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Protein

Neuron navigator 3

Gene

Nav3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate IL2 production by T-cells. May be involved in neuron regeneration.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron navigator 3
Alternative name(s):
Pore membrane and/or filament-interacting-like protein 1
Gene namesi
Name:Nav3
Synonyms:Kiaa0938, Pomfil1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2183703. Nav3.

Subcellular locationi

GO - Cellular componenti

  • nuclear envelope Source: MGI
  • nuclear outer membrane Source: UniProtKB-SubCell
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23592359Neuron navigator 3PRO_0000286977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1462 – 14621PhosphoserineCombined sources
Modified residuei1466 – 14661PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80TN7.
MaxQBiQ80TN7.
PaxDbiQ80TN7.
PRIDEiQ80TN7.

PTM databases

iPTMnetiQ80TN7.
PhosphoSiteiQ80TN7.

Expressioni

Tissue specificityi

Present in neurons from central and peripheral nervous systems (at protein level). Highly expressed in brain cortex, midbrain, cerebellum and hippocampus.1 Publication

Developmental stagei

Specifically expressed in neuronal cells during development. First detectable at E9.5 in prosencephalon. At E16.5, expressed in all brain areas, spinal cord and spinal ganglia. Within the brain, highest expression is found in maturing zones where neurons differentiate and lowest expression is found in ventricular zones where proliferation takes place. Brain expression remains high at later embryonic stages and during postnatal brain development.1 Publication

Inductioni

In astrocytes after brain injury.1 Publication

Gene expression databases

BgeeiQ80TN7.
CleanExiMM_NAV3.

Interactioni

Protein-protein interaction databases

BioGridi234432. 1 interaction.
IntActiQ80TN7. 1 interaction.
STRINGi10090.ENSMUSP00000032719.

Structurei

3D structure databases

ProteinModelPortaliQ80TN7.
SMRiQ80TN7. Positions 77-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 184108CHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili680 – 70829Sequence analysisAdd
BLAST
Coiled coili1565 – 165692Sequence analysisAdd
BLAST
Coiled coili1768 – 183568Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi619 – 6224Poly-Gln
Compositional biasi1035 – 1563529Ser-richAdd
BLAST
Compositional biasi1697 – 17026Poly-Lys

Sequence similaritiesi

Belongs to the Nav/unc-53 family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGVF. Eukaryota.
ENOG410XRG8. LUCA.
HOGENOMiHOG000293189.
HOVERGENiHBG058814.
InParanoidiQ80TN7.
PhylomeDBiQ80TN7.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR001715. CH-domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80TN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVLGVASKL RQPAVGPKPV HAALPIPNLG ISVSRRCSSR PLEFATPERS
60 70 80 90 100
MLSCQLTLKS TCEFGEKKAL QGTAKEIEDS KIYTDWANHY LAKSGHKRLI
110 120 130 140 150
KDLQQDIADG VLLADIIQII ANEKVEDING CPRSQSQMIE NVDVCLSFLA
160 170 180 190 200
ARGVNVQGLS AEEIRNGNLK AILGLFFSLS RYKQQQHHQQ QYYQSLVELQ
210 220 230 240 250
QRVTHTAPQS EASQAKTQQD MQSSLTARYA AQSKHSGIAT SQKKPTRLPG
260 270 280 290 300
PSRVPAASSS NKAQGASNLN RRSQSFNSID KNKPPNYANG NEKDSPKGPQ
310 320 330 340 350
PSSGINGNTQ PPSTSGQPPA SAIPSPSASK PWRSKSMNVK HSATSTMLTV
360 370 380 390 400
KQPSPATSPT PSSDRLKPPV TEGVKSAPSG QKSMLEKFKL VNARTALRPP
410 420 430 440 450
QAPSSGPNDG GREDDAFSES GEMEGFNSGL NSGGSTNSSP KVSPKLTPPK
460 470 480 490 500
AGSKNFSNKK SLLQPKEKEE KTRDKNKACA EKSGKEEKDQ VTTEAAPKKT
510 520 530 540 550
SKIASLIPKG SKTAAAKKES LIPSSSGIPK PGSKVPTPKQ TISPGSAASK
560 570 580 590 600
ESEKFRTSKG SSSQAFPKAI TAEKASTPSL STPLDGREAG QASPSSSCVM
610 620 630 640 650
QVTHSSGQSP GNGAVQLPQQ QQHSHPNTAT VAPFIYRAHS ENEGTSLPPA
660 670 680 690 700
DSCTSPTKMD SSYSKTAKQC LEEISGEDPE ARRMRTVKNI ADLRQNLEET
710 720 730 740 750
MSSLRGTQIS HSTLETTFDT TVTTEVNGRA IPNLTSRPSP MTWRLGQACP
760 770 780 790 800
RLQAGDAPSM GAGYSRSGTS RFIHTDPSRF MYTTPLRRAA VSRLGNMSQI
810 820 830 840 850
DMSEKASSDL DVSSEVDVGG YMSDGDILGK SLRADDINSG YMTDGGLNLY
860 870 880 890 900
TRSLNRVPDT ATSRDVIQRG VHDVTVDADS WDDSSSVSSG LSDTLDNIST
910 920 930 940 950
DDLNTTSSIS SYSNITVPSR KNTQLKTDAE KRSTTDETWD SPEELKKAEG
960 970 980 990 1000
DCDSHGDGAA KWKGATSGLA EDSEKTGQKA SLSVSQTGSW RRGMSAQGGT
1010 1020 1030 1040 1050
PATARQKTST SALKTPGKTD DAKASEKGKT PLKGSSLQRS PSDAGKSSGD
1060 1070 1080 1090 1100
EGKKPPSGIG RSTASSSFGY KKPSGVGAST MITSSGATIT SGSATLGKIP
1110 1120 1130 1140 1150
KSAAIGGKSN AGRKTSLDGS QNQDDVVLHV SSKTTLQYRS LPRPSKSSTS
1160 1170 1180 1190 1200
GIPGRGGHRS STSSIDSNVS SKSAGATTSK LREPTKIGSG RSSPVTVNQT
1210 1220 1230 1240 1250
DKEKEKVAVS DSESVSLSGS PKSSPTSASA CGTQGLRQPG SKYPDIASPT
1260 1270 1280 1290 1300
FRRLFGAKAG GKSASAPNTE GAKSSSVVLS PSTSLARQGS LESPSSGTGS
1310 1320 1330 1340 1350
MGSAGGLSGS SSPLFNKPSD LTTDVISLSH SLASSPASVH SFTSGGLVWA
1360 1370 1380 1390 1400
ANLSSSSAGS KDTPSYQSMT SLHTSSESID LPLSHHGSLS GLTTGTHEVQ
1410 1420 1430 1440 1450
SLLMRTGSVR STLSESMQLD RNTLPKKGLR YTPSSRQANQ EEGKEWLRSH
1460 1470 1480 1490 1500
STGGLQDTGN QSPLVSPSAM SSSATGKYHF SNLVSPTNLS QFNLPAPSMM
1510 1520 1530 1540 1550
RSSSIPAQDS SFDLYDDAQL CGSATSLEER PRAVSHSGSF RDSMEEVHGS
1560 1570 1580 1590 1600
SLSLVSSTSS LYSTAEEKAH SEQIHKLRRE LVASQEKVAT LTSQLSANAH
1610 1620 1630 1640 1650
LVAAFEKSLG NMTGRLQSLT MTAEQKESEL IELRETIEML KAQNSAAQAA
1660 1670 1680 1690 1700
IQGALNGPDH PPKDLRIRRQ HSSESVSSIN SATSHSSIGS GNDADSKKKK
1710 1720 1730 1740 1750
KKNWLRSSFK QAFGKKKSTK PPSSHSDIEE LTDSSLPASP KLPHNAGESG
1760 1770 1780 1790 1800
SSSMKPSQSA SAICECTEAE AEIILQLKSE LREKELKLTD IRLEALSSAH
1810 1820 1830 1840 1850
HLDQIREAMN RMQNEIEILK AENDRLKAET GNTAKPARPP SDSSSTASSS
1860 1870 1880 1890 1900
SSRQSLGLSL NNLNITESVT SDILLDDTGD ATGHKDGRSV KIIVSISKGY
1910 1920 1930 1940 1950
GRAKDQKSQA YLIGSIGVSG KTKWDVLDGV IRRLFKEYVF RIDTSSSLGL
1960 1970 1980 1990 2000
SSDCIASYCI GDLIRSHNLE VPELLPCGYL VGDNNIITVN LKGVEENSLD
2010 2020 2030 2040 2050
SFVFDTLIPK PITQRYFNLL MEHHRIILSG PSGTGKTYLA NKLAEYVITK
2060 2070 2080 2090 2100
SGRKKTEDAI ATFNVDHKSS KELQQYLANL AEQCSADNNG VELPVVIILD
2110 2120 2130 2140 2150
NLHHVGSLSD IFNGFLNCKY NKCPYIIGTM NQGVSSSPNL ELHHNFRWVL
2160 2170 2180 2190 2200
CANHTEPVKG FLGRYLRRKL IEMEIERNIR NNDLVKIIDW IPKTWHHLNS
2210 2220 2230 2240 2250
FLETHSSSDV TIGPRLFLPC PMDVEGSRVW FMDLWNYSLV PYVLEAVREG
2260 2270 2280 2290 2300
LQMYGKRAPW EDPSKWVLDT YPWSSASLPQ EGPALLQLRP EDVGYEACTS
2310 2320 2330 2340 2350
TKEATTSKHI PQTDTEGDPL MNMLMKLQEA ANYPSTQSCD GDSVSHREDI

LDTSIESTL
Length:2,359
Mass (Da):252,301
Last modified:May 15, 2007 - v2
Checksum:i4C5F57AFC87D3367
GO

Sequence cautioni

The sequence BAC65686.1 differs from that shown. Reason: Erroneous termination at position 978. Translated as Gln.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100120 Genomic DNA. No translation available.
AC122011 Genomic DNA. No translation available.
AC129336 Genomic DNA. No translation available.
AK122404 mRNA. Translation: BAC65686.1. Sequence problems.
RefSeqiXP_006513738.1. XM_006513675.2.
UniGeneiMm.225050.
Mm.394160.
Mm.461280.

Genome annotation databases

GeneIDi260315.
UCSCiuc007gzk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC100120 Genomic DNA. No translation available.
AC122011 Genomic DNA. No translation available.
AC129336 Genomic DNA. No translation available.
AK122404 mRNA. Translation: BAC65686.1. Sequence problems.
RefSeqiXP_006513738.1. XM_006513675.2.
UniGeneiMm.225050.
Mm.394160.
Mm.461280.

3D structure databases

ProteinModelPortaliQ80TN7.
SMRiQ80TN7. Positions 77-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234432. 1 interaction.
IntActiQ80TN7. 1 interaction.
STRINGi10090.ENSMUSP00000032719.

PTM databases

iPTMnetiQ80TN7.
PhosphoSiteiQ80TN7.

Proteomic databases

EPDiQ80TN7.
MaxQBiQ80TN7.
PaxDbiQ80TN7.
PRIDEiQ80TN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi260315.
UCSCiuc007gzk.1. mouse.

Organism-specific databases

CTDi89795.
MGIiMGI:2183703. Nav3.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGVF. Eukaryota.
ENOG410XRG8. LUCA.
HOGENOMiHOG000293189.
HOVERGENiHBG058814.
InParanoidiQ80TN7.
PhylomeDBiQ80TN7.

Miscellaneous databases

PROiQ80TN7.
SOURCEiSearch...

Gene expression databases

BgeeiQ80TN7.
CleanExiMM_NAV3.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR001715. CH-domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 724-2359.
    Tissue: Brain.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1173-1182, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms."
    Coy J.F., Wiemann S., Bechmann I., Baechner D., Nitsch R., Kretz O., Christiansen H., Poustka A.
    Gene 290:73-94(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INDUCTION, FUNCTION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1462, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiNAV3_MOUSE
AccessioniPrimary (citable) accession number: Q80TN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: April 13, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.