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Protein
Submitted name:

MKIAA1027 protein

Gene

Tln1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MKIAA1027 proteinImported
Gene namesi
Name:Tln1Imported
Synonyms:mKIAA1027Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1099832. Tln1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ80TM2.
PRIDEiQ80TM2.

Expressioni

Gene expression databases

GenevisibleiQ80TM2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030187.

Structurei

3D structure databases

ProteinModelPortaliQ80TM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 426318FERMInterPro annotationAdd
BLAST
Domaini2316 – 2556241I/LWEQInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1073 – 110028Sequence analysisAdd
BLAST
Coiled coili2524 – 255128Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4261. Eukaryota.
ENOG410XQ0V. LUCA.
HOGENOMiHOG000006734.
HOVERGENiHBG023870.
KOiK06271.

Family and domain databases

Gene3Di1.20.1410.10. 3 hits.
1.20.1420.10. 1 hit.
1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR032425. FERM_f0.
IPR018979. FERM_N.
IPR002558. ILWEQ_dom.
IPR011993. PH_dom-like.
IPR015710. Talin-1.
IPR015224. Talin_cent.
IPR029071. Ubiquitin-rel_dom.
IPR015009. Vinculin-bd_dom.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR19981:SF7. PTHR19981:SF7. 1 hit.
PfamiPF16511. FERM_f0. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF01608. I_LWEQ. 1 hit.
PF09141. Talin_middle. 1 hit.
PF08913. VBS. 1 hit.
[Graphical view]
ProDomiPD011820. ILWEQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00295. B41. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view]
SUPFAMiSSF109880. SSF109880. 1 hit.
SSF109885. SSF109885. 4 hits.
SSF47031. SSF47031. 1 hit.
SSF47220. SSF47220. 5 hits.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q80TM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RAQGGAQSRA AQVSPGRRAE AATMVALSLK ISIGNVVKTM QFEPSTMVYD
60 70 80 90 100
ACRMIRERIP EALAGPPNDF GLFLSDDDPK KGIWLEAGKA LDYYMLRNGD
110 120 130 140 150
TMEYRKKQRP LKIRMLDGTV KTIMVDDSKT VTDMLMTICA RIGITNHDEY
160 170 180 190 200
SLVRELMEEK KDEGTGTLRK DKTLLRDEKK MEKLKQKLHT DDELNWLDHG
210 220 230 240 250
RTLREQGVEE HETLLLRRKF FYSDQNVDSR DPVQLNLLYV QARDDILNGS
260 270 280 290 300
HPVSFDKACE FAGFQCQIQF GPHNEQKHKA GFLDLKDFLP KEYVKQKGER
310 320 330 340 350
KIFQAHKNCG QMSEIEAKVR YVKLARSLKT YGVSFFLVKE KMKGKNKLVP
360 370 380 390 400
RLLGITKECV MRVDEKTKEV IQEWSLTNIK RWAASPKSFT LDFGDYQDGY
410 420 430 440 450
YSVQTTEGEQ IAQLIAGYID IILKKKKSKD HFGLEGDEES TMLEDSVSPK
460 470 480 490 500
KSTVLQQQYN RVGKVEHGSV ALPAIMRSGA SGPENFQVGS MPPAQQQITS
510 520 530 540 550
GQMHRGHMPP LTSAQQALTG TINSSMQAVQ AAQATLDDFE TLPPLGQDAA
560 570 580 590 600
SKAWRKNKMD ESKHEIHSQV DAITAGTASV VNLTAGDPAE TDYTAVGCAV
610 620 630 640 650
TTISSNLTEM SRGVKLLAAL LEDEGGNGRP LLQAAKGLAG AVSELLRSAQ
660 670 680 690 700
PASAEPRQNL LQAAGNVGQA SGELLQQIGE SDTDPHFQDV LMQLAKAVAS
710 720 730 740 750
AAAALVLKAK SVAQRTEDSG LQTQVIAAAT QCALSTSQLV ACTKVVAPTI
760 770 780 790 800
SSPVCQEQLV EAGRLVAKAV EGCVSASQAA TEDGQLLRGV GAAATAVTQA
810 820 830 840 850
LNELLQHVKA HATGAGPAGR YDQATDTILT VTENIFSSMG DAGEMVRQAR
860 870 880 890 900
ILAQATSDLV NAIKADAEGE SDLENSRKLL SAAKILADAT AKMVEAAKGA
910 920 930 940 950
AAHPDSEEQQ QRLREAAEGL RMATNAAAQN AIKKKLVQRL EHAAKQAAAS
960 970 980 990 1000
ATQTIAAAQH AASAPKASAG PQPLLVQSCK AVAEQIPLLV QGVRGSQAQP
1010 1020 1030 1040 1050
DSPSAQLALI AASQSFLQPG GKMVAAAKAS VPTIQDQASA MQLSQCAKNL
1060 1070 1080 1090 1100
GTALAELRTA AQKAQEACGP LEMDSALSVV QNLEKDLQEI KAAARDGKLK
1110 1120 1130 1140 1150
PLPGETMEKC TQDLGNSTKA VSSAIAKLLG EIAQGNENYA GIAARDVAGG
1160 1170 1180 1190 1200
LRSLAQAARG VAALTSDPAV QAIVLDTASD VLDKASSLIE EAKKASGHPG
1210 1220 1230 1240 1250
DPESQQRLAQ VAKAVTQALN RCVSCLPGQR DVDNALRAVG DASKRLLSDS
1260 1270 1280 1290 1300
LPPSTGTFQE AQSRLNEAAA GLNQAATELV QASRGTPQDL ARASGRFGQD
1310 1320 1330 1340 1350
FSTFLEAGVE MAGQAPSQED RAQVVSILKG ISMSSSKLLL AAKALSTDPA
1360 1370 1380 1390 1400
SPNLKSQLAA AARAVTDSIN QLITMCTQQA PGQKECDNAL RQLETVRELL
1410 1420 1430 1440 1450
ENPVQPINDM SYFGCLDSVM ENSKVLGEAM TGISQNAKNG NLPEFGDAIA
1460 1470 1480 1490 1500
TASKALCGFT EAAAQAAYLV GVSDPNSQAG QQGLVEPTQF ARANQAIQMA
1510 1520 1530 1540 1550
CQSLGEPGCT QAQVLSAATI VAKHTSALCN SCRLASARTA NPTAKRQFVQ
1560 1570 1580 1590 1600
SAKEVANSTA NLVKTIKALD GDFTEENRAQ CRAATAPLLE AVDNLSAFAS
1610 1620 1630 1640 1650
NPEFSSVPAQ ISPEGRAAME PIVISAKTML ESAGGLIQTA RALAVNPRDP
1660 1670 1680 1690 1700
PRWSVLAGHS RTVSDSIKKL ITSMRDKAPG QLECETAIAA LNSCLRDLDQ
1710 1720 1730 1740 1750
ASLAAVSQQL APREGISQEA LHTQMLTAVQ EISHLIEPLA SAARAEASQL
1760 1770 1780 1790 1800
GHKVSQMAQY FEPLTLAAVG AASKTLSHPQ QMALLDQTKT LAESALQLLY
1810 1820 1830 1840 1850
TAKEAGGNPK QAAHTQEALE EAVQMMTEAV EDLTTTLNEA ASAAGVVGGM
1860 1870 1880 1890 1900
VDSITQAINQ LDEGPMGDPE GSFVDYQTTM VRTAKAIAVT VQEMVTKSNT
1910 1920 1930 1940 1950
SPEELGPLAN QLTSDYGRLA SQAKPAAVAA ENEEIGAHIK HRVQELGHGC
1960 1970 1980 1990 2000
SALVTKAGAL QCSPSDVYTK KELIECARRV SEKVSHVLAA LQAGNRGTQA
2010 2020 2030 2040 2050
CITAASAVSG IIADLDTTIM FATAGTLNRE GAETFADHRE GILKTAKVLV
2060 2070 2080 2090 2100
EDTKVLVQNA AGSQEKLAQA AQSSVATITR LADVVKLGAA SLGAEDPETQ
2110 2120 2130 2140 2150
VVLINAVKDV AKALGDLISA TKAAAGKVGD DPAVWQLKNS AKVMVTNVTS
2160 2170 2180 2190 2200
LLKTVKAVED EATKGTRALE ATTEHIRQEL AVFCSPEPPA KTSTPEDFIR
2210 2220 2230 2240 2250
MTKGITMATA KAVAAGNSCR QEDVIATANL SRRAIADMLR ACKEAAFHPE
2260 2270 2280 2290 2300
VAPDVRLRAL HYGRECANGY LELLDHVLLT LQKPNPDLKQ QLTGHSKRVA
2310 2320 2330 2340 2350
GSVTELIQAA EAMKGTEWVD PEDPTVIAEN ELLGAAAAIE AAAKKLEQLK
2360 2370 2380 2390 2400
PRAKPKEADE SLNFEEQILE AAKSIAAATS ALVKAASAAQ RELVAQGKVG
2410 2420 2430 2440 2450
AIPANALDDG QWSQGLISAA RMVAAATNNL CEAANAAVQG HASQEKLISS
2460 2470 2480 2490 2500
AKQVAASTAQ LLVACKVKAD QDSEAMKRLQ AAGNAVKRAS DNLVKAAQKA
2510 2520 2530 2540 2550
AAFEDQENET VVVKEKMVGG IAQIIAAQEE MLRKERELEE ARKKFAQIRQ
2560
QQYKFLPSEL RDEH
Length:2,564
Mass (Da):272,133
Last modified:August 16, 2004 - v4
Checksum:iB702ED3210A5E283
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122420 mRNA. Translation: BAC65702.4.
RefSeqiNP_035732.2. NM_011602.5.
UniGeneiMm.208601.

Genome annotation databases

GeneIDi21894.
KEGGimmu:21894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122420 mRNA. Translation: BAC65702.4.
RefSeqiNP_035732.2. NM_011602.5.
UniGeneiMm.208601.

3D structure databases

ProteinModelPortaliQ80TM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030187.

Proteomic databases

PaxDbiQ80TM2.
PRIDEiQ80TM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi21894.
KEGGimmu:21894.

Organism-specific databases

CTDi7094.
MGIiMGI:1099832. Tln1.

Phylogenomic databases

eggNOGiKOG4261. Eukaryota.
ENOG410XQ0V. LUCA.
HOGENOMiHOG000006734.
HOVERGENiHBG023870.
KOiK06271.

Miscellaneous databases

ChiTaRSiTln1. mouse.
NextBioi301428.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ80TM2. MM.

Family and domain databases

Gene3Di1.20.1410.10. 3 hits.
1.20.1420.10. 1 hit.
1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR032425. FERM_f0.
IPR018979. FERM_N.
IPR002558. ILWEQ_dom.
IPR011993. PH_dom-like.
IPR015710. Talin-1.
IPR015224. Talin_cent.
IPR029071. Ubiquitin-rel_dom.
IPR015009. Vinculin-bd_dom.
IPR006077. Vinculin/catenin.
[Graphical view]
PANTHERiPTHR19981:SF7. PTHR19981:SF7. 1 hit.
PfamiPF16511. FERM_f0. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF01608. I_LWEQ. 1 hit.
PF09141. Talin_middle. 1 hit.
PF08913. VBS. 1 hit.
[Graphical view]
ProDomiPD011820. ILWEQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00295. B41. 1 hit.
SM00307. ILWEQ. 1 hit.
[Graphical view]
SUPFAMiSSF109880. SSF109880. 1 hit.
SSF109885. SSF109885. 4 hits.
SSF47031. SSF47031. 1 hit.
SSF47220. SSF47220. 5 hits.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50945. I_LWEQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Adult pancreatic isletImported.

Entry informationi

Entry nameiQ80TM2_MOUSE
AccessioniPrimary (citable) accession number: Q80TM2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: August 16, 2004
Last modified: March 16, 2016
This is version 89 of the entry and version 4 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.