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Q80TN5

- ZDH17_MOUSE

UniProt

Q80TN5 - ZDH17_MOUSE

Protein

Palmitoyltransferase ZDHHC17

Gene

Zdhhc17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg2+ transport.2 Publications

    Catalytic activityi

    Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei467 – 4671S-palmitoyl cysteine intermediateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri437 – 48751DHHC-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. magnesium ion transmembrane transporter activity Source: UniProtKB
    2. palmitoyltransferase activity Source: MGI
    3. protein-cysteine S-palmitoyltransferase activity Source: UniProtKB
    4. signal transducer activity Source: Ensembl
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. lipoprotein transport Source: Ensembl
    2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    3. protein palmitoylation Source: MGI

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Palmitoyltransferase ZDHHC17 (EC:2.3.1.225)
    Alternative name(s):
    Huntingtin-interacting protein 14
    Zinc finger DHHC domain-containing protein 17
    Short name:
    DHHC-17
    Gene namesi
    Name:Zdhhc17
    Synonyms:Hip14, Kiaa0946
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2445110. Zdhhc17.

    Subcellular locationi

    Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane By similarity; Multi-pass membrane protein By similarity
    Note: Localized predominantly in the perinuclear regions of neurons from the cortex, striatum and hippocampus. Colocalized with HD in the medium spiny neurons of the striatum and the spiny neurons that project into the globus pallidus.1 Publication

    GO - Cellular componenti

    1. Golgi-associated vesicle membrane Source: UniProtKB
    2. Golgi membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 632632Palmitoyltransferase ZDHHC17PRO_0000212901Add
    BLAST

    Post-translational modificationi

    Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg2+ transport By similarity.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ80TN5.
    PRIDEiQ80TN5.

    PTM databases

    PhosphoSiteiQ80TN5.

    Expressioni

    Tissue specificityi

    Expressed in liver, testis, kidney, heart, pancreas and brain. Highest expression was seen in the brain.1 Publication

    Inductioni

    Up-regulated by low extracellular Mg2+.1 Publication

    Gene expression databases

    ArrayExpressiQ80TN5.
    BgeeiQ80TN5.
    CleanExiMM_ZDHHC17.
    GenevestigatoriQ80TN5.

    Interactioni

    Subunit structurei

    Interacts (via ANK repeats) with HD.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ80TN5.
    SMRiQ80TN5. Positions 21-281.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 304304CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini347 – 35711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini379 – 3813LumenalSequence Analysis
    Topological domaini403 – 48078CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini502 – 52928LumenalSequence AnalysisAdd
    BLAST
    Topological domaini551 – 63282CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei358 – 37821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei481 – 50121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei530 – 55021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati89 – 11830ANK 1Add
    BLAST
    Repeati123 – 15230ANK 2Add
    BLAST
    Repeati156 – 18530ANK 3Add
    BLAST
    Repeati189 – 21931ANK 4Add
    BLAST
    Repeati224 – 25330ANK 5Add
    BLAST

    Domaini

    The DHHC domain is required for palmitoyltransferase activity.By similarity

    Sequence similaritiesi

    Contains 5 ANK repeats.PROSITE-ProRule annotation
    Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri437 – 48751DHHC-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00530000063074.
    HOGENOMiHOG000290181.
    HOVERGENiHBG051907.
    InParanoidiQ80TN5.
    OMAiFWNDAHL.
    OrthoDBiEOG70S74V.
    PhylomeDBiQ80TN5.
    TreeFamiTF317342.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001594. Znf_DHHC_palmitoyltrfase.
    [Graphical view]
    PfamiPF12796. Ank_2. 3 hits.
    PF01529. zf-DHHC. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 5 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS50216. ZF_DHHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80TN5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQREEGFNTK MADGPDEYET ETGCVPLLHP EEIKPQSHYN HGYGEPLGRK    50
    THIDDYSTWD IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN 100
    NRIDLVKYYI SKGAIVDQLG GDLNSTPLHW ATRQGHLSMV VQLMKYGADP 150
    SLIDGEGCSC IHLAAQFGHT SIVAYLIAKG QDVDMMDQNG MTPLMWAAYR 200
    THSVDPTRLL LTFNVSVNLG DKYHKNTALH WAVLAGNTTV ISLLLEAGGN 250
    VDAQNVKGES ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE 300
    FRQKVMLGTP FLVIWLVGFI ADLDIDSWLI KGLMYGGVWA TVQFLSKSFF 350
    DHSMHSALPL GIYLATKFWM YVTWFFWFWN DLNFLFIHLP FLANSVALFY 400
    NFGKSWKSDP GIIKATEEQK KKTIVELAET GSLDLSIFCS TCLIRKPVRS 450
    KHCGVCNRCI AKFDHHCPWV GNCVGAGNHR YFMGYLFFLL FMICWMIYGC 500
    VSYWGLHCET TYTKDGFWTY ITQIATCSPW MFWMFLNSVF HFLWVAVLLM 550
    CQLYQITCLG ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF 600
    RCCGLFRPVI VDWTRQYTIE YDQISGSGYQ LV 632
    Length:632
    Mass (Da):72,621
    Last modified:April 13, 2004 - v2
    Checksum:i323EFD47790750DC
    GO
    Isoform 2 (identifier: Q80TN5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         423-429: TIVELAE → VVMYPAN
         430-632: Missing.

    Show »
    Length:429
    Mass (Da):48,784
    Checksum:iFE0E0E96934E4FC9
    GO

    Sequence cautioni

    The sequence AAH58772.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAC30090.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC30097.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC32912.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC65688.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti288 – 2881N → K in BAC32912. (PubMed:12693553)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei423 – 4297TIVELAE → VVMYPAN in isoform 2. 1 PublicationVSP_010026
    Alternative sequencei430 – 632203Missing in isoform 2. 1 PublicationVSP_010027Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122406 mRNA. Translation: BAC65688.1. Different initiation.
    AK038670 mRNA. Translation: BAC30090.2. Different initiation.
    AK038681 mRNA. Translation: BAC30097.2. Different initiation.
    AK046891 mRNA. Translation: BAC32912.1. Different initiation.
    BC058772 mRNA. Translation: AAH58772.1. Sequence problems.
    CCDSiCCDS56748.1. [Q80TN5-1]
    RefSeqiNP_766142.2. NM_172554.2. [Q80TN5-1]
    UniGeneiMm.339281.

    Genome annotation databases

    EnsembliENSMUST00000041723; ENSMUSP00000043279; ENSMUSG00000035798. [Q80TN5-1]
    GeneIDi320150.
    KEGGimmu:320150.
    UCSCiuc007gzu.2. mouse. [Q80TN5-1]
    uc007gzw.2. mouse. [Q80TN5-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122406 mRNA. Translation: BAC65688.1 . Different initiation.
    AK038670 mRNA. Translation: BAC30090.2 . Different initiation.
    AK038681 mRNA. Translation: BAC30097.2 . Different initiation.
    AK046891 mRNA. Translation: BAC32912.1 . Different initiation.
    BC058772 mRNA. Translation: AAH58772.1 . Sequence problems.
    CCDSi CCDS56748.1. [Q80TN5-1 ]
    RefSeqi NP_766142.2. NM_172554.2. [Q80TN5-1 ]
    UniGenei Mm.339281.

    3D structure databases

    ProteinModelPortali Q80TN5.
    SMRi Q80TN5. Positions 21-281.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q80TN5.

    Proteomic databases

    PaxDbi Q80TN5.
    PRIDEi Q80TN5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041723 ; ENSMUSP00000043279 ; ENSMUSG00000035798 . [Q80TN5-1 ]
    GeneIDi 320150.
    KEGGi mmu:320150.
    UCSCi uc007gzu.2. mouse. [Q80TN5-1 ]
    uc007gzw.2. mouse. [Q80TN5-2 ]

    Organism-specific databases

    CTDi 23390.
    MGIi MGI:2445110. Zdhhc17.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00530000063074.
    HOGENOMi HOG000290181.
    HOVERGENi HBG051907.
    InParanoidi Q80TN5.
    OMAi FWNDAHL.
    OrthoDBi EOG70S74V.
    PhylomeDBi Q80TN5.
    TreeFami TF317342.

    Miscellaneous databases

    NextBioi 396133.
    PROi Q80TN5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80TN5.
    Bgeei Q80TN5.
    CleanExi MM_ZDHHC17.
    Genevestigatori Q80TN5.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001594. Znf_DHHC_palmitoyltrfase.
    [Graphical view ]
    Pfami PF12796. Ank_2. 3 hits.
    PF01529. zf-DHHC. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS50216. ZF_DHHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-632 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Cerebellum and Hypothalamus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-418.
      Tissue: Eye.
    4. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "Identification of PSD-95 palmitoylating enzymes."
      Fukata M., Fukata Y., Adesnik H., Nicoll R.A., Bredt D.S.
      Neuron 44:987-996(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase."
      Ducker C.E., Stettler E.M., French K.J., Upson J.J., Smith C.D.
      Oncogene 23:9230-9237(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport."
      Goytain A., Hines R.M., Quamme G.A.
      J. Biol. Chem. 283:33365-33374(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiZDH17_MOUSE
    AccessioniPrimary (citable) accession number: Q80TN5
    Secondary accession number(s): Q8BJ08, Q8BYQ2, Q8BYQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3