Q80TH2 (LAP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein LAP2

Alternative name(s):
Densin-180-like protein
Erbb2-interacting protein
Short name=Erbin

Gene names

Name:	Erbb2ip
Synonyms:	Erbin, Kiaa1225, Lap2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1402 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state By similarity.
Subunit structure	Interacts with ERBB2, BPAG1 and ITGB4. May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin. Interacts (via C-terminus) with DST (via N-terminus) By similarity.
Subcellular location	Cell junction › hemidesmosome By similarity. Nucleus membrane. Note: Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane By similarity. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. Ref.8
Post-translational modification	Isoform 2 is phosphorylated on Ser-1231 and Ser-1234.
Sequence similarities	Belongs to the LAP (LRR and PDZ) protein family. Contains 17 LRR (leucine-rich) repeats. Contains 1 PDZ (DHR) domain.
Sequence caution	The sequence BAC65755.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cell junction Membrane Nucleus
Coding sequence diversity	Alternative splicing
Domain	Leucine-rich repeat Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein targeting Inferred from direct assay Ref.5. Source: MGI
Cellular_component	basolateral plasma membrane Inferred from direct assay Ref.5. Source: MGI cytoplasm Inferred from electronic annotation. Source: Compara hemidesmosome Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q80TH2-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q80TH2-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1243-1268: Missing.

Isoform 2 (identifier: Q80TH2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1203-1203: K → KSMLSRSFNSNLTAVSSSHYGSSRDLHGSQGSLALSVADGRGSGGHIFR

Note: Contains a phosphoserine at position 1231. Contains a phosphoserine at position 1234.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1402	1402	Protein LAP2		PRO_0000188302
Regions
	Repeat	23 – 44	22	LRR 1
	Repeat	47 – 68	22	LRR 2
	Repeat	70 – 91	22	LRR 3
	Repeat	93 – 114	22	LRR 4
	Repeat	116 – 137	22	LRR 5
	Repeat	139 – 161	23	LRR 6
	Repeat	162 – 183	22	LRR 7
	Repeat	185 – 206	22	LRR 8
	Repeat	208 – 229	22	LRR 9
	Repeat	231 – 252	22	LRR 10
	Repeat	254 – 275	22	LRR 11
	Repeat	277 – 298	22	LRR 12
	Repeat	300 – 321	22	LRR 13
	Repeat	323 – 344	22	LRR 14
	Repeat	346 – 367	22	LRR 15
	Repeat	369 – 391	23	LRR 16
	Repeat	392 – 413	22	LRR 17
	Domain	1311 – 1400	90	PDZ
	Compositional bias	928 – 931	4	Poly-Ser
Amino acid modifications
	Modified residue	440	1	Phosphoserine By similarity
	Modified residue	595	1	Phosphoserine Ref.9
	Modified residue	599	1	Phosphoserine Ref.9 Ref.10
	Modified residue	600	1	Phosphoserine Ref.9 Ref.10
	Modified residue	712	1	Phosphoserine Ref.9 Ref.10
	Modified residue	850	1	Phosphothreonine Ref.7
	Modified residue	854	1	Phosphoserine Ref.10
	Modified residue	869	1	Phosphoserine Ref.9
	Modified residue	914	1	Phosphothreonine By similarity
	Modified residue	917	1	Phosphotyrosine By similarity
	Modified residue	928	1	Phosphoserine By similarity
	Modified residue	970	1	Phosphotyrosine By similarity
	Modified residue	1097	1	Phosphotyrosine Ref.6
	Modified residue	1150	1	Phosphoserine By similarity
	Modified residue	1171	1	Phosphoserine Ref.9
	Modified residue	1276	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1203	1	K → KSMLSRSFNSNLTAVSSSHY GSSRDLHGSQGSLALSVADG RGSGGHIFR in isoform 2.		VSP_010808
	Alternative sequence	1243 – 1268	26	Missing in isoform 1.		VSP_010809
Experimental info
	Sequence conflict	255	1	L → P in BAC65755. Ref.1
	Sequence conflict	721 – 723	3	DKK → HAS in AAH28256. Ref.4
	Sequence conflict	908 – 910	3	VRS → ASG in AAF77047. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified July 27, 2011. Version 3. Checksum: DBAFF4BD1BC48019	FASTA	1,402	157,248
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLR EFWMDGNRLT FIPGFIGSLR QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDFLL SSNSLQQLPE TIGSLKNVTT LKIDENQLMY LPDSIGGLRS 310 320 330 340 350 360 IEELDCSFNE IEALPSSIGQ LTNMRTFAAD HNYLQQLPPE IGNWKNITVL FLHCNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDTETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPALW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEESGRDLKQ HEDQQVVNKD KCVKTSESTT 550 560 570 580 590 600 TKSKLDEREK YMNSVQKMSE PEAETNGGNL PVTASMKLSG NLKHIVNHDD VFEESEELSS 610 620 630 640 650 660 DEEMKMAEMR PPLIESSINQ PKVVALSNNK KDDAKDADSL SDEVTHNSNQ NNSNCSSPSR 670 680 690 700 710 720 MSDSVSLNTD SSQDTSLCSP VKQTPVDSNS KVRQEDENFN SLLQNGVNLN NSPEEKFKIN 730 740 750 760 770 780 DKKDFKLPEY DLNIEEQLVL IEKDIDSKAT SDDSRQLDHI NMNINKLVTN NIFQPEVMER 790 800 810 820 830 840 SKMQDIVLGT GFLSIHPKNE AEHIENGAKF PNLESINKVN GLCEDTAPSP GRVEPQKASS 850 860 870 880 890 900 SADVGISKST EDLSPQRSGP TGAVVKSHSI TNMETGGLKI YDILGDDGPQ PPSAAVKIAS 910 920 930 940 950 960 AVDGKNIVRS KSATLLYDQP LQVFTAASSS SELLSGTKAV FKFDSNHNPE EPDIIRAATV 970 980 990 1000 1010 1020 SGPQSTPHLY GPPQYNVQYS GSATVKDTLW HPKQNPQIDP VSFPPQRLPR SESAENHSYA 1030 1040 1050 1060 1070 1080 KHSANMNFSN HNNVRANTGY HLQQRLAPAR HGEMWAISPN DRLVPAVTRT TIQRQSSVSS 1090 1100 1110 1120 1130 1140 TASVNLGDPT RRTEGDYLSY RELHSMGRTP VMSGSQRPLS ARAYSIDGPN TSRPQSARPS 1150 1160 1170 1180 1190 1200 INEIPERTMS VSDFNYSRTS PSKRPNTRVG SEHSLLDPPG KSKVPHDWRE QVLRHIEAKK 1210 1220 1230 1240 1250 1260 LEKHPQTSSP GECCQDDRFM SEEQNHPSGA LSHRGLPDSL MKMPLSNGQM GQPLRPQAHY 1270 1280 1290 1300 1310 1320 SQTHHPPQAS VARHPSREQL IDYLMLKVAH QPPYTHPHCS PRQGHELAKQ EIRVRVEKDP 1330 1340 1350 1360 1370 1380 ELGFSISGGV GGRGNPFRPD DDGIFVTRVQ PEGPASKLLQ PGDKIIQANG YSFINIEHGQ 1390 1400 AVSLLKTFHN AVDLIIVREV SS
	Isoform 1 [UniParc]. Checksum: 97A2B69F116DB166	FASTA	1,376	154,328
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLR EFWMDGNRLT FIPGFIGSLR QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDFLL SSNSLQQLPE TIGSLKNVTT LKIDENQLMY LPDSIGGLRS 310 320 330 340 350 360 IEELDCSFNE IEALPSSIGQ LTNMRTFAAD HNYLQQLPPE IGNWKNITVL FLHCNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDTETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPALW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEESGRDLKQ HEDQQVVNKD KCVKTSESTT 550 560 570 580 590 600 TKSKLDEREK YMNSVQKMSE PEAETNGGNL PVTASMKLSG NLKHIVNHDD VFEESEELSS 610 620 630 640 650 660 DEEMKMAEMR PPLIESSINQ PKVVALSNNK KDDAKDADSL SDEVTHNSNQ NNSNCSSPSR 670 680 690 700 710 720 MSDSVSLNTD SSQDTSLCSP VKQTPVDSNS KVRQEDENFN SLLQNGVNLN NSPEEKFKIN 730 740 750 760 770 780 DKKDFKLPEY DLNIEEQLVL IEKDIDSKAT SDDSRQLDHI NMNINKLVTN NIFQPEVMER 790 800 810 820 830 840 SKMQDIVLGT GFLSIHPKNE AEHIENGAKF PNLESINKVN GLCEDTAPSP GRVEPQKASS 850 860 870 880 890 900 SADVGISKST EDLSPQRSGP TGAVVKSHSI TNMETGGLKI YDILGDDGPQ PPSAAVKIAS 910 920 930 940 950 960 AVDGKNIVRS KSATLLYDQP LQVFTAASSS SELLSGTKAV FKFDSNHNPE EPDIIRAATV 970 980 990 1000 1010 1020 SGPQSTPHLY GPPQYNVQYS GSATVKDTLW HPKQNPQIDP VSFPPQRLPR SESAENHSYA 1030 1040 1050 1060 1070 1080 KHSANMNFSN HNNVRANTGY HLQQRLAPAR HGEMWAISPN DRLVPAVTRT TIQRQSSVSS 1090 1100 1110 1120 1130 1140 TASVNLGDPT RRTEGDYLSY RELHSMGRTP VMSGSQRPLS ARAYSIDGPN TSRPQSARPS 1150 1160 1170 1180 1190 1200 INEIPERTMS VSDFNYSRTS PSKRPNTRVG SEHSLLDPPG KSKVPHDWRE QVLRHIEAKK 1210 1220 1230 1240 1250 1260 LEKHPQTSSP GECCQDDRFM SEEQNHPSGA LSHRGLPDSL MKASVARHPS REQLIDYLML 1270 1280 1290 1300 1310 1320 KVAHQPPYTH PHCSPRQGHE LAKQEIRVRV EKDPELGFSI SGGVGGRGNP FRPDDDGIFV 1330 1340 1350 1360 1370 TRVQPEGPAS KLLQPGDKII QANGYSFINI EHGQAVSLLK TFHNAVDLII VREVSS
	Isoform 2 [UniParc]. Checksum: 4D8113A7636EE4DC	FASTA	1,450	162,183
	10 20 30 40 50 60 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE 70 80 90 100 110 120 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 130 140 150 160 170 180 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 190 200 210 220 230 240 NRLTQLERLD LGSNEFTEVP EVLEQLSGLR EFWMDGNRLT FIPGFIGSLR QLTYLDVSKN 250 260 270 280 290 300 NIEMVEEGIS TCENLQDFLL SSNSLQQLPE TIGSLKNVTT LKIDENQLMY LPDSIGGLRS 310 320 330 340 350 360 IEELDCSFNE IEALPSSIGQ LTNMRTFAAD HNYLQQLPPE IGNWKNITVL FLHCNKLETL 370 380 390 400 410 420 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDTETQKM 430 440 450 460 470 480 VLTNYMFPQQ PRTEDVMFIS DNESFNPALW EEQRKQRAQV AFECDEDKDE REAPPREGNL 490 500 510 520 530 540 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEESGRDLKQ HEDQQVVNKD KCVKTSESTT 550 560 570 580 590 600 TKSKLDEREK YMNSVQKMSE PEAETNGGNL PVTASMKLSG NLKHIVNHDD VFEESEELSS 610 620 630 640 650 660 DEEMKMAEMR PPLIESSINQ PKVVALSNNK KDDAKDADSL SDEVTHNSNQ NNSNCSSPSR 670 680 690 700 710 720 MSDSVSLNTD SSQDTSLCSP VKQTPVDSNS KVRQEDENFN SLLQNGVNLN NSPEEKFKIN 730 740 750 760 770 780 DKKDFKLPEY DLNIEEQLVL IEKDIDSKAT SDDSRQLDHI NMNINKLVTN NIFQPEVMER 790 800 810 820 830 840 SKMQDIVLGT GFLSIHPKNE AEHIENGAKF PNLESINKVN GLCEDTAPSP GRVEPQKASS 850 860 870 880 890 900 SADVGISKST EDLSPQRSGP TGAVVKSHSI TNMETGGLKI YDILGDDGPQ PPSAAVKIAS 910 920 930 940 950 960 AVDGKNIVRS KSATLLYDQP LQVFTAASSS SELLSGTKAV FKFDSNHNPE EPDIIRAATV 970 980 990 1000 1010 1020 SGPQSTPHLY GPPQYNVQYS GSATVKDTLW HPKQNPQIDP VSFPPQRLPR SESAENHSYA 1030 1040 1050 1060 1070 1080 KHSANMNFSN HNNVRANTGY HLQQRLAPAR HGEMWAISPN DRLVPAVTRT TIQRQSSVSS 1090 1100 1110 1120 1130 1140 TASVNLGDPT RRTEGDYLSY RELHSMGRTP VMSGSQRPLS ARAYSIDGPN TSRPQSARPS 1150 1160 1170 1180 1190 1200 INEIPERTMS VSDFNYSRTS PSKRPNTRVG SEHSLLDPPG KSKVPHDWRE QVLRHIEAKK 1210 1220 1230 1240 1250 1260 LEKSMLSRSF NSNLTAVSSS HYGSSRDLHG SQGSLALSVA DGRGSGGHIF RHPQTSSPGE 1270 1280 1290 1300 1310 1320 CCQDDRFMSE EQNHPSGALS HRGLPDSLMK MPLSNGQMGQ PLRPQAHYSQ THHPPQASVA 1330 1340 1350 1360 1370 1380 RHPSREQLID YLMLKVAHQP PYTHPHCSPR QGHELAKQEI RVRVEKDPEL GFSISGGVGG 1390 1400 1410 1420 1430 1440 RGNPFRPDDD GIFVTRVQPE GPASKLLQPG DKIIQANGYS FINIEHGQAV SLLKTFHNAV 1450 DLIIVREVSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 308-1376 (ISOFORMS 2 AND 3). Strain: C57BL/6J. Tissue: Skin and Spinal ganglion.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 721-1402 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1160-1402 (ISOFORM 1). Tissue: Colon and Mammary tumor.
[5]	"ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor." Borg J.-P., Marchetto S., Le Bivic A., Ollendorff V., Jaulin-Bastard F., Saito H., Fournier E., Adelaide J., Margolis B., Birnbaum D. Nat. Cell Biol. 2:407-414(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 908-1402 (ISOFORM 3).
[6]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1097, MASS SPECTROMETRY. Tissue: Mast cell.
[7]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-850, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1231 AND SER-1234 (ISOFORM 2), MASS SPECTROMETRY. Tissue: Liver.
[8]	"Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes." Wright C.D., Chen Q., Baye N.L., Huang Y., Healy C.L., Kasinathan S., O'Connell T.D. Circ. Res. 103:992-1000(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[9]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-595; SER-599; SER-600; SER-712; SER-869 AND SER-1171, MASS SPECTROMETRY. Tissue: Melanoma.
[10]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-599; SER-600; SER-712; SER-854 AND SER-1276, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK122473 mRNA. Translation: BAC65755.1. Different initiation. AC154310 Genomic DNA. No translation available. CT009728 Genomic DNA. No translation available. AK029054 mRNA. Translation: BAC26267.1. AK051733 mRNA. Translation: BAC34742.1. BC005691 mRNA. Translation: AAH05691.3. BC028256 mRNA. Translation: AAH28256.1. AF263743 mRNA. Translation: AAF77047.1.
IPI	IPI00454041. IPI00457485. IPI00896710.
RefSeq	NP_001005868.1. NM_001005868.1. NP_067538.2. NM_021563.2.
UniGene	Mm.277354.
3D structure databases
ProteinModelPortal	Q80TH2.
SMR	Q80TH2. Positions 24-404, 1273-1402.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-138078.
PTM databases
PhosphoSite	Q80TH2.
Proteomic databases
PaxDb	Q80TH2.
PRIDE	Q80TH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022222; ENSMUSP00000022222; ENSMUSG00000021709. ENSMUST00000053927; ENSMUSP00000057956; ENSMUSG00000021709. ENSMUST00000091269; ENSMUSP00000088813; ENSMUSG00000021709.
GeneID	59079.
KEGG	mmu:59079.
UCSC	uc007rsm.1. mouse.
Organism-specific databases
CTD	55914.
MGI	MGI:1890169. Erbb2ip.
Rouge	Search...
Phylogenomic databases
eggNOG	COG4886.
GeneTree	ENSGT00650000093182.
HOVERGEN	HBG052305.
KO	K12796.
OMA	HNNVRAN.
OrthoDB	EOG41JZBG.
Gene expression databases
ArrayExpress	Q80TH2.
Bgee	Q80TH2.
CleanEx	MM_ERBB2IP.
Genevestigator	Q80TH2.
GermOnline	ENSMUSG00000021709. Mus musculus.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR025875. Leu-rich_rpt_4. IPR001478. PDZ. [Graphical view]
Pfam	PF12799. LRR_4. 2 hits. PF00595. PDZ. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit.
PROSITE	PS51450. LRR. 13 hits. PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	314720.
SOURCE	Search...

Entry information

Entry name

LAP2_MOUSE

Accession

Primary (citable) accession number: Q80TH2
Secondary accession number(s): E9QND6 , Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program