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Q80TL0

- PPM1E_MOUSE

UniProt

Q80TL0 - PPM1E_MOUSE

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Protein

Protein phosphatase 1E

Gene

Ppm1e

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 (By similarity). Dephosphorylates PRKAA2.By similarity1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi270 – 2701Manganese 1By similarity
Metal bindingi270 – 2701Manganese 2By similarity
Metal bindingi271 – 2711Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi432 – 4321Manganese 2By similarity
Metal bindingi476 – 4761Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: Ensembl

GO - Biological processi

  1. cellular response to drug Source: Ensembl
  2. negative regulation of protein kinase activity Source: Ensembl
  3. peptidyl-threonine dephosphorylation Source: Ensembl
  4. positive regulation of stress fiber assembly Source: Ensembl
  5. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1E (EC:3.1.3.16)
Alternative name(s):
Ca(2+)/calmodulin-dependent protein kinase phosphatase N
Short name:
CaMKP-N
CaMKP-nucleus
Short name:
CaMKN
Partner of PIX 1
Partner of PIX-alpha
Short name:
Partner of PIXA
Gene namesi
Name:Ppm1e
Synonyms:Camkn, Kiaa1072
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2444096. Ppm1e.

Subcellular locationi

Nucleus. Cytoplasm
Note: A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form, is found in the nucleus (By similarity).By similarity

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
  2. nucleolus Source: Ensembl
  3. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 749749Protein phosphatase 1EPRO_0000286821Add
BLAST

Proteomic databases

MaxQBiQ80TL0.
PaxDbiQ80TL0.
PRIDEiQ80TL0.

PTM databases

PhosphoSiteiQ80TL0.

Expressioni

Gene expression databases

BgeeiQ80TL0.
CleanExiMM_PPM1E.
ExpressionAtlasiQ80TL0. baseline and differential.
GenevestigatoriQ80TL0.

Interactioni

Subunit structurei

Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7) (By similarity).By similarity

Protein-protein interaction databases

IntActiQ80TL0. 1 interaction.
MINTiMINT-4114921.

Structurei

3D structure databases

ProteinModelPortaliQ80TL0.
SMRiQ80TL0. Positions 233-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 3221
Repeati33 – 3422
Repeati35 – 3623
Repeati37 – 3824; approximate
Repeati39 – 4025
Repeati41 – 4226
Repeati43 – 4427
Domaini243 – 485243PP2C-likeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni31 – 44147 X 2 AA tandem repeats of P-EAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 10195Glu-richAdd
BLAST
Compositional biasi111 – 12717Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000114971.
HOGENOMiHOG000059266.
HOVERGENiHBG098260.
InParanoidiQ80TL0.
KOiK17501.
OMAiPVEMFGP.
OrthoDBiEOG7D2FDH.
PhylomeDBiQ80TL0.
TreeFamiTF317617.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80TL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGCIPEEKT YRRFLELFLG EFRGPCGGGE PEPEPESEPE PEPEAELVAA
60 70 80 90 100
EAAEASGEEP GEDAATVEAT EEGEQDQDPE PEDEAVEEET ATEGEEEEEE
110 120 130 140 150
EAAAPGHSAV PPPPQPQLPP LPPLPRPLSE RITREEVEGE SLDLCLQQLY
160 170 180 190 200
KYNCPSFLAA ALARATSDEV LQSDLSAHCI PKETDGTEGT VEIETVKLAR
210 220 230 240 250
SVFSKLHEIC CSWVKDFPLR RRPQIYYETS IHAIKNMRRK MEDKHVCIPD
260 270 280 290 300
FNMLFNLEDQ EEQAYFAVFD GHGGVDAAIY ASVHLHVNLV RQEMFPHDPA
310 320 330 340 350
EALCRAFRVT DERFVQKAAR ESLRCGTTGV VTFIRGNMLH VAWVGDSQVM
360 370 380 390 400
LVRKGQAVEL MKPHKPDRED EKQRIEALGG CVVWFGAWRV NGSLSVSRAI
410 420 430 440 450
GDAEHKPYIC GDADSASTVL DGTEDYLILA CDGFYDTVNP DEAVKVVSDH
460 470 480 490 500
LKENNGDSSM VAHKLVASAR DAGSSDNITV IVVFLRDMNK AVNVSEESEW
510 520 530 540 550
TENSFQGGQE DGGDDKETHG ECKRPWPQHQ CSAPADLGYE GRVDSFTDRT
560 570 580 590 600
SLSPGPQINV LEDPDYLDLT QIEASKPHST QFLPPVEMIG PGAPKKDLNE
610 620 630 640 650
LIMEERSVKS SLPERSGAGE PRVSFNLGST GQQICRMENL SPVSSGLENE
660 670 680 690 700
QFKSRGKTAS RLYHLRHHYS KRQRGFRFNP KFYSFLSARE PSHKIGISLS
710 720 730 740
SLTRSGKRNK MLRSSLPWRE NSWEGYSGNV KIRKRNDIPC PDFPWSYKI
Length:749
Mass (Da):83,419
Last modified:May 15, 2007 - v2
Checksum:iC59BC6CAC3E268B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071H → D in BAC29490. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036583 mRNA. Translation: BAC29490.1.
AK046962 mRNA. Translation: BAC32927.1.
AK053696 mRNA. Translation: BAC35479.1.
AL596130 Genomic DNA. Translation: CAI24490.1.
AK122434 mRNA. Translation: BAC65716.1.
CCDSiCCDS25211.1.
RefSeqiNP_796141.2. NM_177167.4.
UniGeneiMm.341988.

Genome annotation databases

EnsembliENSMUST00000055438; ENSMUSP00000061278; ENSMUSG00000046442.
GeneIDi320472.
KEGGimmu:320472.
UCSCiuc007kto.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036583 mRNA. Translation: BAC29490.1 .
AK046962 mRNA. Translation: BAC32927.1 .
AK053696 mRNA. Translation: BAC35479.1 .
AL596130 Genomic DNA. Translation: CAI24490.1 .
AK122434 mRNA. Translation: BAC65716.1 .
CCDSi CCDS25211.1.
RefSeqi NP_796141.2. NM_177167.4.
UniGenei Mm.341988.

3D structure databases

ProteinModelPortali Q80TL0.
SMRi Q80TL0. Positions 233-486.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80TL0. 1 interaction.
MINTi MINT-4114921.

PTM databases

PhosphoSitei Q80TL0.

Proteomic databases

MaxQBi Q80TL0.
PaxDbi Q80TL0.
PRIDEi Q80TL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055438 ; ENSMUSP00000061278 ; ENSMUSG00000046442 .
GeneIDi 320472.
KEGGi mmu:320472.
UCSCi uc007kto.1. mouse.

Organism-specific databases

CTDi 22843.
MGIi MGI:2444096. Ppm1e.
Rougei Search...

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00740000114971.
HOGENOMi HOG000059266.
HOVERGENi HBG098260.
InParanoidi Q80TL0.
KOi K17501.
OMAi PVEMFGP.
OrthoDBi EOG7D2FDH.
PhylomeDBi Q80TL0.
TreeFami TF317617.

Miscellaneous databases

NextBioi 396789.
PROi Q80TL0.
SOURCEi Search...

Gene expression databases

Bgeei Q80TL0.
CleanExi MM_PPM1E.
ExpressionAtlasi Q80TL0. baseline and differential.
Genevestigatori Q80TL0.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone, Cerebellum and Eye.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-749.
    Tissue: Brain.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 198-205, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. "N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells."
    Chida T., Ando M., Matsuki T., Masu Y., Nagaura Y., Takano-Yamamoto T., Tamura S., Kobayashi T.
    Biochem. J. 449:741-749(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPPM1E_MOUSE
AccessioniPrimary (citable) accession number: Q80TL0
Secondary accession number(s): Q5SX30, Q8BGM6, Q8CB81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 26, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3