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Protein

Sodium/hydrogen exchanger

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • axon extension Source: MGI
  • brain-derived neurotrophic factor receptor signaling pathway Source: MGI
  • dendrite extension Source: MGI
  • dendritic spine development Source: MGI
  • neuron projection morphogenesis Source: MGI
  • proton transport Source: MGI
  • regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  • regulation of pH Source: InterPro
  • synapse organization Source: MGI
Complete GO annotation...

Keywords - Biological processi

AntiportUniRule annotation, Ion transport, Sodium transportUniRule annotation, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_324002. Sodium/Proton exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a6Imported
Synonyms:mKIAA0267Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2443511. Slc9a6.

Subcellular locationi

GO - Cellular componenti

  • axonal spine Source: MGI
  • axon terminus Source: MGI
  • cytoplasmic vesicle Source: MGI
  • dendrite Source: MGI
  • early endosome Source: MGI
  • early endosome membrane Source: MGI
  • endoplasmic reticulum membrane Source: MGI
  • endosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: MGI
  • late endosome Source: MGI
  • mitochondrion Source: MGI
  • plasma membrane Source: MGI
  • recycling endosome Source: MGI
  • recycling endosome membrane Source: MGI
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ80U52.
ExpressionAtlasiQ80U52. baseline and differential.
GenevestigatoriQ80U52.

Structurei

3D structure databases

ProteinModelPortaliQ80U52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOVERGENiHBG055575.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q80U52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GARRGWRLAP VRRGVCGPRA RPLMRPLWLL FAVSFFGWTG ALDGSGGTTR
60 70 80 90 100
AMDEEIVSEK QAEESHRQDS ANLLIFILLL TLTILTIWLF KHRRARFLHE
110 120 130 140 150
TGLAMIYGLL VGLVLRYGIH VPSDVNNVTL SCEVQSSPTT LLVNVSGKFY
160 170 180 190 200
EYTLKGEISS HELNNVQDNE MLRKVTFDPE VFFNILLPPI IFYAGYSLKR
210 220 230 240 250
RHFFRNLGSI LAYAFLGTAI SCFVIGSIMY GCVTLMKVTG QLAGDFYFTD
260 270 280 290 300
CLLFGAIVSA TDPVTVLAIF HELQVDVELY ALLFGESVLN DAVAIVLSSS
310 320 330 340 350
IVAYQPAGDN SHTFDVTAMF KSIGIFLGIF SGSFAMGAAT GVVTALVTKF
360 370 380 390 400
TKLREFQLLE TGLFFLMSWS TFLLAEAWGF TGVVAVLFCG ITQAHYTYNN
410 420 430 440 450
LSTESQHRTK QLFELLNFLA ENFIFSYMGL TLFTFQNHVF NPTFVVGAFI
460 470 480 490 500
AIFLGRAANI YPLSLLLNLG RRSKIGSNFQ HMMMFAGLRG AMAFALAIRD
510 520 530 540 550
TATYARQMMF STTLLIVFFT VWVFGGGTTA MLSCLHIRVG VDSDQEHLGV
560 570 580 590 600
PDNERRTTKA ESAWLFRMWY NFDHNYLKPL LTHSGPPLTT TLPACCGPIA
610 620 630 640 650
RCLTSPQAYE NQEQLKDDDS DLILNDGDIS LTYGDSTVNT ESATASAPRR
660 670 680 690 700
FMGNSSEDAL DRELTFGDHE LVIRGTRLVL PMDDSEPALN SLDDTRHSPA
Length:700
Mass (Da):77,751
Last modified:June 1, 2003 - v1
Checksum:i5CA8EFCB0FD514FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122232 mRNA. Translation: BAC65514.1.
UniGeneiMm.17815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122232 mRNA. Translation: BAC65514.1.
UniGeneiMm.17815.

3D structure databases

ProteinModelPortaliQ80U52.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2443511. Slc9a6.

Phylogenomic databases

HOVERGENiHBG055575.

Enzyme and pathway databases

ReactomeiREACT_324002. Sodium/Proton exchangers.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ80U52.
ExpressionAtlasiQ80U52. baseline and differential.
GenevestigatoriQ80U52.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR002090. Na/H_exchanger_6.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01088. NAHEXCHNGR6.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ80U52_MOUSE
AccessioniPrimary (citable) accession number: Q80U52
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.