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Protein

Arginine-glutamic acid dipeptide repeats protein

Gene

Rere

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri507 – 53226GATA-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • branching morphogenesis of a nerve Source: MGI
  • cerebellar granule cell precursor proliferation Source: MGI
  • cerebellar Purkinje cell layer maturation Source: MGI
  • cerebellum development Source: MGI
  • chromatin remodeling Source: MGI
  • dendrite morphogenesis Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: GOC
  • positive regulation of transcription from RNA polymerase II promoter Source: GOC
  • radial glia guided migration of Purkinje cell Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine-glutamic acid dipeptide repeats protein
Alternative name(s):
Atrophin-2
Gene namesi
Name:Rere
Synonyms:Atr2, Kiaa0458
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2683486. Rere.

Subcellular locationi

  • NucleusPML body By similarity

  • Note: Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs (By similarity).By similarity

GO - Cellular componenti

  • histone deacetylase complex Source: MGI
  • nucleus Source: MGI
  • PML body Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice embryos exhibit a variety of patterning defects that first appear at E8.0. Defects include a specific failure in ventralization of the anterior neural plate, loss of heart looping and irregular partitioning of somites. In mutant embryos, Shh expression fails to initiate along the anterior midline at E8.0, and Fgf8 is delocalized from the anterior neural ridge at E8.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15581558Arginine-glutamic acid dipeptide repeats proteinPRO_0000083505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531PhosphoserineCombined sources
Modified residuei56 – 561PhosphoserineCombined sources
Modified residuei142 – 1421PhosphoserineCombined sources
Modified residuei304 – 3041PhosphoserineBy similarity
Modified residuei593 – 5931PhosphothreonineCombined sources
Modified residuei594 – 5941PhosphoserineCombined sources
Modified residuei600 – 6001PhosphoserineCombined sources
Modified residuei613 – 6131PhosphoserineBy similarity
Cross-linki637 – 637Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei642 – 6421PhosphoserineBy similarity
Modified residuei656 – 6561PhosphoserineBy similarity
Modified residuei675 – 6751PhosphoserineCombined sources
Modified residuei679 – 6791PhosphoserineCombined sources
Modified residuei1098 – 10981PhosphoserineCombined sources
Modified residuei1105 – 11051PhosphoserineCombined sources
Modified residuei1107 – 11071PhosphoserineCombined sources
Modified residuei1111 – 11111PhosphothreonineBy similarity
Modified residuei1150 – 11501N6-acetyllysineCombined sources
Modified residuei1251 – 12511PhosphotyrosineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ80TZ9.
MaxQBiQ80TZ9.
PaxDbiQ80TZ9.
PRIDEiQ80TZ9.

PTM databases

iPTMnetiQ80TZ9.
PhosphoSiteiQ80TZ9.

Expressioni

Developmental stagei

At E8.25 expression is strongly elevated in the anterior midline. At E8.5 expression is elevated throughout the anteroposterior extent of the notochord and is down-regulated in the heart. At E8.75 expression is increased in the ventral brain. At E9.5 strong expression appears besides the notochord including the apical ectodermal ridge (AER), the isthmus and the ventral diencephalon. At E10.5 expression increases in the notochord, the AER and spinal and brain neurons.1 Publication

Gene expression databases

BgeeiQ80TZ9.
CleanExiMM_RERE.
ExpressionAtlasiQ80TZ9. baseline and differential.
GenevisibleiQ80TZ9. MM.

Interactioni

Subunit structurei

Interacts with HDAC1 and ATN1. Interaction with ATN1 is improved when the poly-Gln region of ATN1 is extended. Interacts with FAT1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi213002. 2 interactions.
IntActiQ80TZ9. 3 interactions.
STRINGi10090.ENSMUSP00000101307.

Structurei

3D structure databases

ProteinModelPortaliQ80TZ9.
SMRiQ80TZ9. Positions 392-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 283181BAHPROSITE-ProRule annotationAdd
BLAST
Domaini284 – 387104ELM2PROSITE-ProRule annotationAdd
BLAST
Domaini391 – 44353SANTPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1148 – 120356Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi738 – 1110373Pro-richAdd
BLAST
Compositional biasi1171 – 119626Arg/Glu-rich (mixed charge)Add
BLAST
Compositional biasi1292 – 131423Arg/Glu-rich (mixed charge)Add
BLAST
Compositional biasi1417 – 143721His-richAdd
BLAST
Compositional biasi1443 – 150260Pro-richAdd
BLAST

Domaini

The interaction with ATN1 is mediated by the coiled domain.By similarity

Sequence similaritiesi

Contains 1 BAH domain.PROSITE-ProRule annotation
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 GATA-type zinc finger.Curated
Contains 1 SANT domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri507 – 53226GATA-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2133. Eukaryota.
ENOG410ZIND. LUCA.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000231091.
HOVERGENiHBG079774.
InParanoidiQ80TZ9.
KOiK05628.
OMAiHIKPPPT.
OrthoDBiEOG7D59MN.
TreeFamiTF328554.

Family and domain databases

InterProiIPR002951. Atrophin-like.
IPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF03154. Atrophin-1. 1 hit.
PF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80TZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTADKDKDKD KEKDRDRDRD RERDKRDKAR ESENARPRRS CTLEGGAKNY
60 70 80 90 100
AESDHSEDED NDNNSATTEE SNKKSRKKPP KKKSRYERTD TGEITSYITE
110 120 130 140 150
DDVVYRPGDC VYIESRRPNT PYFICSIQDF KLVHSSQACC RSPAPAFCDP
160 170 180 190 200
PACSLPVAPQ PPQHLSEAGR GPGGSKRDHL LMNVKWYYRQ SEVPDSVYQH
210 220 230 240 250
LVQDRHNEND SGRELVITDP VIKNRELFIS DYVDTYHAAA LRGKCNISHF
260 270 280 290 300
SDIFAAREFK ARVDSFFYIL GYNPETRRLN STQGEIRVGP SHQAKLPDLQ
310 320 330 340 350
PFPSPDGDTV TQHEELVWMP GVSDCDLLMY LRAARSMAAF AGMCDGGSTE
360 370 380 390 400
DGCVAASRDD TTLNALNTLH ESSYDAGKAL QRLVKKPVPK LIEKCWTEDE
410 420 430 440 450
VKRFVKGLRQ YGKNFFRIRK ELLPSKETGE LITFYYYWKK TPEAASSRAH
460 470 480 490 500
RRHRRQAVFR RIKTRTASTP VNTPSRPPSS EFLDLSSASE DDFDSEDSEQ
510 520 530 540 550
ELKGYACRHC FTTTSKDWHH GGRENILLCT DCRIHFKKYG ELPPIEKPVD
560 570 580 590 600
PPPFMFKPVK EEDDGLSGKH SMRTRRSRGS MSTLRSGRKK QPTSPDGRAS
610 620 630 640 650
PINEDIRSSG RNSPSAASTS SNDSKAETVK KSAKKVKEEA ASPLKSTKRQ
660 670 680 690 700
REKVASDTED TDRITSKKTK TQEISRPNSP SEGEGESSDS RSVNDEGSSD
710 720 730 740 750
PKDIDQDNRS TSPSIPSPQD NESDSDSSAQ QQMLQAQPPA LQAPSGAASA
760 770 780 790 800
PSTAPPGTPQ LPTQGPTPSA TAVPPQGSPA TSQPPNQTQS TVAPAAHTHI
810 820 830 840 850
QQAPTLHPPR LPSPHPPLQP MTAPPSQSSA QPHPQPSLHS QGPPGPHSLQ
860 870 880 890 900
TGPLLQHPGP PQPFGLPSQP SQGQGPLGPS PAAAHPHSTI QLPASQSALQ
910 920 930 940 950
PQQPPREQPL PPAPLAMPHI KPPPTTPIPQ LPAPQAHKHP PHLSGPSPFS
960 970 980 990 1000
LNANLPPPPA LKPLSSLSTH HPPSAHPPPL QLMPQSQPLP SSPAQPPGLT
1010 1020 1030 1040 1050
QSQSLPPPAA SHPTTGLHQV PSQSPFPQHP FVPGGPPPIT PPSCPPTSTP
1060 1070 1080 1090 1100
PAGPSSSSQP PCSAAVSSGG SVPGAPSCPL PAVQIKEEAL DEAEEPESPP
1110 1120 1130 1140 1150
PPPRSPSPEP TVVDTPSHAS QSARFYKHLD RGYNSCARTD LYFMPLAGSK
1160 1170 1180 1190 1200
LAKKREEAIE KAKREAEQKA REEREREKEK EKERERERER EREAERAAKA
1210 1220 1230 1240 1250
SSSAHEGRLS DPQLSGPGHM RPSFEPPPTT IAAVPPYIGP DTPALRTLSE
1260 1270 1280 1290 1300
YARPHVMSPT NRNHPFYMPL NPTDPLLAYH MPGLYNVDPT IRERELRERE
1310 1320 1330 1340 1350
IREREIRERE LRERMKPGFE VKPPELDPLH PATNPMEHFA RHSALTIPPA
1360 1370 1380 1390 1400
AGPHPFASFH PGLNPLERER LALAGPQLRP EMSYPDRLAA ERIHAERMAS
1410 1420 1430 1440 1450
LTSDPLARLQ MFNVTPHHHQ HSHIHSHLHL HQQDPLHQGS AGPVHPLVDP
1460 1470 1480 1490 1500
LTAGPHLARF PYPPGTLPNP LLGQPPHEHE MLRHPVFGTP YPRDLPGAIP
1510 1520 1530 1540 1550
PPMSAAHQLQ AMHAQSAELQ RLAMEQQWLH GHPHMHGGHL PSQEDYYSRL

KKEGDKQL
Length:1,558
Mass (Da):171,755
Last modified:July 27, 2011 - v3
Checksum:i723A76184971CAA3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti840 – 8401S → G in BAC65569 (PubMed:12693553).Curated
Sequence conflicti1236 – 12394Missing in BAC65569 (PubMed:12693553).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691453, AL606982, AL606988 Genomic DNA. Translation: CAM16595.1.
AL606982, AL606988, AL691453 Genomic DNA. Translation: CAM21921.1.
AL606988, AL606982, AL691453 Genomic DNA. Translation: CAM22173.1.
CU210934, CU210933 Genomic DNA. Translation: CAQ51525.1.
CU210933, CU210934 Genomic DNA. Translation: CAQ51728.1.
AK122287 Transcribed RNA. Translation: BAC65569.1.
CCDSiCCDS38979.1.
RefSeqiNP_001078961.1. NM_001085492.1.
UniGeneiMm.291274.

Genome annotation databases

EnsembliENSMUST00000105682; ENSMUSP00000101307; ENSMUSG00000039852.
GeneIDi68703.
KEGGimmu:68703.
UCSCiuc008vxr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691453, AL606982, AL606988 Genomic DNA. Translation: CAM16595.1.
AL606982, AL606988, AL691453 Genomic DNA. Translation: CAM21921.1.
AL606988, AL606982, AL691453 Genomic DNA. Translation: CAM22173.1.
CU210934, CU210933 Genomic DNA. Translation: CAQ51525.1.
CU210933, CU210934 Genomic DNA. Translation: CAQ51728.1.
AK122287 Transcribed RNA. Translation: BAC65569.1.
CCDSiCCDS38979.1.
RefSeqiNP_001078961.1. NM_001085492.1.
UniGeneiMm.291274.

3D structure databases

ProteinModelPortaliQ80TZ9.
SMRiQ80TZ9. Positions 392-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213002. 2 interactions.
IntActiQ80TZ9. 3 interactions.
STRINGi10090.ENSMUSP00000101307.

PTM databases

iPTMnetiQ80TZ9.
PhosphoSiteiQ80TZ9.

Proteomic databases

EPDiQ80TZ9.
MaxQBiQ80TZ9.
PaxDbiQ80TZ9.
PRIDEiQ80TZ9.

Protocols and materials databases

DNASUi68703.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105682; ENSMUSP00000101307; ENSMUSG00000039852.
GeneIDi68703.
KEGGimmu:68703.
UCSCiuc008vxr.1. mouse.

Organism-specific databases

CTDi473.
MGIiMGI:2683486. Rere.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2133. Eukaryota.
ENOG410ZIND. LUCA.
GeneTreeiENSGT00580000081398.
HOGENOMiHOG000231091.
HOVERGENiHBG079774.
InParanoidiQ80TZ9.
KOiK05628.
OMAiHIKPPPT.
OrthoDBiEOG7D59MN.
TreeFamiTF328554.

Miscellaneous databases

ChiTaRSiRere. mouse.
NextBioi327726.
PROiQ80TZ9.
SOURCEiSearch...

Gene expression databases

BgeeiQ80TZ9.
CleanExiMM_RERE.
ExpressionAtlasiQ80TZ9. baseline and differential.
GenevisibleiQ80TZ9. MM.

Family and domain databases

InterProiIPR002951. Atrophin-like.
IPR001025. BAH_dom.
IPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR000679. Znf_GATA.
[Graphical view]
PfamiPF03154. Atrophin-1. 1 hit.
PF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
[Graphical view]
SMARTiSM00439. BAH. 1 hit.
SM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 673-1558.
    Tissue: Brain.
  3. "Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis."
    Zoltewicz J.S., Stewart N.J., Leung R., Peterson A.S.
    Development 131:3-14(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ATN1 AND HDAC1, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-675 AND SER-679, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; SER-56; SER-142; THR-593; SER-594; SER-600; SER-675; SER-679; SER-1098; SER-1105 AND SER-1107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen and Testis.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1150, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiRERE_MOUSE
AccessioniPrimary (citable) accession number: Q80TZ9
Secondary accession number(s): A2A7T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.