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Protein

Pleckstrin homology domain-containing family M member 2

Gene

Plekhm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. May play a role in lysosomes movement and localization at the cell periphery.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family M member 2
Short name:
PH domain-containing family M member 2
Gene namesi
Name:Plekhm2
Synonyms:Kiaa0842
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1916832 Plekhm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094561 – 1018Pleckstrin homology domain-containing family M member 2Add BLAST1018

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei423PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ80TQ5
PeptideAtlasiQ80TQ5
PRIDEiQ80TQ5

PTM databases

iPTMnetiQ80TQ5
PhosphoSitePlusiQ80TQ5

Interactioni

Subunit structurei

Interacts with KIF5B (By similarity). Interacts with BORCS5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081221

Structurei

3D structure databases

ProteinModelPortaliQ80TQ5
SMRiQ80TQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 158RUNPROSITE-ProRule annotationAdd BLAST123
Domaini770 – 872PHPROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 289Interaction with KIF5BBy similarityAdd BLAST289

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi296 – 299Poly-Lys4
Compositional biasi302 – 307Poly-Lys6
Compositional biasi485 – 488Poly-Glu4
Compositional biasi592 – 595Poly-Leu4

Phylogenomic databases

eggNOGiENOG410IFVN Eukaryota
ENOG410ZZUG LUCA
HOGENOMiHOG000231299
HOVERGENiHBG059073
InParanoidiQ80TQ5
KOiK15348
TreeFamiTF332641

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR004012 Run_dom
IPR037213 Run_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF02759 RUN, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00593 RUN, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50826 RUN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPREVKDRI LENISLSVKK LQSYFAACED ETPAIRNHDK VLQRLCEHLD
60 70 80 90 100
HALLYGLQDL SSGYWVLVVH FTRREAIRQI EVLQHVATNL GRSRAWLYLA
110 120 130 140 150
LNENSLESYL RLFQENLGLL QKYYVRNALV CSHDHLTLFL TLVSGLEFIR
160 170 180 190 200
FDLDLDAPYL DLAPYMPDYY KPQYLLDFED RLPSSVHGSD SLSLNSFNSV
210 220 230 240 250
TSTNLEWDDS AIAPSSEDGD LTDTISGPRS TASDLTSSKT STKSPTQRHN
260 270 280 290 300
PFNEEQAETA SSDTTPVHTT SQEKEEAQAP DQPDACTELE VIRVTKKKKI
310 320 330 340 350
GKKKKTKLDE DASPLHPTSS QQKCGQQGEG DGLVGTPGLA RDPSDTVLAS
360 370 380 390 400
PQEQGEGLSS TAGSSELSEL SQMGLLIPEM KDTSMECLGQ PLSKVIDKLH
410 420 430 440 450
GQLDPSTWCS HADPPEQSFR AGSPGEAPEK PPFCDFSEGL PAPMDFYRFT
460 470 480 490 500
VESPSTVAPG GGHHDPPGPS QPLHVPGSPA AALQEEEEGG RGEGQTSQPV
510 520 530 540 550
EDRQGEEIQE PEPQEPDSQL PLVSQEPLVS QEPVPEPVSQ PEPGTHEALC
560 570 580 590 600
KLKRDQPSPC LSSAEDSGVE EGQGSPSEMT HPSEFRVDNN HLLLLMIHVF
610 620 630 640 650
RENEEQLFKM IRMSTGHMEG NLQLLYVLLT DCYVYLLRKG ATEKPYLVEE
660 670 680 690 700
AVSYNELDYV SVGLDQQTVK LVCTNRRKQF LLDTADVALA ELFLASLKSA
710 720 730 740 750
MIKGCREPPY PSILTDATME KLALAKFVAQ ESKCEASAVT VHFYGLVHWE
760 770 780 790 800
DPMEEALGPV PCQCSPAEGT ITKEGMLHYK ASTSYLGKEH WKACFVVLSN
810 820 830 840 850
GILYQYPDRT DVIPLLSVNM GGEQCGGCRR SNTTDRPHAF QVILADRPCL
860 870 880 890 900
ELSADSEAEM ADWMQHLCQA VSKGVIPQGI APSPCIPCCL VITEDRLFTC
910 920 930 940 950
HEDCQTSFFR SLGTARLADI TAISTELGKE YCVLEFSQDS PQLLQPWVIY
960 970 980 990 1000
LSCTSELDRF LTALSSGWKA IYQVDLPHKA IHEASIKQKF EDALSLIHSA
1010
WQRSDSLCRG RASRDPWC
Length:1,018
Mass (Da):112,734
Last modified:November 13, 2007 - v2
Checksum:i1024AD61CE90767D
GO
Isoform 2 (identifier: Q80TQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-217: E → EDYDFGDVFPAVPSVPSTDWE
     527-532: Missing.

Note: No experimental confirmation available.
Show »
Length:1,032
Mass (Da):114,305
Checksum:i2462B24EA0F8F9A6
GO
Isoform 3 (identifier: Q80TQ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.
     217-217: E → EDYDFGDVFPAVPSVPSTDWE
     527-532: Missing.

Note: No experimental confirmation available.
Show »
Length:867
Mass (Da):95,047
Checksum:iDED74330FEB5D382
GO

Sequence cautioni

The sequence BAC65668 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti490G → GG in CAM19908 (PubMed:19468303).Curated1
Sequence conflicti490G → GG in AAH58984 (PubMed:15489334).Curated1
Sequence conflicti500V → L in CAM19908 (PubMed:19468303).Curated1
Sequence conflicti500V → L in AAH58984 (PubMed:15489334).Curated1
Sequence conflicti612R → L in AAH58984 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0291621 – 165Missing in isoform 3. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_029163217E → EDYDFGDVFPAVPSVPSTDW E in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_029164527 – 532Missing in isoform 2 and isoform 3. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122386 mRNA Translation: BAC65668.1 Different initiation.
AK156652 mRNA Translation: BAE33794.1
AL670446 Genomic DNA Translation: CAM19908.1
BC058984 mRNA Translation: AAH58984.1
RefSeqiNP_001028322.1, NM_001033150.1
UniGeneiMm.33220

Genome annotation databases

GeneIDi69582
KEGGimmu:69582

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiPKHM2_MOUSE
AccessioniPrimary (citable) accession number: Q80TQ5
Secondary accession number(s): A2ADE1, Q3U0Q7, Q6PD22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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