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Q80TS3 (LPHN3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Latrophilin-3
Alternative name(s):
Lectomedin-3
Gene names
Name:Lphn3
Synonyms:Kiaa0768, Lec3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1537 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85) By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Contains 1 olfactomedin-like domain.

Contains 1 SUEL-type lectin domain.

Ontologies

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q80TS3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q80TS3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1132-1140: Missing.
     1272-1351: EGLLNNARDT...NHERSSEQNR → GAMANHLISN...KCHGYSTTEW
     1352-1537: Missing.
Isoform 3 (identifier: Q80TS3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1272-1272: E → EPYRETK
Note: No experimental confirmation available.
Isoform 4 (identifier: Q80TS3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q80TS3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1132-1140: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: Q80TS3-6)

The sequence of this isoform differs from the canonical sequence as follows:
     195-200: KVEQKV → I
     650-650: H → Q
     651-1537: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 15371518Latrophilin-3
PRO_0000070344

Regions

Topological domain20 – 949930Extracellular Potential
Transmembrane950 – 97021Helical; Name=1; Potential
Topological domain971 – 9788Cytoplasmic Potential
Transmembrane979 – 99921Helical; Name=2; Potential
Topological domain1000 – 10078Extracellular Potential
Transmembrane1008 – 102821Helical; Name=3; Potential
Topological domain1029 – 105022Cytoplasmic Potential
Transmembrane1051 – 107121Helical; Name=4; Potential
Topological domain1072 – 108817Extracellular Potential
Transmembrane1089 – 110921Helical; Name=5; Potential
Topological domain1110 – 114233Cytoplasmic Potential
Transmembrane1143 – 116321Helical; Name=6; Potential
Topological domain1164 – 11696Extracellular Potential
Transmembrane1170 – 119021Helical; Name=7; Potential
Topological domain1191 – 1537347Cytoplasmic Potential
Domain103 – 19290SUEL-type lectin
Domain202 – 461260Olfactomedin-like
Domain883 – 93452GPS
Compositional bias1470 – 14734Poly-Ala

Amino acid modifications

Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation5321N-linked (GlcNAc...) Potential
Glycosylation6171N-linked (GlcNAc...) Potential
Glycosylation8271N-linked (GlcNAc...) Potential
Glycosylation8401N-linked (GlcNAc...) Potential
Glycosylation8851N-linked (GlcNAc...) Potential
Glycosylation9111N-linked (GlcNAc...) Potential
Glycosylation10001N-linked (GlcNAc...) Potential
Glycosylation11661N-linked (GlcNAc...) Potential
Disulfide bond203 ↔ 385 By similarity

Natural variations

Alternative sequence1 – 239239Missing in isoform 4.
VSP_022138
Alternative sequence195 – 2006KVEQKV → I in isoform 6.
VSP_022139
Alternative sequence6501H → Q in isoform 6.
VSP_022140
Alternative sequence651 – 1537887Missing in isoform 6.
VSP_022141
Alternative sequence1132 – 11409Missing in isoform 2 and isoform 5.
VSP_010121
Alternative sequence1272 – 135180EGLLN…SEQNR → GAMANHLISNALLRPHGTNN PYNTLLGEPAVCNNPSISMY NTQEPYRETSMGVKLNIAYQ IGASEQCQGYKCHGYSTTEW in isoform 2.
VSP_010122
Alternative sequence12721E → EPYRETK in isoform 3.
VSP_022142
Alternative sequence1352 – 1537186Missing in isoform 2.
VSP_010123

Experimental info

Sequence conflict3811A → S in AAH94668. Ref.2
Sequence conflict12521K → R in BAE27870. Ref.1
Sequence conflict13751A → T in BAE26219. Ref.1
Sequence conflict14951V → M in BAE26219. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 9, 2007. Version 3.
Checksum: F55EAB142C987A69

FASTA1,537171,080
        10         20         30         40         50         60 
MWPPQLLILT MLLAPVVHGG KHNERHPALA APLRHAERSP GGALPPRHLL QQPAAERSTA 

        70         80         90        100        110        120 
HRGQGPRGAA RGVRGPGAPG AQIAAQAFSR APIPMAVVRR ELSCESYPIE LRCPGTDVIM 

       130        140        150        160        170        180 
IESANYGRTD DKICDSDPAQ MENIRCYLPD AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG 

       190        200        210        220        230        240 
TYKYLEVQYE CVPYKVEQKV FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM 

       250        260        270        280        290        300 
PWTPYRTDTL TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD 

       310        320        330        340        350        360 
LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN GKIVISQLNP 

       370        380        390        400        410        420 
YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN EATGNKIDYI YNTDQSKDSL 

       430        440        450        460        470        480 
VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY HVVKYSLDFG PLDSRSGPVH HGQVSYISPP 

       490        500        510        520        530        540 
IHLDSELERP PVRGISTTGS LGMGSTTTST TLRTTTWNIG RSTTASLPGR RNRSTSTPSP 

       550        560        570        580        590        600 
AVEVLDDVTT HLPSAASQIP AMEESCEAVE AREIMWFKTR QGQVAKQPCP AGTIGVSTYL 

       610        620        630        640        650        660 
CLAPDGIWDP QGPDLSNCSS PWVNHITQKL KSGETAANIA RELAEQTRNH LNAGDITYSV 

       670        680        690        700        710        720 
RAMDQLVGLL DVQLRNLTPG GKDSAARSLN KLQKRERSCR AYVQAMVETV NNLLQPQALN 

       730        740        750        760        770        780 
AWRDLTTSDQ LRAATMLLDT VEESAFVLAD NLLKTDIVRE NTDNIQLEVA RLSTEGNLED 

       790        800        810        820        830        840 
LKFPENMGHG STIQLSANTL KQNGRNGEIR VAFVLYNNLG PYLSTENASM KLGTEAMSTN 

       850        860        870        880        890        900 
HSVIVNSPVI TAAINKEFSN KVYLADPVVF TVKHIKQSEE NFNPNCSFWS YSKRTMTGYW 

       910        920        930        940        950        960 
STQGCRLLTT NKTHTTCSCN HLTNFAVLMA HVEVKHSDAV HDLLLDVITW VGILLSLVCL 

       970        980        990       1000       1010       1020 
LICIFTFCFF RGLQSDRNTI HKNLCISLFV AELLFLIGIN RTDQPIACAV FAALLHFFFL 

      1030       1040       1050       1060       1070       1080 
AAFTWMFLEG VQLYIMLVEV FESEHSRRKY FYLVGYGMPA LIVAVSAAVD YRSYGTDKVC 

      1090       1100       1110       1120       1130       1140 
WLRLDTYFIW SFIGPATLII MLNVIFLGIA LYKMFHHTAI LKPESGCLDN INYEDNRPFI 

      1150       1160       1170       1180       1190       1200 
KSWVIGAIAL LCLLGLTWAF GLMYINESTV IMAYLFTIFN SLQGMFIFIF HCVLQKKVRK 

      1210       1220       1230       1240       1250       1260 
EYGKCLRTHC CSGKSTESSI GSGKTSGSRT PGRYSTGSQS RIRRMWNDTV RKQSESSFIT 

      1270       1280       1290       1300       1310       1320 
GDINSSASLN REGLLNNARD TSVMDTLPLN GNHGNSYSIA GGEYLSNCVQ IIDRGYNHNE 

      1330       1340       1350       1360       1370       1380 
TALEKKILKE LTSNYIPSYL NNHERSSEQN RNMMNKLVNN LGSGSEDDAI VLDDAASFNH 

      1390       1400       1410       1420       1430       1440 
EESLGLELIH EESDAPLLPP RVYSTDNHQP HHYSRRRFPQ DHSESFFPLL TDEHTEDLQS 

      1450       1460       1470       1480       1490       1500 
PHRDSLYTSM PALAGVPAAD SVTTSTQTEA AAAKGGDAED VYYKSMPNLG SRNHVHPLHA 

      1510       1520       1530 
YYQLGRGSSD GFIVPPNKDG ASPEGTSKGP AHLVTSL 

« Hide

Isoform 2 [UniParc].

Checksum: DC564A59AC9FA61D
Show »

FASTA1,342149,585
Isoform 3 [UniParc].

Checksum: 777BF282BBB9F19A
Show »

FASTA1,543171,855
Isoform 4 [UniParc].

Checksum: 6049A189631565C6
Show »

FASTA1,298144,737
Isoform 5 [UniParc].

Checksum: 0821FFBFD18CA9BB
Show »

FASTA1,528169,930
Isoform 6 [UniParc].

Checksum: 4F331FC4398D65BB
Show »

FASTA64571,505

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 672-1537 (ISOFORM 5).
Strain: C57BL/6J.
Tissue: Mammary gland.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 6).
Strain: C57BL/6.
Tissue: Brain and Eye.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 481-1537 (ISOFORM 1).
Tissue: Brain.
[4]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 803-981.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK145069 mRNA. Translation: BAE26219.1.
AK147374 mRNA. Translation: BAE27870.1.
BC058992 mRNA. Translation: AAH58992.1.
BC088989 mRNA. Translation: AAH88989.1.
BC094668 mRNA. Translation: AAH94668.1.
AK122367 mRNA. Translation: BAC65649.1.
AY255584 mRNA. Translation: AAO85096.1.
RefSeqNP_941991.1. NM_198702.2.
UniGeneMm.273631.
Mm.461016.

3D structure databases

ProteinModelPortalQ80TS3.
SMRQ80TS3. Positions 93-197, 566-922, 947-1194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ80TS3. 1 interaction.

Protein family/group databases

MEROPSS63.014.
GPCRDBSearch...

PTM databases

PhosphoSiteQ80TS3.

Proteomic databases

PaxDbQ80TS3.
PRIDEQ80TS3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000072521; ENSMUSP00000072336; ENSMUSG00000037605. [Q80TS3-3]
ENSMUST00000117407; ENSMUSP00000112388; ENSMUSG00000037605. [Q80TS3-2]
ENSMUST00000122356; ENSMUSP00000113600; ENSMUSG00000037605. [Q80TS3-5]
GeneID319387.
KEGGmmu:319387.
UCSCuc008xwk.1. mouse. [Q80TS3-6]
uc008xwn.1. mouse. [Q80TS3-1]
uc008xwp.1. mouse. [Q80TS3-3]

Organism-specific databases

CTD23284.
MGIMGI:2441950. Lphn3.
RougeSearch...

Phylogenomic databases

eggNOGNOG253931.
GeneTreeENSGT00710000106375.
HOGENOMHOG000049065.
HOVERGENHBG052337.
KOK04594.
PhylomeDBQ80TS3.

Gene expression databases

ArrayExpressQ80TS3.
BgeeQ80TS3.
CleanExMM_LPHN3.
GenevestigatorQ80TS3.

Family and domain databases

InterProIPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR015630. GPCR_2_latrophilin3.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view]
PANTHERPTHR12011:SF60. PTHR12011:SF60. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 2 hits.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTSM00303. GPS. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLPHN3. mouse.
NextBio394668.
PROQ80TS3.
SOURCESearch...

Entry information

Entry nameLPHN3_MOUSE
AccessionPrimary (citable) accession number: Q80TS3
Secondary accession number(s): Q3UHI7 expand/collapse secondary AC list , Q3UM79, Q504Z9, Q5HZJ6, Q80T56
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries