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Q80TR1

- LPHN1_MOUSE

UniProt

Q80TR1 - LPHN1_MOUSE

Protein

Latrophilin-1

Gene

Lphn1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421Carbohydrate
    Sitei832 – 8332CleavageBy similarity
    Sitei832 – 8332Cleavage; by autocatalysisBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. cell adhesion molecule binding Source: UniProtKB
    3. G-protein coupled receptor activity Source: UniProtKB-KW
    4. latrotoxin receptor activity Source: UniProtKB

    GO - Biological processi

    1. calcium-mediated signaling using intracellular calcium source Source: UniProtKB
    2. heterophilic cell-cell adhesion Source: UniProtKB
    3. neuropeptide signaling pathway Source: InterPro
    4. positive regulation of synapse maturation Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    MEROPSiS63.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Latrophilin-1
    Alternative name(s):
    Calcium-independent alpha-latrotoxin receptor 1
    Short name:
    CIRL-1
    Lectomedin-2
    Gene namesi
    Name:Lphn1
    Synonyms:Kiaa0821, Lec2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1929461. Lphn1.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Cell projectionaxon By similarity. Cell projectiongrowth cone By similarity. Cell junctionsynapse By similarity. Cell junctionsynapsepresynaptic cell membrane By similarity. Cell junctionsynapsesynaptosome By similarity
    Note: Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts.By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cell junction Source: UniProtKB-KW
    3. growth cone Source: UniProtKB
    4. integral component of membrane Source: UniProtKB-KW
    5. neuron projection Source: UniProtKB
    6. plasma membrane Source: UniProtKB
    7. presynaptic membrane Source: UniProtKB
    8. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi42 – 421E → A or R: Abrogates L-rhamnose binding. 1 Publication
    Mutagenesisi42 – 421E → D or Q: 100-fold decreased affinity for L-rhamnose. 1 Publication
    Mutagenesisi120 – 1201K → A or R: Abrogates L-rhamnose binding. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 14661438Latrophilin-1PRO_0000070342Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 711 PublicationPROSITE-ProRule annotation
    Disulfide bondi50 ↔ 1281 PublicationPROSITE-ProRule annotation
    Disulfide bondi83 ↔ 1151 PublicationPROSITE-ProRule annotation
    Disulfide bondi96 ↔ 1021 PublicationPROSITE-ProRule annotation
    Glycosylationi98 – 981N-linked (GlcNAc...)1 Publication
    Disulfide bondi135 ↔ 317PROSITE-ProRule annotation
    Disulfide bondi475 ↔ 510PROSITE-ProRule annotation
    Disulfide bondi498 ↔ 527PROSITE-ProRule annotation
    Glycosylationi526 – 5261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi635 – 6351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi736 – 7361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi795 – 7951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi796 ↔ 827PROSITE-ProRule annotation
    Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi815 ↔ 829PROSITE-ProRule annotation
    Glycosylationi821 – 8211N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ80TR1.
    PaxDbiQ80TR1.
    PRIDEiQ80TR1.

    PTM databases

    PhosphoSiteiQ80TR1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80TR1.
    BgeeiQ80TR1.
    CleanExiMM_LPHN1.
    GenevestigatoriQ80TR1.

    Interactioni

    Subunit structurei

    Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ80TR1. 1 interaction.
    STRINGi10090.ENSMUSP00000115295.

    Structurei

    Secondary structure

    1
    1466
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi36 – 416
    Beta strandi44 – 496
    Beta strandi54 – 6613
    Beta strandi68 – 714
    Helixi75 – 784
    Helixi87 – 9610
    Beta strandi99 – 1079
    Helixi108 – 1103
    Beta strandi121 – 13111

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2JX9NMR-A29-131[»]
    2JXANMR-A29-131[»]
    ProteinModelPortaliQ80TR1.
    SMRiQ80TR1. Positions 29-131, 469-832, 855-1094.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ80TR1.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 852824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini874 – 88714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini909 – 9146ExtracellularSequence Analysis
    Topological domaini936 – 95823CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini980 – 99617ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1018 – 104427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1066 – 10694ExtracellularSequence Analysis
    Topological domaini1091 – 1466376CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei853 – 87321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei888 – 90821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei915 – 93521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei959 – 97921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei997 – 101721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1045 – 106521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1070 – 109021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 12990SUEL-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 393260Olfactomedin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini793 – 84452GPSPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 1204Carbohydrate binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi408 – 4114Poly-Thr
    Compositional biasi1402 – 141211Poly-ProAdd
    BLAST

    Domaini

    The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.By similarity

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation
    Contains 1 SUEL-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253931.
    GeneTreeiENSGT00710000106375.
    HOGENOMiHOG000049065.
    HOVERGENiHBG052337.
    InParanoidiQ80TR1.
    KOiK04592.
    OrthoDBiEOG76DTRK.
    PhylomeDBiQ80TR1.
    TreeFamiTF351999.

    Family and domain databases

    InterProiIPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003924. GPCR_2_latrophilin.
    IPR003334. GPCR_2_latrophilin_rcpt_C.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000922. Lectin_gal-bd_dom.
    IPR003112. Olfac-like.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF02140. Gal_Lectin. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF02354. Latrophilin. 1 hit.
    PF02191. OLF. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01444. LATROPHILIN.
    SMARTiSM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00284. OLF. 1 hit.
    [Graphical view]
    PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS51132. OLF. 1 hit.
    PS50228. SUEL_LECTIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80TR1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARLAAALWS LCVTTVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC     50
    PGSDVIMVEN ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT 100
    QCVVVAGSDA FPDPCPGTYK YLEVQYDCVP YIFVCPGTLQ KVLEPTSTHE 150
    SEHQSGAWCK DPLQAGDRIY VMPWIPYRTD TLTEYASWED YVAARHTTTY 200
    RLPNRVDGTG FVVYDGAVFY NKERTRNIVK YDLRTRIKSG ETVINTANYH 250
    DTSPYRWGGK TDIDLAVDEN GLWVIYATEG NNGRLVVSQL NPYTLRFEGT 300
    WETGYDKRSA SNAFMVCGVL YVLRSVYVDD DSEAAGNRVD YAFNTNANRE 350
    EPVSLAFPNP YQFVSSVDYN PRDNQLYVWN NYFVVRYSLE FGPPDPSAGP 400
    ATSPPLSTTT TARPTPLTST ASPAATTPLR RAPLTTHPVG AINQLGPDLP 450
    PATAPAPSTR RPPAPNLHVS PELFCEPREV RRVQWPATQQ GMLVERPCPK 500
    GTRGIASFQC LPALGLWNPR GPDLSNCTSP WVNQVAQKIK SGENAANIAS 550
    ELARHTRGSI YAGDVSSSVK LMEQLLDILD AQLQALRPIE RESAGKNYNK 600
    MHKRERTCKD YIKAVVETVD NLLRPEALES WKDMNATEQV HTATMLLDVL 650
    EEGAFLLADN VREPARFLAA KQNVVLEVTV LNTEGQVQEL VFPQEYPSEN 700
    SIQLSANTIK QNSRNGVVKV VFILYNNLGL FLSTENATVK LAGEAGTGGP 750
    GGASLVVNSQ VIAASINKES SRVFLMDPVI FTVAHLEAKN HFNANCSFWN 800
    YSERSMLGYW STQGCRLVES NKTHTTCACS HLTNFAVLMA HREIYQGRIN 850
    ELLLSVITWV GIVISLVCLA ICISTFCFLR GLQTDRNTIH KNLCINLFLA 900
    ELLFLVGIDK TQYEVACPIF AGLLHYFFLA AFSWLCLEGV HLYLLLVEVF 950
    ESEYSRTKYY YLGGYCFPAL VVGIAAAIDY RSYGTEKACW LRVDNYFIWS 1000
    FIGPVSFVIV VNLVFLMVTL HKMIRSSSVL KPDSSRLDNI KSWALGAIAL 1050
    LFLLGLTWAF GLLFINKESV VMAYLFTTFN AFQGVFIFVF HCALQKKVHK 1100
    EYSKCLRHSY CCIRSPPGGT HGSLKTSAMR SNTRYYTGTQ SRIRRMWNDT 1150
    VRKQTESSFM AGDINSTPTL NRGTMGNHLL TNPVLQPRGG TSPYNTLIAE 1200
    SVGFNPSSPP VFNSPGSYRE PKHPLGGREA CGMDTLPLNG NFNNSYSLRS 1250
    GDFPPGDGGP EPPRGRNLAD AAAFEKMIIS ELVHNNLRGA SGGAKGPPPE 1300
    PPVPPVPGVS EDEAGGPGSA DRAEIELLYK ALEEPLLLPR AQSVLYQSDL 1350
    DESESCTAED GATSRPLSSP PGRDSLYASG ANLRDSPSYP DSSPEGPNEA 1400
    LPPPPPAPPG PPEIYYTSRP PALVARNPLQ GYYQVRRPSH EGYLAAPSLE 1450
    GPGPDGDGQM QLVTSL 1466
    Length:1,466
    Mass (Da):161,686
    Last modified:January 9, 2007 - v2
    Checksum:i937199B072336C9E
    GO
    Isoform 2 (identifier: Q80TR1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-171: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,295
    Mass (Da):142,775
    Checksum:i23B2CAE4C15B72E4
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 171171Missing in isoform 2. 1 PublicationVSP_022137Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK147519 mRNA. Translation: BAE27967.1.
    AK122380 mRNA. Translation: BAC65662.1.
    AC156028 Genomic DNA. No translation available.
    AY255594 mRNA. Translation: AAO85106.1.
    BC055793 mRNA. Translation: AAH55793.1.
    CCDSiCCDS52613.1. [Q80TR1-1]
    RefSeqiNP_851382.2. NM_181039.2. [Q80TR1-1]
    XP_006531189.1. XM_006531126.1. [Q80TR1-2]
    XP_006531190.1. XM_006531127.1. [Q80TR1-2]
    XP_006531191.1. XM_006531128.1. [Q80TR1-2]
    UniGeneiMm.260733.

    Genome annotation databases

    EnsembliENSMUST00000131717; ENSMUSP00000118579; ENSMUSG00000013033. [Q80TR1-2]
    ENSMUST00000141158; ENSMUSP00000118452; ENSMUSG00000013033. [Q80TR1-1]
    GeneIDi330814.
    KEGGimmu:330814.
    UCSCiuc009mlh.2. mouse. [Q80TR1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK147519 mRNA. Translation: BAE27967.1 .
    AK122380 mRNA. Translation: BAC65662.1 .
    AC156028 Genomic DNA. No translation available.
    AY255594 mRNA. Translation: AAO85106.1 .
    BC055793 mRNA. Translation: AAH55793.1 .
    CCDSi CCDS52613.1. [Q80TR1-1 ]
    RefSeqi NP_851382.2. NM_181039.2. [Q80TR1-1 ]
    XP_006531189.1. XM_006531126.1. [Q80TR1-2 ]
    XP_006531190.1. XM_006531127.1. [Q80TR1-2 ]
    XP_006531191.1. XM_006531128.1. [Q80TR1-2 ]
    UniGenei Mm.260733.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2JX9 NMR - A 29-131 [» ]
    2JXA NMR - A 29-131 [» ]
    ProteinModelPortali Q80TR1.
    SMRi Q80TR1. Positions 29-131, 469-832, 855-1094.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q80TR1. 1 interaction.
    STRINGi 10090.ENSMUSP00000115295.

    Protein family/group databases

    MEROPSi S63.013.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q80TR1.

    Proteomic databases

    MaxQBi Q80TR1.
    PaxDbi Q80TR1.
    PRIDEi Q80TR1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000131717 ; ENSMUSP00000118579 ; ENSMUSG00000013033 . [Q80TR1-2 ]
    ENSMUST00000141158 ; ENSMUSP00000118452 ; ENSMUSG00000013033 . [Q80TR1-1 ]
    GeneIDi 330814.
    KEGGi mmu:330814.
    UCSCi uc009mlh.2. mouse. [Q80TR1-1 ]

    Organism-specific databases

    CTDi 22859.
    MGIi MGI:1929461. Lphn1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG253931.
    GeneTreei ENSGT00710000106375.
    HOGENOMi HOG000049065.
    HOVERGENi HBG052337.
    InParanoidi Q80TR1.
    KOi K04592.
    OrthoDBi EOG76DTRK.
    PhylomeDBi Q80TR1.
    TreeFami TF351999.

    Miscellaneous databases

    ChiTaRSi LPHN1. mouse.
    EvolutionaryTracei Q80TR1.
    NextBioi 399562.
    PROi Q80TR1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80TR1.
    Bgeei Q80TR1.
    CleanExi MM_LPHN1.
    Genevestigatori Q80TR1.

    Family and domain databases

    InterProi IPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003924. GPCR_2_latrophilin.
    IPR003334. GPCR_2_latrophilin_rcpt_C.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR000203. GPS.
    IPR000922. Lectin_gal-bd_dom.
    IPR003112. Olfac-like.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF02140. Gal_Lectin. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF02354. Latrophilin. 1 hit.
    PF02191. OLF. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01444. LATROPHILIN.
    SMARTi SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00284. OLF. 1 hit.
    [Graphical view ]
    PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS51132. OLF. 1 hit.
    PS50228. SUEL_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-1466 (ISOFORM 1).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 814-978.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1145-1466.
      Strain: C57BL/6.
      Tissue: Brain.
    6. "Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain."
      Vakonakis I., Langenhan T., Promel S., Russ A., Campbell I.D.
      Structure 16:944-953(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 29-132 IN COMPLEX WITH D-GALACTOSE AND L-RHAMNOSE, GLYCOSYLATION AT ASN-98, MUTAGENESIS OF GLU-42 AND LYS-120, DISULFIDE BONDS.

    Entry informationi

    Entry nameiLPHN1_MOUSE
    AccessioniPrimary (citable) accession number: Q80TR1
    Secondary accession number(s): Q3UH90, Q7TNE5, Q80T49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3