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Q80TR4

- SLIT1_MOUSE

UniProt

Q80TR4 - SLIT1_MOUSE

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Protein

Slit homolog 1 protein

Gene

Slit1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.By similarity2 Publications

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. receptor binding Source: MGI
  3. Roundabout binding Source: MGI

GO - Biological processi

  1. axon extension involved in axon guidance Source: Ensembl
  2. axon guidance Source: MGI
  3. axonogenesis Source: MGI
  4. dorsal/ventral axon guidance Source: MGI
  5. establishment of nucleus localization Source: MGI
  6. motor neuron axon guidance Source: Ensembl
  7. negative chemotaxis Source: MGI
  8. negative regulation of axon extension involved in axon guidance Source: Ensembl
  9. negative regulation of synapse assembly Source: UniProtKB
  10. neuron projection morphogenesis Source: MGI
  11. olfactory bulb development Source: MGI
  12. retinal ganglion cell axon guidance Source: MGI
  13. spinal cord development Source: Ensembl
  14. tangential migration from the subventricular zone to the olfactory bulb Source: MGI
  15. telencephalon cell migration Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_229826. Netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Slit homolog 1 protein
Short name:
Slit-1
Gene namesi
Name:Slit1
Synonyms:Kiaa0813
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1315203. Slit1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice show significant axon guidance errors in a variety of pathways, including corticofugal, callosal and thalamocortical tracts. Mice double-deficient in SLIT1 and SLIT2 show retinal axon guidance defects and a disorganized lateral olfactory tract (LOT).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 15311498Slit homolog 1 proteinPRO_0000007723Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi286 ↔ 295By similarity
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi443 ↔ 466By similarity
Disulfide bondi445 ↔ 487By similarity
Disulfide bondi513 ↔ 519By similarity
Disulfide bondi517 ↔ 526By similarity
Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi675 ↔ 698By similarity
Disulfide bondi677 ↔ 719By similarity
Glycosylationi762 – 7621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi806 – 8061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi929 ↔ 940By similarity
Disulfide bondi934 ↔ 950By similarity
Disulfide bondi952 ↔ 961By similarity
Disulfide bondi968 ↔ 979By similarity
Disulfide bondi973 ↔ 991By similarity
Disulfide bondi993 ↔ 1002By similarity
Disulfide bondi1009 ↔ 1020By similarity
Disulfide bondi1014 ↔ 1029By similarity
Glycosylationi1026 – 10261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1031 ↔ 1040By similarity
Disulfide bondi1047 ↔ 1060By similarity
Disulfide bondi1054 ↔ 1069By similarity
Disulfide bondi1071 ↔ 1080By similarity
Glycosylationi1079 – 10791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1087 ↔ 1098By similarity
Disulfide bondi1092 ↔ 1107By similarity
Disulfide bondi1109 ↔ 1118By similarity
Disulfide bondi1128 ↔ 1139By similarity
Disulfide bondi1133 ↔ 1148By similarity
Disulfide bondi1150 ↔ 1159By similarity
Glycosylationi1186 – 11861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1256 – 12561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1303 – 13031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1310 ↔ 1336By similarity
Disulfide bondi1339 ↔ 1349By similarity
Disulfide bondi1344 ↔ 1359By similarity
Disulfide bondi1361 ↔ 1370By similarity
Disulfide bondi1378 ↔ 1388By similarity
Disulfide bondi1383 ↔ 1398By similarity
Disulfide bondi1400 ↔ 1409By similarity
Disulfide bondi1419 ↔ 1429By similarity
Disulfide bondi1424 ↔ 1439By similarity
Disulfide bondi1441 ↔ 1450By similarity
Disulfide bondi1456 ↔ 1495By similarity
Disulfide bondi1474 ↔ 1509By similarity
Disulfide bondi1485 ↔ 1525By similarity
Disulfide bondi1489 ↔ 1527By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80TR4.
PaxDbiQ80TR4.
PRIDEiQ80TR4.

PTM databases

PhosphoSiteiQ80TR4.

Expressioni

Developmental stagei

During retinal development, is expressed at E12.5 in the dorsocentral region of the retina, and at E17.5 is only very weakly expressed. In the developing optic chiasm is expressed at E12.5 around the junction of the optic nerve and the brain, with strongest expression dorsal to the site at which the optic stalk joins the diencephalon, and also weakly in a subset of the CD44/SSEA neurons. In the more dorsal region of the developing optic chiasm, is expressed in some distance posterior to the axons. However, more ventrally, is expressed in a region directly adjacent to the path taken by the RGC axons. By E17.5 is not longer be detected at the junction of the brain and optic nerve and is only weakly expressed by the CD44/SSEA neurons. Outside the developing brain detected at between E8.5 and E9.5 in the primordiun of the branchial arches, between E9.5 and 10.5 in the posterior dermamyotome. By E11.5 the expression pattern along somite boundaries was most prominent caudally. Weak expression was also observed in the nasal pit at E11.5. From E13.5 to E17.5 expression was observed in the trigeminal ganglion, in the olfactory epithelium, and in the neural layer of the retina in the developing eye (with strongest expression in the inner nuclear layer).2 Publications

Gene expression databases

BgeeiQ80TR4.
CleanExiMM_SLIT1.
ExpressionAtlasiQ80TR4. baseline and differential.
GenevestigatoriQ80TR4.

Interactioni

Subunit structurei

Interacts with GREM1 (By similarity) and ROBO1.1 Publication

Protein-protein interaction databases

BioGridi203327. 1 interaction.
STRINGi10090.ENSMUSP00000025993.

Structurei

3D structure databases

ProteinModelPortaliQ80TR4.
SMRiQ80TR4. Positions 30-1451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 6128LRRNTAdd
BLAST
Repeati62 – 8322LRR 1Add
BLAST
Repeati86 – 10722LRR 2Add
BLAST
Repeati110 – 13122LRR 3Add
BLAST
Repeati134 – 15522LRR 4Add
BLAST
Repeati158 – 17922LRR 5Add
BLAST
Repeati182 – 20322LRR 6Add
BLAST
Domaini215 – 26551LRRCT 1Add
BLAST
Domaini273 – 30937LRRNT 23Add
BLAST
Repeati310 – 33122LRR 7Add
BLAST
Repeati334 – 35522LRR 8Add
BLAST
Repeati358 – 37922LRR 9Add
BLAST
Repeati382 – 40322LRR 10Add
BLAST
Repeati406 – 42722LRR 11Add
BLAST
Domaini439 – 48951LRRCT 2Add
BLAST
Domaini504 – 54037LRRNT 3Add
BLAST
Repeati541 – 56222LRR 12Add
BLAST
Repeati566 – 58722LRR 13Add
BLAST
Repeati590 – 61122LRR 14Add
BLAST
Repeati614 – 63522LRR 15Add
BLAST
Repeati638 – 65922LRR 16Add
BLAST
Domaini671 – 72151LRRCT 3Add
BLAST
Domaini725 – 76137LRRNT 4Add
BLAST
Repeati762 – 78322LRR 17Add
BLAST
Repeati785 – 80622LRR 18Add
BLAST
Repeati809 – 83022LRR 19Add
BLAST
Repeati833 – 85422LRR 20Add
BLAST
Domaini866 – 91651LRRCT 4Add
BLAST
Domaini927 – 96236EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini964 – 100340EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini1005 – 104137EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini1043 – 108139EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini1083 – 111937EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini1124 – 116037EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini1163 – 1336174Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini1337 – 137135EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini1374 – 141037EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini1415 – 145137EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini1456 – 153176CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 9 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation
Contains 20 LRR (leucine-rich) repeats.Curated
Contains 4 LRRCT domains.Curated
Contains 4 LRRNT domains.Curated

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118786.
HOGENOMiHOG000116120.
HOVERGENiHBG057959.
InParanoidiQ80TR4.
KOiK06838.
OMAiKCVHGKC.
PhylomeDBiQ80TR4.
TreeFamiTF332887.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00008. EGF. 4 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 2 hits.
SM00274. FOLN. 3 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 21 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80TR4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALTPQRGSS SGLSRPELWL LLWAAAWRLG ATACPALCTC TGTTVDCHGT
60 70 80 90 100
GLQAIPKNIP RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV
110 120 130 140 150
ERGAFDDMKE LERLRLNRNQ LQVLPELLFQ NNQALSRLDL SENFLQAVPR
160 170 180 190 200
KAFRGATDLK NLQLDKNRIS CIEEGAFRAL RGLEVLTLNN NNITTIPVSS
210 220 230 240 250
FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT QCSGPASLRG
260 270 280 290 300
LNVAEVQKGE FSCSGQGEAA GAPACTLSSG SCPAMCSCSS GIVDCRGKGL
310 320 330 340 350
TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP
360 370 380 390 400
DAFQGLRSLN SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA
410 420 430 440 450
FQDLQNLSLL SLYDNKIQSL AKGTFTSLRA IQTLHLAQNP FICDCNLKWL
460 470 480 490 500
ADFLRTNPIE TTGARCASPR RLANKRIGQI KSKKFRCSAK EQYFIPGTED
510 520 530 540 550
YHLNSECTSD VACPHKCRCE ASVVECSSLK LSKIPERIPQ STTELRLNNN
560 570 580 590 600
EISILEATGL FKKLSHLKKI NLSNNKVSEI EDGTFEGAAS VSELHLTANQ
610 620 630 640 650
LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNHIT
660 670 680 690 700
TISPGAFDTL QALSTLNLLA NPFNCNCHLS WLGDWLRKRK IVTGNPRCQN
710 720 730 740 750
PDFLRQIPLQ DVAFPDFRCE EGQEEVGCLP RPQCPQECAC LDTVVRCSNK
760 770 780 790 800
HLQALPKGIP KNVTELYLDG NQFTLVPGQL STFKYLQLVD LSNNKISSLS
810 820 830 840 850
NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH GNDVSTLQEG
860 870 880 890 900
IFADVTSLSH LAIGANPLYC DCRLRWLSSW VKTGYKEPGI ARCAGPPEME
910 920 930 940 950
GKLLLTTPAK KFECQGPPSL AVQAKCDPCL SSPCQNQGTC HNDPLEVYRC
960 970 980 990 1000
TCPSGYKGRH CEVSLDGCSS NPCGNGGTCH AQEGEDAGFT CSCPSGFEGP
1010 1020 1030 1040 1050
TCGVDTDDCV KHACVNGGVC VDGVGNYTCQ CPLQYTGRAC EQLVDFCSPD
1060 1070 1080 1090 1100
MNPCQHEAQC VGTPDGPRCE CMLGYTGDNC SENQDDCKDH KCQNGAQCVD
1110 1120 1130 1140 1150
EVNSYACLCV EGYSGQLCEI PPAPRSSCEG TECQNGANCV DQGSRPVCQC
1160 1170 1180 1190 1200
LPGFGGPECE KLLSVNFVDR DTYLQFTDLQ NWPRANITLQ VSTAEDNGIL
1210 1220 1230 1240 1250
LYNGDNDHIA VELYQGHVRV SYDPGSYPSS AIYSAETIND GQFHTVELVT
1260 1270 1280 1290 1300
FDQMVNLSID GGSPMTMDNF GKHYTLNSEA PLYVGGMPVD VNSAAFRLWQ
1310 1320 1330 1340 1350
ILNGTSFHGC IRNLYINNEL QDFTKTQMKP GVVPGCEPCR KLYCLHGICQ
1360 1370 1380 1390 1400
PNATPGPVCH CEAGWGGLHC DQPVDGPCHG HKCVHGKCVP LDALAYSCQC
1410 1420 1430 1440 1450
QDGYSGALCN QVGAVAEPCG GLQCLHGHCQ ASATKGAHCV CSPGFSGELC
1460 1470 1480 1490 1500
EQESECRGDP VRDFHRVQRG YAICQTTRPL SWVECRGACP GQGCCQGLRL
1510 1520 1530
KRRKLTFECS DGTSFAEEVE KPTKCGCAQC A
Length:1,531
Mass (Da):167,420
Last modified:March 15, 2004 - v2
Checksum:iC0F1C5A4E3DF6108
GO

Sequence cautioni

The sequence BAC65658.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441Missing in AAH57131. (PubMed:15489334)Curated
Sequence conflicti44 – 441Missing in AAH62091. (PubMed:15489334)Curated
Sequence conflicti830 – 8301G → R in AAD44758. (PubMed:10433822)Curated
Sequence conflicti1531 – 15311A → V in AAD44758. (PubMed:10433822)Curated
Sequence conflicti1531 – 15311A → V in BAC65658. (PubMed:12693553)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144627 mRNA. Translation: AAD44758.1.
AK122376 mRNA. Translation: BAC65658.1. Different initiation.
BC057131 mRNA. Translation: AAH57131.1.
BC062091 mRNA. Translation: AAH62091.1.
CCDSiCCDS29812.1.
RefSeqiNP_056563.2. NM_015748.3.
UniGeneiMm.40322.

Genome annotation databases

EnsembliENSMUST00000025993; ENSMUSP00000025993; ENSMUSG00000025020.
GeneIDi20562.
KEGGimmu:20562.
UCSCiuc008hmf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF144627 mRNA. Translation: AAD44758.1 .
AK122376 mRNA. Translation: BAC65658.1 . Different initiation.
BC057131 mRNA. Translation: AAH57131.1 .
BC062091 mRNA. Translation: AAH62091.1 .
CCDSi CCDS29812.1.
RefSeqi NP_056563.2. NM_015748.3.
UniGenei Mm.40322.

3D structure databases

ProteinModelPortali Q80TR4.
SMRi Q80TR4. Positions 30-1451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203327. 1 interaction.
STRINGi 10090.ENSMUSP00000025993.

PTM databases

PhosphoSitei Q80TR4.

Proteomic databases

MaxQBi Q80TR4.
PaxDbi Q80TR4.
PRIDEi Q80TR4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025993 ; ENSMUSP00000025993 ; ENSMUSG00000025020 .
GeneIDi 20562.
KEGGi mmu:20562.
UCSCi uc008hmf.2. mouse.

Organism-specific databases

CTDi 6585.
MGIi MGI:1315203. Slit1.
Rougei Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118786.
HOGENOMi HOG000116120.
HOVERGENi HBG057959.
InParanoidi Q80TR4.
KOi K06838.
OMAi KCVHGKC.
PhylomeDBi Q80TR4.
TreeFami TF332887.

Enzyme and pathway databases

Reactomei REACT_229826. Netrin-1 signaling.

Miscellaneous databases

NextBioi 298853.
PROi Q80TR4.
SOURCEi Search...

Gene expression databases

Bgeei Q80TR4.
CleanExi MM_SLIT1.
ExpressionAtlasi Q80TR4. baseline and differential.
Genevestigatori Q80TR4.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00008. EGF. 4 hits.
PF12661. hEGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view ]
SMARTi SM00041. CT. 1 hit.
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 2 hits.
SM00274. FOLN. 3 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 21 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance."
    Yuan W., Zhou L., Chen J.H., Wu J.Y., Rao Y., Ornitz D.M.
    Dev. Biol. 212:290-306(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ROBO1, DEVELOPMENTAL STAGE.
    Strain: ICR X Swiss Webster.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Slit1 and slit2 proteins control the development of the lateral olfactory tract."
    Nguyen-Ba-Charvet K.T., Plump A.S., Tessier-Lavigne M., Chedotal A.
    J. Neurosci. 22:5473-5480(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. "Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain."
    Bagri A., Marin O., Plump A.S., Mak J., Pleasure S.J., Rubenstein J.L., Tessier-Lavigne M.
    Neuron 33:233-248(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits."
    Erskine L., Williams S.E., Brose K., Kidd T., Rachel R.A., Goodman C.S., Tessier-Lavigne M., Mason C.A.
    J. Neurosci. 20:4975-4982(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSLIT1_MOUSE
AccessioniPrimary (citable) accession number: Q80TR4
Secondary accession number(s): Q9WVB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: November 26, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3