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Protein

Centrosomal protein of 170 kDa protein B

Gene

Cep170b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in microtubule organization.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 170 kDa protein B
Alternative name(s):
Centrosomal protein 170B
Short name:
Cep170B
Gene namesi
Name:Cep170b
Synonyms:Kiaa0284
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2145043. Cep170b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15741574Centrosomal protein of 170 kDa protein BPRO_0000282890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki289 – 289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei360 – 3601PhosphoserineCombined sources
Modified residuei421 – 4211PhosphoserineBy similarity
Modified residuei478 – 4781PhosphoserineCombined sources
Modified residuei490 – 4901PhosphoserineBy similarity
Modified residuei534 – 5341PhosphoserineCombined sources
Modified residuei540 – 5401PhosphothreonineBy similarity
Modified residuei541 – 5411PhosphothreonineCombined sources
Modified residuei595 – 5951PhosphoserineBy similarity
Modified residuei617 – 6171PhosphoserineBy similarity
Modified residuei653 – 6531PhosphoserineBy similarity
Modified residuei709 – 7091PhosphoserineCombined sources
Modified residuei744 – 7441PhosphoserineBy similarity
Modified residuei746 – 7461PhosphoserineBy similarity
Modified residuei749 – 7491PhosphoserineBy similarity
Modified residuei751 – 7511PhosphoserineBy similarity
Modified residuei819 – 8191PhosphoserineBy similarity
Modified residuei843 – 8431PhosphoserineBy similarity
Modified residuei947 – 9471PhosphoserineCombined sources
Modified residuei965 – 9651PhosphoserineCombined sources
Modified residuei981 – 9811PhosphoserineCombined sources
Modified residuei1122 – 11221PhosphoserineCombined sources
Modified residuei1166 – 11661PhosphoserineCombined sources
Modified residuei1186 – 11861PhosphoserineCombined sources
Modified residuei1289 – 12891PhosphothreonineCombined sources
Modified residuei1341 – 13411PhosphoserineCombined sources
Modified residuei1345 – 13451PhosphothreonineCombined sources
Modified residuei1347 – 13471PhosphoserineCombined sources
Modified residuei1530 – 15301PhosphoserineBy similarity
Modified residuei1533 – 15331PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ80U49.
MaxQBiQ80U49.
PaxDbiQ80U49.
PeptideAtlasiQ80U49.
PRIDEiQ80U49.

PTM databases

iPTMnetiQ80U49.
PhosphoSiteiQ80U49.

Expressioni

Gene expression databases

BgeeiENSMUSG00000072825.
CleanExiMM_AW555464.
GenevisibleiQ80U49. MM.

Interactioni

Protein-protein interaction databases

BioGridi229975. 1 interaction.
STRINGi10090.ENSMUSP00000098580.

Structurei

3D structure databases

ProteinModelPortaliQ80U49.
SMRiQ80U49. Positions 1-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 7351FHAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CEP170 family.Curated
Contains 1 FHA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJXX. Eukaryota.
ENOG410XQU2. LUCA.
GeneTreeiENSGT00640000091476.
HOGENOMiHOG000111524.
HOVERGENiHBG108016.
InParanoidiQ80U49.
KOiK16463.
OMAiAQDFMAQ.
OrthoDBiEOG091G00LH.
PhylomeDBiQ80U49.
TreeFamiTF328469.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR029300. CEP170_C.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF15308. CEP170_C. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80U49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVTSWFLVS SSGTRHRLPR ELIFVGRDEC ELMLQSRSVD KQHAVINYDQ
60 70 80 90 100
DRDEHWVKDL GSLNGTFVND VRIPDQKYIT LKLNDVIRFG YDSNMYVLER
110 120 130 140 150
VQHRVPEEAL KHEKYTSQLQ VSVKVSAPKR GDALPDHTPY CESSQPRPEK
160 170 180 190 200
GDRRHGAEAV AYRTPLYGQP SWWGEDDSGA PSEDRHQEEP YSERPKDLAQ
210 220 230 240 250
QNGELDSCRA PAEPPDYSFR REPSYFEIPT KETPQPPRLP EVPTQEVPTK
260 270 280 290 300
DQEAGVGGTA PVVQSHASFT IEFDDCSPGK VKIKDHITKF SLRQRRAPSK
310 320 330 340 350
ETTPVETVSA ETKVADWLVQ NDPSLLRRDG PGDDRHSTKS DLPVHTRTLK
360 370 380 390 400
GHKHEDGTQS DSEDPLAKTA SVSGASAEAS GEQVRLQRQI KRDPQELLHN
410 420 430 440 450
QQAFVIEFFD GDTPRKKRSQ SFTHTPPADP KADKRRGPGT SDRDRPGVSV
460 470 480 490 500
RATGSSSGPQ RASSLKREKT EERLGNTSPV PRASTRSFGS VGRRSRLAQD
510 520 530 540 550
FMAQCMRDSS PATRPAPEKT PPVLPAPLTP RGASPVTPST TPPPPTDPQL
560 570 580 590 600
TKARKQEEDD SLSDAGTYTI ETEAQDQEVE EARRMIDQVF GVFESPELSR
610 620 630 640 650
VSSATFRPVI RGDKDESSDG GMAQRMALLQ EFASRAPGMA PQMEQQSLLV
660 670 680 690 700
PGSPGGQKWV SRWASLADSY SDAGLPEDGP GRRTGEPEGP LPVRTRRLLP
710 720 730 740 750
QLPSGRADSP AGLEAARRNG PGPPELGSEP ANCLIGQEDL DPDSLSDASG
760 770 780 790 800
SDGGRGPEPG TERQEDLAWV RGRRSPRAPG ELVPTSFFIG DQNGEATFPK
810 820 830 840 850
KSFVGPGEVD GPGRVVQTSP SARDGLYVSS NGRMVIQLRS GRSPEPDPAP
860 870 880 890 900
PKETLTFARQ ESFTKEPTSG PPAPGKLPHI SSHPLLQDLA AARASRLDFH
910 920 930 940 950
AQDTHLILKE TETALAALEA RLRSKSADEC DGGSTPRPPE DSLSGDSDVD
960 970 980 990 1000
TASTISLLSG KNGPSPTTPQ TPGPQKESPL SPPTVPDPGG ATPGSARERM
1010 1020 1030 1040 1050
SERQHRPTPA DLGPGDTSRR AAMRRGHGSR GSLDWPEEER GSGLAHLPSS
1060 1070 1080 1090 1100
NHETPEATLA GRQGPRRKPA APPPSPAARE EQSRSSATAQ KVQQALTRSN
1110 1120 1130 1140 1150
SLSTPRPTRA SRLRRARLGD ASDTEAVDGE RGTAANPEPA NRAAPEQAKK
1160 1170 1180 1190 1200
LTRLDILAMP RKRAGSFTGP SDSETAPART GFSGRSAELY STSRKPTIAE
1210 1220 1230 1240 1250
ARAAAKKAAA TAANTGPRQP FSRARPGSAR YSSNTRRRQQ GSDYTSTSEE
1260 1270 1280 1290 1300
EYGSHHSSPK HTRSHASTAT QTPRGSSSTR ARSQGPRDTD DDEEEPDPYG
1310 1320 1330 1340 1350
FIVQTAEIAE IARLSQTLVK DVAILAREIH DVAGDGDSLG SPGPTRSPSL
1360 1370 1380 1390 1400
GNVPNTPAST ISAREELVQR IPEASLNFQK VPPGSMNSHN LDQNMNDSRD
1410 1420 1430 1440 1450
DALTNKTRPR NREEVIFDNL MLNPVSQLSH AIRENTEHLA EKMKVLFQNT
1460 1470 1480 1490 1500
GRAWEDLEAR INSENEVPIL KTSNKEISSI LKELRRVQKQ LEVINAIVDP
1510 1520 1530 1540 1550
SLNLDLLMGN RAPSGSGQPG LGKARPAAQS STSPASVDTL LPALPLRSFP
1560 1570
QRANCGPPGL PEPAFLPDAE RFLI
Length:1,574
Mass (Da):170,821
Last modified:April 3, 2007 - v2
Checksum:i9CB9DB93413B3B1F
GO
Isoform 2 (identifier: Q80U49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-1174: Missing.

Note: No experimental confirmation available.
Show »
Length:658
Mass (Da):72,862
Checksum:i39778FA66C03C543
GO

Sequence cautioni

The sequence BAC65518 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541E → V in BAE28024 (PubMed:16141072).Curated
Sequence conflicti237 – 2371P → L in AAH50077 (PubMed:15489334).Curated
Sequence conflicti1365 – 13651E → G in BAE27896 (PubMed:16141072).Curated
Sequence conflicti1428 – 14281L → P in AAH50077 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei259 – 1174916Missing in isoform 2. 1 PublicationVSP_024249Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122236 mRNA. Translation: BAC65518.1. Different initiation.
AK147410 mRNA. Translation: BAE27896.1.
AK147612 mRNA. Translation: BAE28024.1.
BC050077 mRNA. Translation: AAH50077.1.
CCDSiCCDS56867.1. [Q80U49-1]
RefSeqiNP_001019773.2. NM_001024602.3. [Q80U49-1]
XP_006515829.1. XM_006515766.2. [Q80U49-1]
XP_006515830.1. XM_006515767.2. [Q80U49-1]
UniGeneiMm.23689.

Genome annotation databases

EnsembliENSMUST00000092279; ENSMUSP00000089930; ENSMUSG00000072825. [Q80U49-2]
ENSMUST00000101018; ENSMUSP00000098580; ENSMUSG00000072825. [Q80U49-1]
ENSMUST00000179041; ENSMUSP00000137331; ENSMUSG00000072825. [Q80U49-1]
GeneIDi217882.
KEGGimmu:217882.
UCSCiuc007pfb.1. mouse. [Q80U49-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122236 mRNA. Translation: BAC65518.1. Different initiation.
AK147410 mRNA. Translation: BAE27896.1.
AK147612 mRNA. Translation: BAE28024.1.
BC050077 mRNA. Translation: AAH50077.1.
CCDSiCCDS56867.1. [Q80U49-1]
RefSeqiNP_001019773.2. NM_001024602.3. [Q80U49-1]
XP_006515829.1. XM_006515766.2. [Q80U49-1]
XP_006515830.1. XM_006515767.2. [Q80U49-1]
UniGeneiMm.23689.

3D structure databases

ProteinModelPortaliQ80U49.
SMRiQ80U49. Positions 1-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229975. 1 interaction.
STRINGi10090.ENSMUSP00000098580.

PTM databases

iPTMnetiQ80U49.
PhosphoSiteiQ80U49.

Proteomic databases

EPDiQ80U49.
MaxQBiQ80U49.
PaxDbiQ80U49.
PeptideAtlasiQ80U49.
PRIDEiQ80U49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092279; ENSMUSP00000089930; ENSMUSG00000072825. [Q80U49-2]
ENSMUST00000101018; ENSMUSP00000098580; ENSMUSG00000072825. [Q80U49-1]
ENSMUST00000179041; ENSMUSP00000137331; ENSMUSG00000072825. [Q80U49-1]
GeneIDi217882.
KEGGimmu:217882.
UCSCiuc007pfb.1. mouse. [Q80U49-1]

Organism-specific databases

CTDi283638.
MGIiMGI:2145043. Cep170b.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJXX. Eukaryota.
ENOG410XQU2. LUCA.
GeneTreeiENSGT00640000091476.
HOGENOMiHOG000111524.
HOVERGENiHBG108016.
InParanoidiQ80U49.
KOiK16463.
OMAiAQDFMAQ.
OrthoDBiEOG091G00LH.
PhylomeDBiQ80U49.
TreeFamiTF328469.

Miscellaneous databases

PROiQ80U49.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072825.
CleanExiMM_AW555464.
GenevisibleiQ80U49. MM.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR029300. CEP170_C.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF15308. CEP170_C. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC170B_MOUSE
AccessioniPrimary (citable) accession number: Q80U49
Secondary accession number(s): Q3UH33, Q3UHG1, Q80UM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.