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Q80TS3

- LPHN3_MOUSE

UniProt

Q80TS3 - LPHN3_MOUSE

Protein

Latrophilin-3

Gene

Lphn3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    May be involved in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.1 Publication

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    MEROPSiS63.014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Latrophilin-3
    Alternative name(s):
    Lectomedin-3
    Gene namesi
    Name:Lphn3
    Synonyms:Kiaa0768, Lec3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2441950. Lphn3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 15371518Latrophilin-3PRO_0000070344Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi203 ↔ 385PROSITE-ProRule annotation
    Glycosylationi532 – 5321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi827 – 8271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi840 – 8401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi885 – 8851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi911 – 9111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1000 – 10001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1166 – 11661N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity
    O-glycosylated (major) and N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ80TS3.
    PaxDbiQ80TS3.
    PRIDEiQ80TS3.

    PTM databases

    PhosphoSiteiQ80TS3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80TS3.
    BgeeiQ80TS3.
    CleanExiMM_LPHN3.
    GenevestigatoriQ80TS3.

    Interactioni

    Subunit structurei

    Interacts with FLRT3 and TEN1.1 Publication

    Protein-protein interaction databases

    IntActiQ80TS3. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80TS3.
    SMRiQ80TS3. Positions 93-197, 566-922, 947-1194.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 949930ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini971 – 9788CytoplasmicSequence Analysis
    Topological domaini1000 – 10078ExtracellularSequence Analysis
    Topological domaini1029 – 105022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1072 – 108817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1110 – 114233CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1164 – 11696ExtracellularSequence Analysis
    Topological domaini1191 – 1537347CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei950 – 97021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei979 – 99921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei1008 – 102821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei1051 – 107121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei1089 – 110921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1143 – 116321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1170 – 119021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini103 – 19290SUEL-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini202 – 461260Olfactomedin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini883 – 93452GPSPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1470 – 14734Poly-Ala

    Domaini

    The Olfactomedin-like domain is required for the synapse-promoting function and the interaction with FLRT3. The Olfactomedin-like and the SUEL-type lectin domains are required for the interaction with TEN1.

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation
    Contains 1 SUEL-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253931.
    GeneTreeiENSGT00710000106375.
    HOGENOMiHOG000049065.
    HOVERGENiHBG052337.
    KOiK04594.
    PhylomeDBiQ80TS3.

    Family and domain databases

    InterProiIPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003924. GPCR_2_latrophilin.
    IPR015630. GPCR_2_latrophilin3.
    IPR003334. GPCR_2_latrophilin_rcpt_C.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000922. Lectin_gal-bd_dom.
    IPR003112. Olfac-like.
    [Graphical view]
    PANTHERiPTHR12011:SF60. PTHR12011:SF60. 1 hit.
    PfamiPF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF02140. Gal_Lectin. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF02354. Latrophilin. 2 hits.
    PF02191. OLF. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01444. LATROPHILIN.
    SMARTiSM00303. GPS. 1 hit.
    SM00284. OLF. 1 hit.
    [Graphical view]
    PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS51132. OLF. 1 hit.
    PS50228. SUEL_LECTIN. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80TS3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWPPQLLILT MLLAPVVHGG KHNERHPALA APLRHAERSP GGALPPRHLL     50
    QQPAAERSTA HRGQGPRGAA RGVRGPGAPG AQIAAQAFSR APIPMAVVRR 100
    ELSCESYPIE LRCPGTDVIM IESANYGRTD DKICDSDPAQ MENIRCYLPD 150
    AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG TYKYLEVQYE CVPYKVEQKV 200
    FLCPGLLKGV YQSEHLFESD HQSGAWCKDP LQASDKIYYM PWTPYRTDTL 250
    TEYSSKDDFI AGRPTTTYKL PHRVDGTGFV VYDGALFFNK ERTRNIVKFD 300
    LRTRIKSGEA IIANANYHDT SPYRWGGKSD IDLAVDENGL WVIYATEQNN 350
    GKIVISQLNP YTLRIEGTWD TAYDKRSASN AFMICGILYV VKSVYEDDDN 400
    EATGNKIDYI YNTDQSKDSL VDVPFPNSYQ YIAAVDYNPR DNLLYVWNNY 450
    HVVKYSLDFG PLDSRSGPVH HGQVSYISPP IHLDSELERP PVRGISTTGS 500
    LGMGSTTTST TLRTTTWNIG RSTTASLPGR RNRSTSTPSP AVEVLDDVTT 550
    HLPSAASQIP AMEESCEAVE AREIMWFKTR QGQVAKQPCP AGTIGVSTYL 600
    CLAPDGIWDP QGPDLSNCSS PWVNHITQKL KSGETAANIA RELAEQTRNH 650
    LNAGDITYSV RAMDQLVGLL DVQLRNLTPG GKDSAARSLN KLQKRERSCR 700
    AYVQAMVETV NNLLQPQALN AWRDLTTSDQ LRAATMLLDT VEESAFVLAD 750
    NLLKTDIVRE NTDNIQLEVA RLSTEGNLED LKFPENMGHG STIQLSANTL 800
    KQNGRNGEIR VAFVLYNNLG PYLSTENASM KLGTEAMSTN HSVIVNSPVI 850
    TAAINKEFSN KVYLADPVVF TVKHIKQSEE NFNPNCSFWS YSKRTMTGYW 900
    STQGCRLLTT NKTHTTCSCN HLTNFAVLMA HVEVKHSDAV HDLLLDVITW 950
    VGILLSLVCL LICIFTFCFF RGLQSDRNTI HKNLCISLFV AELLFLIGIN 1000
    RTDQPIACAV FAALLHFFFL AAFTWMFLEG VQLYIMLVEV FESEHSRRKY 1050
    FYLVGYGMPA LIVAVSAAVD YRSYGTDKVC WLRLDTYFIW SFIGPATLII 1100
    MLNVIFLGIA LYKMFHHTAI LKPESGCLDN INYEDNRPFI KSWVIGAIAL 1150
    LCLLGLTWAF GLMYINESTV IMAYLFTIFN SLQGMFIFIF HCVLQKKVRK 1200
    EYGKCLRTHC CSGKSTESSI GSGKTSGSRT PGRYSTGSQS RIRRMWNDTV 1250
    RKQSESSFIT GDINSSASLN REGLLNNARD TSVMDTLPLN GNHGNSYSIA 1300
    GGEYLSNCVQ IIDRGYNHNE TALEKKILKE LTSNYIPSYL NNHERSSEQN 1350
    RNMMNKLVNN LGSGSEDDAI VLDDAASFNH EESLGLELIH EESDAPLLPP 1400
    RVYSTDNHQP HHYSRRRFPQ DHSESFFPLL TDEHTEDLQS PHRDSLYTSM 1450
    PALAGVPAAD SVTTSTQTEA AAAKGGDAED VYYKSMPNLG SRNHVHPLHA 1500
    YYQLGRGSSD GFIVPPNKDG ASPEGTSKGP AHLVTSL 1537
    Length:1,537
    Mass (Da):171,080
    Last modified:January 9, 2007 - v3
    Checksum:iF55EAB142C987A69
    GO
    Isoform 2 (identifier: Q80TS3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1132-1140: Missing.
         1272-1351: EGLLNNARDT...NHERSSEQNR → GAMANHLISN...KCHGYSTTEW
         1352-1537: Missing.

    Show »
    Length:1,342
    Mass (Da):149,585
    Checksum:iDC564A59AC9FA61D
    GO
    Isoform 3 (identifier: Q80TS3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1272-1272: E → EPYRETK

    Note: No experimental confirmation available.

    Show »
    Length:1,543
    Mass (Da):171,855
    Checksum:i777BF282BBB9F19A
    GO
    Isoform 4 (identifier: Q80TS3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-239: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,298
    Mass (Da):144,737
    Checksum:i6049A189631565C6
    GO
    Isoform 5 (identifier: Q80TS3-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1132-1140: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,528
    Mass (Da):169,930
    Checksum:i0821FFBFD18CA9BB
    GO
    Isoform 6 (identifier: Q80TS3-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         195-200: KVEQKV → I
         650-650: H → Q
         651-1537: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:645
    Mass (Da):71,505
    Checksum:i4F331FC4398D65BB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti381 – 3811A → S in AAH94668. (PubMed:15489334)Curated
    Sequence conflicti1252 – 12521K → R in BAE27870. (PubMed:16141072)Curated
    Sequence conflicti1375 – 13751A → T in BAE26219. (PubMed:16141072)Curated
    Sequence conflicti1495 – 14951V → M in BAE26219. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 239239Missing in isoform 4. 1 PublicationVSP_022138Add
    BLAST
    Alternative sequencei195 – 2006KVEQKV → I in isoform 6. 1 PublicationVSP_022139
    Alternative sequencei650 – 6501H → Q in isoform 6. 1 PublicationVSP_022140
    Alternative sequencei651 – 1537887Missing in isoform 6. 1 PublicationVSP_022141Add
    BLAST
    Alternative sequencei1132 – 11409Missing in isoform 2 and isoform 5. 2 PublicationsVSP_010121
    Alternative sequencei1272 – 135180EGLLN…SEQNR → GAMANHLISNALLRPHGTNN PYNTLLGEPAVCNNPSISMY NTQEPYRETSMGVKLNIAYQ IGASEQCQGYKCHGYSTTEW in isoform 2. 1 PublicationVSP_010122Add
    BLAST
    Alternative sequencei1272 – 12721E → EPYRETK in isoform 3. 1 PublicationVSP_022142
    Alternative sequencei1352 – 1537186Missing in isoform 2. 1 PublicationVSP_010123Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK145069 mRNA. Translation: BAE26219.1.
    AK147374 mRNA. Translation: BAE27870.1.
    BC058992 mRNA. Translation: AAH58992.1.
    BC088989 mRNA. Translation: AAH88989.1.
    BC094668 mRNA. Translation: AAH94668.1.
    AK122367 mRNA. Translation: BAC65649.1.
    AY255584 mRNA. Translation: AAO85096.1.
    CCDSiCCDS39122.1. [Q80TS3-3]
    RefSeqiNP_941991.1. NM_198702.2. [Q80TS3-3]
    UniGeneiMm.273631.
    Mm.461016.

    Genome annotation databases

    EnsembliENSMUST00000072521; ENSMUSP00000072336; ENSMUSG00000037605. [Q80TS3-3]
    ENSMUST00000117407; ENSMUSP00000112388; ENSMUSG00000037605. [Q80TS3-2]
    ENSMUST00000122356; ENSMUSP00000113600; ENSMUSG00000037605. [Q80TS3-5]
    GeneIDi319387.
    KEGGimmu:319387.
    UCSCiuc008xwk.1. mouse. [Q80TS3-6]
    uc008xwn.1. mouse. [Q80TS3-1]
    uc008xwp.1. mouse. [Q80TS3-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK145069 mRNA. Translation: BAE26219.1 .
    AK147374 mRNA. Translation: BAE27870.1 .
    BC058992 mRNA. Translation: AAH58992.1 .
    BC088989 mRNA. Translation: AAH88989.1 .
    BC094668 mRNA. Translation: AAH94668.1 .
    AK122367 mRNA. Translation: BAC65649.1 .
    AY255584 mRNA. Translation: AAO85096.1 .
    CCDSi CCDS39122.1. [Q80TS3-3 ]
    RefSeqi NP_941991.1. NM_198702.2. [Q80TS3-3 ]
    UniGenei Mm.273631.
    Mm.461016.

    3D structure databases

    ProteinModelPortali Q80TS3.
    SMRi Q80TS3. Positions 93-197, 566-922, 947-1194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q80TS3. 1 interaction.

    Protein family/group databases

    MEROPSi S63.014.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q80TS3.

    Proteomic databases

    MaxQBi Q80TS3.
    PaxDbi Q80TS3.
    PRIDEi Q80TS3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072521 ; ENSMUSP00000072336 ; ENSMUSG00000037605 . [Q80TS3-3 ]
    ENSMUST00000117407 ; ENSMUSP00000112388 ; ENSMUSG00000037605 . [Q80TS3-2 ]
    ENSMUST00000122356 ; ENSMUSP00000113600 ; ENSMUSG00000037605 . [Q80TS3-5 ]
    GeneIDi 319387.
    KEGGi mmu:319387.
    UCSCi uc008xwk.1. mouse. [Q80TS3-6 ]
    uc008xwn.1. mouse. [Q80TS3-1 ]
    uc008xwp.1. mouse. [Q80TS3-3 ]

    Organism-specific databases

    CTDi 23284.
    MGIi MGI:2441950. Lphn3.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG253931.
    GeneTreei ENSGT00710000106375.
    HOGENOMi HOG000049065.
    HOVERGENi HBG052337.
    KOi K04594.
    PhylomeDBi Q80TS3.

    Miscellaneous databases

    ChiTaRSi LPHN3. mouse.
    NextBioi 394668.
    PROi Q80TS3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80TS3.
    Bgeei Q80TS3.
    CleanExi MM_LPHN3.
    Genevestigatori Q80TS3.

    Family and domain databases

    InterProi IPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003924. GPCR_2_latrophilin.
    IPR015630. GPCR_2_latrophilin3.
    IPR003334. GPCR_2_latrophilin_rcpt_C.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000922. Lectin_gal-bd_dom.
    IPR003112. Olfac-like.
    [Graphical view ]
    PANTHERi PTHR12011:SF60. PTHR12011:SF60. 1 hit.
    Pfami PF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF02140. Gal_Lectin. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF02354. Latrophilin. 2 hits.
    PF02191. OLF. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01444. LATROPHILIN.
    SMARTi SM00303. GPS. 1 hit.
    SM00284. OLF. 1 hit.
    [Graphical view ]
    PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS51132. OLF. 1 hit.
    PS50228. SUEL_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 672-1537 (ISOFORM 5).
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 6).
      Strain: C57BL/6.
      Tissue: Brain and Eye.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 481-1537 (ISOFORM 1).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 803-981.
    5. "LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5."
      O'Sullivan M.L., Martini F., von Daake S., Comoletti D., Ghosh A.
      Neural Dev. 9:7-7(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, GLYCOSYLATION, INTERACTION WITH FLRT3 AND TEN1.

    Entry informationi

    Entry nameiLPHN3_MOUSE
    AccessioniPrimary (citable) accession number: Q80TS3
    Secondary accession number(s): Q3UHI7
    , Q3UM79, Q504Z9, Q5HZJ6, Q80T56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3