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Protein

Protein scribble homolog

Gene

Scrib

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.4 Publications

GO - Biological processi

  • activation of GTPase activity Source: UniProtKB
  • apoptotic process involved in morphogenesis Source: UniProtKB
  • astrocyte cell migration Source: Ensembl
  • asymmetric protein localization Source: MGI
  • auditory receptor cell morphogenesis Source: MGI
  • auditory receptor cell stereocilium organization Source: MGI
  • cell migration Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • cochlear nucleus development Source: MGI
  • establishment of apical/basal cell polarity Source: UniProtKB
  • mammary gland duct morphogenesis Source: UniProtKB
  • morphogenesis of embryonic epithelium Source: MGI
  • negative regulation of mitotic cell cycle Source: UniProtKB
  • neural tube closure Source: MGI
  • positive chemotaxis Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of receptor recycling Source: MGI
  • protein localization to adherens junction Source: MGI
  • single organismal cell-cell adhesion Source: UniProtKB
  • synaptic vesicle endocytosis Source: UniProtKB
  • synaptic vesicle targeting Source: UniProtKB
  • Wnt signaling pathway, planar cell polarity pathway Source: Reactome
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-4608870. Asymmetric localization of PCP proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein scribble homolog
Short name:
Scribble
Alternative name(s):
Protein LAP4
Gene namesi
Name:Scrib
Synonyms:Kiaa0147, Lap4, Scrib1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2145950. Scrib.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16121612Protein scribble homologPRO_0000188304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371PhosphoserineBy similarity
Modified residuei378 – 3781PhosphothreonineBy similarity
Modified residuei475 – 4751PhosphothreonineBy similarity
Modified residuei583 – 5831PhosphoserineCombined sources
Modified residuei674 – 6741PhosphothreonineCombined sources
Modified residuei675 – 6751PhosphothreonineCombined sources
Modified residuei694 – 6941PhosphoserineBy similarity
Modified residuei750 – 7501PhosphoserineBy similarity
Modified residuei812 – 8121PhosphothreonineBy similarity
Modified residuei821 – 8211PhosphoserineBy similarity
Modified residuei861 – 8611PhosphoserineBy similarity
Modified residuei925 – 9251PhosphoserineCombined sources
Modified residuei1126 – 11261PhosphoserineBy similarity
Modified residuei1206 – 12061PhosphoserineCombined sources
Modified residuei1209 – 12091PhosphoserineBy similarity
Modified residuei1212 – 12121PhosphoserineBy similarity
Modified residuei1218 – 12181PhosphoserineBy similarity
Modified residuei1262 – 12621PhosphoserineBy similarity
Modified residuei1265 – 12651PhosphoserineBy similarity
Modified residuei1284 – 12841PhosphoserineBy similarity
Modified residuei1292 – 12921PhosphoserineCombined sources
Modified residuei1325 – 13251PhosphothreonineBy similarity
Modified residuei1331 – 13311PhosphoserineBy similarity
Modified residuei1361 – 13611PhosphoserineCombined sources
Modified residuei1427 – 14271PhosphoserineBy similarity
Modified residuei1430 – 14301PhosphoserineBy similarity
Modified residuei1457 – 14571PhosphoserineCombined sources
Modified residuei1468 – 14681PhosphoserineBy similarity
Modified residuei1490 – 14901PhosphoserineCombined sources
Modified residuei1523 – 15231PhosphoserineBy similarity
Modified residuei1527 – 15271PhosphothreonineBy similarity
Modified residuei1529 – 15291PhosphoserineCombined sources
Modified residuei1543 – 15431PhosphoserineCombined sources
Modified residuei1548 – 15481PhosphoserineCombined sources
Isoform 4 (identifier: Q80U72-4)
Modified residuei1299 – 12991PhosphoserineCombined sources
Isoform 3 (identifier: Q80U72-3)
Modified residuei1320 – 13201PhosphoserineCombined sources

Post-translational modificationi

Ubiquitinated; targeted for UBE3A-dependent multiubiquitination and degraded.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ80U72.
PaxDbiQ80U72.
PeptideAtlasiQ80U72.
PRIDEiQ80U72.

PTM databases

iPTMnetiQ80U72.
PhosphoSiteiQ80U72.
SwissPalmiQ80U72.

Expressioni

Tissue specificityi

Found in a wide range of tissues including liver, brain, kidney and spleen.1 Publication

Developmental stagei

First detected at E7.5 in the neuroepithelium at the time of initial neural tube closure. Also expressed in cranial mesenchyme, branchial arches, somitic mesoderm and lateral mesoderm. At later stages it is expressed in the eyelid epithelium, submandibular glands, whisker and hair follicles, sympathetic glanglia, inner ear, thymus, testis, kidney, esophagus, lung, stomach, trigeminal and dorsal root glanglia.1 Publication

Gene expression databases

BgeeiENSMUSG00000022568.
CleanExiMM_SCRIB.
ExpressionAtlasiQ80U72. baseline and differential.
GenevisibleiQ80U72. MM.

Interactioni

Subunit structurei

Interacts with UBE3A. Interacts with PAK1 and PAK2. Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct. Interacts (via PDZ domains) with TJP2. Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function (By similarity). Interacts (via PDZ domains) with VANGL2. Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7. Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells. Interacts with CTNNB1 and MAPK12. Interacts (via PDZ domains 1 and 3) with MCC (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CrtamQ149L74EBI-1766028,EBI-1766072
PHLPP1O603462EBI-1766028,EBI-2511516From a different organism.

Protein-protein interaction databases

BioGridi222921. 2 interactions.
DIPiDIP-40660N.
IntActiQ80U72. 7 interactions.
MINTiMINT-4120321.
STRINGi10090.ENSMUSP00000002603.

Structurei

3D structure databases

ProteinModelPortaliQ80U72.
SMRiQ80U72. Positions 704-800, 846-937, 1084-1185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati37 – 5822LRR 1Add
BLAST
Repeati60 – 8122LRR 2Add
BLAST
Repeati83 – 10422LRR 3Add
BLAST
Repeati106 – 12722LRR 4Add
BLAST
Repeati129 – 15022LRR 5Add
BLAST
Repeati152 – 17423LRR 6Add
BLAST
Repeati175 – 19723LRR 7Add
BLAST
Repeati198 – 21922LRR 8Add
BLAST
Repeati221 – 24323LRR 9Add
BLAST
Repeati244 – 26522LRR 10Add
BLAST
Repeati267 – 28822LRR 11Add
BLAST
Repeati290 – 31223LRR 12Add
BLAST
Repeati313 – 33422LRR 13Add
BLAST
Repeati336 – 35722LRR 14Add
BLAST
Repeati359 – 38123LRR 15Add
BLAST
Repeati382 – 40221LRR 16Add
BLAST
Domaini714 – 80188PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini848 – 93689PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini990 – 107990PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini1086 – 118095PDZ 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 804804Sufficient for targeting to adherens junction and to inhibit cell proliferationBy similarityAdd
BLAST
Regioni703 – 1215513Interaction with ARHGEF7By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili455 – 47521Sequence analysisAdd
BLAST
Coiled coili653 – 68735Sequence analysisAdd
BLAST
Coiled coili1362 – 139332Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi656 – 68227Glu-richAdd
BLAST
Compositional biasi656 – 6649Poly-Glu
Compositional biasi709 – 7124Poly-Glu
Compositional biasi1079 – 10824Poly-Pro

Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Curated
Contains 16 LRR (leucine-rich) repeats.Curated
Contains 4 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KCZ0. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
InParanoidiQ80U72.
KOiK16175.
OMAiICIEKAP.
OrthoDBiEOG091G01EF.
PhylomeDBiQ80U72.
TreeFamiTF351429.

Family and domain databases

Gene3Di2.30.42.10. 4 hits.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001478. PDZ.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF00595. PDZ. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00228. PDZ. 4 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 4 hits.
SSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 13 hits.
PS50106. PDZ. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80U72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKCIPLWRC NRHVESVDKR HCSLQVVPEE IYRYSRSLEE LLLDANQLRE
60 70 80 90 100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES
110 120 130 140 150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL
160 170 180 190 200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR
210 220 230 240 250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPVELG GLALLTDLLL
260 270 280 290 300
SQNLLQRLPE GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL
310 320 330 340 350
LTALPHSLGK LTKLTNLNVD RNHLEVLPPE IGGCVALSVL SLRDNRLAVL
360 370 380 390 400
PPELAHTAEL HVLDVAGNRL RSLPFALTHL NLKALWLAEN QAQPMLRFQT
410 420 430 440 450
EDDAQTGEKV LTCYLLPQQP LPSLEDAGQQ SSPSESCSDA PLSRVSVIQF
460 470 480 490 500
EDTLEGEEDA EEAAAEKRGL QRRATPHPSE LKVMKRGIEE RRNEAFVCKP
510 520 530 540 550
DPSPPSPSEE EKRLSAESAL SGGSVPSAST ASEGEPEILP AEVQGLGQHE
560 570 580 590 600
AMPAQEEYTE DDYNEPTVHF AEDTLIPRED GESEEGQPEA AWPLPSGRQR
610 620 630 640 650
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG VQTDREGPTA GWHNGPHTPW
660 670 680 690 700
APRAHEEEEE EEEENRDEEE GEATTEEDDK EEAVASAPSV KGVSFDQANN
710 720 730 740 750
LLIEPARIEE EELTLTIVRQ TGGLGISIAG GKGSTPYKGD DEGIFISRVS
760 770 780 790 800
EEGPAARAGV RVGDKLLEVN GVALQDAEHH EAVEALRGAG AAVQMRVWRE
810 820 830 840 850
RMVEPENAVT ITPLRPEDDY SPREWRGGGL RLPLLQPETP VSLRQRHAAC
860 870 880 890 900
LVRSEKGLGF SIAGGKGSTP YRAGDGGIFI SRIAEGGAAH RAGTLQVGDR
910 920 930 940 950
VLSINGVDMT EARHDHAVSL LTAASPTISL LLERETGGTY PPSPPPHSSP
960 970 980 990 1000
TPAATVAATV STAVPGEPLL PRLSPSLLAT ALEGPYPVEE ICLPRAGGPL
1010 1020 1030 1040 1050
GLSIVGGSDH SSHPFGVQDP GVFISKVLPR GLAARCGLRV GDRILAVNGQ
1060 1070 1080 1090 1100
DVREATHQEA VSALLRPCLE LCLLVRRDPP PPGMRELCIQ KAPGEKLGIS
1110 1120 1130 1140 1150
IRGGAKGHAG NPCDPTDEGI FISKVSPTGA AGRDGRLRVG LRLLEVNQQS
1160 1170 1180 1190 1200
LLGLTHAEAV QLLRSVGDTL TVLVCDGFDT STTTALEVSP GVIANPFAAG
1210 1220 1230 1240 1250
LGHRNSLESI SSIDRELSPE GPGKEKELAS QALPWESESA ETTGRNLEPL
1260 1270 1280 1290 1300
KLDYRALAAL PSAGSLQRGP SATTGGKTTE APCSPGSQQP PSPDELPANV
1310 1320 1330 1340 1350
KQAYRAFAAV PTVHPPENSA TQPPTPGPAA SPEQLSFRER QKYFELEVRV
1360 1370 1380 1390 1400
PQAEGPPKRV SLVGADDLRK MQEEEARKLQ QKRAQMLREE AVTSGPDMGL
1410 1420 1430 1440 1450
ASDRESPDDQ QEAEQPWAVP SHAGGSSPSS PPPLGGNAPV RTAKAERRHQ
1460 1470 1480 1490 1500
ERLRMQSPEL PAPERALSPA ERRALEAEKR ALWRAARMKS LEQDALRAQM
1510 1520 1530 1540 1550
VLSKSQEGRG KRGPLERLAE APSPAPTPSP TPLEDFGLQT SASPGRLSPD
1560 1570 1580 1590 1600
FVEELRTLEA SPSPGSQEED GEVALVLLGR PSPGAVGPED MTLCSSRRSV
1610
RPGRRGLGPV PS
Length:1,612
Mass (Da):174,059
Last modified:July 19, 2004 - v2
Checksum:i8C85DB322D738EDE
GO
Isoform 2 (identifier: Q80U72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1547-1547: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

Show »
Length:1,637
Mass (Da):176,868
Checksum:i46D6D137902F4D6B
GO
Isoform 3 (identifier: Q80U72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1289-1289: Q → QTKPGVIQPLAQAWPRNSPAPRGRGGPCS
     1547-1547: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

Show »
Length:1,665
Mass (Da):179,750
Checksum:iBE1272F4ECBF010E
GO
Isoform 4 (identifier: Q80U72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     692-712: Missing.
     1289-1289: Q → QTKPGVIQPLAQAWPRNSPAPRGRGGPCS

Note: No experimental confirmation available.Combined sources
Show »
Length:1,619
Mass (Da):174,585
Checksum:iF667D8CA5592E8D9
GO

Sequence cautioni

The sequence BAC65493 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti588 – 5881P → L in AAH62888 (PubMed:15489334).Curated
Sequence conflicti676 – 6838EEDDKEEA → GRVGGRVG in AAH06859 (PubMed:15489334).Curated
Sequence conflicti947 – 9493HSS → RVR in AAH37480 (PubMed:15489334).Curated
Sequence conflicti1080 – 10801P → H in AAP88019 (PubMed:15649318).Curated
Sequence conflicti1109 – 11091A → T in AAP88019 (PubMed:15649318).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei692 – 71221Missing in isoform 4. 1 PublicationVSP_010909Add
BLAST
Alternative sequencei1289 – 12891Q → QTKPGVIQPLAQAWPRNSPA PRGRGGPCS in isoform 3 and isoform 4. 2 PublicationsVSP_010910
Alternative sequencei1547 – 15471L → LPLSGKKFDYRAFAALPSSR PVYDIQ in isoform 2 and isoform 3. 3 PublicationsVSP_010911

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441233 mRNA. Translation: AAL32469.1.
AK122211 mRNA. Translation: BAC65493.1. Different initiation.
BC006859 mRNA. Translation: AAH06859.1.
BC037480 mRNA. Translation: AAH37480.1.
BC049942 mRNA. Translation: AAH49942.1.
BC062888 mRNA. Translation: AAH62888.1.
AF271735 mRNA. Translation: AAP88019.1.
CCDSiCCDS27560.1. [Q80U72-3]
CCDS79381.1. [Q80U72-1]
CCDS79382.1. [Q80U72-2]
RefSeqiNP_001297471.1. NM_001310542.1. [Q80U72-2]
NP_001297472.1. NM_001310543.1. [Q80U72-1]
NP_598850.1. NM_134089.2. [Q80U72-3]
UniGeneiMm.25568.

Genome annotation databases

EnsembliENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568. [Q80U72-3]
ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568. [Q80U72-1]
ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568. [Q80U72-2]
GeneIDi105782.
KEGGimmu:105782.
UCSCiuc007wig.1. mouse. [Q80U72-3]
uc007wih.1. mouse. [Q80U72-2]
uc007wii.1. mouse. [Q80U72-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441233 mRNA. Translation: AAL32469.1.
AK122211 mRNA. Translation: BAC65493.1. Different initiation.
BC006859 mRNA. Translation: AAH06859.1.
BC037480 mRNA. Translation: AAH37480.1.
BC049942 mRNA. Translation: AAH49942.1.
BC062888 mRNA. Translation: AAH62888.1.
AF271735 mRNA. Translation: AAP88019.1.
CCDSiCCDS27560.1. [Q80U72-3]
CCDS79381.1. [Q80U72-1]
CCDS79382.1. [Q80U72-2]
RefSeqiNP_001297471.1. NM_001310542.1. [Q80U72-2]
NP_001297472.1. NM_001310543.1. [Q80U72-1]
NP_598850.1. NM_134089.2. [Q80U72-3]
UniGeneiMm.25568.

3D structure databases

ProteinModelPortaliQ80U72.
SMRiQ80U72. Positions 704-800, 846-937, 1084-1185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222921. 2 interactions.
DIPiDIP-40660N.
IntActiQ80U72. 7 interactions.
MINTiMINT-4120321.
STRINGi10090.ENSMUSP00000002603.

PTM databases

iPTMnetiQ80U72.
PhosphoSiteiQ80U72.
SwissPalmiQ80U72.

Proteomic databases

MaxQBiQ80U72.
PaxDbiQ80U72.
PeptideAtlasiQ80U72.
PRIDEiQ80U72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568. [Q80U72-3]
ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568. [Q80U72-1]
ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568. [Q80U72-2]
GeneIDi105782.
KEGGimmu:105782.
UCSCiuc007wig.1. mouse. [Q80U72-3]
uc007wih.1. mouse. [Q80U72-2]
uc007wii.1. mouse. [Q80U72-1]

Organism-specific databases

CTDi23513.
MGIiMGI:2145950. Scrib.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410KCZ0. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
InParanoidiQ80U72.
KOiK16175.
OMAiICIEKAP.
OrthoDBiEOG091G01EF.
PhylomeDBiQ80U72.
TreeFamiTF351429.

Enzyme and pathway databases

ReactomeiR-MMU-4608870. Asymmetric localization of PCP proteins.

Miscellaneous databases

ChiTaRSiScrib. mouse.
PROiQ80U72.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022568.
CleanExiMM_SCRIB.
ExpressionAtlasiQ80U72. baseline and differential.
GenevisibleiQ80U72. MM.

Family and domain databases

Gene3Di2.30.42.10. 4 hits.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001478. PDZ.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF00595. PDZ. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00228. PDZ. 4 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 4 hits.
SSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 13 hits.
PS50106. PDZ. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCRIB_MOUSE
AccessioniPrimary (citable) accession number: Q80U72
Secondary accession number(s): Q6P5H7
, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 7, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The circletail (Crc) mice exhibit craniorachishicisis a severe form of neural tube defect. This is due to a single base insertion in the Scrib gene creating a frameshift which leads to synthesis of a truncated protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.