ID   Q80U52_MOUSE            Unreviewed;       700 AA.
AC   Q80U52;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 105.
DE   RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
DE   Flags: Fragment;
GN   Name=Slc9a6 {ECO:0000313|MGI:MGI:2443511};
GN   Synonyms=mKIAA0267 {ECO:0000313|EMBL:BAC65514.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC65514.1};
RN   [1] {ECO:0000313|EMBL:BAC65514.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAC65514.1};
RX   PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA   Nakajima D., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT   The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:35-48(2003).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome
CC       membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Recycling endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004195}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR   EMBL; AK122232; BAC65514.1; -; mRNA.
DR   AlphaFoldDB; Q80U52; -.
DR   AGR; MGI:2443511; -.
DR   MGI; MGI:2443511; Slc9a6.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0051453; P:regulation of intracellular pH; IEA:UniProt.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004709; NaH_exchanger.
DR   InterPro; IPR002090; NHE-6/7/9.
DR   NCBIfam; TIGR00840; b_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF94; SODIUM_HYDROGEN EXCHANGER 6; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
DR   PRINTS; PR01088; NAHEXCHNGR6.
PE   2: Evidence at transcript level;
KW   Antiport {ECO:0000256|RuleBase:RU003722};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003722};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT   TRANSMEM        23..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        73..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        102..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        325..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        367..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        445..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        479..498
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        504..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          77..533
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAC65514.1"
SQ   SEQUENCE   700 AA;  77751 MW;  5CA8EFCB0FD514FA CRC64;
     GARRGWRLAP VRRGVCGPRA RPLMRPLWLL FAVSFFGWTG ALDGSGGTTR AMDEEIVSEK
     QAEESHRQDS ANLLIFILLL TLTILTIWLF KHRRARFLHE TGLAMIYGLL VGLVLRYGIH
     VPSDVNNVTL SCEVQSSPTT LLVNVSGKFY EYTLKGEISS HELNNVQDNE MLRKVTFDPE
     VFFNILLPPI IFYAGYSLKR RHFFRNLGSI LAYAFLGTAI SCFVIGSIMY GCVTLMKVTG
     QLAGDFYFTD CLLFGAIVSA TDPVTVLAIF HELQVDVELY ALLFGESVLN DAVAIVLSSS
     IVAYQPAGDN SHTFDVTAMF KSIGIFLGIF SGSFAMGAAT GVVTALVTKF TKLREFQLLE
     TGLFFLMSWS TFLLAEAWGF TGVVAVLFCG ITQAHYTYNN LSTESQHRTK QLFELLNFLA
     ENFIFSYMGL TLFTFQNHVF NPTFVVGAFI AIFLGRAANI YPLSLLLNLG RRSKIGSNFQ
     HMMMFAGLRG AMAFALAIRD TATYARQMMF STTLLIVFFT VWVFGGGTTA MLSCLHIRVG
     VDSDQEHLGV PDNERRTTKA ESAWLFRMWY NFDHNYLKPL LTHSGPPLTT TLPACCGPIA
     RCLTSPQAYE NQEQLKDDDS DLILNDGDIS LTYGDSTVNT ESATASAPRR FMGNSSEDAL
     DRELTFGDHE LVIRGTRLVL PMDDSEPALN SLDDTRHSPA
//