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Q80TG1

- KANL1_MOUSE

UniProt

Q80TG1 - KANL1_MOUSE

Protein

KAT8 regulatory NSL complex subunit 1

Gene

Kansl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.By similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity (H4-K16 specific) Source: Ensembl
    2. histone acetyltransferase activity (H4-K5 specific) Source: Ensembl
    3. histone acetyltransferase activity (H4-K8 specific) Source: Ensembl

    GO - Biological processi

    1. histone H4-K16 acetylation Source: UniProtKB
    2. histone H4-K5 acetylation Source: UniProtKB
    3. histone H4-K8 acetylation Source: UniProtKB

    Keywords - Molecular functioni

    Chromatin regulator

    Enzyme and pathway databases

    ReactomeiREACT_226917. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KAT8 regulatory NSL complex subunit 1
    Alternative name(s):
    NSL complex protein NSL1
    Non-specific lethal 1 homolog
    Gene namesi
    Name:Kansl1
    Synonyms:Kiaa1267, Nsl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1923969. Kansl1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. histone acetyltransferase complex Source: UniProtKB
    2. MLL1 complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10361036KAT8 regulatory NSL complex subunit 1PRO_0000234566Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei104 – 1041N6-acetyllysineBy similarity
    Modified residuei249 – 2491PhosphoserineBy similarity
    Modified residuei268 – 2681PhosphoserineBy similarity
    Modified residuei922 – 9221PhosphoserineBy similarity
    Modified residuei934 – 9341PhosphothreonineBy similarity
    Modified residuei976 – 9761PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ80TG1.
    PRIDEiQ80TG1.

    PTM databases

    PhosphoSiteiQ80TG1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80TG1.
    BgeeiQ80TG1.
    CleanExiMM_1700081L11RIK.
    GenevestigatoriQ80TG1.

    Interactioni

    Subunit structurei

    Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KAT8; the interaction is direct By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ80TG1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni781 – 81333Required for activation of KAT8 histone acetyltransferase activityBy similarityAdd
    BLAST
    Regioni814 – 1036223Sufficient for interaction with KAT8By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili285 – 31228Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG87566.
    GeneTreeiENSGT00530000063688.
    HOVERGENiHBG080054.
    OrthoDBiEOG7VQJF6.

    Family and domain databases

    InterProiIPR026180. NSL1.
    IPR029332. PEHE_dom.
    [Graphical view]
    PANTHERiPTHR22443. PTHR22443. 1 hit.
    PfamiPF15275. PEHE. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80TG1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAMAPALTD AAAEAHHIRF KLAPPSSTLS PGSAENNGNA NILISANGTK     50
    RKAIAAEDPS LDFRNNPTKE DLGKLQPLVA SYLCSDVTSV PAKESLKLQG 100
    VFSKQTVLKS HPLLSQSYEL RAELLGRQPV LEFSLENLRT MNTSGQTALP 150
    QAPVNGLAKK LTKSSTHSDH DNSSSLNGGK RSLTSSSLQG GEVGGPDSGN 200
    LKGGMTNCTL PHRSLDIQHT TLYSNNSTAN KSSVNSMDQP ALQGSSRLSP 250
    STDSSSNLTN VKLEVKKSPL SSILFSALDS DTRITALLRR QADIEIRARR 300
    LQKRLQVVQA KQVERHLQHQ LGGFLETTLS KLPNLESLRS RSQLMLTRKA 350
    EAALRKAASE SATSEGLSNF LKSDSISEEL ERFTASGIAN LRCSEQAFDS 400
    DVTDSSSGGE SDIEEEELTR ADPEQCHVPL KRRSEWRWAA DRAAIVSRWN 450
    WLQAHVSDLE YRIRQQTDIY KQIRANKGLI VLGEAPFPDH TTDLLSLSSE 500
    VKTDHGRDKL IESVSQPSEN HGILVSNITE SLSTKSCGAP RPVNGVVNSL 550
    QPVLADQVPG DSSDAEEQLH KKQRLNLVSS SDGTCVAART RPVLTCKKRR 600
    LVRPSSIVPL SKKVHRNVRS GCDVNPSCAL CGSGSVNTMP PEIHYEAPLL 650
    ERLSQLDSCV HPVLAFPDDV PTSLHFQSML KSQWQNKPFD KIKPTKKFSL 700
    KHRATMPCSL SDPVRKDRHK LVNSFLTTAM LKHHTDMSSP SYLTATHHPP 750
    HSPLVRQLST SSDTSTPTSS GSQVAASTSQ PVRRRRGESS FDINNIVIPM 800
    SVAATTRVEK LQYKEILTPS WREVDVQSLK GSPDEENEEI EDLSDAAFAA 850
    LHAKCEEMER ARWLWTTSVP PQRRGSRSYR SSDGRTTPQL GSANPSTPQP 900
    ASPDVSSSHS LSEFSHGQSP RSPISPELHS APLTPVARDS LRHLASEDTR 950
    CSTPELGLDE QSVQPWERRT FPLAYSPQAE CEEQLDAQDT AARCTRRTSG 1000
    SKTGREAEVA PTSPPVVPLK SRHLAATVTA QRPAHR 1036
    Length:1,036
    Mass (Da):113,179
    Last modified:June 1, 2003 - v1
    Checksum:iF619B60DEEE93A62
    GO
    Isoform 2 (identifier: Q80TG1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         615-643: HRNVRSGCDVNPSCALCGSGSVNTMPPEI → GAQRTGLRSALILSRVGEPPSSPVNLQNY
         644-1036: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:643
    Mass (Da):69,724
    Checksum:i74B228E59E1B3DA6
    GO
    Isoform 3 (identifier: Q80TG1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         478-510: Missing.
         615-643: HRNVRSGCDVNPSCALCGSGSVNTMPPEI → GAQRTGLRSALILSRVGEPPSSPVNLQNY
         644-1036: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:610
    Mass (Da):66,180
    Checksum:iEF19107E16ABE383
    GO
    Isoform 4 (identifier: Q80TG1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         431-1036: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:430
    Mass (Da):46,184
    Checksum:i832BDE9011CBA181
    GO
    Isoform 5 (identifier: Q80TG1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-770: Missing.
         771-779: GSQVAASTS → MCSLRSWNQ

    Note: No experimental confirmation available.

    Show »
    Length:266
    Mass (Da):29,518
    Checksum:iEE0BA4E50B0A6286
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti197 – 1971D → N in BAE36437. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 770770Missing in isoform 5. 1 PublicationVSP_018360Add
    BLAST
    Alternative sequencei431 – 1036606Missing in isoform 4. 1 PublicationVSP_018361Add
    BLAST
    Alternative sequencei478 – 51033Missing in isoform 3. 1 PublicationVSP_018362Add
    BLAST
    Alternative sequencei615 – 64329HRNVR…MPPEI → GAQRTGLRSALILSRVGEPP SSPVNLQNY in isoform 2 and isoform 3. 2 PublicationsVSP_018363Add
    BLAST
    Alternative sequencei644 – 1036393Missing in isoform 2 and isoform 3. 2 PublicationsVSP_018364Add
    BLAST
    Alternative sequencei771 – 7799GSQVAASTS → MCSLRSWNQ in isoform 5. 1 PublicationVSP_018365

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122484 mRNA. Translation: BAC65766.1.
    AK006970 mRNA. Translation: BAB24813.1.
    AK037800 mRNA. Translation: BAE20523.1.
    AK153679 mRNA. Translation: BAE32141.1.
    AK161514 mRNA. Translation: BAE36437.1.
    AL593843 Genomic DNA. Translation: CAM14793.1.
    BC025052 mRNA. Translation: AAH25052.1.
    BC043121 mRNA. Translation: AAH43121.2.
    BC053389 mRNA. Translation: AAH53389.2.
    BC054752 mRNA. Translation: AAH54752.2.
    BC079594 mRNA. Translation: AAH79594.1.
    CCDSiCCDS48953.1. [Q80TG1-1]
    RefSeqiNP_001074514.1. NM_001081045.1. [Q80TG1-1]
    XP_006534516.1. XM_006534453.1. [Q80TG1-1]
    UniGeneiMm.136418.

    Genome annotation databases

    EnsembliENSMUST00000018556; ENSMUSP00000018556; ENSMUSG00000018412. [Q80TG1-1]
    ENSMUST00000106977; ENSMUSP00000102590; ENSMUSG00000018412. [Q80TG1-1]
    GeneIDi76719.
    KEGGimmu:76719.
    UCSCiuc007lwj.1. mouse. [Q80TG1-1]
    uc007lwm.1. mouse. [Q80TG1-3]
    uc007lwn.1. mouse. [Q80TG1-2]
    uc007lwo.1. mouse. [Q80TG1-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122484 mRNA. Translation: BAC65766.1 .
    AK006970 mRNA. Translation: BAB24813.1 .
    AK037800 mRNA. Translation: BAE20523.1 .
    AK153679 mRNA. Translation: BAE32141.1 .
    AK161514 mRNA. Translation: BAE36437.1 .
    AL593843 Genomic DNA. Translation: CAM14793.1 .
    BC025052 mRNA. Translation: AAH25052.1 .
    BC043121 mRNA. Translation: AAH43121.2 .
    BC053389 mRNA. Translation: AAH53389.2 .
    BC054752 mRNA. Translation: AAH54752.2 .
    BC079594 mRNA. Translation: AAH79594.1 .
    CCDSi CCDS48953.1. [Q80TG1-1 ]
    RefSeqi NP_001074514.1. NM_001081045.1. [Q80TG1-1 ]
    XP_006534516.1. XM_006534453.1. [Q80TG1-1 ]
    UniGenei Mm.136418.

    3D structure databases

    ProteinModelPortali Q80TG1.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q80TG1.

    Proteomic databases

    PaxDbi Q80TG1.
    PRIDEi Q80TG1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018556 ; ENSMUSP00000018556 ; ENSMUSG00000018412 . [Q80TG1-1 ]
    ENSMUST00000106977 ; ENSMUSP00000102590 ; ENSMUSG00000018412 . [Q80TG1-1 ]
    GeneIDi 76719.
    KEGGi mmu:76719.
    UCSCi uc007lwj.1. mouse. [Q80TG1-1 ]
    uc007lwm.1. mouse. [Q80TG1-3 ]
    uc007lwn.1. mouse. [Q80TG1-2 ]
    uc007lwo.1. mouse. [Q80TG1-4 ]

    Organism-specific databases

    CTDi 284058.
    MGIi MGI:1923969. Kansl1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG87566.
    GeneTreei ENSGT00530000063688.
    HOVERGENi HBG080054.
    OrthoDBi EOG7VQJF6.

    Enzyme and pathway databases

    Reactomei REACT_226917. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 345681.
    PROi Q80TG1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80TG1.
    Bgeei Q80TG1.
    CleanExi MM_1700081L11RIK.
    Genevestigatori Q80TG1.

    Family and domain databases

    InterProi IPR026180. NSL1.
    IPR029332. PEHE_dom.
    [Graphical view ]
    PANTHERi PTHR22443. PTHR22443. 1 hit.
    Pfami PF15275. PEHE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 5).
      Strain: C57BL/6J.
      Tissue: Testis and Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: C3H/He, C57BL/6 and FVB/N.
      Tissue: Embryonic brain, Mammary gland and Mesenchymal stem cell.

    Entry informationi

    Entry nameiKANL1_MOUSE
    AccessioniPrimary (citable) accession number: Q80TG1
    Secondary accession number(s): A2A5Y5
    , Q3TT88, Q3U5D8, Q3V3N3, Q7TMU3, Q80XP7, Q8R3L6, Q9D9G0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3