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Q80TE7 (LRRC7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat-containing protein 7
Alternative name(s):
Densin-180
Short name=Densin
Protein LAP1
Gene names
Name:Lrrc7
Synonyms:Kiaa1365, Lap1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. Ref.4

Subunit structure

Interacts with CAMKII and CTNND2/Catenin delta-2. Interacts with CNKSR2 and DLG4 and forms a complex with N-cadherin through CTNND2 By similarity.

Subcellular location

Cytoplasm By similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density Ref.4.

Tissue specificity

Expressed in brain (at protein level). Ref.4

Disruption phenotype

Mutant mice are viable and were born at the expected Mendelian ratio, but they have a mortality rate of about 20%. They show early growth retardation. Mutant animals exhibit behavioral abnormalities, including clasping when suspended by the tail, impaired both hippocampus-dependent and hippocampus-independent short-term memories and absence of acoustic prepulse inhibition. They also exhibit significantly higher levels of anxiety. They become hyperactive in response to stress or novelty, but are more sedentary than wild-type in a familiar environment. Males have a profound deficit in nest-making behavior and were aggressive when group-housed, even with littermates. Ref.4

Sequence similarities

Belongs to the LAP (LRR and PDZ) protein family.

Contains 17 LRR (leucine-rich) repeats.

Contains 1 PDZ (DHR) domain.

Sequence caution

The sequence BAC65780.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14901490Leucine-rich repeat-containing protein 7
PRO_0000188299

Regions

Repeat23 – 4422LRR 1
Repeat47 – 6822LRR 2
Repeat70 – 9122LRR 3
Repeat93 – 11422LRR 4
Repeat116 – 13722LRR 5
Repeat139 – 16123LRR 6
Repeat162 – 18322LRR 7
Repeat185 – 20622LRR 8
Repeat208 – 22922LRR 9
Repeat231 – 25323LRR 10
Repeat254 – 27522LRR 11
Repeat277 – 29822LRR 12
Repeat300 – 32122LRR 13
Repeat323 – 34422LRR 14
Repeat346 – 36722LRR 15
Repeat369 – 39123LRR 16
Repeat392 – 41322LRR 17
Domain1398 – 148891PDZ

Amino acid modifications

Modified residue8501Phosphoserine Ref.2 Ref.3
Modified residue8651Phosphothreonine Ref.3
Modified residue9331Phosphoserine Ref.2
Modified residue9491Phosphoserine Ref.2 Ref.3
Modified residue13921Phosphoserine Ref.2 Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q80TE7 [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: A27F2892981A2982

FASTA1,490166,901
        10         20         30         40         50         60 
MTTKRKLIGR LVPCRCFRGE EEIISVLDYS HCSLQQVPKE VFNFERTLEE LYLDANQIEE 

        70         80         90        100        110        120 
LPKQLFNCQA LRKLSIPDND LSSLPTSIAS LVNLKELDIS KNGVQEFPEN IKCCKCLTII 

       130        140        150        160        170        180 
EASVNPISKL PDGFTQLLNL TQLYLNDAFL EFLPANFGRL VKLRILELRE NHLKTLPKSM 

       190        200        210        220        230        240 
HKLAQLERLD LGNNEFSELP EVLDQIQNLR ELWMDNNALQ VLPGSIGKLK MLVYLDMSKN 

       250        260        270        280        290        300 
RIETVDMDIS GCEALEDLLL SSNMLQQLPD SIGLLKKLTT LKVDDNQLTM LPNTIGNLSL 

       310        320        330        340        350        360 
LEEFDCSCNE LESLPPTIGY LHSLRTLAVD ENFLPELPRE IGSCKNVTVM SLRSNKLEFL 

       370        380        390        400        410        420 
PEEIGQMQRL RVLNLSDNRL KNLPFSFTKL KELAALWLSD NQSKALIPLQ TEAHPETKQR 

       430        440        450        460        470        480 
VLTNYMFPQQ PRGDEDFQSD SDSFNPTLWE EQRQQRMTVA FEFEDKKEDD ESAGKVKALS 

       490        500        510        520        530        540 
CQAPWDRGQR GITLQPARLS GDCCTPWARC DQQIQDMPVP QSDPQLAWGC ISGLQQERSM 

       550        560        570        580        590        600 
CAPLPVAAQS TTLPSLSGRQ VEINLKRYPT PYPEDLKNMV KSVQNLVGKP SHGVRVENSN 

       610        620        630        640        650        660 
PTANTEQTVK EKFEHKWPVA PKEITVEDSF VHPANEMRIG ELHPSLAETP LYPPKLVLLG 

       670        680        690        700        710        720 
KDKKESTDES EVDKTHCLNN SVSSGTYSDY SPSQASSASS NTRMKVGSLQ ATAKDAVHNS 

       730        740        750        760        770        780 
LWGNRIAPPF PQPLDAKPLL SQREAVPPGN IPQRPDRLPM SDAFPDNWTD GSHYDNTGFV 

       790        800        810        820        830        840 
SEEAAGENAN NNPLLSSKAR SVPAHGRRPL IRQERIVGVP LELEQSTHRH TPETEVPPSN 

       850        860        870        880        890        900 
PWQNWTRTPS PFEDRTAFPS KLETTPTTSP LPERKDHMKE PTETPGPFSP GVPWEYHDPT 

       910        920        930        940        950        960 
PNRSLGNVFS QIHCRPDSSK GVIAISKSTE RLSPLMKDIK SNKFKKSQSI DEIDVGTYKV 

       970        980        990       1000       1010       1020 
YNIPLENYAS GSDHLGSHER PDKFLGPEHG MSSMSRSQSV PMLDDEMLMY GSSKGPPQQK 

      1030       1040       1050       1060       1070       1080 
ASMTKKVYQF DQSFNPQGAV EVKAEKRIPP PFAHNSEYVQ QPSKNIAKDL VSPRAYRGYP 

      1090       1100       1110       1120       1130       1140 
PMEQMFSFSQ PSVNEDAMVN AQFASQGPRA GFLRRADSLA SSTEMAMFRR VSEPHELPPG 

      1150       1160       1170       1180       1190       1200 
DRYGRATYRG GLEGQSSISM TDPQFLKRNG RYEDEHPSYQ EVKAQAGSFP AKNLTQRRPL 

      1210       1220       1230       1240       1250       1260 
SARSYSTESY GASQTRPVSA RPTMAALLEK IPSDYNLGNY GDKTSDNSDI KTRPTPVKGE 

      1270       1280       1290       1300       1310       1320 
ESCGKMPADW RQQLLRHIEA RRLDRTPSQQ SNILDNGQED VSPSGQWNPY PLGRRDVPPD 

      1330       1340       1350       1360       1370       1380 
TITKKAGSHI QTLMGSQSLQ HRSREQQPYE GNINKVTIQQ FQSPLPIQIP SSQATRGPQP 

      1390       1400       1410       1420       1430       1440 
GRCLIQTKGQ RSMDGYPEQF CVRIEKNPGL GFSISGGISG QGNPFKPSDK GIFVTRVQPD 

      1450       1460       1470       1480       1490 
GPASNLLQPG DKILQANGHS FVHMEHEKAV LLLKSFQNTV DLVIQRELTV

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-850; SER-933; SER-949 AND SER-1392, MASS SPECTROMETRY.
Tissue: Brain.
[3]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-850; THR-865; SER-949 AND SER-1392, MASS SPECTROMETRY.
Tissue: Brain cortex.
[4]"Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction."
Carlisle H.J., Luong T.N., Medina-Marino A., Schenker L., Khorosheva E., Indersmitten T., Gunapala K.M., Steele A.D., O'Dell T.J., Patterson P.H., Kennedy M.B.
J. Neurosci. 31:16194-16207(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK122498 mRNA. Translation: BAC65780.1. Different initiation.
IPIIPI00831714.
UniGeneMm.132162.

3D structure databases

ProteinModelPortalQ80TE7.
SMRQ80TE7. Positions 24-411, 1407-1487.
ModBaseSearch...

Protein-protein interaction databases

IntActQ80TE7. 1 interaction.

PTM databases

PhosphoSiteQ80TE7.

Proteomic databases

PaxDbQ80TE7.
PRIDEQ80TE7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc008rvw.1. mouse.

Organism-specific databases

MGIMGI:2676665. Lrrc7.
RougeSearch...

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000060229.
HOVERGENHBG052305.

Gene expression databases

CleanExMM_LRRC7.
GenevestigatorQ80TE7.
GermOnlineENSMUSG00000028176. Mus musculus.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR001478. PDZ.
[Graphical view]
PfamPF00560. LRR_1. 1 hit.
PF12799. LRR_4. 2 hits.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. PDZ. 1 hit.
PROSITEPS51450. LRR. 15 hits.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameLRRC7_MOUSE
AccessionPrimary (citable) accession number: Q80TE7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents