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Protein

MAP kinase-activating death domain protein

Gene

Madd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis).2 Publications

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • execution phase of apoptosis Source: UniProtKB
  • negative regulation of apoptotic signaling pathway Source: MGI
  • regulation of apoptotic process Source: MGI
  • regulation of cell cycle Source: UniProtKB
  • regulation of extrinsic apoptotic signaling pathway Source: MGI
  • regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  • regulation of Rab protein signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase-activating death domain protein
Alternative name(s):
Rab3 GDP/GTP exchange factor
Gene namesi
Name:MaddImported
Synonyms:Kiaa0358Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2444672. Madd.

Subcellular locationi

  • Membrane By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002781392 – 1577MAP kinase-activating death domain proteinBy similarityAdd BLAST1576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei155PhosphoserineBy similarity1
Modified residuei688PhosphoserineBy similarity1
Modified residuei691PhosphoserineBy similarity1
Modified residuei812PhosphoserineBy similarity1
Modified residuei817PhosphoserineCombined sources1
Modified residuei819PhosphoserineCombined sources1
Modified residuei857PhosphoserineBy similarity1
Modified residuei861PhosphoserineBy similarity1
Modified residuei915PhosphoserineBy similarity1
Modified residuei920PhosphoserineBy similarity1
Modified residuei929PhosphoserineBy similarity1
Modified residuei1058PhosphoserineCombined sources1
Modified residuei1060PhosphothreonineBy similarity1
Modified residuei1065PhosphothreonineCombined sources1
Modified residuei1109PhosphoserineCombined sources1
Modified residuei1235PhosphothreonineCombined sources1
Modified residuei1237PhosphoserineCombined sources1
Modified residuei1266PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80U28.
PeptideAtlasiQ80U28.
PRIDEiQ80U28.

PTM databases

iPTMnetiQ80U28.
PhosphoSitePlusiQ80U28.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040687.
CleanExiMM_MADD.

Interactioni

Subunit structurei

Interacts with the death domain of TNFRSF1A through its own death domain. Interacts with PIDD1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi230724. 1 interactor.
IntActiQ80U28. 2 interactors.
MINTiMINT-4378944.
STRINGi10090.ENSMUSP00000069350.

Structurei

3D structure databases

ProteinModelPortaliQ80U28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 97UDENNAdd BLAST74
Domaini171 – 401DENNPROSITE-ProRule annotationAdd BLAST231
Domaini484 – 557dDENNPROSITE-ProRule annotationAdd BLAST74
Domaini1336 – 1411DeathSequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1156 – 1248Ser-richSequence analysisAdd BLAST93

Sequence similaritiesi

Belongs to the MADD family.Curated
Contains 1 dDENN domain.PROSITE-ProRule annotation
Contains 1 death domain.Sequence analysis
Contains 1 DENN domain.PROSITE-ProRule annotation
Contains 1 uDENN domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3570. Eukaryota.
ENOG410XP23. LUCA.
HOVERGENiHBG079455.
InParanoidiQ80U28.

Family and domain databases

InterProiIPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
[Graphical view]
PfamiPF02141. DENN. 1 hit.
PF03456. uDENN. 1 hit.
[Graphical view]
SMARTiSM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00800. uDENN. 1 hit.
[Graphical view]
PROSITEiPS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS50946. UDENN. 1 hit.
[Graphical view]

Sequences (15)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 15 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q80U28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQKKFCPRL LDYLVIVGAR HPSSDSVAQT PELLRRYPLE DHPEFPLPPD
60 70 80 90 100
VVFFCQPEGC LSVRQRRMSL RDDTSFVFTL TDKDTGVTRY GICVNFYRSF
110 120 130 140 150
QKRMPKEKVE GGAGPRGKEG AHTSGASEEA ATGSSESGST LQPPSADSTP
160 170 180 190 200
DINQSPWGKR RAKAGSRSRN STLTSLCVLS HYPFFSTFRE CLYTLKRLVD
210 220 230 240 250
CCSERLLGKK LGIPRGVQRD TMWRIFTGSL LVEEKSSALL QDLREIEAWI
260 270 280 290 300
YRLLRSPVPV SGQKRVDIEV LPQELQQALT FALPDPSRFT LVDFPLHLPL
310 320 330 340 350
ELLGVDACLQ VLTCILLEHK VVLQSRDYNA LSMSVMAFVA MIYPLEYMFP
360 370 380 390 400
VIPLLPTCMA SAEQLLLAPT PYIIGVPASF FLYKLDFKMP DDVWLVDLDS
410 420 430 440 450
NRVIAPTNAE VLPILPEPES LELKKHLKQA LASMSLNTQP ILNLEKFHEG
460 470 480 490 500
QEIPLLLGRP SNDLQSTPST EFNPLIYGND VDSVDVATRV AMVRFFNSAN
510 520 530 540 550
VLQGFQMHTR TLRLFPRPVV AFQAGSFLAS RPRQTPFAEK LARTQAVEYF
560 570 580 590 600
GEWILNPSNY AFQRIHNNTF DPALIGDKPK WYAHQLQPIH YRVYDGNSQL
610 620 630 640 650
AEALSVPPER DSDSDPTEDS GSDSQDYDDS SSSYSSLGDF VSEMMKCDIN
660 670 680 690 700
GDTPNVDPLT HAALGDASEV EIDELQPQKE GEEPGPDSEN SQENPPLRSS
710 720 730 740 750
SSTTASSSPS TVVHSAHSEA ADSTEMGDKA TAGISKPLPP VPPSICKSTV
760 770 780 790 800
DRRQTETGEG SVCQRTYDNP YFEPQYGFPP EEDEEEQGES YTPRFSQHVS
810 820 830 840 850
GSRAQKLLRP NSLKLASDSD AESDSRASSP NSTVSNNSTE GFGGIMSFAS
860 870 880 890 900
SLYRNHSTSF SLSNLTLPTK GAREKTTPFP SLKVFGLNTL MEIVTEAGPG
910 920 930 940 950
SGEGNRRALV DQKSSVIKHS PTVKREPSSP QGRSSNSSEN QQFLKEVVHS
960 970 980 990 1000
VLDGQGVGWL NMKKVRRLLE SEQLRVFVLS KLNRAVQSED DARQDVIQDV
1010 1020 1030 1040 1050
EISRKVYKGM LDLLKCTVLS LEQSYAHAGL GGMASIFGLL EIAQTHYYSK
1060 1070 1080 1090 1100
EPDKRKRSPT ENVNTPVGKD PGLAGRGDPK AMAQLRVPQL GPRAPSATGK
1110 1120 1130 1140 1150
GPKELDTRSL KEENFVASVE LWNKHQEVKK QKALEKQRPE GIKPVFDLGE
1160 1170 1180 1190 1200
TEEKKSQMSA DSGVSLTSAS QRTDQDSVIG VSPAVMIRSS SQDSEVSTVS
1210 1220 1230 1240 1250
NSSGETLGAD SDLSSNAGDG PGGEGSAHLA SSRATLSDSE IETNSATSAI
1260 1270 1280 1290 1300
FGKAHSLKPK EKPAGSPIRS SEDVSQRVYL YEGLLGRDKG SMWDQLEDAA
1310 1320 1330 1340 1350
METFSLSKER STLWDQMQFW EDAFLDAVML EREGMGMDQG PQEMIDRYLS
1360 1370 1380 1390 1400
LGEHDRKRLE DDEDRLLATL LHNLISYMLL MKVNKNDIRK KVRRLMGKSH
1410 1420 1430 1440 1450
IGLVYSQQVN EVLDQLNSLN GRDLSIRSSG SRHMKKQTFV VHAGTDTNGD
1460 1470 1480 1490 1500
IFFMEVCDDC VVLRSNIGTV YERWWYEKLI NMTYCPKTKV LCLWRRNGSE
1510 1520 1530 1540 1550
TQLNKFYTKK CRELYYCVKD SMERAAARQQ SIKPGPELGG EFPVQDMKTG
1560 1570
EGGLLQVTLE GINLKFMHNQ FLKLKKW
Note: No experimental confirmation available.Curated
Length:1,577
Mass (Da):175,180
Last modified:February 20, 2007 - v2
Checksum:i5D604F8DDD1EF481
GO
Isoform 21 Publication (identifier: Q80U28-2) [UniParc]FASTAAdd to basket
Also known as: IG201 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1199-1199: V → VV
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHAQPGFHRAESH

Show »
Length:1,567
Mass (Da):173,703
Checksum:i82A821B9418F929E
GO
Isoform 31 Publication (identifier: Q80U28-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     884-903: Missing.
     1199-1199: V → VV

Note: No experimental confirmation available.Curated
Show »
Length:1,558
Mass (Da):173,276
Checksum:i8291C95AE140A9A3
GO
Isoform 41 Publication (identifier: Q80U28-4) [UniParc]FASTAAdd to basket
Also known as: IG20-PASV1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1199-1199: V → VV
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHAQPGFHRAESH

Show »
Length:1,528
Mass (Da):168,957
Checksum:i370F12A91BA83F02
GO
Isoform 51 Publication (identifier: Q80U28-5) [UniParc]FASTAAdd to basket
Also known as: IG20-SV41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-743: Missing.
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1199-1199: V → VV
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHA...LRTPPRPVSS

Show »
Length:1,525
Mass (Da):169,203
Checksum:i2F7BE597770239C9
GO
Isoform 61 Publication (identifier: Q80U28-6) [UniParc]FASTAAdd to basket
Also known as: IG20-SV51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-743: Missing.
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1198-1200: Missing.
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHA...LRTPPRPVSS

Show »
Length:1,521
Mass (Da):168,816
Checksum:iDB43A1308E2B5E01
GO
Isoform 71 Publication (identifier: Q80U28-7) [UniParc]FASTAAdd to basket
Also known as: IG20-SV21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-744: EAADSTEMGDKATAGISKPLPPVPPS → VREHLAG
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1199-1199: V → VV
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHAQPGFHRAESH

Show »
Length:1,509
Mass (Da):167,171
Checksum:iB3E5492FEAAB6368
GO
Isoform 81 Publication (identifier: Q80U28-8) [UniParc]FASTAAdd to basket
Also known as: IG20-SV11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1199-1199: V → VV
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHAQPGFHRAESH

Show »
Length:1,508
Mass (Da):166,954
Checksum:i6122B73F9651FBBF
GO
Isoform 91 Publication (identifier: Q80U28-9) [UniParc]FASTAAdd to basket
Also known as: IG20-SV61 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-743: Missing.
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1183-1200: Missing.
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHA...LRTPPRPVSS

Show »
Length:1,506
Mass (Da):167,242
Checksum:iC0304173486A15B1
GO
Isoform 101 Publication (identifier: Q80U28-10) [UniParc]FASTAAdd to basket
Also known as: IG20-SV71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-743: Missing.
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1172-1198: Missing.
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHA...LRTPPRPVSS

Show »
Length:1,497
Mass (Da):166,270
Checksum:i6D669FD76AAE3DE6
GO
Isoform 111 Publication (identifier: Q80U28-11) [UniParc]FASTAAdd to basket
Also known as: IG20-SV31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-744: EAADSTEMGDKATAGISKPLPPVPPS → VREHLAG
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1199-1199: V → VV
     1287-1307: Missing.
     1511-1534: CRELYYCVKDSMERAAARQQSIKP → VLRVCVWAGDWI
     1559-1577: LEGINLKFMHNQFLKLKKW → PGRDQSQVHAQPGFHRAESH

Show »
Length:1,489
Mass (Da):165,168
Checksum:i2A32B8899E4A502A
GO
Isoform 121 Publication (identifier: Q80U28-12) [UniParc]FASTAAdd to basket
Also known as: IG20-SV81 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     719-743: Missing.
     884-903: Missing.
     1120-1138: ELWNKHQEVKKQKALEKQR → G
     1172-1198: Missing.
     1219-1577: Missing.

Show »
Length:1,128
Mass (Da):124,520
Checksum:i983116C5660A386C
GO
Isoform 131 Publication (identifier: Q80U28-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     884-903: Missing.
     1120-1135: ELWNKHQEVKKQKALE → DLTENLLMFGVSLFTL
     1136-1577: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,115
Mass (Da):123,434
Checksum:i2D48347DBAC3FFE8
GO
Isoform 141 Publication (identifier: Q80U28-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     884-903: Missing.
     1199-1199: V → VV
     1571-1577: FLKLKKW → ERKVFIELNH...LRTPPRPVSS

Note: No experimental confirmation available.Curated
Show »
Length:1,627
Mass (Da):181,095
Checksum:i490E2FB090295D61
GO
Isoform 151 Publication (identifier: Q80U28-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1196-1198: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,574
Mass (Da):174,892
Checksum:iE2937BB33AC89625
GO

Sequence cautioni

The sequence BAC65539 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132T → A in BAC29392 (PubMed:16141072).Curated1
Sequence conflicti132T → A in CAM17578 (PubMed:19468303).Curated1
Sequence conflicti132T → A in AAH63386 (PubMed:15489334).Curated1
Sequence conflicti152I → V in BAC29392 (PubMed:16141072).Curated1
Sequence conflicti152I → V in CAM17578 (PubMed:19468303).Curated1
Sequence conflicti152I → V in AAH63386 (PubMed:15489334).Curated1
Sequence conflicti157W → R in AAP22159 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22160 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22161 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22162 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22163 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22164 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22165 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22166 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22167 (Ref. 1) Curated1
Sequence conflicti157W → R in AAP22168 (Ref. 1) Curated1
Sequence conflicti157W → R in BAC29392 (PubMed:16141072).Curated1
Sequence conflicti157W → R in CAM17578 (PubMed:19468303).Curated1
Sequence conflicti157W → R in AAH63386 (PubMed:15489334).Curated1
Sequence conflicti1159S → R in BAE37379 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052299719 – 744EAADS…PVPPS → VREHLAG in isoform 7 and isoform 11. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_052300719 – 743Missing in isoform 5, isoform 6, isoform 9, isoform 10 and isoform 12. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_052301884 – 903Missing in isoform 3, isoform 5, isoform 6, isoform 8, isoform 9, isoform 10, isoform 11, isoform 12, isoform 13 and isoform 14. 3 PublicationsAdd BLAST20
Alternative sequenceiVSP_0523021120 – 1138ELWNK…LEKQR → G in isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0523031120 – 1135ELWNK…QKALE → DLTENLLMFGVSLFTL in isoform 13. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0523041136 – 1577Missing in isoform 13. 1 PublicationAdd BLAST442
Alternative sequenceiVSP_0523051172 – 1198Missing in isoform 10 and isoform 12. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_0523061183 – 1200Missing in isoform 9. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0523071196 – 1198Missing in isoform 15. 1 Publication3
Alternative sequenceiVSP_0523081198 – 1200Missing in isoform 6. 1 Publication3
Alternative sequenceiVSP_0523091199V → VV in isoform 2, isoform 3, isoform 4, isoform 5, isoform 7, isoform 8, isoform 11 and isoform 14. 2 Publications1
Alternative sequenceiVSP_0523101219 – 1577Missing in isoform 12. 1 PublicationAdd BLAST359
Alternative sequenceiVSP_0523111287 – 1307Missing in isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0523121511 – 1534CRELY…QSIKP → VLRVCVWAGDWI in isoform 2, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0523131559 – 1577LEGIN…KLKKW → PGRDQSQVHAQPGFHRAESH in isoform 2, isoform 4, isoform 7, isoform 8 and isoform 11. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0523141559 – 1577LEGIN…KLKKW → PGRDQSQVHAQPVPEIKEVV SHKYKTPMAHEICYSVLCLF SYVAAVRSSEEDLRTPPRPV SS in isoform 5, isoform 6, isoform 9 and isoform 10. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0523151571 – 1577FLKLKKW → ERKVFIELNHIKKCNTVRGV FVLEEFVPEIKEVVSHKYKT PMAHEICYSVLCLFSYVAAV RSSEEDLRTPPRPVSS in isoform 14. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263980 mRNA. Translation: AAP22159.1.
AY263981 mRNA. Translation: AAP22160.1.
AY263982 mRNA. Translation: AAP22161.1.
AY263983 mRNA. Translation: AAP22162.1.
AY263984 mRNA. Translation: AAP22163.1.
AY263985 mRNA. Translation: AAP22164.1.
AY263986 mRNA. Translation: AAP22165.1.
AY263987 mRNA. Translation: AAP22166.1.
AY263988 mRNA. Translation: AAP22167.1.
AY263989 mRNA. Translation: AAP22168.1.
AK122257 mRNA. Translation: BAC65539.1. Different initiation.
AK036347 mRNA. Translation: BAC29392.1.
AK163518 mRNA. Translation: BAE37379.1.
AL691450 Genomic DNA. Translation: CAM17578.1.
BC042212 mRNA. Translation: AAH42212.1.
BC063386 mRNA. Translation: AAH63386.1.
CCDSiCCDS38178.1. [Q80U28-3]
CCDS50635.1. [Q80U28-14]
CCDS50638.1. [Q80U28-1]
RefSeqiNP_001171190.1. NM_001177719.1.
NP_001171191.1. NM_001177720.1.
NP_663502.3. NM_145527.4.
XP_017173117.1. XM_017317628.1.
UniGeneiMm.36410.

Genome annotation databases

GeneIDi228355.
KEGGimmu:228355.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263980 mRNA. Translation: AAP22159.1.
AY263981 mRNA. Translation: AAP22160.1.
AY263982 mRNA. Translation: AAP22161.1.
AY263983 mRNA. Translation: AAP22162.1.
AY263984 mRNA. Translation: AAP22163.1.
AY263985 mRNA. Translation: AAP22164.1.
AY263986 mRNA. Translation: AAP22165.1.
AY263987 mRNA. Translation: AAP22166.1.
AY263988 mRNA. Translation: AAP22167.1.
AY263989 mRNA. Translation: AAP22168.1.
AK122257 mRNA. Translation: BAC65539.1. Different initiation.
AK036347 mRNA. Translation: BAC29392.1.
AK163518 mRNA. Translation: BAE37379.1.
AL691450 Genomic DNA. Translation: CAM17578.1.
BC042212 mRNA. Translation: AAH42212.1.
BC063386 mRNA. Translation: AAH63386.1.
CCDSiCCDS38178.1. [Q80U28-3]
CCDS50635.1. [Q80U28-14]
CCDS50638.1. [Q80U28-1]
RefSeqiNP_001171190.1. NM_001177719.1.
NP_001171191.1. NM_001177720.1.
NP_663502.3. NM_145527.4.
XP_017173117.1. XM_017317628.1.
UniGeneiMm.36410.

3D structure databases

ProteinModelPortaliQ80U28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230724. 1 interactor.
IntActiQ80U28. 2 interactors.
MINTiMINT-4378944.
STRINGi10090.ENSMUSP00000069350.

PTM databases

iPTMnetiQ80U28.
PhosphoSitePlusiQ80U28.

Proteomic databases

PaxDbiQ80U28.
PeptideAtlasiQ80U28.
PRIDEiQ80U28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi228355.
KEGGimmu:228355.

Organism-specific databases

CTDi8567.
MGIiMGI:2444672. Madd.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3570. Eukaryota.
ENOG410XP23. LUCA.
HOVERGENiHBG079455.
InParanoidiQ80U28.

Miscellaneous databases

PROiQ80U28.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040687.
CleanExiMM_MADD.

Family and domain databases

InterProiIPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR005113. uDENN_dom.
[Graphical view]
PfamiPF02141. DENN. 1 hit.
PF03456. uDENN. 1 hit.
[Graphical view]
SMARTiSM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00800. uDENN. 1 hit.
[Graphical view]
PROSITEiPS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS50946. UDENN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMADD_MOUSE
AccessioniPrimary (citable) accession number: Q80U28
Secondary accession number(s): Q3TQK3
, Q6P4I6, Q80W52, Q80WL3, Q80WL4, Q80WL5, Q80WL6, Q80WL7, Q80WL8, Q80WL9, Q80WM0, Q80WM1, Q80WM2, Q8CBC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.