Reviewed, UniProtKB/Swiss-Prot Q80TL1 (ADCY2_MOUSE)

Names and origin

Protein names

Recommended name:
    Adenylate cyclase type 2
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type II
    ATP pyrophosphate-lyase 2
    Adenylyl cyclase 2

Gene names

Name:	Adcy2
Synonyms:	Kiaa1060

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1090 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This is a membrane-bound, calmodulin-insensitive adenylyl cyclase By similarity.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Enzyme regulation	Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	G-protein signaling, coupled to cAMP nucleotide second messenger Traceable author statement. Source: MGI activation of adenylate cyclase activity Traceable author statement. Source: MGI cAMP biosynthetic process Traceable author statement. Source: MGI
Cellular component	dendrite Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: MGI
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Traceable author statement. Source: MGI magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1090	1090	Adenylate cyclase type 2		PRO_0000195685
Regions
	Topological domain	1 – 44	44	Cytoplasmic Potential
	Transmembrane	45 – 65	21	Potential
	Transmembrane	75 – 95	21	Potential
	Transmembrane	107 – 127	21	Potential
	Transmembrane	132 – 152	21	Potential
	Transmembrane	157 – 177	21	Potential
	Transmembrane	186 – 206	21	Potential
	Topological domain	207 – 600	394	Cytoplasmic Potential
	Transmembrane	601 – 621	21	Potential
	Transmembrane	626 – 646	21	Potential
	Transmembrane	679 – 699	21	Potential
	Transmembrane	734 – 754	21	Potential
	Transmembrane	763 – 783	21	Potential
	Transmembrane	800 – 820	21	Potential
	Topological domain	821 – 1090	270	Cytoplasmic Potential
Sites
	Metal binding	294	1	Magnesium 1 By similarity
	Metal binding	294	1	Magnesium 2 By similarity
	Metal binding	295	1	Magnesium 2; via carbonyl oxygen By similarity
	Metal binding	338	1	Magnesium 1 By similarity
	Metal binding	338	1	Magnesium 2 By similarity
Amino acid modifications
	Glycosylation	712	1	N-linked (GlcNAc...) Potential
	Glycosylation	717	1	N-linked (GlcNAc...) Potential
	Glycosylation	723	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q80TL1-1 [UniParc]. Last modified December 21, 2004. Version 2. Checksum: 461CDF5E6C828CCB	FASTA	1,090	123,270
	10 20 30 40 50 60 MRRRRYLRDR AEAAAAAAAG GGEGLQRSRD WLYESYYCMS QQHPLIVFLL LIVMGACLAL 70 80 90 100 110 120 LAVFFALGLE VEDHVAFLIT VPTALAIFFA IFILVCIESV FKKLLRVFSL VIWICLVAMG 130 140 150 160 170 180 YLFMCFGGTV SAWDQVSFFL FIIFVVYTML PFNMRDAIIA SVLTSSSHTI VLSVYLSATP 190 200 210 220 230 240 GAKEHLFWQI LANVIIFICG NLAGAYHKHL MELALQQTYR DTCNCIKSRI KLEFEKRQQE 250 260 270 280 290 300 RLLLSLLPAH IAMEMKAEII QRLQGPKAGQ MENTNNFHNL YVKRHTNVSI LYADIVGFTR 310 320 330 340 350 360 LASDCSPGEL VHMLNELFGK FDQIAKENEC MRIKILGDCY YCVSGLPISL PNHAKNCVKM 370 380 390 400 410 420 GLDMCEAIKK VRDATGVDIN MRVGVHSGNV LCGVIGLQKW QYDVWSHDVT LANHMEAGGV 430 440 450 460 470 480 PGRVHISSVT LEHLNGAYKV EEGDGEIRDP YLKQHLVKTY FVINPKGERR SPQHLFRPRH 490 500 510 520 530 540 TLDGAKMRAS VRMTRYLESW GAAKPFAHLH HRDSMTTENG KISTTDVPMG QHNFQNRTLR 550 560 570 580 590 600 TKSQKKRFEE ELNERMIQAI DGINAQKQWL KSEDIQRISL FFYNKNIEKE YRATALPAFK 610 620 630 640 650 660 YYVTCACLIF LCIFIVQILV LPKTSILGFS FGAAFLSLIF ILFVCFAGQL LQCSKKASAS 670 680 690 700 710 720 LLWLLKSSGI IANRPWPRIS LTIVTTAIIL TMAVFNMFFL SNSEETTLPT ANASNANVSV 730 740 750 760 770 780 PDNQTAILHA RNLFFLPYFI YSCILGLISC SVFLRVNYEL KMLIMMVALV GYNIILLHTH 790 800 810 820 830 840 AHVLDAYSQV LFQRPGIWKD LKTMGSVSLS IFFITLLVLG RQSEYYCRLD FLWKNKFKKE 850 860 870 880 890 900 REEIETMENL NRVLLENVLP AHVAEHFLAR SLKNEELYHQ SYDCVCVMFA SIPDFKEFYT 910 920 930 940 950 960 ESDVNKEGLE CLRLLNEIIA DFDDLLSKPK FSGVEKIKTI GSTYMAATGL SAVPSQEHAQ 970 980 990 1000 1010 1020 EPERQYMHIG TMVEFAYALV GKLDAINKHS FNDFKLRVGI NHGPVIAGVI GAQKPQYDIW 1030 1040 1050 1060 1070 1080 GNTVNVASRM DSTGVLDKIQ VTEETSLILQ TLGYTCTCRG IINVKGKGDL KTYFVNTEMS 1090 RSLSQSNLAS

References

[1]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed: 12693553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK122432 mRNA. Translation: BAC65714.1. Different initiation. BC037107 mRNA. Translation: AAH37107.1.
IPI	IPI00377680.
UniGene	Mm.390617
3D structure databases
HSSP	HSSP built from PDB template 1CUL based on UniProtKB P26769.
SMR	Q80TL1. Positions 878-1077.
ModBase	Search...
PTM databases
PhosphoSite	Q80TL1.
Proteomic databases
PRIDE	Q80TL1.
Genome annotation databases
Ensembl	ENSMUSG00000021536. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:99676. Adcy2.
Rouge	Search...
Phylogenomic databases
HOVERGEN	Q80TL1.
Enzyme and pathway databases
BRENDA	4.6.1.1. 244.
Gene expression databases
ArrayExpress	Q80TL1.
Bgee	Q80TL1.
CleanEx	MM_ADCY2.
GermOnline	ENSMUSG00000021536. Mus musculus.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Aden_cycl-like. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
Pfam	PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 2 hits. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

ADCY2_MOUSE

Accession

Primary (citable) accession number: Q80TL1
Secondary accession number(s): Q8CFU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	June 16, 2009
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)