Q80TY9 (Q80TY9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Adenylate cyclase 3, isoform CRA_b EMBL EDL01375.1

Submitted name:
MKIAA0511 protein EMBL BAC65580.1

Gene names

Name:	Adcy3 EMBL EDL01375.1 MGI 99675
Synonyms:	mKIAA0511 EMBL BAC65580.1
ORF Names:	mCG_116984 EMBL EDL01375.1

Organism

Mus musculus (Mouse) EMBL BAC65580.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1150 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. RuleBase RU000405

Ontologies

Keywords
Ligand	Nucleotide-binding SAAS SAAS001054
Molecular function	Lyase SAAS SAAS001054 RuleBase RU000405
Gene Ontology (GO)
Biological_process	activation of adenylate cyclase activity Traceable author statement PubMed 7766992. Source: MGI intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cilium Inferred from direct assay PubMed 22179047. Source: MGI plasma membrane Traceable author statement PubMed 7766992. Source: MGI
Molecular_function	adenylate cyclase activity Traceable author statement PubMed 7766992. Source: MGI nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAC65580.1

Sequences

	Sequence		Length	Mass (Da)
	Q80TY9 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 734089FD1C0819B7	FASTA	1,150	129,608
	10 20 30 40 50 60 KQPAANMPRN QGFSDPEYSA EYSAEYSVSL PSDPDRGVGR THEISVRNSG SCLCLPRFMR 70 80 90 100 110 120 LTFVPESLEN LYQTYFKRQR HETLLVLVVF AALFDCYVVV MCAVVFSSDK LAPLMVAGFG 130 140 150 160 170 180 LVLDIILFVL CKKGLLPDRV SRKVVPYLLW LLISAQIFSY LGLNFSRAHA ASDTVGWQAF 190 200 210 220 230 240 FVFSFFITLP LSLSPIVIIS VVSCVVHTLV LGVTVAQQQQ DELEGMQLLR EILANVFLYL 250 260 270 280 290 300 CAIIVGIMSY YMADRKHRKA FLEARQSLEV KMNLEEQSQQ QENLMLSILP KHVADEMLKD 310 320 330 340 350 360 MKKDESQKDQ QQFNTMYMYR HENVSILFAD IVGFTQLSSA CSAQELVKLL NELFARFDKL 370 380 390 400 410 420 AAKYHQLRIK ILGDCYYCIC GLPDYREDHA VCSILMGLAM VEAISYVREK TKTGVDMRVG 430 440 450 460 470 480 VHTGTVLGGV LGQKRWQYDV WSTDVTVANK MEAGGIPGRV HISQSTMDCL KGEFDVEPGD 490 500 510 520 530 540 GGSRCDYLDE KGIETYLIIA SKPEVKKTAQ NGLNGSAVPN GAPASSKPSS PALIETKEPN 550 560 570 580 590 600 GSAHASGSTS EEAEEQEAQA DNPSFPNPRR RLRLQDLADR VVDASEDEHE LNQLLNEALL 610 620 630 640 650 660 ERESAQVVKK RNTFLLTMRF MDPEMETRYS VEKEKQSGAA FSCSCVVLFC TAMVEILIDP 670 680 690 700 710 720 WLMTNYVTFV VGEVLLLILT ICSMAAIFPR SFPKKLVAFS SWIDRTRWAR NTWAMLAIFI 730 740 750 760 770 780 LVMANVVDML SCLQYYMGPY NMTAGMELDG GCMENPKYYN YVAVLSLIAT IMLVQVSHMV 790 800 810 820 830 840 KLTLMLLVTG AVTALNLYAW CPVFDEYDHK RFQEKDSPMV ALEKMQVLAT PGLNGTDRLP 850 860 870 880 890 900 LVPSKYSMTV MMFVMMLSFY YFSRHVEKLA RTLFLWKIEV HDQKERVYEM RRWNEALVTN 910 920 930 940 950 960 MLPEHVARHF LGSKKRDEEL YSQSYDEIGV MFASLPNFAD FYTEESINNG GIECLRFLNE 970 980 990 1000 1010 1020 IISDFDSLLD NPKFRVITKI KTIGSTYMAA SGVTPDVNTN GFTSSSKEEK SDKERWQHLA 1030 1040 1050 1060 1070 1080 DLADFALAMK DTLTNINNQS FNNFMLRIGM NKGGVLAGVI GARKPHYDIW GNTVNVASRM 1090 1100 1110 1120 1130 1140 ESTGVMGNIQ VVEETQVILR EYGFRFVRRG PIFVKGKGEL LTFFLKGRDR PAAFPNGSSV 1150 TLPHQVVDNP

References

[1]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL01375.1.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAC65580.1.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL01375.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK122298 mRNA. Translation: BAC65580.1. CH466623 Genomic DNA. Translation: EDL01375.1. CH466623 Genomic DNA. Translation: EDL01376.1.
IPI	IPI00128323.
RefSeq	NP_001153008.1. NM_001159536.1. NP_001153009.1. NM_001159537.1. NP_612178.2. NM_138305.3.
UniGene	Mm.489807.
3D structure databases
HSSP	HSSP built from PDB template 1AB8 based on UniProtKB P26769.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	104111.
KEGG	mmu:104111.
Organism-specific databases
CTD	109.
MGI	MGI:99675. Adcy3.
Phylogenomic databases
HOGENOM	HOG000006941.
HOVERGEN	HBG050458.
InParanoid	Q80TY9.
KO	K08043.
Gene expression databases
Genevestigator	Q80TY9.
Family and domain databases
Gene3D	3.30.70.1230. 2 hits.
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. [Graphical view]
Pfam	PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 2 hits.
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ADCY3. mouse.
NextBio	356544.
SOURCE	Search...

Entry information

Entry name

Q80TY9_MOUSE

Accession

Primary (citable) accession number: Q80TY9

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)