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Protein

Signal-induced proliferation-associated 1-like protein 2

Gene

Sipa1l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 2
Short name:
SIPA1-like protein 2
Gene namesi
Name:Sipa1l2
Synonyms:Kiaa0545
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2676970. Sipa1l2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17221722Signal-induced proliferation-associated 1-like protein 2PRO_0000056750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491PhosphoserineBy similarity
Modified residuei380 – 3801PhosphoserineCombined sources
Modified residuei384 – 3841PhosphoserineCombined sources
Modified residuei1030 – 10301PhosphoserineBy similarity
Modified residuei1245 – 12451PhosphoserineBy similarity
Modified residuei1461 – 14611PhosphoserineCombined sources
Modified residuei1472 – 14721PhosphoserineCombined sources
Modified residuei1478 – 14781PhosphoserineCombined sources
Modified residuei1488 – 14881PhosphoserineCombined sources
Modified residuei1549 – 15491PhosphoserineCombined sources
Modified residuei1552 – 15521PhosphoserineCombined sources
Modified residuei1591 – 15911PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80TE4.
PaxDbiQ80TE4.
PRIDEiQ80TE4.

PTM databases

iPTMnetiQ80TE4.
PhosphoSiteiQ80TE4.

Expressioni

Gene expression databases

BgeeiQ80TE4.
CleanExiMM_SIPA1L2.
GenevisibleiQ80TE4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104405.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini596 – 813218Rap-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini951 – 102777PDZPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1652 – 171261Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 564Poly-Ser
Compositional biasi58 – 647Poly-Gly
Compositional biasi1126 – 11294Poly-Ser
Compositional biasi1322 – 136645Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 Rap-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000154319.
HOVERGENiHBG056135.
InParanoidiQ80TE4.
KOiK17702.
OMAiEFIMLIE.
OrthoDBiEOG7DVD9F.
TreeFamiTF318626.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
IPR031203. SIPA1L2.
IPR021818. SIPA1L_C.
[Graphical view]
PANTHERiPTHR15711:SF7. PTHR15711:SF7. 3 hits.
PfamiPF02145. Rap_GAP. 1 hit.
PF11881. SPAR_C. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDPRPSQAE KHKLGRAAAK LKDPSRTMQA DDYFARKFKA INGSMGPATL
60 70 80 90 100
NTSSSSEGGG GGGGPANGTP AVPKMGVRAR VSEWPPKKDC SKDLACKTLW
110 120 130 140 150
ESRSQSSYES VTSIIQNGQN DQGDRQPEEQ LDLDFVEAKY TIGDIFVHSP
160 170 180 190 200
QRGLHPIRQR SNSDITISDI DTEDVLDQHA VNPNTGAALH REYGSTSSID
210 220 230 240 250
RQGLSGENVF AMLRGYRIES YDPKVTGSFG FPDFFPCDTA ISPSLHAAAQ
260 270 280 290 300
ISRGEFVRIS GLDYMDGGLL MGRDRDKPFK RRLKSESVET SLFRKLRAVK
310 320 330 340 350
SEHETFKFTS DLEEGRLDRG IRPWSCQRCF AHYDVQSILF NINEAMATRA
360 370 380 390 400
SVGKRKNITT GASAASQTPV PVGPAGGCES PLGSKEDLNS KENPDADEGD
410 420 430 440 450
GKSNDLVLSC PYFRNETGGE GDRRIALSRA NSASFSSGES CSFESSLSSH
460 470 480 490 500
CTNAGVSVLE VPRESQPIHR EKVKRYIIEH VDLGAYYYRK FFYGKEHQNY
510 520 530 540 550
FGIDENLGPV AVSIRREKVE DPREKEGSQF NYRVAFRTSE LTTLRGAILE
560 570 580 590 600
DAVPSTARHG TARGLPLKEV LEYVIPELSI QCLRQAANSP KVPEQLLKLD
610 620 630 640 650
EQGLSFQHKI GILYCRAGQS TEEEMYNNET AGPAFEEFLD LLGQRVRLKG
660 670 680 690 700
FSKYRAQLDN KTDSTGTHSL YTTYKDFELM FHVSTLLPYM PNNRQQLLRK
710 720 730 740 750
RHIGNDIVTI VFQEPGALPF TPKNIRSHFQ HVFVIVKVHN PCTENVCYSV
760 770 780 790 800
GVSRSKDVPP FGPPIPKGVT FPKSAVFRDF LLAKVINAEN AAHKSEKFRA
810 820 830 840 850
MATRTRQEYL KDLAENFVTT ATVDTSAKFS FITLGAKKKE RVKPRKDAHL
860 870 880 890 900
FSIGAIMWHV VARDFGQSAD IECLLGISNE FIMLIEKDSK NVVFNCSCRD
910 920 930 940 950
VIGWTSGLVS IKAFYERGEC LLLSSVDNRS EDIREIVQRL LIVTRGCETV
960 970 980 990 1000
EMTLRRNGLG QLGFHVNFEG IVADVEPFGF AWKAGLRQGS RLVEICKVAV
1010 1020 1030 1040 1050
ATLTHEQMID LLRTSVTVKV VIIQPHEDGS PRRGCSELCR IPMVEYKLDS
1060 1070 1080 1090 1100
EGTPCEYKTP FRRNTTWHRV PTPALQPVSR ASPVPGTPDR LQCQPLLQQA
1110 1120 1130 1140 1150
QAAIPRSTSF DRKLPDGTRS SPSNQSSSSD PGPGGSGPWR PQVGYDGCPS
1160 1170 1180 1190 1200
PLLLEHQGPG SVECDGTGEQ EDLLEGGRLP ETKWHGPPSK VLSSYKERVL
1210 1220 1230 1240 1250
QKDGSCKESP NKLSHIGDKS CSSHSSSNTL SSNTSSNSDD KHFGSGDLMD
1260 1270 1280 1290 1300
PELLGLTYIK GASTDSGIDT TPCMPATILG PVHLTGSRSL MHSRAEQWAD
1310 1320 1330 1340 1350
AADVSVADDD PAKMYALHGY ASAISSSAAD GSMGDLSEVS SHSSGSQHSG
1360 1370 1380 1390 1400
SPSAHCSKST GSLDSSKVYI VTHGGGQQAP GAVTKPYHRQ GAANKYVIGW
1410 1420 1430 1440 1450
KKSEGSPPPE EPEVTECPRI YGEMDIMSTA TQHPAVVGDS VSETQHVLSK
1460 1470 1480 1490 1500
DDFLKLMLPD SPLVEEGRRK FSFYGNVSPR RSLYRTLSDE SVCSNRRGSS
1510 1520 1530 1540 1550
FASSRSSILE QALPNDILFS TTPPYHSTLP PRTHPAPSMG SLRNEFWFSD
1560 1570 1580 1590 1600
GSLSDKSKCA DPGLMPLPDT AAGLDWSHLV DAARAFEGLD SDEELGLLCH
1610 1620 1630 1640 1650
HASYLDQRVA SFCTLTDLQH GQELEGAPEL SLCVDPTSGK EFMDTPGERS
1660 1670 1680 1690 1700
PSTLTGKVNQ LELILRQLQT DLRKEKQDKA VLQAEVQHLR QDNMRLQEES
1710 1720
QTATAQLRKF TEWFFSTIDK KA
Length:1,722
Mass (Da):189,413
Last modified:July 27, 2011 - v3
Checksum:i1E25D598014B1792
GO
Isoform 2 (identifier: Q80TE4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1587-1605: Missing.

Show »
Length:1,703
Mass (Da):187,329
Checksum:i67CC43B6DA062A1A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1361 – 13611G → S in BAC65783 (PubMed:12693553).Curated
Sequence conflicti1649 – 16491R → Q in BAC65783 (PubMed:12693553).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1587 – 160519Missing in isoform 2. 1 PublicationVSP_016999Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073946 Genomic DNA. No translation available.
BC058408 mRNA. Translation: AAH58408.1.
BC072593 mRNA. No translation available.
AK122501 mRNA. Translation: BAC65783.1.
CCDSiCCDS40518.1. [Q80TE4-1]
RefSeqiNP_001074806.1. NM_001081337.1. [Q80TE4-1]
XP_006531087.1. XM_006531024.1. [Q80TE4-1]
UniGeneiMm.271668.

Genome annotation databases

EnsembliENSMUST00000108775; ENSMUSP00000104405; ENSMUSG00000001995. [Q80TE4-1]
GeneIDi244668.
KEGGimmu:244668.
UCSCiuc009nye.1. mouse. [Q80TE4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073946 Genomic DNA. No translation available.
BC058408 mRNA. Translation: AAH58408.1.
BC072593 mRNA. No translation available.
AK122501 mRNA. Translation: BAC65783.1.
CCDSiCCDS40518.1. [Q80TE4-1]
RefSeqiNP_001074806.1. NM_001081337.1. [Q80TE4-1]
XP_006531087.1. XM_006531024.1. [Q80TE4-1]
UniGeneiMm.271668.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104405.

PTM databases

iPTMnetiQ80TE4.
PhosphoSiteiQ80TE4.

Proteomic databases

MaxQBiQ80TE4.
PaxDbiQ80TE4.
PRIDEiQ80TE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108775; ENSMUSP00000104405; ENSMUSG00000001995. [Q80TE4-1]
GeneIDi244668.
KEGGimmu:244668.
UCSCiuc009nye.1. mouse. [Q80TE4-1]

Organism-specific databases

CTDi57568.
MGIiMGI:2676970. Sipa1l2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000154319.
HOVERGENiHBG056135.
InParanoidiQ80TE4.
KOiK17702.
OMAiEFIMLIE.
OrthoDBiEOG7DVD9F.
TreeFamiTF318626.

Miscellaneous databases

ChiTaRSiSipa1l2. mouse.
PROiQ80TE4.
SOURCEiSearch...

Gene expression databases

BgeeiQ80TE4.
CleanExiMM_SIPA1L2.
GenevisibleiQ80TE4. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
IPR031203. SIPA1L2.
IPR021818. SIPA1L_C.
[Graphical view]
PANTHERiPTHR15711:SF7. PTHR15711:SF7. 3 hits.
PfamiPF02145. Rap_GAP. 1 hit.
PF11881. SPAR_C. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 538-1722 (ISOFORM 1).
    Tissue: Brain.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-384; SER-1461; SER-1472; SER-1478; SER-1488; SER-1549; SER-1552 AND SER-1591, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiSI1L2_MOUSE
AccessioniPrimary (citable) accession number: Q80TE4
Secondary accession number(s): E9QPK7, Q6PDY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.