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Q80U52

- Q80U52_MOUSE

UniProt

Q80U52 - Q80U52_MOUSE

Protein

Sodium/hydrogen exchanger

Gene

Slc9a6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sodium:proton antiporter activity Source: InterPro

    GO - Biological processi

    1. axon extension Source: MGI
    2. brain-derived neurotrophic factor receptor signaling pathway Source: MGI
    3. dendrite extension Source: MGI
    4. dendritic spine development Source: MGI
    5. neuron projection morphogenesis Source: MGI
    6. proton transport Source: MGI
    7. regulation of neurotrophin TRK receptor signaling pathway Source: MGI
    8. regulation of pH Source: InterPro
    9. synapse organization Source: MGI

    Keywords - Biological processi

    AntiportUniRule annotation, Ion transport, Sodium transportUniRule annotation, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/hydrogen exchangerUniRule annotation
    Gene namesi
    Name:Slc9a6Imported
    Synonyms:mKIAA0267Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:2443511. Slc9a6.

    Subcellular locationi

    GO - Cellular componenti

    1. axonal spine Source: MGI
    2. axon terminus Source: MGI
    3. cytoplasmic vesicle Source: MGI
    4. dendrite Source: MGI
    5. early endosome Source: MGI
    6. early endosome membrane Source: Ensembl
    7. endoplasmic reticulum membrane Source: Ensembl
    8. endosome Source: MGI
    9. integral component of membrane Source: UniProtKB-KW
    10. late endosome Source: MGI
    11. mitochondrion Source: MGI
    12. plasma membrane Source: MGI
    13. recycling endosome Source: MGI
    14. recycling endosome membrane Source: Ensembl
    15. synapse Source: MGI

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    BgeeiQ80U52.
    GenevestigatoriQ80U52.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80U52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG055575.
    InParanoidiQ80U52.

    Family and domain databases

    InterProiIPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR002090. Na/H_exchanger_6.
    IPR004709. NaH_exchanger.
    [Graphical view]
    PANTHERiPTHR10110. PTHR10110. 1 hit.
    PfamiPF00999. Na_H_Exchanger. 1 hit.
    [Graphical view]
    PRINTSiPR01084. NAHEXCHNGR.
    PR01088. NAHEXCHNGR6.
    TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q80U52-1 [UniParc]FASTAAdd to Basket

    « Hide

    GARRGWRLAP VRRGVCGPRA RPLMRPLWLL FAVSFFGWTG ALDGSGGTTR    50
    AMDEEIVSEK QAEESHRQDS ANLLIFILLL TLTILTIWLF KHRRARFLHE 100
    TGLAMIYGLL VGLVLRYGIH VPSDVNNVTL SCEVQSSPTT LLVNVSGKFY 150
    EYTLKGEISS HELNNVQDNE MLRKVTFDPE VFFNILLPPI IFYAGYSLKR 200
    RHFFRNLGSI LAYAFLGTAI SCFVIGSIMY GCVTLMKVTG QLAGDFYFTD 250
    CLLFGAIVSA TDPVTVLAIF HELQVDVELY ALLFGESVLN DAVAIVLSSS 300
    IVAYQPAGDN SHTFDVTAMF KSIGIFLGIF SGSFAMGAAT GVVTALVTKF 350
    TKLREFQLLE TGLFFLMSWS TFLLAEAWGF TGVVAVLFCG ITQAHYTYNN 400
    LSTESQHRTK QLFELLNFLA ENFIFSYMGL TLFTFQNHVF NPTFVVGAFI 450
    AIFLGRAANI YPLSLLLNLG RRSKIGSNFQ HMMMFAGLRG AMAFALAIRD 500
    TATYARQMMF STTLLIVFFT VWVFGGGTTA MLSCLHIRVG VDSDQEHLGV 550
    PDNERRTTKA ESAWLFRMWY NFDHNYLKPL LTHSGPPLTT TLPACCGPIA 600
    RCLTSPQAYE NQEQLKDDDS DLILNDGDIS LTYGDSTVNT ESATASAPRR 650
    FMGNSSEDAL DRELTFGDHE LVIRGTRLVL PMDDSEPALN SLDDTRHSPA 700
    Length:700
    Mass (Da):77,751
    Last modified:June 1, 2003 - v1
    Checksum:i5CA8EFCB0FD514FA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122232 mRNA. Translation: BAC65514.1.
    UniGeneiMm.17815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122232 mRNA. Translation: BAC65514.1 .
    UniGenei Mm.17815.

    3D structure databases

    ProteinModelPortali Q80U52.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:2443511. Slc9a6.

    Phylogenomic databases

    HOVERGENi HBG055575.
    InParanoidi Q80U52.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Bgeei Q80U52.
    Genevestigatori Q80U52.

    Family and domain databases

    InterProi IPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR002090. Na/H_exchanger_6.
    IPR004709. NaH_exchanger.
    [Graphical view ]
    PANTHERi PTHR10110. PTHR10110. 1 hit.
    Pfami PF00999. Na_H_Exchanger. 1 hit.
    [Graphical view ]
    PRINTSi PR01084. NAHEXCHNGR.
    PR01088. NAHEXCHNGR6.
    TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiQ80U52_MOUSE
    AccessioniPrimary (citable) accession number: Q80U52
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)