U93.
Bgeei Q80U93.
Genevestigatori Q80U93.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930 AND SER-1139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNU214_MOUSE
AccessioniPrimary (citable) accession number: Q80U93
Secondary accession number(s): A2ATN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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