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Q80TN5

- ZDH17_MOUSE

UniProt

Q80TN5 - ZDH17_MOUSE

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Protein

Palmitoyltransferase ZDHHC17

Gene

Zdhhc17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg2+ transport.2 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei467 – 4671S-palmitoyl cysteine intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri437 – 48751DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. magnesium ion transmembrane transporter activity Source: UniProtKB
  2. palmitoyltransferase activity Source: MGI
  3. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB
  4. signal transducer activity Source: Ensembl
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. lipoprotein transport Source: Ensembl
  2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  3. protein palmitoylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC17 (EC:2.3.1.225)
Alternative name(s):
Huntingtin-interacting protein 14
Zinc finger DHHC domain-containing protein 17
Short name:
DHHC-17
Gene namesi
Name:Zdhhc17
Synonyms:Hip14, Kiaa0946
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2445110. Zdhhc17.

Subcellular locationi

Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein By similarity
Note: Localized predominantly in the perinuclear regions of neurons from the cortex, striatum and hippocampus. Colocalized with HD in the medium spiny neurons of the striatum and the spiny neurons that project into the globus pallidus.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 304304CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence AnalysisAdd
BLAST
Topological domaini347 – 35711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei358 – 37821HelicalSequence AnalysisAdd
BLAST
Topological domaini379 – 3813LumenalSequence Analysis
Transmembranei382 – 40221HelicalSequence AnalysisAdd
BLAST
Topological domaini403 – 48078CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei481 – 50121HelicalSequence AnalysisAdd
BLAST
Topological domaini502 – 52928LumenalSequence AnalysisAdd
BLAST
Transmembranei530 – 55021HelicalSequence AnalysisAdd
BLAST
Topological domaini551 – 63282CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi-associated vesicle membrane Source: UniProtKB
  2. Golgi membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632Palmitoyltransferase ZDHHC17PRO_0000212901Add
BLAST

Post-translational modificationi

Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg2+ transport (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ80TN5.
PaxDbiQ80TN5.
PRIDEiQ80TN5.

PTM databases

PhosphoSiteiQ80TN5.

Expressioni

Tissue specificityi

Expressed in liver, testis, kidney, heart, pancreas and brain. Highest expression was seen in the brain.1 Publication

Inductioni

Up-regulated by low extracellular Mg2+.1 Publication

Gene expression databases

BgeeiQ80TN5.
CleanExiMM_ZDHHC17.
ExpressionAtlasiQ80TN5. baseline and differential.
GenevestigatoriQ80TN5.

Interactioni

Subunit structurei

Interacts (via ANK repeats) with HD.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ80TN5.
SMRiQ80TN5. Positions 25-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati89 – 11830ANK 1Add
BLAST
Repeati123 – 15230ANK 2Add
BLAST
Repeati156 – 18530ANK 3Add
BLAST
Repeati189 – 21931ANK 4Add
BLAST
Repeati224 – 25330ANK 5Add
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri437 – 48751DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00530000063074.
HOGENOMiHOG000290181.
HOVERGENiHBG051907.
InParanoidiQ80TN5.
OMAiFWNDAHL.
OrthoDBiEOG70S74V.
PhylomeDBiQ80TN5.
TreeFamiTF317342.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80TN5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQREEGFNTK MADGPDEYET ETGCVPLLHP EEIKPQSHYN HGYGEPLGRK
60 70 80 90 100
THIDDYSTWD IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN
110 120 130 140 150
NRIDLVKYYI SKGAIVDQLG GDLNSTPLHW ATRQGHLSMV VQLMKYGADP
160 170 180 190 200
SLIDGEGCSC IHLAAQFGHT SIVAYLIAKG QDVDMMDQNG MTPLMWAAYR
210 220 230 240 250
THSVDPTRLL LTFNVSVNLG DKYHKNTALH WAVLAGNTTV ISLLLEAGGN
260 270 280 290 300
VDAQNVKGES ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE
310 320 330 340 350
FRQKVMLGTP FLVIWLVGFI ADLDIDSWLI KGLMYGGVWA TVQFLSKSFF
360 370 380 390 400
DHSMHSALPL GIYLATKFWM YVTWFFWFWN DLNFLFIHLP FLANSVALFY
410 420 430 440 450
NFGKSWKSDP GIIKATEEQK KKTIVELAET GSLDLSIFCS TCLIRKPVRS
460 470 480 490 500
KHCGVCNRCI AKFDHHCPWV GNCVGAGNHR YFMGYLFFLL FMICWMIYGC
510 520 530 540 550
VSYWGLHCET TYTKDGFWTY ITQIATCSPW MFWMFLNSVF HFLWVAVLLM
560 570 580 590 600
CQLYQITCLG ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF
610 620 630
RCCGLFRPVI VDWTRQYTIE YDQISGSGYQ LV
Length:632
Mass (Da):72,621
Last modified:April 13, 2004 - v2
Checksum:i323EFD47790750DC
GO
Isoform 2 (identifier: Q80TN5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-429: TIVELAE → VVMYPAN
     430-632: Missing.

Show »
Length:429
Mass (Da):48,784
Checksum:iFE0E0E96934E4FC9
GO

Sequence cautioni

The sequence AAH58772.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC30090.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC30097.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC32912.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC65688.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881N → K in BAC32912. (PubMed:12693553)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei423 – 4297TIVELAE → VVMYPAN in isoform 2. 1 PublicationVSP_010026
Alternative sequencei430 – 632203Missing in isoform 2. 1 PublicationVSP_010027Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122406 mRNA. Translation: BAC65688.1. Different initiation.
AK038670 mRNA. Translation: BAC30090.2. Different initiation.
AK038681 mRNA. Translation: BAC30097.2. Different initiation.
AK046891 mRNA. Translation: BAC32912.1. Different initiation.
BC058772 mRNA. Translation: AAH58772.1. Sequence problems.
CCDSiCCDS56748.1. [Q80TN5-1]
RefSeqiNP_766142.2. NM_172554.2. [Q80TN5-1]
UniGeneiMm.339281.

Genome annotation databases

EnsembliENSMUST00000041723; ENSMUSP00000043279; ENSMUSG00000035798. [Q80TN5-1]
GeneIDi320150.
KEGGimmu:320150.
UCSCiuc007gzu.2. mouse. [Q80TN5-1]
uc007gzw.2. mouse. [Q80TN5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122406 mRNA. Translation: BAC65688.1 . Different initiation.
AK038670 mRNA. Translation: BAC30090.2 . Different initiation.
AK038681 mRNA. Translation: BAC30097.2 . Different initiation.
AK046891 mRNA. Translation: BAC32912.1 . Different initiation.
BC058772 mRNA. Translation: AAH58772.1 . Sequence problems.
CCDSi CCDS56748.1. [Q80TN5-1 ]
RefSeqi NP_766142.2. NM_172554.2. [Q80TN5-1 ]
UniGenei Mm.339281.

3D structure databases

ProteinModelPortali Q80TN5.
SMRi Q80TN5. Positions 25-281.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q80TN5.

Proteomic databases

MaxQBi Q80TN5.
PaxDbi Q80TN5.
PRIDEi Q80TN5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041723 ; ENSMUSP00000043279 ; ENSMUSG00000035798 . [Q80TN5-1 ]
GeneIDi 320150.
KEGGi mmu:320150.
UCSCi uc007gzu.2. mouse. [Q80TN5-1 ]
uc007gzw.2. mouse. [Q80TN5-2 ]

Organism-specific databases

CTDi 23390.
MGIi MGI:2445110. Zdhhc17.
Rougei Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00530000063074.
HOGENOMi HOG000290181.
HOVERGENi HBG051907.
InParanoidi Q80TN5.
OMAi FWNDAHL.
OrthoDBi EOG70S74V.
PhylomeDBi Q80TN5.
TreeFami TF317342.

Miscellaneous databases

NextBioi 396133.
PROi Q80TN5.
SOURCEi Search...

Gene expression databases

Bgeei Q80TN5.
CleanExi MM_ZDHHC17.
ExpressionAtlasi Q80TN5. baseline and differential.
Genevestigatori Q80TN5.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view ]
Pfami PF12796. Ank_2. 3 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 5 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50216. ZF_DHHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-632 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Hypothalamus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-418.
    Tissue: Eye.
  4. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "Identification of PSD-95 palmitoylating enzymes."
    Fukata M., Fukata Y., Adesnik H., Nicoll R.A., Bredt D.S.
    Neuron 44:987-996(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase."
    Ducker C.E., Stettler E.M., French K.J., Upson J.J., Smith C.D.
    Oncogene 23:9230-9237(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport."
    Goytain A., Hines R.M., Quamme G.A.
    J. Biol. Chem. 283:33365-33374(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiZDH17_MOUSE
AccessioniPrimary (citable) accession number: Q80TN5
Secondary accession number(s): Q8BJ08, Q8BYQ2, Q8BYQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3