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Q80TY9

- Q80TY9_MOUSE

UniProt

Q80TY9 - Q80TY9_MOUSE

Protein
Submitted name:

Adenylate cyclase 3, isoform CRA_b

Gene

Adcy3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. adenylate cyclase activity Source: MGI
    2. nucleotide binding Source: UniProtKB-KW
    3. protein binding Source: MGI

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: MGI
    2. cAMP biosynthetic process Source: MGI
    3. intracellular signal transduction Source: InterPro
    4. sensory perception of smell Source: MGI

    Keywords - Molecular functioni

    LyaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Nucleotide-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Adenylate cyclase 3, isoform CRA_bImported
    Submitted name:
    MKIAA0511 proteinImported
    Gene namesi
    Name:Adcy3Imported
    Synonyms:mKIAA0511Imported
    ORF Names:mCG_116984Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:99675. Adcy3.

    Subcellular locationi

    GO - Cellular componenti

    1. cilium Source: MGI
    2. plasma membrane Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ80TY9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000006941.
    HOVERGENiHBG050458.
    InParanoidiQ80TY9.
    KOiK08043.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q80TY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    KQPAANMPRN QGFSDPEYSA EYSAEYSVSL PSDPDRGVGR THEISVRNSG     50
    SCLCLPRFMR LTFVPESLEN LYQTYFKRQR HETLLVLVVF AALFDCYVVV 100
    MCAVVFSSDK LAPLMVAGFG LVLDIILFVL CKKGLLPDRV SRKVVPYLLW 150
    LLISAQIFSY LGLNFSRAHA ASDTVGWQAF FVFSFFITLP LSLSPIVIIS 200
    VVSCVVHTLV LGVTVAQQQQ DELEGMQLLR EILANVFLYL CAIIVGIMSY 250
    YMADRKHRKA FLEARQSLEV KMNLEEQSQQ QENLMLSILP KHVADEMLKD 300
    MKKDESQKDQ QQFNTMYMYR HENVSILFAD IVGFTQLSSA CSAQELVKLL 350
    NELFARFDKL AAKYHQLRIK ILGDCYYCIC GLPDYREDHA VCSILMGLAM 400
    VEAISYVREK TKTGVDMRVG VHTGTVLGGV LGQKRWQYDV WSTDVTVANK 450
    MEAGGIPGRV HISQSTMDCL KGEFDVEPGD GGSRCDYLDE KGIETYLIIA 500
    SKPEVKKTAQ NGLNGSAVPN GAPASSKPSS PALIETKEPN GSAHASGSTS 550
    EEAEEQEAQA DNPSFPNPRR RLRLQDLADR VVDASEDEHE LNQLLNEALL 600
    ERESAQVVKK RNTFLLTMRF MDPEMETRYS VEKEKQSGAA FSCSCVVLFC 650
    TAMVEILIDP WLMTNYVTFV VGEVLLLILT ICSMAAIFPR SFPKKLVAFS 700
    SWIDRTRWAR NTWAMLAIFI LVMANVVDML SCLQYYMGPY NMTAGMELDG 750
    GCMENPKYYN YVAVLSLIAT IMLVQVSHMV KLTLMLLVTG AVTALNLYAW 800
    CPVFDEYDHK RFQEKDSPMV ALEKMQVLAT PGLNGTDRLP LVPSKYSMTV 850
    MMFVMMLSFY YFSRHVEKLA RTLFLWKIEV HDQKERVYEM RRWNEALVTN 900
    MLPEHVARHF LGSKKRDEEL YSQSYDEIGV MFASLPNFAD FYTEESINNG 950
    GIECLRFLNE IISDFDSLLD NPKFRVITKI KTIGSTYMAA SGVTPDVNTN 1000
    GFTSSSKEEK SDKERWQHLA DLADFALAMK DTLTNINNQS FNNFMLRIGM 1050
    NKGGVLAGVI GARKPHYDIW GNTVNVASRM ESTGVMGNIQ VVEETQVILR 1100
    EYGFRFVRRG PIFVKGKGEL LTFFLKGRDR PAAFPNGSSV TLPHQVVDNP 1150
    Length:1,150
    Mass (Da):129,608
    Last modified:June 1, 2003 - v1
    Checksum:i734089FD1C0819B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122298 mRNA. Translation: BAC65580.1.
    CH466623 Genomic DNA. Translation: EDL01375.1.
    CH466623 Genomic DNA. Translation: EDL01376.1.
    RefSeqiNP_001153008.1. NM_001159536.1.
    NP_001153009.1. NM_001159537.1.
    NP_612178.2. NM_138305.3.
    UniGeneiMm.489807.

    Genome annotation databases

    GeneIDi104111.
    KEGGimmu:104111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122298 mRNA. Translation: BAC65580.1 .
    CH466623 Genomic DNA. Translation: EDL01375.1 .
    CH466623 Genomic DNA. Translation: EDL01376.1 .
    RefSeqi NP_001153008.1. NM_001159536.1.
    NP_001153009.1. NM_001159537.1.
    NP_612178.2. NM_138305.3.
    UniGenei Mm.489807.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 104111.
    KEGGi mmu:104111.

    Organism-specific databases

    CTDi 109.
    MGIi MGI:99675. Adcy3.

    Phylogenomic databases

    HOGENOMi HOG000006941.
    HOVERGENi HBG050458.
    InParanoidi Q80TY9.
    KOi K08043.

    Miscellaneous databases

    ChiTaRSi ADCY3. mouse.
    NextBioi 356544.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q80TY9.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ80TY9_MOUSE
    AccessioniPrimary (citable) accession number: Q80TY9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)