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Protein

KAT8 regulatory NSL complex subunit 1

Gene

Kansl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Enzyme and pathway databases

ReactomeiR-MMU-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
KAT8 regulatory NSL complex subunit 1
Alternative name(s):
NSL complex protein NSL1
Non-specific lethal 1 homolog
Gene namesi
Name:Kansl1
Synonyms:Kiaa1267, Nsl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923969. Kansl1.

Subcellular locationi

  • Nucleus By similarity
  • Chromosomecentromerekinetochore By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345661 – 1036KAT8 regulatory NSL complex subunit 1Add BLAST1036

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104N6-acetyllysineBy similarity1
Modified residuei249PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1
Modified residuei922PhosphoserineBy similarity1
Modified residuei925PhosphoserineBy similarity1
Modified residuei934PhosphothreonineBy similarity1
Modified residuei976PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80TG1.
PaxDbiQ80TG1.
PeptideAtlasiQ80TG1.
PRIDEiQ80TG1.

PTM databases

iPTMnetiQ80TG1.
PhosphoSitePlusiQ80TG1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018412.
CleanExiMM_1700081L11RIK.
ExpressionAtlasiQ80TG1. baseline and differential.
GenevisibleiQ80TG1. MM.

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KAT8; the interaction is direct (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018556.

Structurei

3D structure databases

ProteinModelPortaliQ80TG1.
SMRiQ80TG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni781 – 813Required for activation of KAT8 histone acetyltransferase activityBy similarityAdd BLAST33
Regioni814 – 1036Sufficient for interaction with KAT8By similarityAdd BLAST223

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili285 – 312Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKZN. Eukaryota.
ENOG410ZYQQ. LUCA.
GeneTreeiENSGT00530000063688.
HOVERGENiHBG080054.
InParanoidiQ80TG1.
KOiK18400.

Family and domain databases

InterProiIPR026180. NSL1.
IPR029332. PEHE_dom.
[Graphical view]
PANTHERiPTHR22443. PTHR22443. 1 hit.
PfamiPF15275. PEHE. 1 hit.
[Graphical view]
SMARTiSM01300. PEHE. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMAPALTD AAAEAHHIRF KLAPPSSTLS PGSAENNGNA NILISANGTK
60 70 80 90 100
RKAIAAEDPS LDFRNNPTKE DLGKLQPLVA SYLCSDVTSV PAKESLKLQG
110 120 130 140 150
VFSKQTVLKS HPLLSQSYEL RAELLGRQPV LEFSLENLRT MNTSGQTALP
160 170 180 190 200
QAPVNGLAKK LTKSSTHSDH DNSSSLNGGK RSLTSSSLQG GEVGGPDSGN
210 220 230 240 250
LKGGMTNCTL PHRSLDIQHT TLYSNNSTAN KSSVNSMDQP ALQGSSRLSP
260 270 280 290 300
STDSSSNLTN VKLEVKKSPL SSILFSALDS DTRITALLRR QADIEIRARR
310 320 330 340 350
LQKRLQVVQA KQVERHLQHQ LGGFLETTLS KLPNLESLRS RSQLMLTRKA
360 370 380 390 400
EAALRKAASE SATSEGLSNF LKSDSISEEL ERFTASGIAN LRCSEQAFDS
410 420 430 440 450
DVTDSSSGGE SDIEEEELTR ADPEQCHVPL KRRSEWRWAA DRAAIVSRWN
460 470 480 490 500
WLQAHVSDLE YRIRQQTDIY KQIRANKGLI VLGEAPFPDH TTDLLSLSSE
510 520 530 540 550
VKTDHGRDKL IESVSQPSEN HGILVSNITE SLSTKSCGAP RPVNGVVNSL
560 570 580 590 600
QPVLADQVPG DSSDAEEQLH KKQRLNLVSS SDGTCVAART RPVLTCKKRR
610 620 630 640 650
LVRPSSIVPL SKKVHRNVRS GCDVNPSCAL CGSGSVNTMP PEIHYEAPLL
660 670 680 690 700
ERLSQLDSCV HPVLAFPDDV PTSLHFQSML KSQWQNKPFD KIKPTKKFSL
710 720 730 740 750
KHRATMPCSL SDPVRKDRHK LVNSFLTTAM LKHHTDMSSP SYLTATHHPP
760 770 780 790 800
HSPLVRQLST SSDTSTPTSS GSQVAASTSQ PVRRRRGESS FDINNIVIPM
810 820 830 840 850
SVAATTRVEK LQYKEILTPS WREVDVQSLK GSPDEENEEI EDLSDAAFAA
860 870 880 890 900
LHAKCEEMER ARWLWTTSVP PQRRGSRSYR SSDGRTTPQL GSANPSTPQP
910 920 930 940 950
ASPDVSSSHS LSEFSHGQSP RSPISPELHS APLTPVARDS LRHLASEDTR
960 970 980 990 1000
CSTPELGLDE QSVQPWERRT FPLAYSPQAE CEEQLDAQDT AARCTRRTSG
1010 1020 1030
SKTGREAEVA PTSPPVVPLK SRHLAATVTA QRPAHR
Length:1,036
Mass (Da):113,179
Last modified:June 1, 2003 - v1
Checksum:iF619B60DEEE93A62
GO
Isoform 2 (identifier: Q80TG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     615-643: HRNVRSGCDVNPSCALCGSGSVNTMPPEI → GAQRTGLRSALILSRVGEPPSSPVNLQNY
     644-1036: Missing.

Note: No experimental confirmation available.
Show »
Length:643
Mass (Da):69,724
Checksum:i74B228E59E1B3DA6
GO
Isoform 3 (identifier: Q80TG1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     478-510: Missing.
     615-643: HRNVRSGCDVNPSCALCGSGSVNTMPPEI → GAQRTGLRSALILSRVGEPPSSPVNLQNY
     644-1036: Missing.

Note: No experimental confirmation available.
Show »
Length:610
Mass (Da):66,180
Checksum:iEF19107E16ABE383
GO
Isoform 4 (identifier: Q80TG1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-1036: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):46,184
Checksum:i832BDE9011CBA181
GO
Isoform 5 (identifier: Q80TG1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-770: Missing.
     771-779: GSQVAASTS → MCSLRSWNQ

Note: No experimental confirmation available.
Show »
Length:266
Mass (Da):29,518
Checksum:iEE0BA4E50B0A6286
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197D → N in BAE36437 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0183601 – 770Missing in isoform 5. 1 PublicationAdd BLAST770
Alternative sequenceiVSP_018361431 – 1036Missing in isoform 4. 1 PublicationAdd BLAST606
Alternative sequenceiVSP_018362478 – 510Missing in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_018363615 – 643HRNVR…MPPEI → GAQRTGLRSALILSRVGEPP SSPVNLQNY in isoform 2 and isoform 3. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_018364644 – 1036Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST393
Alternative sequenceiVSP_018365771 – 779GSQVAASTS → MCSLRSWNQ in isoform 5. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122484 mRNA. Translation: BAC65766.1.
AK006970 mRNA. Translation: BAB24813.1.
AK037800 mRNA. Translation: BAE20523.1.
AK153679 mRNA. Translation: BAE32141.1.
AK161514 mRNA. Translation: BAE36437.1.
AL593843 Genomic DNA. Translation: CAM14793.1.
BC025052 mRNA. Translation: AAH25052.1.
BC043121 mRNA. Translation: AAH43121.2.
BC053389 mRNA. Translation: AAH53389.2.
BC054752 mRNA. Translation: AAH54752.2.
BC079594 mRNA. Translation: AAH79594.1.
CCDSiCCDS48953.1. [Q80TG1-1]
RefSeqiNP_001074514.1. NM_001081045.1. [Q80TG1-1]
XP_006534516.1. XM_006534453.3. [Q80TG1-1]
XP_011247610.1. XM_011249308.2. [Q80TG1-1]
XP_017170320.1. XM_017314831.1. [Q80TG1-1]
UniGeneiMm.136418.

Genome annotation databases

EnsembliENSMUST00000018556; ENSMUSP00000018556; ENSMUSG00000018412. [Q80TG1-1]
ENSMUST00000106977; ENSMUSP00000102590; ENSMUSG00000018412. [Q80TG1-1]
GeneIDi76719.
KEGGimmu:76719.
UCSCiuc007lwj.1. mouse. [Q80TG1-1]
uc007lwm.1. mouse. [Q80TG1-3]
uc007lwn.1. mouse. [Q80TG1-2]
uc007lwo.1. mouse. [Q80TG1-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122484 mRNA. Translation: BAC65766.1.
AK006970 mRNA. Translation: BAB24813.1.
AK037800 mRNA. Translation: BAE20523.1.
AK153679 mRNA. Translation: BAE32141.1.
AK161514 mRNA. Translation: BAE36437.1.
AL593843 Genomic DNA. Translation: CAM14793.1.
BC025052 mRNA. Translation: AAH25052.1.
BC043121 mRNA. Translation: AAH43121.2.
BC053389 mRNA. Translation: AAH53389.2.
BC054752 mRNA. Translation: AAH54752.2.
BC079594 mRNA. Translation: AAH79594.1.
CCDSiCCDS48953.1. [Q80TG1-1]
RefSeqiNP_001074514.1. NM_001081045.1. [Q80TG1-1]
XP_006534516.1. XM_006534453.3. [Q80TG1-1]
XP_011247610.1. XM_011249308.2. [Q80TG1-1]
XP_017170320.1. XM_017314831.1. [Q80TG1-1]
UniGeneiMm.136418.

3D structure databases

ProteinModelPortaliQ80TG1.
SMRiQ80TG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018556.

PTM databases

iPTMnetiQ80TG1.
PhosphoSitePlusiQ80TG1.

Proteomic databases

EPDiQ80TG1.
PaxDbiQ80TG1.
PeptideAtlasiQ80TG1.
PRIDEiQ80TG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018556; ENSMUSP00000018556; ENSMUSG00000018412. [Q80TG1-1]
ENSMUST00000106977; ENSMUSP00000102590; ENSMUSG00000018412. [Q80TG1-1]
GeneIDi76719.
KEGGimmu:76719.
UCSCiuc007lwj.1. mouse. [Q80TG1-1]
uc007lwm.1. mouse. [Q80TG1-3]
uc007lwn.1. mouse. [Q80TG1-2]
uc007lwo.1. mouse. [Q80TG1-4]

Organism-specific databases

CTDi284058.
MGIiMGI:1923969. Kansl1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IKZN. Eukaryota.
ENOG410ZYQQ. LUCA.
GeneTreeiENSGT00530000063688.
HOVERGENiHBG080054.
InParanoidiQ80TG1.
KOiK18400.

Enzyme and pathway databases

ReactomeiR-MMU-3214847. HATs acetylate histones.

Miscellaneous databases

PROiQ80TG1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018412.
CleanExiMM_1700081L11RIK.
ExpressionAtlasiQ80TG1. baseline and differential.
GenevisibleiQ80TG1. MM.

Family and domain databases

InterProiIPR026180. NSL1.
IPR029332. PEHE_dom.
[Graphical view]
PANTHERiPTHR22443. PTHR22443. 1 hit.
PfamiPF15275. PEHE. 1 hit.
[Graphical view]
SMARTiSM01300. PEHE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKANL1_MOUSE
AccessioniPrimary (citable) accession number: Q80TG1
Secondary accession number(s): A2A5Y5
, Q3TT88, Q3U5D8, Q3V3N3, Q7TMU3, Q80XP7, Q8R3L6, Q9D9G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.