Q80TV8 (CLAP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CLIP-associating protein 1

Alternative name(s):
Cytoplasmic linker-associated protein 1

Gene names

Name:	Clasp1
Synonyms:	Kiaa0622

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1535 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle By similarity.
Subunit structure	Interacts with ERC1, MAPRE1, MAPRE3, microtubules, and PHLDB2. The interaction with ERC1 may be mediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes By similarity. Interacts with CLIP2 and RSN. Interacts with MACF1. Ref.2 Ref.8
Subcellular location	Cytoplasm › cytoskeleton By similarity. Cytoplasm › cytoskeleton › centrosome By similarity. Chromosome › centromere › kinetochore By similarity. Cytoplasm › cytoskeleton › spindle By similarity. Golgi apparatus › trans-Golgi network By similarity. Note: Localizes to microtubule plus ends By similarity. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase By similarity. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase By similarity. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella By similarity. Localizes to the cell cortex and this requires ERC1 and PHLDB2 By similarity.
Tissue specificity	Highly expressed in brain and heart and at lower levels in kidney, lung, skeletal muscle and testis. Ref.2
Sequence similarities	Belongs to the CLASP family. Contains 7 HEAT repeats.
Sequence caution	The sequence BAB24639.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC38020.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Centromere Chromosome Cytoplasm Cytoskeleton Golgi apparatus Kinetochore Microtubule
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from sequence orthology PubMed 21822276. Source: MGI establishment of spindle orientation Inferred from sequence orthology PubMed 21822276. Source: MGI exit from mitosis Inferred from electronic annotation. Source: Compara microtubule anchoring Inferred from sequence or structural similarity. Source: UniProtKB microtubule bundle formation Inferred from electronic annotation. Source: Compara microtubule nucleation Inferred from sequence or structural similarity. Source: UniProtKB microtubule organizing center organization Inferred from sequence or structural similarity. Source: UniProtKB mitosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of microtubule depolymerization Inferred from direct assay Ref.2. Source: MGI
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell centrosomal corona Inferred from electronic annotation. Source: Compara condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell cortical microtubule cytoskeleton Inferred from electronic annotation. Source: Compara cytoplasmic microtubule Inferred from direct assay Ref.2. Source: MGI spindle microtubule Inferred from electronic annotation. Source: Compara
Molecular_function	kinetochore binding Inferred from electronic annotation. Source: Compara microtubule binding Inferred from direct assay Ref.2. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Clip2	O55156	3	EBI-908322,EBI-349416	From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q80TV8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q80TV8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     770-770: L → LASRRHSRSTSALSTAESVGQS
     805-805: L → LLLGDARSK
     1120-1158: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1535	1535	CLIP-associating protein 1		PRO_0000272274
Regions
	Repeat	87 – 124	38	HEAT 1
	Repeat	163 – 200	38	HEAT 2
	Repeat	405 – 440	36	HEAT 3
	Repeat	441 – 477	37	HEAT 4
	Repeat	971 – 1008	38	HEAT 5
	Repeat	1339 – 1376	38	HEAT 6
	Repeat	1457 – 1494	38	HEAT 7
	Region	662 – 782	121	Interaction with microtubules, MAPRE1 and MAPRE3 By similarity
	Region	1251 – 1535	285	Interaction with CLIP2 and RSN
	Region	1251 – 1535	285	Interaction with PHLDB2 By similarity
	Region	1253 – 1535	283	Localization to kinetochores By similarity
	Coiled coil	1296 – 1327	32	Potential
	Compositional bias	530 – 762	233	Ser-rich
Amino acid modifications
	Modified residue	545	1	Phosphoserine Ref.7
	Modified residue	598	1	Phosphoserine Ref.7
	Modified residue	600	1	Phosphoserine Ref.7
	Modified residue	646	1	Phosphoserine By similarity
	Modified residue	649	1	Phosphoserine By similarity
	Modified residue	656	1	Phosphothreonine By similarity
	Modified residue	684	1	Phosphoserine By similarity
	Modified residue	688	1	Phosphoserine By similarity
	Modified residue	695	1	Phosphoserine By similarity
	Modified residue	708	1	Phosphothreonine By similarity
	Modified residue	711	1	Phosphoserine By similarity
	Modified residue	794	1	Phosphoserine By similarity
	Modified residue	1088	1	Phosphoserine By similarity
	Modified residue	1096	1	Phosphothreonine By similarity
	Modified residue	1193	1	Phosphoserine Ref.6
	Modified residue	1220	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	770	1	L → LASRRHSRSTSALSTAESVG QS in isoform 2.		VSP_022390
	Alternative sequence	805	1	L → LLLGDARSK in isoform 2.		VSP_022391
	Alternative sequence	1120 – 1158	39	Missing in isoform 2.		VSP_022392
Experimental info
	Sequence conflict	1231	1	I → K in BAB24639. Ref.3
	Sequence conflict	1417	1	P → S in AAH75708. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 5EE40CCE493C64D2	FASTA	1,535	169,227
	10 20 30 40 50 60 MEPRMESCLA QVLQKDVGKR LQVGQELIDY FSDRQKSADL EHDQTLLDKL VDGLATSWVN 70 80 90 100 110 120 SSNYKVVLLG MDILSALVTR LQDRFKAQIG TVLPSLIDRL GDAKDSVREQ DQTLLLKIMD 130 140 150 160 170 180 QAANPQYVWD RMLGGFKHKN FRTREGICLC LIATLNASGA QTLTLSKIVP HICNLLGDPN 190 200 210 220 230 240 SQVRDAAINS LVEIYRHVGE RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSANEKN 250 260 270 280 290 300 FDDEDSVDGN RPSSASSSSS KAPSSSRRNV NLGTTRRLMS SSLGSKSSAA KEGAGAVDEE 310 320 330 340 350 360 DFIKAFDDVP VVQIYSSRDL EESINKIREI LSDDKHDWEQ RVNALKKIRS LLLAGAAEYD 370 380 390 400 410 420 NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG NKFDHGAEAI MPTIFNLIPN 430 440 450 460 470 480 SAKIMATSGV VAVRLIIRHT HIPRLIPVIT SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL 490 500 510 520 530 540 ERHISVLAET IKKGIHDADS EARIEARKCY WGFHSHFSRE AEHLYHTLES SYQKALQSHL 550 560 570 580 590 600 KNSDSIVSLP QSDRSSSSSQ ESLNRPLSAK RSPTGSTASR GSTVSTKSVS TTGSLQRSRS 610 620 630 640 650 660 DIDVNAAASA KSKVSSSSGS PAFSSAAALP PGSYASLGRI RTRRQSSGST TNVASTPDSR 670 680 690 700 710 720 GRSRAKVVSQ SQRSRSANPA GAGSRSSSPG KLLGSGLAGG SSRGPPVTPS SEKRSKIPRS 730 740 750 760 770 780 QGCSRETSPN RIGLARSSRI PRPSMSQGCS RDTSRESSRD TSPARGFTPL DRFGLGQSGR 790 800 810 820 830 840 IPGSVNAMRV LSTSTDLEAA VADALKKPVR RRYEPYGMYS DDDANSDASS VCSERSYGSR 850 860 870 880 890 900 NGGIPHYLRQ TEDVAEVLNH CASSNWSERK EGLLGLQNLL KSQRTLSRVE LKRLCEIFTR 910 920 930 940 950 960 MFADPHSKRV FSMFLETLVD FIIIHKDDLQ DWLFVLLTQL LKKMGADLLG SVQAKVQKAL 970 980 990 1000 1010 1020 DVTRDSFPFD QQFNILMRFI VDQTQTPNLK VKVAILKYIE SLARQMDPTD FVNSSETRLA 1030 1040 1050 1060 1070 1080 VSRIITWTTE PKSSDVRKAA QIVLISLFEL NTPEFTMLLG ALPKTFQDGA TKLLHNHLKN 1090 1100 1110 1120 1130 1140 SSNTGVGSPS NTIGRTPSRH PSSRTSPLTS PTNCSHGGLS PSRLWGWSAD GLSKPPPPFS 1150 1160 1170 1180 1190 1200 QPNSIPTAPS HKTLRRSYSP SMLDYDTENL NSEEIYSSLR GVTEAIEKFS FRSQEDLNEP 1210 1220 1230 1240 1250 1260 IKRDGKKDCD IVSRDGGAAS PATEGRGGSE IEGGRMALDN KTSLLNTQPP RAFPGPRARE 1270 1280 1290 1300 1310 1320 YNPYPYSDTI NTYDKTALKE AVFDDDMEQL RDVPIDHSDL VADLLKELSN HNERVEERKG 1330 1340 1350 1360 1370 1380 ALLELLKITR EDSLGVWEEH FKTILLLLLE TLGDKDHSIR ALALRVLREI LRNQPARFKN 1390 1400 1410 1420 1430 1440 YAELTIMKTL EAHKDSHKEV VRAAEEAAST LASSIHPEQC IKVLCPIIQT ADYPINLAAI 1450 1460 1470 1480 1490 1500 KMQTKVVERI TKESLLQLLV DIIPGLLQGY DNTESSVRKA SVFCLVAIYS VIGEDLKPHL 1510 1520 1530 AQLTGSKMKL LNLYIKRAQT TNSNSSSSSD VSTHS
	Isoform 2 [UniParc]. Checksum: CA1BA686C4C8CB03	FASTA	1,525	167,939
	10 20 30 40 50 60 MEPRMESCLA QVLQKDVGKR LQVGQELIDY FSDRQKSADL EHDQTLLDKL VDGLATSWVN 70 80 90 100 110 120 SSNYKVVLLG MDILSALVTR LQDRFKAQIG TVLPSLIDRL GDAKDSVREQ DQTLLLKIMD 130 140 150 160 170 180 QAANPQYVWD RMLGGFKHKN FRTREGICLC LIATLNASGA QTLTLSKIVP HICNLLGDPN 190 200 210 220 230 240 SQVRDAAINS LVEIYRHVGE RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSANEKN 250 260 270 280 290 300 FDDEDSVDGN RPSSASSSSS KAPSSSRRNV NLGTTRRLMS SSLGSKSSAA KEGAGAVDEE 310 320 330 340 350 360 DFIKAFDDVP VVQIYSSRDL EESINKIREI LSDDKHDWEQ RVNALKKIRS LLLAGAAEYD 370 380 390 400 410 420 NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG NKFDHGAEAI MPTIFNLIPN 430 440 450 460 470 480 SAKIMATSGV VAVRLIIRHT HIPRLIPVIT SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL 490 500 510 520 530 540 ERHISVLAET IKKGIHDADS EARIEARKCY WGFHSHFSRE AEHLYHTLES SYQKALQSHL 550 560 570 580 590 600 KNSDSIVSLP QSDRSSSSSQ ESLNRPLSAK RSPTGSTASR GSTVSTKSVS TTGSLQRSRS 610 620 630 640 650 660 DIDVNAAASA KSKVSSSSGS PAFSSAAALP PGSYASLGRI RTRRQSSGST TNVASTPDSR 670 680 690 700 710 720 GRSRAKVVSQ SQRSRSANPA GAGSRSSSPG KLLGSGLAGG SSRGPPVTPS SEKRSKIPRS 730 740 750 760 770 780 QGCSRETSPN RIGLARSSRI PRPSMSQGCS RDTSRESSRD TSPARGFTPL ASRRHSRSTS 790 800 810 820 830 840 ALSTAESVGQ SDRFGLGQSG RIPGSVNAMR VLSTSTDLEA AVADALLLGD ARSKKKPVRR 850 860 870 880 890 900 RYEPYGMYSD DDANSDASSV CSERSYGSRN GGIPHYLRQT EDVAEVLNHC ASSNWSERKE 910 920 930 940 950 960 GLLGLQNLLK SQRTLSRVEL KRLCEIFTRM FADPHSKRVF SMFLETLVDF IIIHKDDLQD 970 980 990 1000 1010 1020 WLFVLLTQLL KKMGADLLGS VQAKVQKALD VTRDSFPFDQ QFNILMRFIV DQTQTPNLKV 1030 1040 1050 1060 1070 1080 KVAILKYIES LARQMDPTDF VNSSETRLAV SRIITWTTEP KSSDVRKAAQ IVLISLFELN 1090 1100 1110 1120 1130 1140 TPEFTMLLGA LPKTFQDGAT KLLHNHLKNS SNTGVGSPSN TIGRTPSRHP SSRTSPLTSP 1150 1160 1170 1180 1190 1200 TNCSHGGLSP SMLDYDTENL NSEEIYSSLR GVTEAIEKFS FRSQEDLNEP IKRDGKKDCD 1210 1220 1230 1240 1250 1260 IVSRDGGAAS PATEGRGGSE IEGGRMALDN KTSLLNTQPP RAFPGPRARE YNPYPYSDTI 1270 1280 1290 1300 1310 1320 NTYDKTALKE AVFDDDMEQL RDVPIDHSDL VADLLKELSN HNERVEERKG ALLELLKITR 1330 1340 1350 1360 1370 1380 EDSLGVWEEH FKTILLLLLE TLGDKDHSIR ALALRVLREI LRNQPARFKN YAELTIMKTL 1390 1400 1410 1420 1430 1440 EAHKDSHKEV VRAAEEAAST LASSIHPEQC IKVLCPIIQT ADYPINLAAI KMQTKVVERI 1450 1460 1470 1480 1490 1500 TKESLLQLLV DIIPGLLQGY DNTESSVRKA SVFCLVAIYS VIGEDLKPHL AQLTGSKMKL 1510 1520 LNLYIKRAQT TNSNSSSSSD VSTHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts." Akhmanova A., Hoogenraad C.C., Drabek K., Stepanova T., Dortland B., Verkerk T., Vermeulen W., Burgering B.M., de Zeeuw C.I., Grosveld F., Galjart N. Cell 104:923-935(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-306 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [MRNA] OF 1251-1535 (ISOFORMS 1/2), INTERACTION WITH CLIP2 AND RSN, TISSUE SPECIFICITY. Tissue: Brain.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-393 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1187-1535 (ISOFORMS 1/2). Strain: C57BL/6J. Tissue: Embryo and Testis.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 735-1535 (ISOFORM 2). Tissue: Brain.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 985-1535 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 997-1535 (ISOFORM 2). Strain: C57BL/6 and FVB/N. Tissue: Brain and Salivary gland.
[6]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1193 AND SER-1220, MASS SPECTROMETRY. Tissue: Brain.
[7]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-545; SER-598 AND SER-600, MASS SPECTROMETRY. Tissue: Liver.
[8]	"ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity." Wu X., Kodama A., Fuchs E. Cell 135:137-148(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MACF1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC109294 Genomic DNA. No translation available. AC131804 Genomic DNA. No translation available. AC136636 Genomic DNA. No translation available. AJ276962 mRNA. Translation: CAC35162.1. AJ288061 mRNA. Translation: CAC35163.1. AK006534 mRNA. Translation: BAB24639.2. Different initiation. AK080782 mRNA. Translation: BAC38020.1. Sequence problems. AK122330 mRNA. Translation: BAC65612.1. BC057312 mRNA. Translation: AAH57312.1. BC075708 mRNA. Translation: AAH75708.1. BC094554 mRNA. Translation: AAH94554.1.
IPI	IPI00669522. IPI00672213.
RefSeq	NP_083985.2. NM_029709.2. NP_808216.2. NM_177548.2.
UniGene	Mm.138740.
3D structure databases
ProteinModelPortal	Q80TV8.
SMR	Q80TV8. Positions 169-195, 1345-1371, 1462-1488.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q80TV8. 5 interactions.
MINT	MINT-4123448.
STRING	10090.ENSMUSP00000042266.
PTM databases
PhosphoSite	Q80TV8.
Proteomic databases
PaxDb	Q80TV8.
PRIDE	Q80TV8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	76707.
KEGG	mmu:76707.
Organism-specific databases
CTD	23332.
MGI	MGI:1923957. Clasp1.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG81443.
HOVERGEN	HBG079692.
InParanoid	Q80TV8.
KO	K16578.
OrthoDB	EOG42Z4PC.
Gene expression databases
ArrayExpress	Q80TV8.
Bgee	Q80TV8.
CleanEx	MM_CLASP1.
Genevestigator	Q80TV8.
Family and domain databases
Gene3D	1.25.10.10. 4 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR024395. CLASP_N_dom. IPR021133. HEAT_type_2. [Graphical view]
Pfam	PF12348. CLASP_N. 2 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 2 hits.
PROSITE	PS50077. HEAT_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	345659.
SOURCE	Search...

Entry information

Entry name

CLAP1_MOUSE

Accession

Primary (citable) accession number: Q80TV8
Secondary accession number(s): Q505G6 , Q6DI75, Q6PG14, Q8BNS4, Q99JH5, Q99JI2, Q9CVU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program