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Protein

Pleckstrin homology domain-containing family H member 1

Gene

Plekhh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family H member 1
Short name:
PH domain-containing family H member 1
Gene namesi
Name:Plekhh1
Synonyms:Kiaa1200
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2144989. Plekhh1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13561356Pleckstrin homology domain-containing family H member 1PRO_0000310949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei451 – 4511PhosphoserineCombined sources
Modified residuei739 – 7391PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80TI1.
PaxDbiQ80TI1.
PRIDEiQ80TI1.

PTM databases

iPTMnetiQ80TI1.
PhosphoSiteiQ80TI1.

Expressioni

Gene expression databases

BgeeiQ80TI1.
GenevisibleiQ80TI1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049460.

Structurei

3D structure databases

ProteinModelPortaliQ80TI1.
SMRiQ80TI1. Positions 575-674, 843-1318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini572 – 66695PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini681 – 790110PH 2PROSITE-ProRule annotationAdd
BLAST
Domaini826 – 980155MyTH4PROSITE-ProRule annotationAdd
BLAST
Domaini991 – 1327337FERMPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili27 – 172146Sequence analysisAdd
BLAST
Coiled coili359 – 40749Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 MyTH4 domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0248. Eukaryota.
ENOG410XPCT. LUCA.
GeneTreeiENSGT00780000121979.
HOGENOMiHOG000046075.
HOVERGENiHBG108258.
InParanoidiQ80TI1.
OMAiEATFIMA.
OrthoDBiEOG72VH56.
PhylomeDBiQ80TI1.
TreeFamiTF312866.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000857. MyTH4_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00784. MyTH4. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00139. MyTH4. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 3 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS51016. MYTH4. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEVKVEVAS IDWQKRCLSL ETQLFRFRLQ ASKIRELLAD KMQELEQRLL
60 70 80 90 100
EAEQRAENAE TQVGVMEEKI KLSNLKSVDS TGTLHQKYQE LLRAVQGKDE
110 120 130 140 150
LISQLQAQLE KQKQTRAEEA KIVQEKAAKI KEWVTVKLAE LEMENQQLKT
160 170 180 190 200
CNQQLVEQVA ALQDALEDLR MTPSEELLVV PEGTPERDPV PSGPSDQPVE
210 220 230 240 250
QDSNPHTQIL KVAVPTPSLG TLQSRDSLSE ARSLEDLRFS MVHPGETAEA
260 270 280 290 300
KTLQSHLQKE GSPSQLCMKP GNPKHGSASY RESLVTAQGG TFPGTKTSAR
310 320 330 340 350
EGGPGSSLTL PKVRAPSIPR DSFQVAKRHH SQPQVGPGHC DHVVSIEIGA
360 370 380 390 400
LSALHSPGSS KSEARAKVRE EAEKMEMEAL PPSGKQEERE SLKSRRGELE
410 420 430 440 450
DVELENKPPT PPLHRFPSWE SRIYAMATSG MQLSEVSSRR SNAACYASGP
460 470 480 490 500
SALAFPGAFS GLVYKNVTVP VYTALKGKAT QISNVPFVDE SSGSDDDCGS
510 520 530 540 550
QASFRMSVPC SEYRKTSGLG SPRAIKRGVS MSSLSSEGDY AIPPDACSLD
560 570 580 590 600
SDYSEPEHKL QRTSSYSTDG EALEKSGYLL KMGSRVKTWK RRWFVLRQGQ
610 620 630 640 650
ILYYKSPSDV IRKPQGQVDL NSHCQIVREE EAQTFQLISG NKTYYLTAES
660 670 680 690 700
PSLLEEWIRV LQSLLKVQVT GPPALHQGGT KPTVKGWLTK VKHGHSKLVW
710 720 730 740 750
CALVGKTFYY YRSHEDKRPL GCLPVQDAHI EEVDRSCDSD EDYEAGGTGR
760 770 780 790 800
LLSSHCTLVI HPPEHSPTYL LIGTKHEKDT WLYHLTVAAG GSNAKVGTVY
810 820 830 840 850
EQLIGKLMDG EGNPDSPLWR HPMLCYSQEG LCASLTTLPS EALQTEALKL
860 870 880 890 900
FKSCQLFINV PVEAASVDYH VSLAQTALQV CLVHPELQSE IYCQLMKQIS
910 920 930 940 950
CRPPQKYSLM QCWQLLALCA PLFLPQHHFL WYVKQQLQRH ADPRSETGQY
960 970 980 990 1000
AIYCQRAVER TLQTGEREAR PSRMEVVSIL LRNPFHHSLP FSIPVHFANG
1010 1020 1030 1040 1050
TYQVVGFDGS STVDEFLQRL NQETGMRKPS QSGFALFTDD PSGRDLEHCL
1060 1070 1080 1090 1100
QGRVKICDAI SKWEQTLKEL HPGKSEGGTR VVKLMYKNRL YFRSQVKGET
1110 1120 1130 1140 1150
ERERLLLAFQ ASGEIVAGRF PVTKELALEM AALMAQVEYG DLEKPTLPGP
1160 1170 1180 1190 1200
GGTPPTKAQH LLQQVLDRFY PRRYRNGAPP EQLRHLADMM ATKWAALQGC
1210 1220 1230 1240 1250
SPPECIRIYL TVARKWPLFG AKLFAAQPAQ LSPKENTVVW IAVNEDGVSI
1260 1270 1280 1290 1300
LDHRTMQVNI TYPYSSVTTF GGCRDDFMLV IRSIPDQSSG KTRIDKLTFR
1310 1320 1330 1340 1350
MPAPKITETT LMMASYMNHC SATVNLSAKL PAARQPRDLD GQFFASVSCT

KGSALL
Length:1,356
Mass (Da):150,909
Last modified:November 13, 2007 - v2
Checksum:i023328737EF57F44
GO
Isoform 2 (identifier: Q80TI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-681: Missing.
     682-690: PTVKGWLTK → MCVCSCCSL

Note: No experimental confirmation available.
Show »
Length:675
Mass (Da):75,687
Checksum:iC65CB340E84515F7
GO

Sequence cautioni

The sequence BAC65746.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931R → K in BAC65746 (PubMed:12693553).Curated
Sequence conflicti726 – 7261Q → E in AAH28900 (PubMed:15489334).Curated
Sequence conflicti800 – 8034YEQL → HASV in AAH06045 (PubMed:15489334).Curated
Sequence conflicti1016 – 10161F → L in AAH28900 (PubMed:15489334).Curated
Sequence conflicti1156 – 11561T → A in BAC65746 (PubMed:12693553).Curated
Sequence conflicti1156 – 11561T → A in AAH06045 (PubMed:15489334).Curated
Sequence conflicti1156 – 11561T → A in AAH28900 (PubMed:15489334).Curated
Sequence conflicti1159 – 117214QHLLQ…RFYPR → PRPGWTVLCFCFLH in AAH06045 (PubMed:15489334).CuratedAdd
BLAST
Sequence conflicti1257 – 12571Missing in AAH28900 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 681681Missing in isoform 2. 1 PublicationVSP_029350Add
BLAST
Alternative sequencei682 – 6909PTVKGWLTK → MCVCSCCSL in isoform 2. 1 PublicationVSP_029351

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122464 mRNA. Translation: BAC65746.1. Different initiation.
AK052692 mRNA. Translation: BAC35099.1.
AK143387 mRNA. Translation: BAE25361.1.
BC006045 mRNA. Translation: AAH06045.1.
BC028900 mRNA. Translation: AAH28900.1.
CCDSiCCDS49097.1. [Q80TI1-1]
RefSeqiNP_851418.2. NM_181073.3. [Q80TI1-1]
XP_006515708.1. XM_006515645.2. [Q80TI1-1]
UniGeneiMm.478321.

Genome annotation databases

EnsembliENSMUST00000039928; ENSMUSP00000049460; ENSMUSG00000060716. [Q80TI1-1]
GeneIDi211945.
KEGGimmu:211945.
UCSCiuc007nzr.2. mouse. [Q80TI1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122464 mRNA. Translation: BAC65746.1. Different initiation.
AK052692 mRNA. Translation: BAC35099.1.
AK143387 mRNA. Translation: BAE25361.1.
BC006045 mRNA. Translation: AAH06045.1.
BC028900 mRNA. Translation: AAH28900.1.
CCDSiCCDS49097.1. [Q80TI1-1]
RefSeqiNP_851418.2. NM_181073.3. [Q80TI1-1]
XP_006515708.1. XM_006515645.2. [Q80TI1-1]
UniGeneiMm.478321.

3D structure databases

ProteinModelPortaliQ80TI1.
SMRiQ80TI1. Positions 575-674, 843-1318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049460.

PTM databases

iPTMnetiQ80TI1.
PhosphoSiteiQ80TI1.

Proteomic databases

MaxQBiQ80TI1.
PaxDbiQ80TI1.
PRIDEiQ80TI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039928; ENSMUSP00000049460; ENSMUSG00000060716. [Q80TI1-1]
GeneIDi211945.
KEGGimmu:211945.
UCSCiuc007nzr.2. mouse. [Q80TI1-1]

Organism-specific databases

CTDi57475.
MGIiMGI:2144989. Plekhh1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0248. Eukaryota.
ENOG410XPCT. LUCA.
GeneTreeiENSGT00780000121979.
HOGENOMiHOG000046075.
HOVERGENiHBG108258.
InParanoidiQ80TI1.
OMAiEATFIMA.
OrthoDBiEOG72VH56.
PhylomeDBiQ80TI1.
TreeFamiTF312866.

Miscellaneous databases

ChiTaRSiPlekhh1. mouse.
PROiQ80TI1.
SOURCEiSearch...

Gene expression databases

BgeeiQ80TI1.
GenevisibleiQ80TI1. MM.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000857. MyTH4_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00784. MyTH4. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00295. B41. 1 hit.
SM00139. MyTH4. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 3 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS51016. MYTH4. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Kidney and Ovary.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 726-1356.
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451 AND SER-739, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiPKHH1_MOUSE
AccessioniPrimary (citable) accession number: Q80TI1
Secondary accession number(s): Q3UPN4
, Q8BWF3, Q8K334, Q99JL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 8, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.