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Protein

Protein scribble homolog

Gene

Scrib

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.4 Publications

GO - Molecular functioni

GO - Biological processi

  • activation of GTPase activity Source: UniProtKB
  • apoptotic process involved in morphogenesis Source: UniProtKB
  • astrocyte cell migration Source: Ensembl
  • asymmetric protein localization Source: MGI
  • auditory receptor cell morphogenesis Source: MGI
  • auditory receptor cell stereocilium organization Source: MGI
  • cell migration Source: UniProtKB
  • cell proliferation Source: UniProtKB
  • cochlear nucleus development Source: MGI
  • establishment of apical/basal cell polarity Source: UniProtKB
  • mammary gland duct morphogenesis Source: UniProtKB
  • morphogenesis of embryonic epithelium Source: MGI
  • negative regulation of mitotic cell cycle Source: UniProtKB
  • neural tube closure Source: MGI
  • positive chemotaxis Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of receptor recycling Source: MGI
  • protein localization to adherens junction Source: MGI
  • single organismal cell-cell adhesion Source: UniProtKB
  • synaptic vesicle endocytosis Source: UniProtKB
  • synaptic vesicle targeting Source: UniProtKB
  • Wnt signaling pathway, planar cell polarity pathway Source: Reactome
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-4608870. Asymmetric localization of PCP proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein scribble homolog
Short name:
Scribble
Alternative name(s):
Protein LAP4
Gene namesi
Name:Scrib
Synonyms:Kiaa0147, Lap4, Scrib1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2145950. Scrib.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001883041 – 1612Protein scribble homologAdd BLAST1612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineBy similarity1
Modified residuei378PhosphothreonineBy similarity1
Modified residuei475PhosphothreonineBy similarity1
Modified residuei583PhosphoserineCombined sources1
Modified residuei674PhosphothreonineCombined sources1
Modified residuei675PhosphothreonineCombined sources1
Modified residuei694PhosphoserineBy similarity1
Modified residuei750PhosphoserineBy similarity1
Modified residuei812PhosphothreonineBy similarity1
Modified residuei821PhosphoserineBy similarity1
Modified residuei861PhosphoserineBy similarity1
Modified residuei925PhosphoserineCombined sources1
Modified residuei1126PhosphoserineBy similarity1
Modified residuei1206PhosphoserineCombined sources1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1212PhosphoserineBy similarity1
Modified residuei1218PhosphoserineBy similarity1
Modified residuei1262PhosphoserineBy similarity1
Modified residuei1265PhosphoserineBy similarity1
Modified residuei1284PhosphoserineBy similarity1
Modified residuei1292PhosphoserineCombined sources1
Modified residuei1325PhosphothreonineBy similarity1
Modified residuei1331PhosphoserineBy similarity1
Modified residuei1361PhosphoserineCombined sources1
Modified residuei1427PhosphoserineBy similarity1
Modified residuei1430PhosphoserineBy similarity1
Modified residuei1457PhosphoserineCombined sources1
Modified residuei1468PhosphoserineBy similarity1
Modified residuei1490PhosphoserineCombined sources1
Modified residuei1523PhosphoserineBy similarity1
Modified residuei1527PhosphothreonineBy similarity1
Modified residuei1529PhosphoserineCombined sources1
Modified residuei1543PhosphoserineCombined sources1
Modified residuei1548PhosphoserineCombined sources1
Isoform 4 (identifier: Q80U72-4)
Modified residuei1291Omega-N-methylarginineCombined sources1
Modified residuei1299PhosphoserineCombined sources1
Isoform 3 (identifier: Q80U72-3)
Modified residuei1312Omega-N-methylarginineCombined sources1
Modified residuei1320PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated; targeted for UBE3A-dependent multiubiquitination and degraded.By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ80U72.
PeptideAtlasiQ80U72.
PRIDEiQ80U72.

PTM databases

iPTMnetiQ80U72.
PhosphoSitePlusiQ80U72.
SwissPalmiQ80U72.

Expressioni

Tissue specificityi

Found in a wide range of tissues including liver, brain, kidney and spleen.1 Publication

Developmental stagei

First detected at E7.5 in the neuroepithelium at the time of initial neural tube closure. Also expressed in cranial mesenchyme, branchial arches, somitic mesoderm and lateral mesoderm. At later stages it is expressed in the eyelid epithelium, submandibular glands, whisker and hair follicles, sympathetic glanglia, inner ear, thymus, testis, kidney, esophagus, lung, stomach, trigeminal and dorsal root glanglia.1 Publication

Gene expression databases

BgeeiENSMUSG00000022568.
CleanExiMM_SCRIB.
ExpressionAtlasiQ80U72. baseline and differential.
GenevisibleiQ80U72. MM.

Interactioni

Subunit structurei

Interacts with UBE3A. Interacts with PAK1 and PAK2. Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct. Interacts (via PDZ domains) with TJP2. Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function (By similarity). Interacts (via PDZ domains) with VANGL2. Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7. Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells. Interacts with CTNNB1 and MAPK12. Interacts (via PDZ domains 1 and 3) with MCC (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CrtamQ149L74EBI-1766028,EBI-1766072
PHLPP1O603462EBI-1766028,EBI-2511516From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222921. 2 interactors.
DIPiDIP-40660N.
IntActiQ80U72. 7 interactors.
MINTiMINT-4120321.
STRINGi10090.ENSMUSP00000002603.

Structurei

3D structure databases

ProteinModelPortaliQ80U72.
SMRiQ80U72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 58LRR 1Add BLAST22
Repeati60 – 81LRR 2Add BLAST22
Repeati83 – 104LRR 3Add BLAST22
Repeati106 – 127LRR 4Add BLAST22
Repeati129 – 150LRR 5Add BLAST22
Repeati152 – 174LRR 6Add BLAST23
Repeati175 – 197LRR 7Add BLAST23
Repeati198 – 219LRR 8Add BLAST22
Repeati221 – 243LRR 9Add BLAST23
Repeati244 – 265LRR 10Add BLAST22
Repeati267 – 288LRR 11Add BLAST22
Repeati290 – 312LRR 12Add BLAST23
Repeati313 – 334LRR 13Add BLAST22
Repeati336 – 357LRR 14Add BLAST22
Repeati359 – 381LRR 15Add BLAST23
Repeati382 – 402LRR 16Add BLAST21
Domaini714 – 801PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini848 – 936PDZ 2PROSITE-ProRule annotationAdd BLAST89
Domaini990 – 1079PDZ 3PROSITE-ProRule annotationAdd BLAST90
Domaini1086 – 1180PDZ 4PROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 804Sufficient for targeting to adherens junction and to inhibit cell proliferationBy similarityAdd BLAST804
Regioni703 – 1215Interaction with ARHGEF7By similarityAdd BLAST513

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili455 – 475Sequence analysisAdd BLAST21
Coiled coili653 – 687Sequence analysisAdd BLAST35
Coiled coili1362 – 1393Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi656 – 682Glu-richAdd BLAST27
Compositional biasi656 – 664Poly-Glu9
Compositional biasi709 – 712Poly-Glu4
Compositional biasi1079 – 1082Poly-Pro4

Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Curated
Contains 16 LRR (leucine-rich) repeats.Curated
Contains 4 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410KCZ0. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
InParanoidiQ80U72.
KOiK16175.
OMAiICIEKAP.
OrthoDBiEOG091G01EF.
PhylomeDBiQ80U72.
TreeFamiTF351429.

Family and domain databases

Gene3Di2.30.42.10. 4 hits.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001478. PDZ.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF00595. PDZ. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00228. PDZ. 4 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 4 hits.
SSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 13 hits.
PS50106. PDZ. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80U72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKCIPLWRC NRHVESVDKR HCSLQVVPEE IYRYSRSLEE LLLDANQLRE
60 70 80 90 100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES
110 120 130 140 150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL
160 170 180 190 200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR
210 220 230 240 250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPVELG GLALLTDLLL
260 270 280 290 300
SQNLLQRLPE GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL
310 320 330 340 350
LTALPHSLGK LTKLTNLNVD RNHLEVLPPE IGGCVALSVL SLRDNRLAVL
360 370 380 390 400
PPELAHTAEL HVLDVAGNRL RSLPFALTHL NLKALWLAEN QAQPMLRFQT
410 420 430 440 450
EDDAQTGEKV LTCYLLPQQP LPSLEDAGQQ SSPSESCSDA PLSRVSVIQF
460 470 480 490 500
EDTLEGEEDA EEAAAEKRGL QRRATPHPSE LKVMKRGIEE RRNEAFVCKP
510 520 530 540 550
DPSPPSPSEE EKRLSAESAL SGGSVPSAST ASEGEPEILP AEVQGLGQHE
560 570 580 590 600
AMPAQEEYTE DDYNEPTVHF AEDTLIPRED GESEEGQPEA AWPLPSGRQR
610 620 630 640 650
LIRKDTPHYK KHFKISKLPQ PEAVVALLQG VQTDREGPTA GWHNGPHTPW
660 670 680 690 700
APRAHEEEEE EEEENRDEEE GEATTEEDDK EEAVASAPSV KGVSFDQANN
710 720 730 740 750
LLIEPARIEE EELTLTIVRQ TGGLGISIAG GKGSTPYKGD DEGIFISRVS
760 770 780 790 800
EEGPAARAGV RVGDKLLEVN GVALQDAEHH EAVEALRGAG AAVQMRVWRE
810 820 830 840 850
RMVEPENAVT ITPLRPEDDY SPREWRGGGL RLPLLQPETP VSLRQRHAAC
860 870 880 890 900
LVRSEKGLGF SIAGGKGSTP YRAGDGGIFI SRIAEGGAAH RAGTLQVGDR
910 920 930 940 950
VLSINGVDMT EARHDHAVSL LTAASPTISL LLERETGGTY PPSPPPHSSP
960 970 980 990 1000
TPAATVAATV STAVPGEPLL PRLSPSLLAT ALEGPYPVEE ICLPRAGGPL
1010 1020 1030 1040 1050
GLSIVGGSDH SSHPFGVQDP GVFISKVLPR GLAARCGLRV GDRILAVNGQ
1060 1070 1080 1090 1100
DVREATHQEA VSALLRPCLE LCLLVRRDPP PPGMRELCIQ KAPGEKLGIS
1110 1120 1130 1140 1150
IRGGAKGHAG NPCDPTDEGI FISKVSPTGA AGRDGRLRVG LRLLEVNQQS
1160 1170 1180 1190 1200
LLGLTHAEAV QLLRSVGDTL TVLVCDGFDT STTTALEVSP GVIANPFAAG
1210 1220 1230 1240 1250
LGHRNSLESI SSIDRELSPE GPGKEKELAS QALPWESESA ETTGRNLEPL
1260 1270 1280 1290 1300
KLDYRALAAL PSAGSLQRGP SATTGGKTTE APCSPGSQQP PSPDELPANV
1310 1320 1330 1340 1350
KQAYRAFAAV PTVHPPENSA TQPPTPGPAA SPEQLSFRER QKYFELEVRV
1360 1370 1380 1390 1400
PQAEGPPKRV SLVGADDLRK MQEEEARKLQ QKRAQMLREE AVTSGPDMGL
1410 1420 1430 1440 1450
ASDRESPDDQ QEAEQPWAVP SHAGGSSPSS PPPLGGNAPV RTAKAERRHQ
1460 1470 1480 1490 1500
ERLRMQSPEL PAPERALSPA ERRALEAEKR ALWRAARMKS LEQDALRAQM
1510 1520 1530 1540 1550
VLSKSQEGRG KRGPLERLAE APSPAPTPSP TPLEDFGLQT SASPGRLSPD
1560 1570 1580 1590 1600
FVEELRTLEA SPSPGSQEED GEVALVLLGR PSPGAVGPED MTLCSSRRSV
1610
RPGRRGLGPV PS
Length:1,612
Mass (Da):174,059
Last modified:July 19, 2004 - v2
Checksum:i8C85DB322D738EDE
GO
Isoform 2 (identifier: Q80U72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1547-1547: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

Show »
Length:1,637
Mass (Da):176,868
Checksum:i46D6D137902F4D6B
GO
Isoform 3 (identifier: Q80U72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1289-1289: Q → QTKPGVIQPLAQAWPRNSPAPRGRGGPCS
     1547-1547: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

Show »
Length:1,665
Mass (Da):179,750
Checksum:iBE1272F4ECBF010E
GO
Isoform 4 (identifier: Q80U72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     692-712: Missing.
     1289-1289: Q → QTKPGVIQPLAQAWPRNSPAPRGRGGPCS

Note: No experimental confirmation available.Combined sources
Show »
Length:1,619
Mass (Da):174,585
Checksum:iF667D8CA5592E8D9
GO

Sequence cautioni

The sequence BAC65493 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti588P → L in AAH62888 (PubMed:15489334).Curated1
Sequence conflicti676 – 683EEDDKEEA → GRVGGRVG in AAH06859 (PubMed:15489334).Curated8
Sequence conflicti947 – 949HSS → RVR in AAH37480 (PubMed:15489334).Curated3
Sequence conflicti1080P → H in AAP88019 (PubMed:15649318).Curated1
Sequence conflicti1109A → T in AAP88019 (PubMed:15649318).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010909692 – 712Missing in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0109101289Q → QTKPGVIQPLAQAWPRNSPA PRGRGGPCS in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0109111547L → LPLSGKKFDYRAFAALPSSR PVYDIQ in isoform 2 and isoform 3. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441233 mRNA. Translation: AAL32469.1.
AK122211 mRNA. Translation: BAC65493.1. Different initiation.
BC006859 mRNA. Translation: AAH06859.1.
BC037480 mRNA. Translation: AAH37480.1.
BC049942 mRNA. Translation: AAH49942.1.
BC062888 mRNA. Translation: AAH62888.1.
AF271735 mRNA. Translation: AAP88019.1.
CCDSiCCDS27560.1. [Q80U72-3]
CCDS79381.1. [Q80U72-1]
CCDS79382.1. [Q80U72-2]
RefSeqiNP_001297471.1. NM_001310542.1. [Q80U72-2]
NP_001297472.1. NM_001310543.1. [Q80U72-1]
NP_598850.1. NM_134089.2. [Q80U72-3]
XP_017171844.1. XM_017316355.1. [Q80U72-4]
UniGeneiMm.25568.

Genome annotation databases

EnsembliENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568. [Q80U72-3]
ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568. [Q80U72-1]
ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568. [Q80U72-2]
GeneIDi105782.
KEGGimmu:105782.
UCSCiuc007wig.1. mouse. [Q80U72-3]
uc007wih.1. mouse. [Q80U72-2]
uc007wii.1. mouse. [Q80U72-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441233 mRNA. Translation: AAL32469.1.
AK122211 mRNA. Translation: BAC65493.1. Different initiation.
BC006859 mRNA. Translation: AAH06859.1.
BC037480 mRNA. Translation: AAH37480.1.
BC049942 mRNA. Translation: AAH49942.1.
BC062888 mRNA. Translation: AAH62888.1.
AF271735 mRNA. Translation: AAP88019.1.
CCDSiCCDS27560.1. [Q80U72-3]
CCDS79381.1. [Q80U72-1]
CCDS79382.1. [Q80U72-2]
RefSeqiNP_001297471.1. NM_001310542.1. [Q80U72-2]
NP_001297472.1. NM_001310543.1. [Q80U72-1]
NP_598850.1. NM_134089.2. [Q80U72-3]
XP_017171844.1. XM_017316355.1. [Q80U72-4]
UniGeneiMm.25568.

3D structure databases

ProteinModelPortaliQ80U72.
SMRiQ80U72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222921. 2 interactors.
DIPiDIP-40660N.
IntActiQ80U72. 7 interactors.
MINTiMINT-4120321.
STRINGi10090.ENSMUSP00000002603.

PTM databases

iPTMnetiQ80U72.
PhosphoSitePlusiQ80U72.
SwissPalmiQ80U72.

Proteomic databases

PaxDbiQ80U72.
PeptideAtlasiQ80U72.
PRIDEiQ80U72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002603; ENSMUSP00000002603; ENSMUSG00000022568. [Q80U72-3]
ENSMUST00000063747; ENSMUSP00000068056; ENSMUSG00000022568. [Q80U72-1]
ENSMUST00000109946; ENSMUSP00000105572; ENSMUSG00000022568. [Q80U72-2]
GeneIDi105782.
KEGGimmu:105782.
UCSCiuc007wig.1. mouse. [Q80U72-3]
uc007wih.1. mouse. [Q80U72-2]
uc007wii.1. mouse. [Q80U72-1]

Organism-specific databases

CTDi23513.
MGIiMGI:2145950. Scrib.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410KCZ0. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
InParanoidiQ80U72.
KOiK16175.
OMAiICIEKAP.
OrthoDBiEOG091G01EF.
PhylomeDBiQ80U72.
TreeFamiTF351429.

Enzyme and pathway databases

ReactomeiR-MMU-4608870. Asymmetric localization of PCP proteins.

Miscellaneous databases

ChiTaRSiScrib. mouse.
PROiQ80U72.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022568.
CleanExiMM_SCRIB.
ExpressionAtlasiQ80U72. baseline and differential.
GenevisibleiQ80U72. MM.

Family and domain databases

Gene3Di2.30.42.10. 4 hits.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001478. PDZ.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF00595. PDZ. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00228. PDZ. 4 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 4 hits.
SSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 13 hits.
PS50106. PDZ. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCRIB_MOUSE
AccessioniPrimary (citable) accession number: Q80U72
Secondary accession number(s): Q6P5H7
, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The circletail (Crc) mice exhibit craniorachishicisis a severe form of neural tube defect. This is due to a single base insertion in the Scrib gene creating a frameshift which leads to synthesis of a truncated protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.