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Protein
Submitted name:

Adenylate cyclase 3, isoform CRA_b

Gene

Adcy3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase 3, isoform CRA_bImported
Submitted name:
MKIAA0511 proteinImported
Gene namesi
Name:Adcy3Imported
Synonyms:mKIAA0511Imported
ORF Names:mCG_116984Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:99675. Adcy3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 106HelicalSequence analysisAdd BLAST23
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Transmembranei144 – 163HelicalSequence analysisAdd BLAST20
Transmembranei175 – 191HelicalSequence analysisAdd BLAST17
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei236 – 253HelicalSequence analysisAdd BLAST18
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Transmembranei670 – 692HelicalSequence analysisAdd BLAST23
Transmembranei713 – 738HelicalSequence analysisAdd BLAST26
Transmembranei758 – 775HelicalSequence analysisAdd BLAST18
Transmembranei782 – 800HelicalSequence analysisAdd BLAST19
Transmembranei846 – 863HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000020654.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020984.

Structurei

3D structure databases

ProteinModelPortaliQ80TY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 452Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini929 – 1081Guanylate cyclaseInterPro annotationAdd BLAST153

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
KOiK08043.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR030672. Adcy.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q80TY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KQPAANMPRN QGFSDPEYSA EYSAEYSVSL PSDPDRGVGR THEISVRNSG
60 70 80 90 100
SCLCLPRFMR LTFVPESLEN LYQTYFKRQR HETLLVLVVF AALFDCYVVV
110 120 130 140 150
MCAVVFSSDK LAPLMVAGFG LVLDIILFVL CKKGLLPDRV SRKVVPYLLW
160 170 180 190 200
LLISAQIFSY LGLNFSRAHA ASDTVGWQAF FVFSFFITLP LSLSPIVIIS
210 220 230 240 250
VVSCVVHTLV LGVTVAQQQQ DELEGMQLLR EILANVFLYL CAIIVGIMSY
260 270 280 290 300
YMADRKHRKA FLEARQSLEV KMNLEEQSQQ QENLMLSILP KHVADEMLKD
310 320 330 340 350
MKKDESQKDQ QQFNTMYMYR HENVSILFAD IVGFTQLSSA CSAQELVKLL
360 370 380 390 400
NELFARFDKL AAKYHQLRIK ILGDCYYCIC GLPDYREDHA VCSILMGLAM
410 420 430 440 450
VEAISYVREK TKTGVDMRVG VHTGTVLGGV LGQKRWQYDV WSTDVTVANK
460 470 480 490 500
MEAGGIPGRV HISQSTMDCL KGEFDVEPGD GGSRCDYLDE KGIETYLIIA
510 520 530 540 550
SKPEVKKTAQ NGLNGSAVPN GAPASSKPSS PALIETKEPN GSAHASGSTS
560 570 580 590 600
EEAEEQEAQA DNPSFPNPRR RLRLQDLADR VVDASEDEHE LNQLLNEALL
610 620 630 640 650
ERESAQVVKK RNTFLLTMRF MDPEMETRYS VEKEKQSGAA FSCSCVVLFC
660 670 680 690 700
TAMVEILIDP WLMTNYVTFV VGEVLLLILT ICSMAAIFPR SFPKKLVAFS
710 720 730 740 750
SWIDRTRWAR NTWAMLAIFI LVMANVVDML SCLQYYMGPY NMTAGMELDG
760 770 780 790 800
GCMENPKYYN YVAVLSLIAT IMLVQVSHMV KLTLMLLVTG AVTALNLYAW
810 820 830 840 850
CPVFDEYDHK RFQEKDSPMV ALEKMQVLAT PGLNGTDRLP LVPSKYSMTV
860 870 880 890 900
MMFVMMLSFY YFSRHVEKLA RTLFLWKIEV HDQKERVYEM RRWNEALVTN
910 920 930 940 950
MLPEHVARHF LGSKKRDEEL YSQSYDEIGV MFASLPNFAD FYTEESINNG
960 970 980 990 1000
GIECLRFLNE IISDFDSLLD NPKFRVITKI KTIGSTYMAA SGVTPDVNTN
1010 1020 1030 1040 1050
GFTSSSKEEK SDKERWQHLA DLADFALAMK DTLTNINNQS FNNFMLRIGM
1060 1070 1080 1090 1100
NKGGVLAGVI GARKPHYDIW GNTVNVASRM ESTGVMGNIQ VVEETQVILR
1110 1120 1130 1140 1150
EYGFRFVRRG PIFVKGKGEL LTFFLKGRDR PAAFPNGSSV TLPHQVVDNP
Length:1,150
Mass (Da):129,608
Last modified:June 1, 2003 - v1
Checksum:i734089FD1C0819B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122298 mRNA. Translation: BAC65580.1.
CH466623 Genomic DNA. Translation: EDL01375.1.
CH466623 Genomic DNA. Translation: EDL01376.1.
RefSeqiNP_001153008.1. NM_001159536.1.
NP_001153009.1. NM_001159537.1.
NP_612178.2. NM_138305.3.
UniGeneiMm.489807.

Genome annotation databases

GeneIDi104111.
KEGGimmu:104111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122298 mRNA. Translation: BAC65580.1.
CH466623 Genomic DNA. Translation: EDL01375.1.
CH466623 Genomic DNA. Translation: EDL01376.1.
RefSeqiNP_001153008.1. NM_001159536.1.
NP_001153009.1. NM_001159537.1.
NP_612178.2. NM_138305.3.
UniGeneiMm.489807.

3D structure databases

ProteinModelPortaliQ80TY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi104111.
KEGGimmu:104111.

Organism-specific databases

CTDi109.
MGIiMGI:99675. Adcy3.

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
KOiK08043.

Miscellaneous databases

ChiTaRSiAdcy3. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020654.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR030672. Adcy.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFiPIRSF039050. Ade_cyc. 1 hit.
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ80TY9_MOUSE
AccessioniPrimary (citable) accession number: Q80TY9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.