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Q80TR4

- SLIT1_MOUSE

UniProt

Q80TR4 - SLIT1_MOUSE

Protein

Slit homolog 1 protein

Gene

Slit1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions By similarity. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.By similarity2 Publications

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. receptor binding Source: MGI
    3. Roundabout binding Source: MGI

    GO - Biological processi

    1. axon extension involved in axon guidance Source: Ensembl
    2. axon guidance Source: MGI
    3. axonogenesis Source: MGI
    4. dorsal/ventral axon guidance Source: MGI
    5. establishment of nucleus localization Source: MGI
    6. motor neuron axon guidance Source: Ensembl
    7. negative chemotaxis Source: MGI
    8. negative regulation of axon extension involved in axon guidance Source: Ensembl
    9. negative regulation of synapse assembly Source: UniProtKB
    10. neuron projection morphogenesis Source: MGI
    11. olfactory bulb development Source: MGI
    12. retinal ganglion cell axon guidance Source: MGI
    13. spinal cord development Source: Ensembl
    14. tangential migration from the subventricular zone to the olfactory bulb Source: MGI
    15. telencephalon cell migration Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Slit homolog 1 protein
    Short name:
    Slit-1
    Gene namesi
    Name:Slit1
    Synonyms:Kiaa0813
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1315203. Slit1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice show significant axon guidance errors in a variety of pathways, including corticofugal, callosal and thalamocortical tracts. Mice double-deficient in SLIT1 and SLIT2 show retinal axon guidance defects and a disorganized lateral olfactory tract (LOT).1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 15311498Slit homolog 1 proteinPRO_0000007723Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi286 ↔ 295By similarity
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi443 ↔ 466By similarity
    Disulfide bondi445 ↔ 487By similarity
    Disulfide bondi513 ↔ 519By similarity
    Disulfide bondi517 ↔ 526By similarity
    Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi675 ↔ 698By similarity
    Disulfide bondi677 ↔ 719By similarity
    Glycosylationi762 – 7621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi801 – 8011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi806 – 8061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi929 ↔ 940By similarity
    Disulfide bondi934 ↔ 950By similarity
    Disulfide bondi952 ↔ 961By similarity
    Disulfide bondi968 ↔ 979By similarity
    Disulfide bondi973 ↔ 991By similarity
    Disulfide bondi993 ↔ 1002By similarity
    Disulfide bondi1009 ↔ 1020By similarity
    Disulfide bondi1014 ↔ 1029By similarity
    Glycosylationi1026 – 10261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1031 ↔ 1040By similarity
    Disulfide bondi1047 ↔ 1060By similarity
    Disulfide bondi1054 ↔ 1069By similarity
    Disulfide bondi1071 ↔ 1080By similarity
    Glycosylationi1079 – 10791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1087 ↔ 1098By similarity
    Disulfide bondi1092 ↔ 1107By similarity
    Disulfide bondi1109 ↔ 1118By similarity
    Disulfide bondi1128 ↔ 1139By similarity
    Disulfide bondi1133 ↔ 1148By similarity
    Disulfide bondi1150 ↔ 1159By similarity
    Glycosylationi1186 – 11861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1256 – 12561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1303 – 13031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1310 ↔ 1336By similarity
    Disulfide bondi1339 ↔ 1349By similarity
    Disulfide bondi1344 ↔ 1359By similarity
    Disulfide bondi1361 ↔ 1370By similarity
    Disulfide bondi1378 ↔ 1388By similarity
    Disulfide bondi1383 ↔ 1398By similarity
    Disulfide bondi1400 ↔ 1409By similarity
    Disulfide bondi1419 ↔ 1429By similarity
    Disulfide bondi1424 ↔ 1439By similarity
    Disulfide bondi1441 ↔ 1450By similarity
    Disulfide bondi1456 ↔ 1495By similarity
    Disulfide bondi1474 ↔ 1509By similarity
    Disulfide bondi1485 ↔ 1525By similarity
    Disulfide bondi1489 ↔ 1527By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ80TR4.
    PRIDEiQ80TR4.

    PTM databases

    PhosphoSiteiQ80TR4.

    Expressioni

    Developmental stagei

    During retinal development, is expressed at E12.5 in the dorsocentral region of the retina, and at E17.5 is only very weakly expressed. In the developing optic chiasm is expressed at E12.5 around the junction of the optic nerve and the brain, with strongest expression dorsal to the site at which the optic stalk joins the diencephalon, and also weakly in a subset of the CD44/SSEA neurons. In the more dorsal region of the developing optic chiasm, is expressed in some distance posterior to the axons. However, more ventrally, is expressed in a region directly adjacent to the path taken by the RGC axons. By E17.5 is not longer be detected at the junction of the brain and optic nerve and is only weakly expressed by the CD44/SSEA neurons. Outside the developing brain detected at between E8.5 and E9.5 in the primordiun of the branchial arches, between E9.5 and 10.5 in the posterior dermamyotome. By E11.5 the expression pattern along somite boundaries was most prominent caudally. Weak expression was also observed in the nasal pit at E11.5. From E13.5 to E17.5 expression was observed in the trigeminal ganglion, in the olfactory epithelium, and in the neural layer of the retina in the developing eye (with strongest expression in the inner nuclear layer).2 Publications

    Gene expression databases

    BgeeiQ80TR4.
    CleanExiMM_SLIT1.
    GenevestigatoriQ80TR4.

    Interactioni

    Subunit structurei

    Interacts with GREM1 By similarity and ROBO1.1 Publication

    Protein-protein interaction databases

    BioGridi203327. 1 interaction.
    STRINGi10090.ENSMUSP00000025993.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80TR4.
    SMRiQ80TR4. Positions 30-1451.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 6128LRRNTAdd
    BLAST
    Repeati62 – 8322LRR 1Add
    BLAST
    Repeati86 – 10722LRR 2Add
    BLAST
    Repeati110 – 13122LRR 3Add
    BLAST
    Repeati134 – 15522LRR 4Add
    BLAST
    Repeati158 – 17922LRR 5Add
    BLAST
    Repeati182 – 20322LRR 6Add
    BLAST
    Domaini215 – 26551LRRCT 1Add
    BLAST
    Domaini273 – 30937LRRNT 23Add
    BLAST
    Repeati310 – 33122LRR 7Add
    BLAST
    Repeati334 – 35522LRR 8Add
    BLAST
    Repeati358 – 37922LRR 9Add
    BLAST
    Repeati382 – 40322LRR 10Add
    BLAST
    Repeati406 – 42722LRR 11Add
    BLAST
    Domaini439 – 48951LRRCT 2Add
    BLAST
    Domaini504 – 54037LRRNT 3Add
    BLAST
    Repeati541 – 56222LRR 12Add
    BLAST
    Repeati566 – 58722LRR 13Add
    BLAST
    Repeati590 – 61122LRR 14Add
    BLAST
    Repeati614 – 63522LRR 15Add
    BLAST
    Repeati638 – 65922LRR 16Add
    BLAST
    Domaini671 – 72151LRRCT 3Add
    BLAST
    Domaini725 – 76137LRRNT 4Add
    BLAST
    Repeati762 – 78322LRR 17Add
    BLAST
    Repeati785 – 80622LRR 18Add
    BLAST
    Repeati809 – 83022LRR 19Add
    BLAST
    Repeati833 – 85422LRR 20Add
    BLAST
    Domaini866 – 91651LRRCT 4Add
    BLAST
    Domaini927 – 96236EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini964 – 100340EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1005 – 104137EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1043 – 108139EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1083 – 111937EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1124 – 116037EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1163 – 1336174Laminin G-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini1337 – 137135EGF-like 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1374 – 141037EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1415 – 145137EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1456 – 153176CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 9 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.PROSITE-ProRule annotation
    Contains 20 LRR (leucine-rich) repeats.Curated
    Contains 4 LRRCT domains.Curated
    Contains 4 LRRNT domains.Curated

    Keywords - Domaini

    EGF-like domain, Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00750000117236.
    HOGENOMiHOG000116120.
    HOVERGENiHBG057959.
    InParanoidiQ80TR4.
    KOiK06838.
    OMAiKCVHGKC.
    PhylomeDBiQ80TR4.
    TreeFamiTF332887.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000483. Cys-rich_flank_reg_C.
    IPR006207. Cys_knot_C.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR003645. Fol_N.
    IPR001791. Laminin_G.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF00008. EGF. 4 hits.
    PF12661. hEGF. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 5 hits.
    PF01463. LRRCT. 4 hits.
    PF01462. LRRNT. 4 hits.
    [Graphical view]
    SMARTiSM00041. CT. 1 hit.
    SM00181. EGF. 7 hits.
    SM00179. EGF_CA. 2 hits.
    SM00274. FOLN. 3 hits.
    SM00282. LamG. 1 hit.
    SM00369. LRR_TYP. 10 hits.
    SM00082. LRRCT. 4 hits.
    SM00013. LRRNT. 4 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00022. EGF_1. 9 hits.
    PS01186. EGF_2. 8 hits.
    PS50026. EGF_3. 9 hits.
    PS01187. EGF_CA. 2 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS51450. LRR. 21 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q80TR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALTPQRGSS SGLSRPELWL LLWAAAWRLG ATACPALCTC TGTTVDCHGT     50
    GLQAIPKNIP RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV 100
    ERGAFDDMKE LERLRLNRNQ LQVLPELLFQ NNQALSRLDL SENFLQAVPR 150
    KAFRGATDLK NLQLDKNRIS CIEEGAFRAL RGLEVLTLNN NNITTIPVSS 200
    FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT QCSGPASLRG 250
    LNVAEVQKGE FSCSGQGEAA GAPACTLSSG SCPAMCSCSS GIVDCRGKGL 300
    TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP 350
    DAFQGLRSLN SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA 400
    FQDLQNLSLL SLYDNKIQSL AKGTFTSLRA IQTLHLAQNP FICDCNLKWL 450
    ADFLRTNPIE TTGARCASPR RLANKRIGQI KSKKFRCSAK EQYFIPGTED 500
    YHLNSECTSD VACPHKCRCE ASVVECSSLK LSKIPERIPQ STTELRLNNN 550
    EISILEATGL FKKLSHLKKI NLSNNKVSEI EDGTFEGAAS VSELHLTANQ 600
    LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNHIT 650
    TISPGAFDTL QALSTLNLLA NPFNCNCHLS WLGDWLRKRK IVTGNPRCQN 700
    PDFLRQIPLQ DVAFPDFRCE EGQEEVGCLP RPQCPQECAC LDTVVRCSNK 750
    HLQALPKGIP KNVTELYLDG NQFTLVPGQL STFKYLQLVD LSNNKISSLS 800
    NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH GNDVSTLQEG 850
    IFADVTSLSH LAIGANPLYC DCRLRWLSSW VKTGYKEPGI ARCAGPPEME 900
    GKLLLTTPAK KFECQGPPSL AVQAKCDPCL SSPCQNQGTC HNDPLEVYRC 950
    TCPSGYKGRH CEVSLDGCSS NPCGNGGTCH AQEGEDAGFT CSCPSGFEGP 1000
    TCGVDTDDCV KHACVNGGVC VDGVGNYTCQ CPLQYTGRAC EQLVDFCSPD 1050
    MNPCQHEAQC VGTPDGPRCE CMLGYTGDNC SENQDDCKDH KCQNGAQCVD 1100
    EVNSYACLCV EGYSGQLCEI PPAPRSSCEG TECQNGANCV DQGSRPVCQC 1150
    LPGFGGPECE KLLSVNFVDR DTYLQFTDLQ NWPRANITLQ VSTAEDNGIL 1200
    LYNGDNDHIA VELYQGHVRV SYDPGSYPSS AIYSAETIND GQFHTVELVT 1250
    FDQMVNLSID GGSPMTMDNF GKHYTLNSEA PLYVGGMPVD VNSAAFRLWQ 1300
    ILNGTSFHGC IRNLYINNEL QDFTKTQMKP GVVPGCEPCR KLYCLHGICQ 1350
    PNATPGPVCH CEAGWGGLHC DQPVDGPCHG HKCVHGKCVP LDALAYSCQC 1400
    QDGYSGALCN QVGAVAEPCG GLQCLHGHCQ ASATKGAHCV CSPGFSGELC 1450
    EQESECRGDP VRDFHRVQRG YAICQTTRPL SWVECRGACP GQGCCQGLRL 1500
    KRRKLTFECS DGTSFAEEVE KPTKCGCAQC A 1531
    Length:1,531
    Mass (Da):167,420
    Last modified:March 15, 2004 - v2
    Checksum:iC0F1C5A4E3DF6108
    GO

    Sequence cautioni

    The sequence BAC65658.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441Missing in AAH57131. (PubMed:15489334)Curated
    Sequence conflicti44 – 441Missing in AAH62091. (PubMed:15489334)Curated
    Sequence conflicti830 – 8301G → R in AAD44758. (PubMed:10433822)Curated
    Sequence conflicti1531 – 15311A → V in AAD44758. (PubMed:10433822)Curated
    Sequence conflicti1531 – 15311A → V in BAC65658. (PubMed:12693553)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF144627 mRNA. Translation: AAD44758.1.
    AK122376 mRNA. Translation: BAC65658.1. Different initiation.
    BC057131 mRNA. Translation: AAH57131.1.
    BC062091 mRNA. Translation: AAH62091.1.
    CCDSiCCDS29812.1.
    RefSeqiNP_056563.2. NM_015748.3.
    UniGeneiMm.40322.

    Genome annotation databases

    EnsembliENSMUST00000025993; ENSMUSP00000025993; ENSMUSG00000025020.
    GeneIDi20562.
    KEGGimmu:20562.
    UCSCiuc008hmf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF144627 mRNA. Translation: AAD44758.1 .
    AK122376 mRNA. Translation: BAC65658.1 . Different initiation.
    BC057131 mRNA. Translation: AAH57131.1 .
    BC062091 mRNA. Translation: AAH62091.1 .
    CCDSi CCDS29812.1.
    RefSeqi NP_056563.2. NM_015748.3.
    UniGenei Mm.40322.

    3D structure databases

    ProteinModelPortali Q80TR4.
    SMRi Q80TR4. Positions 30-1451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203327. 1 interaction.
    STRINGi 10090.ENSMUSP00000025993.

    PTM databases

    PhosphoSitei Q80TR4.

    Proteomic databases

    PaxDbi Q80TR4.
    PRIDEi Q80TR4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025993 ; ENSMUSP00000025993 ; ENSMUSG00000025020 .
    GeneIDi 20562.
    KEGGi mmu:20562.
    UCSCi uc008hmf.2. mouse.

    Organism-specific databases

    CTDi 6585.
    MGIi MGI:1315203. Slit1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00750000117236.
    HOGENOMi HOG000116120.
    HOVERGENi HBG057959.
    InParanoidi Q80TR4.
    KOi K06838.
    OMAi KCVHGKC.
    PhylomeDBi Q80TR4.
    TreeFami TF332887.

    Miscellaneous databases

    NextBioi 298853.
    PROi Q80TR4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80TR4.
    CleanExi MM_SLIT1.
    Genevestigatori Q80TR4.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000483. Cys-rich_flank_reg_C.
    IPR006207. Cys_knot_C.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR003645. Fol_N.
    IPR001791. Laminin_G.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF00008. EGF. 4 hits.
    PF12661. hEGF. 2 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 5 hits.
    PF01463. LRRCT. 4 hits.
    PF01462. LRRNT. 4 hits.
    [Graphical view ]
    SMARTi SM00041. CT. 1 hit.
    SM00181. EGF. 7 hits.
    SM00179. EGF_CA. 2 hits.
    SM00274. FOLN. 3 hits.
    SM00282. LamG. 1 hit.
    SM00369. LRR_TYP. 10 hits.
    SM00082. LRRCT. 4 hits.
    SM00013. LRRNT. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00022. EGF_1. 9 hits.
    PS01186. EGF_2. 8 hits.
    PS50026. EGF_3. 9 hits.
    PS01187. EGF_CA. 2 hits.
    PS50025. LAM_G_DOMAIN. 1 hit.
    PS51450. LRR. 21 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance."
      Yuan W., Zhou L., Chen J.H., Wu J.Y., Rao Y., Ornitz D.M.
      Dev. Biol. 212:290-306(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH ROBO1, DEVELOPMENTAL STAGE.
      Strain: ICR X Swiss Webster.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Slit1 and slit2 proteins control the development of the lateral olfactory tract."
      Nguyen-Ba-Charvet K.T., Plump A.S., Tessier-Lavigne M., Chedotal A.
      J. Neurosci. 22:5473-5480(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    5. "Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain."
      Bagri A., Marin O., Plump A.S., Mak J., Pleasure S.J., Rubenstein J.L., Tessier-Lavigne M.
      Neuron 33:233-248(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits."
      Erskine L., Williams S.E., Brose K., Kidd T., Rachel R.A., Goodman C.S., Tessier-Lavigne M., Mason C.A.
      J. Neurosci. 20:4975-4982(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiSLIT1_MOUSE
    AccessioniPrimary (citable) accession number: Q80TR4
    Secondary accession number(s): Q9WVB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

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