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Protein

Protein phosphatase 1E

Gene

Ppm1e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 (By similarity). Dephosphorylates PRKAA2.By similarity1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi270Manganese 1By similarity1
Metal bindingi270Manganese 2By similarity1
Metal bindingi271Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi432Manganese 2By similarity1
Metal bindingi476Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1E (EC:3.1.3.16)
Alternative name(s):
Ca(2+)/calmodulin-dependent protein kinase phosphatase N
Short name:
CaMKP-N
CaMKP-nucleus
Short name:
CaMKN
Partner of PIX 1
Partner of PIX-alpha
Short name:
Partner of PIXA
Gene namesi
Name:Ppm1e
Synonyms:Camkn, Kiaa1072
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444096 Ppm1e

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868211 – 749Protein phosphatase 1EAdd BLAST749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei532PhosphoserineCombined sources1
Modified residuei545PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80TL0
PaxDbiQ80TL0
PRIDEiQ80TL0

PTM databases

iPTMnetiQ80TL0
PhosphoSitePlusiQ80TL0

Expressioni

Gene expression databases

BgeeiENSMUSG00000046442
CleanExiMM_PPM1E
ExpressionAtlasiQ80TL0 baseline and differential
GenevisibleiQ80TL0 MM

Interactioni

Subunit structurei

Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7) (By similarity).By similarity

Protein-protein interaction databases

BioGridi236046, 1 interactor
IntActiQ80TL0, 2 interactors
MINTiQ80TL0
STRINGi10090.ENSMUSP00000061278

Structurei

3D structure databases

ProteinModelPortaliQ80TL0
SMRiQ80TL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 3212
Repeati33 – 3422
Repeati35 – 3632
Repeati37 – 384; approximate2
Repeati39 – 4052
Repeati41 – 4262
Repeati43 – 4472
Domaini224 – 485PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 447 X 2 AA tandem repeats of P-EAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 101Glu-richAdd BLAST95
Compositional biasi111 – 127Pro-richAdd BLAST17

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00900000140907
HOGENOMiHOG000059266
HOVERGENiHBG098260
InParanoidiQ80TL0
KOiK17501
OMAiPVEMFGP
OrthoDBiEOG091G08KG
PhylomeDBiQ80TL0
TreeFamiTF317617

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q80TL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGCIPEEKT YRRFLELFLG EFRGPCGGGE PEPEPESEPE PEPEAELVAA
60 70 80 90 100
EAAEASGEEP GEDAATVEAT EEGEQDQDPE PEDEAVEEET ATEGEEEEEE
110 120 130 140 150
EAAAPGHSAV PPPPQPQLPP LPPLPRPLSE RITREEVEGE SLDLCLQQLY
160 170 180 190 200
KYNCPSFLAA ALARATSDEV LQSDLSAHCI PKETDGTEGT VEIETVKLAR
210 220 230 240 250
SVFSKLHEIC CSWVKDFPLR RRPQIYYETS IHAIKNMRRK MEDKHVCIPD
260 270 280 290 300
FNMLFNLEDQ EEQAYFAVFD GHGGVDAAIY ASVHLHVNLV RQEMFPHDPA
310 320 330 340 350
EALCRAFRVT DERFVQKAAR ESLRCGTTGV VTFIRGNMLH VAWVGDSQVM
360 370 380 390 400
LVRKGQAVEL MKPHKPDRED EKQRIEALGG CVVWFGAWRV NGSLSVSRAI
410 420 430 440 450
GDAEHKPYIC GDADSASTVL DGTEDYLILA CDGFYDTVNP DEAVKVVSDH
460 470 480 490 500
LKENNGDSSM VAHKLVASAR DAGSSDNITV IVVFLRDMNK AVNVSEESEW
510 520 530 540 550
TENSFQGGQE DGGDDKETHG ECKRPWPQHQ CSAPADLGYE GRVDSFTDRT
560 570 580 590 600
SLSPGPQINV LEDPDYLDLT QIEASKPHST QFLPPVEMIG PGAPKKDLNE
610 620 630 640 650
LIMEERSVKS SLPERSGAGE PRVSFNLGST GQQICRMENL SPVSSGLENE
660 670 680 690 700
QFKSRGKTAS RLYHLRHHYS KRQRGFRFNP KFYSFLSARE PSHKIGISLS
710 720 730 740
SLTRSGKRNK MLRSSLPWRE NSWEGYSGNV KIRKRNDIPC PDFPWSYKI
Length:749
Mass (Da):83,419
Last modified:May 15, 2007 - v2
Checksum:iC59BC6CAC3E268B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107H → D in BAC29490 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036583 mRNA Translation: BAC29490.1
AK046962 mRNA Translation: BAC32927.1
AK053696 mRNA Translation: BAC35479.1
AL596130 Genomic DNA No translation available.
AK122434 mRNA Translation: BAC65716.1
CCDSiCCDS25211.1
RefSeqiNP_796141.2, NM_177167.4
UniGeneiMm.341988

Genome annotation databases

EnsembliENSMUST00000055438; ENSMUSP00000061278; ENSMUSG00000046442
GeneIDi320472
KEGGimmu:320472
UCSCiuc007kto.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPPM1E_MOUSE
AccessioniPrimary (citable) accession number: Q80TL0
Secondary accession number(s): Q5SX30, Q8BGM6, Q8CB81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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