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Q80U93

- NU214_MOUSE

UniProt

Q80U93 - NU214_MOUSE

Protein

Nuclear pore complex protein Nup214

Gene

Nup214

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.By similarity

    GO - Molecular functioni

    1. nucleocytoplasmic transporter activity Source: MGI

    GO - Biological processi

    1. mRNA export from nucleus Source: MGI
    2. protein export from nucleus Source: Ensembl
    3. protein import into nucleus Source: MGI
    4. regulation of cell cycle Source: MGI

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_198691. HuR stabilizes mRNA.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear pore complex protein Nup214
    Alternative name(s):
    214 kDa nucleoporin
    Nucleoporin Nup214
    Gene namesi
    Name:Nup214
    Synonyms:Kiaa0023
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1095411. Nup214.

    Subcellular locationi

    Nucleusnuclear pore complex By similarity
    Note: Cytoplasmic filaments.By similarity

    GO - Cellular componenti

    1. nuclear pore Source: MGI

    Keywords - Cellular componenti

    Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 20852084Nuclear pore complex protein Nup214PRO_0000345014Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity
    Modified residuei430 – 4301PhosphoserineBy similarity
    Modified residuei433 – 4331PhosphoserineBy similarity
    Modified residuei437 – 4371PhosphothreonineBy similarity
    Modified residuei645 – 6451PhosphoserineBy similarity
    Modified residuei651 – 6511PhosphoserineBy similarity
    Modified residuei660 – 6601PhosphoserineBy similarity
    Modified residuei672 – 6721PhosphoserineBy similarity
    Modified residuei930 – 9301Phosphoserine1 Publication
    Modified residuei960 – 9601PhosphoserineBy similarity
    Modified residuei964 – 9641PhosphoserineBy similarity
    Modified residuei979 – 9791PhosphoserineBy similarity
    Modified residuei1029 – 10291PhosphoserineBy similarity
    Modified residuei1051 – 10511PhosphoserineBy similarity
    Modified residuei1139 – 11391Phosphoserine1 Publication
    Modified residuei1156 – 11561PhosphothreonineBy similarity
    Modified residuei1162 – 11621PhosphothreonineBy similarity
    Modified residuei1187 – 11871PhosphoserineBy similarity
    Modified residuei1324 – 13241PhosphothreonineBy similarity
    Modified residuei1980 – 19801PhosphoserineBy similarity

    Post-translational modificationi

    Probably glycosylated as it reacts with wheat germ agglutinin (WGA).By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ80U93.
    PaxDbiQ80U93.
    PRIDEiQ80U93.

    PTM databases

    PhosphoSiteiQ80U93.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80U93.
    BgeeiQ80U93.
    GenevestigatoriQ80U93.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with DDX19, NUP88, XPO1 and XPO5 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi230673. 11 interactions.
    IntActiQ80U93. 8 interactions.
    STRINGi10090.ENSMUSP00000066492.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80U93.
    SMRiQ80U93. Positions 1-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati41 – 9353Blade 1By similarityAdd
    BLAST
    Repeati94 – 15057Blade 2By similarityAdd
    BLAST
    Repeati151 – 19343Blade 3By similarityAdd
    BLAST
    Repeati194 – 23946Blade 4By similarityAdd
    BLAST
    Repeati240 – 30364Blade 5By similarityAdd
    BLAST
    Repeati304 – 35956Blade 6By similarityAdd
    BLAST
    Repeati360 – 40445Blade 7By similarityAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni41 – 404364Seven-bladed beta propellerBy similarityAdd
    BLAST
    Regioni479 – 2071159311 X 5 AA approximate repeatsAdd
    BLAST
    Regioni734 – 76229Leucine-zipper 1Add
    BLAST
    Regioni855 – 87622Leucine-zipper 2Add
    BLAST
    Regioni1421 – 207965918 X 4 AA approximate repeatsAdd
    BLAST
    Regioni1439 – 208064211 X 3 AA approximate repeatsAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili674 – 1217544By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1221 – 2085865Pro/Ser/Thr-richAdd
    BLAST

    Domaini

    Contains FG repeats.
    The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B.By similarity

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00730000111045.
    HOGENOMiHOG000113878.
    HOVERGENiHBG052683.
    InParanoidiQ80U93.
    KOiK14317.
    OMAiNERNRDS.
    OrthoDBiEOG7V765H.
    PhylomeDBiQ80U93.
    TreeFamiTF323517.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q80U93-1 [UniParc]FASTAAdd to Basket

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    MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS VLTISNKYGM     50
    LFAGGTNGLN VFPTKSLLIQ NKPGDDPNKI VDTIQGLNVP MKFPVHHLAL 100
    SCDSLTLSAC MMSSEYGSII AFFDVRTFSN QAKPLKRPFT YHKVSNDASG 150
    MVNDMKWNPT VPSMVAVCLA DGSISVLQVT DVVKVCATLP PSTGVTCVCW 200
    SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP VRVLDVLWIG 250
    TYVFTIVYAG ADGTLETCPD VVMALLPKKE EKHPEIFVNF MEPCYSSCTE 300
    RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQNDQTNWES WLLEDSSRAE 350
    LPVTDKSDDS LPMGVAIDYT NEVEVTINEE KTLPPAPVLL LLSTDGVLCP 400
    FYMINQNPGV RSLIKTLELI STEGERQPKS SGSFPGTPSS PQAPQNLDAP 450
    ATASSPLPPV SAAPTSTFPM PSAAGSPSVF SFGPSSFKSS ASVTGEPPLY 500
    PTGSDSSRAA PGSGTSTFSF APPSKGSLAS TPAVAPVATS AAPFTFGFKP 550
    TLESTPMSST PNTGMKPSFP PSASSVKVNL NEKFTAVASS APVHSSTSTP 600
    SVLPFSSSPK PTASGPLSHP TPLPASSSSM PLKSSVSPSP AAGRSTQTAP 650
    SSAPSTGQKS PRVNPPVPKS GSSQAKALQP PVTEKQRPQW KDSDPVLAGI 700
    GEEIAHFQKE LEELKARTAK ACLQVGTSEE MKMLRTESDD LHTFLFEIRE 750
    TTESLHGDIS TLKTTLLEGF AGVEEAREQH GRNHDSGYLH LLYKRPLDPK 800
    SEAQLQEIRR LHQYVKFAVQ DVNDVLDLEW DRHLEQKKRQ RRLIVPERET 850
    LFNTLANNRE IINQQRKRLN QLVDSLQQLR LYNHTAPWSL PSALSTQSNS 900
    HSFDSDLECL LKTTIESHTK PSPRVPGKLS PAKQAQLRNF LAKRKTPPVR 950
    STAPASLSRS AFLSQRYYED LDEGSSASSV AQPLEGEDAR PTCTSVAQPL 1000
    EGEDAQPICK EEEAVVPVPR HAPVVRTPSI QPSLLPQSMP FAKPHLIHSS 1050
    SPAVMSSAVS TSATKVIPQG ADSTMLATKT VKHGAPGPSH TVAAPQAAAA 1100
    AALRRQMASQ APAMSTLTES TLKTVPQVVN VQELRSNPSP PSAAMGSAVQ 1150
    HSAAKTPHAV LTPVANSQAK QGSLINSFKP SGPTAASCQL SSGDKAVGQG 1200
    TAKTESAATS TPSAAGQLNK PFSFASPGTF TFGTITPTPS SSFTATPGAG 1250
    PPTKEPTQLE AFSFGGGGKP FSEAIPGNSP ATGATSAPST SVTAASLEDS 1300
    APSSSKPAAP PETTVSSASS KLETPPSKLG ELLFPSSLAG ETLGSFSGLR 1350
    VGQAEDSTKP VSKASSTNLA GAQPAKPSGV SFPNTSVLGK PVEPAVTSSV 1400
    SPAPAAPASA LNVSTSSSSA TVFGSVPLTS AGPPGLISFG GAALASSKAS 1450
    FSFGNQQTSS STASSATPTS TSVAPSLPAS FPTLSFGGLL SSPSASSLPV 1500
    SSGKSTEEAA PPAVPDKSDS SEVSATTPSL PVQPQSTQAS LQTSDPVKKE 1550
    PVLVQTTDSS PSRPASSASF VASTESMPVT LGAPDSKIEA VSPASTFAGP 1600
    GQAAVATAVL PGAGSAATEA SGTPTTSTVS SSSPTSATET AVFGTATSGS 1650
    SVFTQPPAAS SSSAFSQLSS NTATAPSATP VFGQVAASIT STAAATPQAS 1700
    SSGFGSPAFG ASAPGVFGQT AFGQTPAFGQ ATSSPASGFS FSQPGFSSVP 1750
    AFGQSVSSTP ASTSANVFGA TSSTSSPGSF SFGQASTNTG GTLFGQNNPP 1800
    AFGQSPGFGQ GSSVFGGTSA TTSTAAPSGF SFCQASGFGS SNTGSVFGQA 1850
    ANTGGSVFGQ SSTSSGGVFG SGNATRGGGF FSGLGGKPSQ DAANKNPFSS 1900
    AGGGFGSTAA PNTSNLFGNS GAKTFGGFGS SSFGEQKPAG TFSSGGGSVA 1950
    SQGFGFSTPN KTGGFGAAPV FGSPPTFGGS PGFGGVPAFG SAPAFTSPLG 2000
    STGGKVFGEG TAAASAGGFG FGSSGNTASF GTLASQNAPT FGSLSQQTSG 2050
    FGTPSSGFAG FGSGTGAFTF GSSNSSVQGF GGWRS 2085
    Length:2,085
    Mass (Da):212,979
    Last modified:July 22, 2008 - v2
    Checksum:iC9998CC8BC27EE4A
    GO

    Sequence cautioni

    The sequence BAC65471.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1973 – 19731S → G in BAC65471. (PubMed:12693553)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122189 mRNA. Translation: BAC65471.1. Different initiation.
    AL928893 Genomic DNA. Translation: CAM26045.1.
    CCDSiCCDS38098.1.
    RefSeqiNP_758472.2. NM_172268.2.
    UniGeneiMm.289686.

    Genome annotation databases

    EnsembliENSMUST00000065398; ENSMUSP00000066492; ENSMUSG00000001855.
    GeneIDi227720.
    KEGGimmu:227720.
    UCSCiuc008jeh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122189 mRNA. Translation: BAC65471.1 . Different initiation.
    AL928893 Genomic DNA. Translation: CAM26045.1 .
    CCDSi CCDS38098.1.
    RefSeqi NP_758472.2. NM_172268.2.
    UniGenei Mm.289686.

    3D structure databases

    ProteinModelPortali Q80U93.
    SMRi Q80U93. Positions 1-433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230673. 11 interactions.
    IntActi Q80U93. 8 interactions.
    STRINGi 10090.ENSMUSP00000066492.

    PTM databases

    PhosphoSitei Q80U93.

    Proteomic databases

    MaxQBi Q80U93.
    PaxDbi Q80U93.
    PRIDEi Q80U93.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000065398 ; ENSMUSP00000066492 ; ENSMUSG00000001855 .
    GeneIDi 227720.
    KEGGi mmu:227720.
    UCSCi uc008jeh.1. mouse.

    Organism-specific databases

    CTDi 8021.
    MGIi MGI:1095411. Nup214.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00730000111045.
    HOGENOMi HOG000113878.
    HOVERGENi HBG052683.
    InParanoidi Q80U93.
    KOi K14317.
    OMAi NERNRDS.
    OrthoDBi EOG7V765H.
    PhylomeDBi Q80U93.
    TreeFami TF323517.

    Enzyme and pathway databases

    Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_198691. HuR stabilizes mRNA.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.

    Miscellaneous databases

    ChiTaRSi NUP214. mouse.
    NextBioi 378784.
    PROi Q80U93.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80U93.
    Bgeei Q80U93.
    Genevestigatori Q80U93.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930 AND SER-1139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNU214_MOUSE
    AccessioniPrimary (citable) accession number: Q80U93
    Secondary accession number(s): A2ATN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3