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Q80TS3

- LPHN3_MOUSE

UniProt

Q80TS3 - LPHN3_MOUSE

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Protein

Latrophilin-3

Gene

Lphn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.1 Publication

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiS63.014.

Names & Taxonomyi

Protein namesi
Recommended name:
Latrophilin-3
Alternative name(s):
Lectomedin-3
Gene namesi
Name:Lphn3
Synonyms:Kiaa0768, Lec3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2441950. Lphn3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 949930ExtracellularSequence AnalysisAdd
BLAST
Transmembranei950 – 97021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini971 – 9788CytoplasmicSequence Analysis
Transmembranei979 – 99921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini1000 – 10078ExtracellularSequence Analysis
Transmembranei1008 – 102821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini1029 – 105022CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1051 – 107121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini1072 – 108817ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1089 – 110921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini1110 – 114233CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1143 – 116321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini1164 – 11696ExtracellularSequence Analysis
Transmembranei1170 – 119021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini1191 – 1537347CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 15371518Latrophilin-3PRO_0000070344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi203 ↔ 385PROSITE-ProRule annotation
Glycosylationi532 – 5321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi827 – 8271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi840 – 8401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi885 – 8851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi911 – 9111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1000 – 10001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1166 – 11661N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity
O-glycosylated (major) and N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80TS3.
PaxDbiQ80TS3.
PRIDEiQ80TS3.

PTM databases

PhosphoSiteiQ80TS3.

Expressioni

Gene expression databases

BgeeiQ80TS3.
CleanExiMM_LPHN3.
ExpressionAtlasiQ80TS3. baseline and differential.
GenevestigatoriQ80TS3.

Interactioni

Subunit structurei

Interacts with FLRT3 and TEN1.1 Publication

Protein-protein interaction databases

IntActiQ80TS3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ80TS3.
SMRiQ80TS3. Positions 93-197, 566-922, 947-1194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 19290SUEL-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini202 – 461260Olfactomedin-likePROSITE-ProRule annotationAdd
BLAST
Domaini883 – 93452GPSPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1470 – 14734Poly-Ala

Domaini

The Olfactomedin-like domain is required for the synapse-promoting function and the interaction with FLRT3. The Olfactomedin-like and the SUEL-type lectin domains are required for the interaction with TEN1.

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation
Contains 1 SUEL-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253931.
GeneTreeiENSGT00760000118787.
HOGENOMiHOG000049065.
HOVERGENiHBG052337.
InParanoidiQ80TS3.
KOiK04594.
PhylomeDBiQ80TS3.

Family and domain databases

InterProiIPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR015630. GPCR_2_latrophilin3.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view]
PANTHERiPTHR12011:SF60. PTHR12011:SF60. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 2 hits.
PF02191. OLF. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTiSM00303. GPS. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80TS3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPPQLLILT MLLAPVVHGG KHNERHPALA APLRHAERSP GGALPPRHLL
60 70 80 90 100
QQPAAERSTA HRGQGPRGAA RGVRGPGAPG AQIAAQAFSR APIPMAVVRR
110 120 130 140 150
ELSCESYPIE LRCPGTDVIM IESANYGRTD DKICDSDPAQ MENIRCYLPD
160 170 180 190 200
AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG TYKYLEVQYE CVPYKVEQKV
210 220 230 240 250
FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM PWTPYRTDTL
260 270 280 290 300
TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD
310 320 330 340 350
LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN
360 370 380 390 400
GKIVISQLNP YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN
410 420 430 440 450
EATGNKIDYI YNTDQSKDSL VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY
460 470 480 490 500
HVVKYSLDFG PLDSRSGPVH HGQVSYISPP IHLDSELERP PVRGISTTGS
510 520 530 540 550
LGMGSTTTST TLRTTTWNIG RSTTASLPGR RNRSTSTPSP AVEVLDDVTT
560 570 580 590 600
HLPSAASQIP AMEESCEAVE AREIMWFKTR QGQVAKQPCP AGTIGVSTYL
610 620 630 640 650
CLAPDGIWDP QGPDLSNCSS PWVNHITQKL KSGETAANIA RELAEQTRNH
660 670 680 690 700
LNAGDITYSV RAMDQLVGLL DVQLRNLTPG GKDSAARSLN KLQKRERSCR
710 720 730 740 750
AYVQAMVETV NNLLQPQALN AWRDLTTSDQ LRAATMLLDT VEESAFVLAD
760 770 780 790 800
NLLKTDIVRE NTDNIQLEVA RLSTEGNLED LKFPENMGHG STIQLSANTL
810 820 830 840 850
KQNGRNGEIR VAFVLYNNLG PYLSTENASM KLGTEAMSTN HSVIVNSPVI
860 870 880 890 900
TAAINKEFSN KVYLADPVVF TVKHIKQSEE NFNPNCSFWS YSKRTMTGYW
910 920 930 940 950
STQGCRLLTT NKTHTTCSCN HLTNFAVLMA HVEVKHSDAV HDLLLDVITW
960 970 980 990 1000
VGILLSLVCL LICIFTFCFF RGLQSDRNTI HKNLCISLFV AELLFLIGIN
1010 1020 1030 1040 1050
RTDQPIACAV FAALLHFFFL AAFTWMFLEG VQLYIMLVEV FESEHSRRKY
1060 1070 1080 1090 1100
FYLVGYGMPA LIVAVSAAVD YRSYGTDKVC WLRLDTYFIW SFIGPATLII
1110 1120 1130 1140 1150
MLNVIFLGIA LYKMFHHTAI LKPESGCLDN INYEDNRPFI KSWVIGAIAL
1160 1170 1180 1190 1200
LCLLGLTWAF GLMYINESTV IMAYLFTIFN SLQGMFIFIF HCVLQKKVRK
1210 1220 1230 1240 1250
EYGKCLRTHC CSGKSTESSI GSGKTSGSRT PGRYSTGSQS RIRRMWNDTV
1260 1270 1280 1290 1300
RKQSESSFIT GDINSSASLN REGLLNNARD TSVMDTLPLN GNHGNSYSIA
1310 1320 1330 1340 1350
GGEYLSNCVQ IIDRGYNHNE TALEKKILKE LTSNYIPSYL NNHERSSEQN
1360 1370 1380 1390 1400
RNMMNKLVNN LGSGSEDDAI VLDDAASFNH EESLGLELIH EESDAPLLPP
1410 1420 1430 1440 1450
RVYSTDNHQP HHYSRRRFPQ DHSESFFPLL TDEHTEDLQS PHRDSLYTSM
1460 1470 1480 1490 1500
PALAGVPAAD SVTTSTQTEA AAAKGGDAED VYYKSMPNLG SRNHVHPLHA
1510 1520 1530
YYQLGRGSSD GFIVPPNKDG ASPEGTSKGP AHLVTSL
Length:1,537
Mass (Da):171,080
Last modified:January 9, 2007 - v3
Checksum:iF55EAB142C987A69
GO
Isoform 2 (identifier: Q80TS3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1132-1140: Missing.
     1272-1351: EGLLNNARDT...NHERSSEQNR → GAMANHLISN...KCHGYSTTEW
     1352-1537: Missing.

Show »
Length:1,342
Mass (Da):149,585
Checksum:iDC564A59AC9FA61D
GO
Isoform 3 (identifier: Q80TS3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1272-1272: E → EPYRETK

Note: No experimental confirmation available.

Show »
Length:1,543
Mass (Da):171,855
Checksum:i777BF282BBB9F19A
GO
Isoform 4 (identifier: Q80TS3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.

Note: No experimental confirmation available.

Show »
Length:1,298
Mass (Da):144,737
Checksum:i6049A189631565C6
GO
Isoform 5 (identifier: Q80TS3-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1132-1140: Missing.

Note: No experimental confirmation available.

Show »
Length:1,528
Mass (Da):169,930
Checksum:i0821FFBFD18CA9BB
GO
Isoform 6 (identifier: Q80TS3-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-200: KVEQKV → I
     650-650: H → Q
     651-1537: Missing.

Note: No experimental confirmation available.

Show »
Length:645
Mass (Da):71,505
Checksum:i4F331FC4398D65BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti381 – 3811A → S in AAH94668. (PubMed:15489334)Curated
Sequence conflicti1252 – 12521K → R in BAE27870. (PubMed:16141072)Curated
Sequence conflicti1375 – 13751A → T in BAE26219. (PubMed:16141072)Curated
Sequence conflicti1495 – 14951V → M in BAE26219. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 239239Missing in isoform 4. 1 PublicationVSP_022138Add
BLAST
Alternative sequencei195 – 2006KVEQKV → I in isoform 6. 1 PublicationVSP_022139
Alternative sequencei650 – 6501H → Q in isoform 6. 1 PublicationVSP_022140
Alternative sequencei651 – 1537887Missing in isoform 6. 1 PublicationVSP_022141Add
BLAST
Alternative sequencei1132 – 11409Missing in isoform 2 and isoform 5. 2 PublicationsVSP_010121
Alternative sequencei1272 – 135180EGLLN…SEQNR → GAMANHLISNALLRPHGTNN PYNTLLGEPAVCNNPSISMY NTQEPYRETSMGVKLNIAYQ IGASEQCQGYKCHGYSTTEW in isoform 2. 1 PublicationVSP_010122Add
BLAST
Alternative sequencei1272 – 12721E → EPYRETK in isoform 3. 1 PublicationVSP_022142
Alternative sequencei1352 – 1537186Missing in isoform 2. 1 PublicationVSP_010123Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145069 mRNA. Translation: BAE26219.1.
AK147374 mRNA. Translation: BAE27870.1.
BC058992 mRNA. Translation: AAH58992.1.
BC088989 mRNA. Translation: AAH88989.1.
BC094668 mRNA. Translation: AAH94668.1.
AK122367 mRNA. Translation: BAC65649.1.
AY255584 mRNA. Translation: AAO85096.1.
CCDSiCCDS39122.1. [Q80TS3-3]
RefSeqiNP_941991.1. NM_198702.2. [Q80TS3-3]
UniGeneiMm.273631.
Mm.461016.

Genome annotation databases

EnsembliENSMUST00000072521; ENSMUSP00000072336; ENSMUSG00000037605. [Q80TS3-3]
ENSMUST00000117407; ENSMUSP00000112388; ENSMUSG00000037605. [Q80TS3-2]
ENSMUST00000122356; ENSMUSP00000113600; ENSMUSG00000037605. [Q80TS3-5]
GeneIDi319387.
KEGGimmu:319387.
UCSCiuc008xwk.1. mouse. [Q80TS3-6]
uc008xwn.1. mouse. [Q80TS3-1]
uc008xwp.1. mouse. [Q80TS3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145069 mRNA. Translation: BAE26219.1 .
AK147374 mRNA. Translation: BAE27870.1 .
BC058992 mRNA. Translation: AAH58992.1 .
BC088989 mRNA. Translation: AAH88989.1 .
BC094668 mRNA. Translation: AAH94668.1 .
AK122367 mRNA. Translation: BAC65649.1 .
AY255584 mRNA. Translation: AAO85096.1 .
CCDSi CCDS39122.1. [Q80TS3-3 ]
RefSeqi NP_941991.1. NM_198702.2. [Q80TS3-3 ]
UniGenei Mm.273631.
Mm.461016.

3D structure databases

ProteinModelPortali Q80TS3.
SMRi Q80TS3. Positions 93-197, 566-922, 947-1194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80TS3. 1 interaction.

Protein family/group databases

MEROPSi S63.014.
GPCRDBi Search...

PTM databases

PhosphoSitei Q80TS3.

Proteomic databases

MaxQBi Q80TS3.
PaxDbi Q80TS3.
PRIDEi Q80TS3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072521 ; ENSMUSP00000072336 ; ENSMUSG00000037605 . [Q80TS3-3 ]
ENSMUST00000117407 ; ENSMUSP00000112388 ; ENSMUSG00000037605 . [Q80TS3-2 ]
ENSMUST00000122356 ; ENSMUSP00000113600 ; ENSMUSG00000037605 . [Q80TS3-5 ]
GeneIDi 319387.
KEGGi mmu:319387.
UCSCi uc008xwk.1. mouse. [Q80TS3-6 ]
uc008xwn.1. mouse. [Q80TS3-1 ]
uc008xwp.1. mouse. [Q80TS3-3 ]

Organism-specific databases

CTDi 23284.
MGIi MGI:2441950. Lphn3.
Rougei Search...

Phylogenomic databases

eggNOGi NOG253931.
GeneTreei ENSGT00760000118787.
HOGENOMi HOG000049065.
HOVERGENi HBG052337.
InParanoidi Q80TS3.
KOi K04594.
PhylomeDBi Q80TS3.

Miscellaneous databases

ChiTaRSi Lphn3. mouse.
NextBioi 394668.
PROi Q80TS3.
SOURCEi Search...

Gene expression databases

Bgeei Q80TS3.
CleanExi MM_LPHN3.
ExpressionAtlasi Q80TS3. baseline and differential.
Genevestigatori Q80TS3.

Family and domain databases

InterProi IPR022624. DUF3497.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003924. GPCR_2_latrophilin.
IPR015630. GPCR_2_latrophilin3.
IPR003334. GPCR_2_latrophilin_rcpt_C.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR000922. Lectin_gal-bd_dom.
IPR003112. Olfac-like.
[Graphical view ]
PANTHERi PTHR12011:SF60. PTHR12011:SF60. 1 hit.
Pfami PF00002. 7tm_2. 1 hit.
PF12003. DUF3497. 1 hit.
PF02140. Gal_Lectin. 1 hit.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF02354. Latrophilin. 2 hits.
PF02191. OLF. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01444. LATROPHILIN.
SMARTi SM00303. GPS. 1 hit.
SM00284. OLF. 1 hit.
[Graphical view ]
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS51132. OLF. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 672-1537 (ISOFORM 5).
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 6).
    Strain: C57BL/6.
    Tissue: Brain and Eye.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 481-1537 (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 803-981.
  5. "LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5."
    O'Sullivan M.L., Martini F., von Daake S., Comoletti D., Ghosh A.
    Neural Dev. 9:7-7(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GLYCOSYLATION, INTERACTION WITH FLRT3 AND TEN1.

Entry informationi

Entry nameiLPHN3_MOUSE
AccessioniPrimary (citable) accession number: Q80TS3
Secondary accession number(s): Q3UHI7
, Q3UM79, Q504Z9, Q5HZJ6, Q80T56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3