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Protein

KAT8 regulatory NSL complex subunit 1

Gene

Kansl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Enzyme and pathway databases

ReactomeiREACT_291621. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
KAT8 regulatory NSL complex subunit 1
Alternative name(s):
NSL complex protein NSL1
Non-specific lethal 1 homolog
Gene namesi
Name:Kansl1
Synonyms:Kiaa1267, Nsl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923969. Kansl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10361036KAT8 regulatory NSL complex subunit 1PRO_0000234566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041N6-acetyllysineBy similarity
Modified residuei249 – 2491PhosphoserineBy similarity
Modified residuei268 – 2681PhosphoserineBy similarity
Modified residuei922 – 9221PhosphoserineBy similarity
Modified residuei934 – 9341PhosphothreonineBy similarity
Modified residuei976 – 9761PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ80TG1.
PaxDbiQ80TG1.
PRIDEiQ80TG1.

PTM databases

PhosphoSiteiQ80TG1.

Expressioni

Gene expression databases

BgeeiQ80TG1.
CleanExiMM_1700081L11RIK.
ExpressionAtlasiQ80TG1. baseline and differential.
GenevisibleiQ80TG1. MM.

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KAT8; the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018556.

Structurei

3D structure databases

ProteinModelPortaliQ80TG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni781 – 81333Required for activation of KAT8 histone acetyltransferase activityBy similarityAdd
BLAST
Regioni814 – 1036223Sufficient for interaction with KAT8By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili285 – 31228Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG87566.
GeneTreeiENSGT00530000063688.
HOVERGENiHBG080054.
InParanoidiQ80TG1.
KOiK18400.
OrthoDBiEOG7VQJF6.

Family and domain databases

InterProiIPR026180. NSL1.
IPR029332. PEHE_dom.
[Graphical view]
PANTHERiPTHR22443. PTHR22443. 1 hit.
PfamiPF15275. PEHE. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMAPALTD AAAEAHHIRF KLAPPSSTLS PGSAENNGNA NILISANGTK
60 70 80 90 100
RKAIAAEDPS LDFRNNPTKE DLGKLQPLVA SYLCSDVTSV PAKESLKLQG
110 120 130 140 150
VFSKQTVLKS HPLLSQSYEL RAELLGRQPV LEFSLENLRT MNTSGQTALP
160 170 180 190 200
QAPVNGLAKK LTKSSTHSDH DNSSSLNGGK RSLTSSSLQG GEVGGPDSGN
210 220 230 240 250
LKGGMTNCTL PHRSLDIQHT TLYSNNSTAN KSSVNSMDQP ALQGSSRLSP
260 270 280 290 300
STDSSSNLTN VKLEVKKSPL SSILFSALDS DTRITALLRR QADIEIRARR
310 320 330 340 350
LQKRLQVVQA KQVERHLQHQ LGGFLETTLS KLPNLESLRS RSQLMLTRKA
360 370 380 390 400
EAALRKAASE SATSEGLSNF LKSDSISEEL ERFTASGIAN LRCSEQAFDS
410 420 430 440 450
DVTDSSSGGE SDIEEEELTR ADPEQCHVPL KRRSEWRWAA DRAAIVSRWN
460 470 480 490 500
WLQAHVSDLE YRIRQQTDIY KQIRANKGLI VLGEAPFPDH TTDLLSLSSE
510 520 530 540 550
VKTDHGRDKL IESVSQPSEN HGILVSNITE SLSTKSCGAP RPVNGVVNSL
560 570 580 590 600
QPVLADQVPG DSSDAEEQLH KKQRLNLVSS SDGTCVAART RPVLTCKKRR
610 620 630 640 650
LVRPSSIVPL SKKVHRNVRS GCDVNPSCAL CGSGSVNTMP PEIHYEAPLL
660 670 680 690 700
ERLSQLDSCV HPVLAFPDDV PTSLHFQSML KSQWQNKPFD KIKPTKKFSL
710 720 730 740 750
KHRATMPCSL SDPVRKDRHK LVNSFLTTAM LKHHTDMSSP SYLTATHHPP
760 770 780 790 800
HSPLVRQLST SSDTSTPTSS GSQVAASTSQ PVRRRRGESS FDINNIVIPM
810 820 830 840 850
SVAATTRVEK LQYKEILTPS WREVDVQSLK GSPDEENEEI EDLSDAAFAA
860 870 880 890 900
LHAKCEEMER ARWLWTTSVP PQRRGSRSYR SSDGRTTPQL GSANPSTPQP
910 920 930 940 950
ASPDVSSSHS LSEFSHGQSP RSPISPELHS APLTPVARDS LRHLASEDTR
960 970 980 990 1000
CSTPELGLDE QSVQPWERRT FPLAYSPQAE CEEQLDAQDT AARCTRRTSG
1010 1020 1030
SKTGREAEVA PTSPPVVPLK SRHLAATVTA QRPAHR
Length:1,036
Mass (Da):113,179
Last modified:June 1, 2003 - v1
Checksum:iF619B60DEEE93A62
GO
Isoform 2 (identifier: Q80TG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     615-643: HRNVRSGCDVNPSCALCGSGSVNTMPPEI → GAQRTGLRSALILSRVGEPPSSPVNLQNY
     644-1036: Missing.

Note: No experimental confirmation available.
Show »
Length:643
Mass (Da):69,724
Checksum:i74B228E59E1B3DA6
GO
Isoform 3 (identifier: Q80TG1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     478-510: Missing.
     615-643: HRNVRSGCDVNPSCALCGSGSVNTMPPEI → GAQRTGLRSALILSRVGEPPSSPVNLQNY
     644-1036: Missing.

Note: No experimental confirmation available.
Show »
Length:610
Mass (Da):66,180
Checksum:iEF19107E16ABE383
GO
Isoform 4 (identifier: Q80TG1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-1036: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):46,184
Checksum:i832BDE9011CBA181
GO
Isoform 5 (identifier: Q80TG1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-770: Missing.
     771-779: GSQVAASTS → MCSLRSWNQ

Note: No experimental confirmation available.
Show »
Length:266
Mass (Da):29,518
Checksum:iEE0BA4E50B0A6286
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971D → N in BAE36437 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 770770Missing in isoform 5. 1 PublicationVSP_018360Add
BLAST
Alternative sequencei431 – 1036606Missing in isoform 4. 1 PublicationVSP_018361Add
BLAST
Alternative sequencei478 – 51033Missing in isoform 3. 1 PublicationVSP_018362Add
BLAST
Alternative sequencei615 – 64329HRNVR…MPPEI → GAQRTGLRSALILSRVGEPP SSPVNLQNY in isoform 2 and isoform 3. 2 PublicationsVSP_018363Add
BLAST
Alternative sequencei644 – 1036393Missing in isoform 2 and isoform 3. 2 PublicationsVSP_018364Add
BLAST
Alternative sequencei771 – 7799GSQVAASTS → MCSLRSWNQ in isoform 5. 1 PublicationVSP_018365

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122484 mRNA. Translation: BAC65766.1.
AK006970 mRNA. Translation: BAB24813.1.
AK037800 mRNA. Translation: BAE20523.1.
AK153679 mRNA. Translation: BAE32141.1.
AK161514 mRNA. Translation: BAE36437.1.
AL593843 Genomic DNA. Translation: CAM14793.1.
BC025052 mRNA. Translation: AAH25052.1.
BC043121 mRNA. Translation: AAH43121.2.
BC053389 mRNA. Translation: AAH53389.2.
BC054752 mRNA. Translation: AAH54752.2.
BC079594 mRNA. Translation: AAH79594.1.
CCDSiCCDS48953.1. [Q80TG1-1]
RefSeqiNP_001074514.1. NM_001081045.1. [Q80TG1-1]
XP_006534516.1. XM_006534453.2. [Q80TG1-1]
XP_011247610.1. XM_011249308.1. [Q80TG1-1]
UniGeneiMm.136418.

Genome annotation databases

EnsembliENSMUST00000018556; ENSMUSP00000018556; ENSMUSG00000018412. [Q80TG1-1]
ENSMUST00000106977; ENSMUSP00000102590; ENSMUSG00000018412. [Q80TG1-1]
GeneIDi76719.
KEGGimmu:76719.
UCSCiuc007lwj.1. mouse. [Q80TG1-1]
uc007lwm.1. mouse. [Q80TG1-3]
uc007lwn.1. mouse. [Q80TG1-2]
uc007lwo.1. mouse. [Q80TG1-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122484 mRNA. Translation: BAC65766.1.
AK006970 mRNA. Translation: BAB24813.1.
AK037800 mRNA. Translation: BAE20523.1.
AK153679 mRNA. Translation: BAE32141.1.
AK161514 mRNA. Translation: BAE36437.1.
AL593843 Genomic DNA. Translation: CAM14793.1.
BC025052 mRNA. Translation: AAH25052.1.
BC043121 mRNA. Translation: AAH43121.2.
BC053389 mRNA. Translation: AAH53389.2.
BC054752 mRNA. Translation: AAH54752.2.
BC079594 mRNA. Translation: AAH79594.1.
CCDSiCCDS48953.1. [Q80TG1-1]
RefSeqiNP_001074514.1. NM_001081045.1. [Q80TG1-1]
XP_006534516.1. XM_006534453.2. [Q80TG1-1]
XP_011247610.1. XM_011249308.1. [Q80TG1-1]
UniGeneiMm.136418.

3D structure databases

ProteinModelPortaliQ80TG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018556.

PTM databases

PhosphoSiteiQ80TG1.

Proteomic databases

MaxQBiQ80TG1.
PaxDbiQ80TG1.
PRIDEiQ80TG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018556; ENSMUSP00000018556; ENSMUSG00000018412. [Q80TG1-1]
ENSMUST00000106977; ENSMUSP00000102590; ENSMUSG00000018412. [Q80TG1-1]
GeneIDi76719.
KEGGimmu:76719.
UCSCiuc007lwj.1. mouse. [Q80TG1-1]
uc007lwm.1. mouse. [Q80TG1-3]
uc007lwn.1. mouse. [Q80TG1-2]
uc007lwo.1. mouse. [Q80TG1-4]

Organism-specific databases

CTDi284058.
MGIiMGI:1923969. Kansl1.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG87566.
GeneTreeiENSGT00530000063688.
HOVERGENiHBG080054.
InParanoidiQ80TG1.
KOiK18400.
OrthoDBiEOG7VQJF6.

Enzyme and pathway databases

ReactomeiREACT_291621. HATs acetylate histones.

Miscellaneous databases

NextBioi345681.
PROiQ80TG1.
SOURCEiSearch...

Gene expression databases

BgeeiQ80TG1.
CleanExiMM_1700081L11RIK.
ExpressionAtlasiQ80TG1. baseline and differential.
GenevisibleiQ80TG1. MM.

Family and domain databases

InterProiIPR026180. NSL1.
IPR029332. PEHE_dom.
[Graphical view]
PANTHERiPTHR22443. PTHR22443. 1 hit.
PfamiPF15275. PEHE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 5).
    Strain: C57BL/6J.
    Tissue: Testis and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C3H/He, C57BL/6 and FVB/N.
    Tissue: Embryonic brain, Mammary gland and Mesenchymal stem cell.

Entry informationi

Entry nameiKANL1_MOUSE
AccessioniPrimary (citable) accession number: Q80TG1
Secondary accession number(s): A2A5Y5
, Q3TT88, Q3U5D8, Q3V3N3, Q7TMU3, Q80XP7, Q8R3L6, Q9D9G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.