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Reviewed, UniProtKB/Swiss-Prot Q80TN4 (DJC16_MOUSE)

Last modified May 5, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    DnaJ homolog subfamily C member 16
Gene names
Name: Dnajc16
Synonyms: Kiaa0962
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length772 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Membrane; Single-pass type IV membrane protein Potential.

Sequence similarities

Contains 1 J domain.

Contains 1 thioredoxin domain.

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Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
   PTMGlycoprotein
   Technical term3D-structure
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

protein folding

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionheat shock protein binding

Inferred from electronic annotation. Source: InterPro

unfolded protein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 772747DnaJ homolog subfamily C member 16
PRO_0000236684

Regions

Topological domain26 – 533508Cytoplasmic Potential
Transmembrane534 – 55421Anchor for type IV membrane protein Potential
Topological domain555 – 772218Extracellular Potential
Domain29 – 9365J
Domain119 – 245127Thioredoxin

Amino acid modifications

Glycosylation6291N-linked (GlcNAc...) Potential

Natural variations

Natural variant4781G → A in strain: Czech II. Ref.3

Secondary structure

1 ............. 772
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q80TN4-1 [UniParc].

Last modified May 30, 2006. Version 2.
Checksum: 1B55F9494D6E0465

FASTA77289,136
        10         20         30         40         50         60 
MELKRLGVSW RFLMVLVLIL QSLSALDFDP YRVLGVSRTA SQADIKKAYK KLAREWHPDK 

        70         80         90        100        110        120 
NKDPGAEDRF IQISKAYEIL SNEEKRTNYD HYGDAGENQG YQKQQREHRF RHFHENFYFD 

       130        140        150        160        170        180 
ESFFHFPFNA ERRDSGDEKY LLHFSHYVNE VLPESFKRPY LIKITSDWCF SCIHIEPVWK 

       190        200        210        220        230        240 
EVVQELEGLG VGIGVVHAGY ERRLAHHLGA HSTPSILGVI SGKITFFHNA VVHENLRQFV 

       250        260        270        280        290        300 
ESLLPGNLVE KVTNKNYVRF LSGWQQENKP HALLFGQTPA VPLMYKLTAF AYKDYVSFGY 

       310        320        330        340        350        360 
VYVGLRGVEE MTRQYNVNLY TPTMLIFKEH INKPADVIQA RGLKKQVIED FIAQNKYLLA 

       370        380        390        400        410        420 
SRLTSQRLFH ELCPVKRSHR QRKYCVVLLT AETNKVSKPF EAFLSFALAN TQDTVRFVHV 

       430        440        450        460        470        480 
YSNRQQEFAS TLLPDMEAFQ GKSGVSILER RNTAGRVVFK TLEDPWTGSE SDKFVLLGYL 

       490        500        510        520        530        540 
DQLRKDPAFL SSEAVLPDLT DELAPVFFLR WLYSVSDYLS DFWESLLHSN WREMMPLLSL 

       550        560        570        580        590        600 
IFSALFILFG TVMVQAFSDS NEERESHPAD KEEVPEKAGK TEPSFTKESS SKIPKKGFVE 

       610        620        630        640        650        660 
VTELTDVTYT SNLVRLRPGH MNVVLILSNS TKTSLLQKFA LEVYTFTGSS SLHFSFLTLD 

       670        680        690        700        710        720 
KHREWLEYLL EFAQDAAPIP NQYDKHFMER DYTGYVLALN GHKKYFCLFK PLKTVDEETV 

       730        740        750        760        770 
ASCDPDSSRG KPSCGLGPKP LKGKLSKLSL WMERLLEGSL QRFYIPSWPE LD

« Hide

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References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed: 12693553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Embryo and Skin.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 312-772, VARIANT ALA-478.
Strain: Czech II.
Tissue: Mammary tumor.
[4]"Solution structure of the J domain of the pseudo DnaJ protein, mouse hypothetical mKIAA0962."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 19-93.

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Cross-references

Sequence databases

AK122407 mRNA. Translation: BAC65689.1. Different initiation.
AK028692 mRNA. Translation: BAC26068.1.
AK051048 mRNA. Translation: BAC34510.1.
AK154946 mRNA. Translation: BAE32943.1.
AK164023 mRNA. Translation: BAE37591.1.
BC046424 mRNA. Translation: AAH46424.1. Different initiation.
IPIIPI00336247.
RefSeqNP_758841.1.
UniGeneMm.39102

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2CUGNMR-A19-93[»]
ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000040697. Mus musculus. [Contig view]
GeneID214063.
KEGGmmu:214063.

Organism-specific databases

MGIMGI:2442146. Dnajc16.
RougeSearch...

Phylogenomic databases

HOVERGENQ80TN4.
OMAQ80TN4. KLTAFAY.

Gene expression databases

ArrayExpressQ80TN4.
BgeeQ80TN4.
CleanExMM_DNAJC16.
GermOnlineENSMUSG00000040697. Mus musculus.

Family and domain databases

InterProIPR001623. DnaJ_N.
IPR018253. Heat_shock_DnaJ_CS.
IPR015609. Hsp40/DnaJ_Rel.
IPR003095. Hsp_DnaJ.
IPR017936. Thioredoxin-like.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:1.10.287.110. DnaJ_N. 1 hit.
G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11821. Hsp40/DnaJ_Rel. 1 hit.
PfamPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSPR00625. DNAJPROTEIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio374174.
SOURCESearch...

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Entry information

Entry nameDJC16_MOUSE
AccessionPrimary (citable) accession number: Q80TN4
Secondary accession number(s): Q811G1, Q8BHI2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 5, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents