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Q80TL0

- PPM1E_MOUSE

UniProt

Q80TL0 - PPM1E_MOUSE

Protein

Protein phosphatase 1E

Gene

Ppm1e

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 By similarity. Dephosphorylates PRKAA2.By similarity1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi270 – 2701Manganese 1By similarity
    Metal bindingi270 – 2701Manganese 2By similarity
    Metal bindingi271 – 2711Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi432 – 4321Manganese 2By similarity
    Metal bindingi476 – 4761Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: Ensembl

    GO - Biological processi

    1. cellular response to drug Source: Ensembl
    2. negative regulation of protein kinase activity Source: Ensembl
    3. peptidyl-threonine dephosphorylation Source: Ensembl
    4. positive regulation of stress fiber assembly Source: Ensembl
    5. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1E (EC:3.1.3.16)
    Alternative name(s):
    Ca(2+)/calmodulin-dependent protein kinase phosphatase N
    Short name:
    CaMKP-N
    CaMKP-nucleus
    Short name:
    CaMKN
    Partner of PIX 1
    Partner of PIX-alpha
    Short name:
    Partner of PIXA
    Gene namesi
    Name:Ppm1e
    Synonyms:Camkn, Kiaa1072
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2444096. Ppm1e.

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form, is found in the nucleus By similarity.By similarity

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleolus Source: Ensembl
    3. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 749749Protein phosphatase 1EPRO_0000286821Add
    BLAST

    Proteomic databases

    MaxQBiQ80TL0.
    PaxDbiQ80TL0.
    PRIDEiQ80TL0.

    PTM databases

    PhosphoSiteiQ80TL0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80TL0.
    BgeeiQ80TL0.
    CleanExiMM_PPM1E.
    GenevestigatoriQ80TL0.

    Interactioni

    Subunit structurei

    Heterotrimer. Interacts with PAX1 and ARHGEF6 (or ARHGEF7) By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ80TL0. 1 interaction.
    MINTiMINT-4114921.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80TL0.
    SMRiQ80TL0. Positions 233-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati31 – 3221
    Repeati33 – 3422
    Repeati35 – 3623
    Repeati37 – 3824; approximate
    Repeati39 – 4025
    Repeati41 – 4226
    Repeati43 – 4427
    Domaini243 – 485243PP2C-likeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni31 – 44147 X 2 AA tandem repeats of P-EAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 10195Glu-richAdd
    BLAST
    Compositional biasi111 – 12717Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00740000114971.
    HOGENOMiHOG000059266.
    HOVERGENiHBG098260.
    InParanoidiQ80TL0.
    KOiK17501.
    OMAiPVEMFGP.
    OrthoDBiEOG7D2FDH.
    PhylomeDBiQ80TL0.
    TreeFamiTF317617.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80TL0-1 [UniParc]FASTAAdd to Basket

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    MAGCIPEEKT YRRFLELFLG EFRGPCGGGE PEPEPESEPE PEPEAELVAA    50
    EAAEASGEEP GEDAATVEAT EEGEQDQDPE PEDEAVEEET ATEGEEEEEE 100
    EAAAPGHSAV PPPPQPQLPP LPPLPRPLSE RITREEVEGE SLDLCLQQLY 150
    KYNCPSFLAA ALARATSDEV LQSDLSAHCI PKETDGTEGT VEIETVKLAR 200
    SVFSKLHEIC CSWVKDFPLR RRPQIYYETS IHAIKNMRRK MEDKHVCIPD 250
    FNMLFNLEDQ EEQAYFAVFD GHGGVDAAIY ASVHLHVNLV RQEMFPHDPA 300
    EALCRAFRVT DERFVQKAAR ESLRCGTTGV VTFIRGNMLH VAWVGDSQVM 350
    LVRKGQAVEL MKPHKPDRED EKQRIEALGG CVVWFGAWRV NGSLSVSRAI 400
    GDAEHKPYIC GDADSASTVL DGTEDYLILA CDGFYDTVNP DEAVKVVSDH 450
    LKENNGDSSM VAHKLVASAR DAGSSDNITV IVVFLRDMNK AVNVSEESEW 500
    TENSFQGGQE DGGDDKETHG ECKRPWPQHQ CSAPADLGYE GRVDSFTDRT 550
    SLSPGPQINV LEDPDYLDLT QIEASKPHST QFLPPVEMIG PGAPKKDLNE 600
    LIMEERSVKS SLPERSGAGE PRVSFNLGST GQQICRMENL SPVSSGLENE 650
    QFKSRGKTAS RLYHLRHHYS KRQRGFRFNP KFYSFLSARE PSHKIGISLS 700
    SLTRSGKRNK MLRSSLPWRE NSWEGYSGNV KIRKRNDIPC PDFPWSYKI 749
    Length:749
    Mass (Da):83,419
    Last modified:May 15, 2007 - v2
    Checksum:iC59BC6CAC3E268B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti107 – 1071H → D in BAC29490. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036583 mRNA. Translation: BAC29490.1.
    AK046962 mRNA. Translation: BAC32927.1.
    AK053696 mRNA. Translation: BAC35479.1.
    AL596130 Genomic DNA. Translation: CAI24490.1.
    AK122434 mRNA. Translation: BAC65716.1.
    CCDSiCCDS25211.1.
    RefSeqiNP_796141.2. NM_177167.4.
    UniGeneiMm.341988.

    Genome annotation databases

    EnsembliENSMUST00000055438; ENSMUSP00000061278; ENSMUSG00000046442.
    GeneIDi320472.
    KEGGimmu:320472.
    UCSCiuc007kto.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036583 mRNA. Translation: BAC29490.1 .
    AK046962 mRNA. Translation: BAC32927.1 .
    AK053696 mRNA. Translation: BAC35479.1 .
    AL596130 Genomic DNA. Translation: CAI24490.1 .
    AK122434 mRNA. Translation: BAC65716.1 .
    CCDSi CCDS25211.1.
    RefSeqi NP_796141.2. NM_177167.4.
    UniGenei Mm.341988.

    3D structure databases

    ProteinModelPortali Q80TL0.
    SMRi Q80TL0. Positions 233-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q80TL0. 1 interaction.
    MINTi MINT-4114921.

    PTM databases

    PhosphoSitei Q80TL0.

    Proteomic databases

    MaxQBi Q80TL0.
    PaxDbi Q80TL0.
    PRIDEi Q80TL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055438 ; ENSMUSP00000061278 ; ENSMUSG00000046442 .
    GeneIDi 320472.
    KEGGi mmu:320472.
    UCSCi uc007kto.1. mouse.

    Organism-specific databases

    CTDi 22843.
    MGIi MGI:2444096. Ppm1e.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00740000114971.
    HOGENOMi HOG000059266.
    HOVERGENi HBG098260.
    InParanoidi Q80TL0.
    KOi K17501.
    OMAi PVEMFGP.
    OrthoDBi EOG7D2FDH.
    PhylomeDBi Q80TL0.
    TreeFami TF317617.

    Miscellaneous databases

    NextBioi 396789.
    PROi Q80TL0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80TL0.
    Bgeei Q80TL0.
    CleanExi MM_PPM1E.
    Genevestigatori Q80TL0.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone, Cerebellum and Eye.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-749.
      Tissue: Brain.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 198-205, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    5. "N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells."
      Chida T., Ando M., Matsuki T., Masu Y., Nagaura Y., Takano-Yamamoto T., Tamura S., Kobayashi T.
      Biochem. J. 449:741-749(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPPM1E_MOUSE
    AccessioniPrimary (citable) accession number: Q80TL0
    Secondary accession number(s): Q5SX30, Q8BGM6, Q8CB81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3