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Protein

Palmitoyltransferase ZDHHC17

Gene

Zdhhc17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD (PubMed:15489887, PubMed:15603741, PubMed:25253725). Palmitoylates MPP1 in erythrocytes (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (By similarity). May play a role in Mg2+ transport (By similarity).By similarity3 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei467S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC17Curated (EC:2.3.1.2253 Publications)
Alternative name(s):
Huntingtin-interacting protein 141 Publication
Zinc finger DHHC domain-containing protein 17Imported
Short name:
DHHC-171 Publication
Gene namesi
Name:Zdhhc17Imported
Synonyms:Hip141 Publication, Kiaa0946Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2445110. Zdhhc17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 304CytoplasmicSequence analysisAdd BLAST304
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 357CytoplasmicSequence analysisAdd BLAST11
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Topological domaini379 – 381LumenalSequence analysis3
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 480CytoplasmicSequence analysisAdd BLAST78
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Topological domaini502 – 529LumenalSequence analysisAdd BLAST28
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Topological domaini551 – 632CytoplasmicSequence analysisAdd BLAST82

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi465H → Q: Loss of palmitoyltransferase activity toward DNAJC5 and SNAP25. 1 Publication1
Mutagenesisi467C → A: No effect on interaction with DNAJC5 and SNAP25. 1 Publication1

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129011 – 632Palmitoyltransferase ZDHHC17Add BLAST632

Post-translational modificationi

Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg2+ transport.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ80TN5.
PeptideAtlasiQ80TN5.
PRIDEiQ80TN5.

PTM databases

iPTMnetiQ80TN5.
PhosphoSitePlusiQ80TN5.
SwissPalmiQ80TN5.

Expressioni

Tissue specificityi

Expressed in liver, testis, kidney, heart, pancreas and brain. Highest expression was seen in the brain. Localized predominantly in the perinuclear regions of neurons from the cortex, striatum and hippocampus. Colocalized with HD in the medium spiny neurons of the striatum and the spiny neurons that project into the globus pallidus.1 Publication

Inductioni

Up-regulated by low extracellular Mg2+.1 Publication

Gene expression databases

BgeeiENSMUSG00000035798.
CleanExiMM_ZDHHC17.
ExpressionAtlasiQ80TN5. baseline and differential.
GenevisibleiQ80TN5. MM.

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:26198635). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043279.

Structurei

3D structure databases

ProteinModelPortaliQ80TN5.
SMRiQ80TN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 86ANK 1By similarityAdd BLAST36
Repeati89 – 118ANK 2Sequence analysisAdd BLAST30
Repeati123 – 152ANK 3Sequence analysisAdd BLAST30
Repeati156 – 185ANK 4Sequence analysisAdd BLAST30
Repeati189 – 219ANK 5Sequence analysisAdd BLAST31
Repeati224 – 253ANK 6Sequence analysisAdd BLAST30
Repeati257 – 286ANK 7Sequence analysisAdd BLAST30
Domaini437 – 487DHHCPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 305Necessary and sufficient for interaction with DNAJC5 and SNAP251 PublicationAdd BLAST295

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
HOGENOMiHOG000290181.
HOVERGENiHBG051907.
InParanoidiQ80TN5.
KOiK20032.
OMAiIMQLARI.
OrthoDBiEOG091G056H.
PhylomeDBiQ80TN5.
TreeFamiTF317342.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR030289. ZDHHC17.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR24161:SF18. PTHR24161:SF18. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50216. DHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQREEGFNTK MADGPDEYET ETGCVPLLHP EEIKPQSHYN HGYGEPLGRK
60 70 80 90 100
THIDDYSTWD IVKATQYGIY ERCRELVEAG YDVRQPDKEN VTLLHWAAIN
110 120 130 140 150
NRIDLVKYYI SKGAIVDQLG GDLNSTPLHW ATRQGHLSMV VQLMKYGADP
160 170 180 190 200
SLIDGEGCSC IHLAAQFGHT SIVAYLIAKG QDVDMMDQNG MTPLMWAAYR
210 220 230 240 250
THSVDPTRLL LTFNVSVNLG DKYHKNTALH WAVLAGNTTV ISLLLEAGGN
260 270 280 290 300
VDAQNVKGES ALDLAKQRKN VWMINHLQEA RQAKGYDNPS FLRKLKADKE
310 320 330 340 350
FRQKVMLGTP FLVIWLVGFI ADLDIDSWLI KGLMYGGVWA TVQFLSKSFF
360 370 380 390 400
DHSMHSALPL GIYLATKFWM YVTWFFWFWN DLNFLFIHLP FLANSVALFY
410 420 430 440 450
NFGKSWKSDP GIIKATEEQK KKTIVELAET GSLDLSIFCS TCLIRKPVRS
460 470 480 490 500
KHCGVCNRCI AKFDHHCPWV GNCVGAGNHR YFMGYLFFLL FMICWMIYGC
510 520 530 540 550
VSYWGLHCET TYTKDGFWTY ITQIATCSPW MFWMFLNSVF HFLWVAVLLM
560 570 580 590 600
CQLYQITCLG ITTNERMNAR RYKHFKVTTT SIESPFNHGC VRNIIDFFEF
610 620 630
RCCGLFRPVI VDWTRQYTIE YDQISGSGYQ LV
Length:632
Mass (Da):72,621
Last modified:April 13, 2004 - v2
Checksum:i323EFD47790750DC
GO
Isoform 2 (identifier: Q80TN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     423-429: TIVELAE → VVMYPAN
     430-632: Missing.

Show »
Length:429
Mass (Da):48,784
Checksum:iFE0E0E96934E4FC9
GO

Sequence cautioni

The sequence AAH58772 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC30090 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC30097 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC32912 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC65688 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288N → K in BAC32912 (PubMed:12693553).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010026423 – 429TIVELAE → VVMYPAN in isoform 2. 1 Publication7
Alternative sequenceiVSP_010027430 – 632Missing in isoform 2. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122406 mRNA. Translation: BAC65688.1. Different initiation.
AK038670 mRNA. Translation: BAC30090.2. Different initiation.
AK038681 mRNA. Translation: BAC30097.2. Different initiation.
AK046891 mRNA. Translation: BAC32912.1. Different initiation.
BC058772 mRNA. Translation: AAH58772.1. Sequence problems.
CCDSiCCDS56748.1. [Q80TN5-1]
RefSeqiNP_766142.2. NM_172554.2. [Q80TN5-1]
UniGeneiMm.339281.

Genome annotation databases

EnsembliENSMUST00000041723; ENSMUSP00000043279; ENSMUSG00000035798. [Q80TN5-1]
GeneIDi320150.
KEGGimmu:320150.
UCSCiuc007gzw.2. mouse. [Q80TN5-2]
uc033fsq.1. mouse. [Q80TN5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122406 mRNA. Translation: BAC65688.1. Different initiation.
AK038670 mRNA. Translation: BAC30090.2. Different initiation.
AK038681 mRNA. Translation: BAC30097.2. Different initiation.
AK046891 mRNA. Translation: BAC32912.1. Different initiation.
BC058772 mRNA. Translation: AAH58772.1. Sequence problems.
CCDSiCCDS56748.1. [Q80TN5-1]
RefSeqiNP_766142.2. NM_172554.2. [Q80TN5-1]
UniGeneiMm.339281.

3D structure databases

ProteinModelPortaliQ80TN5.
SMRiQ80TN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043279.

PTM databases

iPTMnetiQ80TN5.
PhosphoSitePlusiQ80TN5.
SwissPalmiQ80TN5.

Proteomic databases

PaxDbiQ80TN5.
PeptideAtlasiQ80TN5.
PRIDEiQ80TN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041723; ENSMUSP00000043279; ENSMUSG00000035798. [Q80TN5-1]
GeneIDi320150.
KEGGimmu:320150.
UCSCiuc007gzw.2. mouse. [Q80TN5-2]
uc033fsq.1. mouse. [Q80TN5-1]

Organism-specific databases

CTDi23390.
MGIiMGI:2445110. Zdhhc17.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
HOGENOMiHOG000290181.
HOVERGENiHBG051907.
InParanoidiQ80TN5.
KOiK20032.
OMAiIMQLARI.
OrthoDBiEOG091G056H.
PhylomeDBiQ80TN5.
TreeFamiTF317342.

Miscellaneous databases

PROiQ80TN5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035798.
CleanExiMM_ZDHHC17.
ExpressionAtlasiQ80TN5. baseline and differential.
GenevisibleiQ80TN5. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR030289. ZDHHC17.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR24161:SF18. PTHR24161:SF18. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDH17_MOUSE
AccessioniPrimary (citable) accession number: Q80TN5
Secondary accession number(s): Q8BJ08, Q8BYQ2, Q8BYQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.