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Protein

Zinc finger FYVE domain-containing protein 16

Gene

Zfyve16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri735 – 793FYVE-typePROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-201451. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 16
Alternative name(s):
Endofin
Endosomal-associated FYVE domain protein
Gene namesi
Name:Zfyve16
Synonyms:Kiaa0305
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145181. Zfyve16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000987171 – 1528Zinc finger FYVE domain-containing protein 16Add BLAST1528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphoserineCombined sources1
Modified residuei803PhosphoserineBy similarity1
Modified residuei833PhosphoserineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei927PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80U44.
MaxQBiQ80U44.
PaxDbiQ80U44.
PeptideAtlasiQ80U44.
PRIDEiQ80U44.

PTM databases

iPTMnetiQ80U44.
PhosphoSitePlusiQ80U44.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021706.
CleanExiMM_ZFYVE16.
GenevisibleiQ80U44. MM.

Interactioni

Subunit structurei

Interacts with the C-terminus of TOM1. Does not interact with TOM1L1 or TOM1L2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022217.

Structurei

3D structure databases

ProteinModelPortaliQ80U44.
SMRiQ80U44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P.By similarity

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri735 – 793FYVE-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1841. Eukaryota.
ENOG410XSEQ. LUCA.
GeneTreeiENSGT00840000129741.
HOGENOMiHOG000155780.
HOVERGENiHBG098617.
InParanoidiQ80U44.
KOiK04679.
OMAiFEQNPDE.
OrthoDBiEOG091G0VJ6.
PhylomeDBiQ80U44.
TreeFamiTF324904.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR022557. DUF3480.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR017165. Znf_FYVE_endofin.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR22835:SF43. PTHR22835:SF43. 4 hits.
PfamiPF11979. DUF3480. 1 hit.
PF01363. FYVE. 1 hit.
[Graphical view]
PIRSFiPIRSF037289. SARA/endofin. 1 hit.
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80U44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSYFKAAVS GLDKLLDDFE QNPDKQDYLP DAYAFNQCSV SSESASPQLA
60 70 80 90 100
LLSKDQRCIS TCASSEACCE DANETFLEGK IHEGLTSRPN EKNVAGLDLL
110 120 130 140 150
SSVDASTSDE IQPSCMRRCS KPVCDLISDM GNLVHATNSE EDIKQLLPDD
160 170 180 190 200
PKSSADTLIT LDSSSVSEAL TVSSVDCGSN AVREEQNNIN AGIKNRDISI
210 220 230 240 250
KELGVKVDMA LFDSCKYNRT ENLKDKIISN ELETVDFDMP SVLMEQSSEM
260 270 280 290 300
SNTKDNPQYK RLPCELLKDD GCLAEEKVAV AVNNTECLEE GGGSNTIAMP
310 320 330 340 350
CKLPENEGIS PSDPASKDEN FKLPDFPLQE NRTSVFMKQT VKEDSRNLDL
360 370 380 390 400
KDNNDIVHVS GDDVPPSLSC LSLSGSLCGS LIHNNEHSDI LPPNESEGQN
410 420 430 440 450
NDAVTIHEEI QKSDVLDGET DLSKKETCRS IFLQPVNEKK GEGKVEVEEM
460 470 480 490 500
VISGESLESP EDASSAAAAG SPVALSAASV PEAPGPCEGL TFPSSDMDGQ
510 520 530 540 550
ELDYFNIDES MRSGILISDA ELDAFLKEQC LSNSNTMSAG ENVNDSQLQM
560 570 580 590 600
NQITMKGLHD ENAGDIYFNA EAGAAGENGG VGNCETSDKE NTENNGLSIG
610 620 630 640 650
EKGAIPTERE LSACQPDIRD ELPVPSIKTQ AVGGARPKQL LSLPPGTRSS
660 670 680 690 700
KELNKPDVVD VPESEPCTAN ATAVSTCSAD HIPDSQVSFN SNYIDIESNF
710 720 730 740 750
EDGSSFVTAN KDSLPENKRK ESLVLGQKQP TWVPDSEAPN CMNCQVKFTF
760 770 780 790 800
TKRRHHCRAC GKVFCGVCCN RKCKLQYLEK EARVCVICYE TINKAQAFER
810 820 830 840 850
MMSPGGSCLK SNHSNECATD QPLQETQTSS TPSPTTLPIS ALKQPNVEGP
860 870 880 890 900
CSKEQKRVWF ADGILPNGEV ADTTKLSSGS KRCSDDFSPV LPDVPTMINK
910 920 930 940 950
VDRTHSPTVE KPNNGLGDII RSEISQSPTC HTAPVERLPG NTGTEGLPMP
960 970 980 990 1000
GPFTLEDDVF VDSEEPSTPT VVPANSGLPV ASISDYRLLC SVAKCVCNNI
1010 1020 1030 1040 1050
SLLPDDDIGL PPLLATSGED GSVPVVQERP SHEQIILLLE GEGFPPATFV
1060 1070 1080 1090 1100
LNANLLVNVK LVLYSSEKYW YFSTNGLHGL GQAEIIVLLQ CLPNEDTVPK
1110 1120 1130 1140 1150
DIFRLFITIY KDALKGKYIE NLDNLTFTES FLNSKDHGGF LFITPTFQNL
1160 1170 1180 1190 1200
DGLPVPRSPF LCGILIQKLE IPWAKVFPMR LMLRLGAEYK AYPAPLTSVR
1210 1220 1230 1240 1250
GRKPLFGEIG HTIMNLLVDL RNYQYTLHNI DQLLIHMEMG KSCIKIPRKK
1260 1270 1280 1290 1300
YSDVMKVIHS SNEHVISIGA SFSTEADSHL VCVQSDGVYQ TQANSATGQP
1310 1320 1330 1340 1350
RKVTGASFVV FNGALKTSSG FLAKSSIVED GLMVQITPET MEGLRLALRE
1360 1370 1380 1390 1400
QKDFRIQCGK VDAVDLREYV DICWVDSEER KNKGVISSVD GMSVEGFPSE
1410 1420 1430 1440 1450
KIKLETDFET EEKTVKCTEV FYFLKDQDIS ILSSSYQFAK EIAVACSAAL
1460 1470 1480 1490 1500
CPHLRTLKSN RMNKIGLRVS IDTDMVEFQA GCEGQLLPQH YLNDLDSALI
1510 1520
PVIHGGTSNS SLPLEIELAF FILENLSE
Length:1,528
Mass (Da):166,670
Last modified:July 19, 2004 - v2
Checksum:i063019BFD1665E2A
GO

Sequence cautioni

The sequence BAC65523 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti405T → I in BAC65523 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122241 mRNA. Translation: BAC65523.1. Different initiation.
BC042669 mRNA. Translation: AAH42669.1.
AK045090 mRNA. Translation: BAC32215.1.
CCDSiCCDS26682.1.
RefSeqiNP_775568.1. NM_173392.4.
UniGeneiMm.259585.

Genome annotation databases

EnsembliENSMUST00000022217; ENSMUSP00000022217; ENSMUSG00000021706.
GeneIDi218441.
KEGGimmu:218441.
UCSCiuc007rkq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122241 mRNA. Translation: BAC65523.1. Different initiation.
BC042669 mRNA. Translation: AAH42669.1.
AK045090 mRNA. Translation: BAC32215.1.
CCDSiCCDS26682.1.
RefSeqiNP_775568.1. NM_173392.4.
UniGeneiMm.259585.

3D structure databases

ProteinModelPortaliQ80U44.
SMRiQ80U44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022217.

PTM databases

iPTMnetiQ80U44.
PhosphoSitePlusiQ80U44.

Proteomic databases

EPDiQ80U44.
MaxQBiQ80U44.
PaxDbiQ80U44.
PeptideAtlasiQ80U44.
PRIDEiQ80U44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022217; ENSMUSP00000022217; ENSMUSG00000021706.
GeneIDi218441.
KEGGimmu:218441.
UCSCiuc007rkq.2. mouse.

Organism-specific databases

CTDi9765.
MGIiMGI:2145181. Zfyve16.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1841. Eukaryota.
ENOG410XSEQ. LUCA.
GeneTreeiENSGT00840000129741.
HOGENOMiHOG000155780.
HOVERGENiHBG098617.
InParanoidiQ80U44.
KOiK04679.
OMAiFEQNPDE.
OrthoDBiEOG091G0VJ6.
PhylomeDBiQ80U44.
TreeFamiTF324904.

Enzyme and pathway databases

ReactomeiR-MMU-201451. Signaling by BMP.

Miscellaneous databases

ChiTaRSiZfyve16. mouse.
PROiQ80U44.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021706.
CleanExiMM_ZFYVE16.
GenevisibleiQ80U44. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR022557. DUF3480.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR017165. Znf_FYVE_endofin.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR22835:SF43. PTHR22835:SF43. 4 hits.
PfamiPF11979. DUF3480. 1 hit.
PF01363. FYVE. 1 hit.
[Graphical view]
PIRSFiPIRSF037289. SARA/endofin. 1 hit.
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFY16_MOUSE
AccessioniPrimary (citable) accession number: Q80U44
Secondary accession number(s): Q8BRD2, Q8CG97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.