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Protein

RNA polymerase II-associated protein 1

Gene

Rpap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II-associated protein 1
Gene namesi
Name:Rpap1
Synonyms:Kiaa1403
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916175. Rpap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848421 – 1409RNA polymerase II-associated protein 1Add BLAST1409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei337PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80TE0.
PaxDbiQ80TE0.
PeptideAtlasiQ80TE0.
PRIDEiQ80TE0.

PTM databases

iPTMnetiQ80TE0.
PhosphoSitePlusiQ80TE0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034032.
CleanExiMM_RPAP1.
ExpressionAtlasiQ80TE0. baseline and differential.
GenevisibleiQ80TE0. MM.

Interactioni

Subunit structurei

Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF.By similarity

Protein-protein interaction databases

IntActiQ80TE0. 1 interactor.
STRINGi10090.ENSMUSP00000037275.

Structurei

3D structure databases

ProteinModelPortaliQ80TE0.
SMRiQ80TE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi843 – 1302Leu-richAdd BLAST460

Sequence similaritiesi

Belongs to the RPAP1 family.Curated

Phylogenomic databases

eggNOGiKOG1894. Eukaryota.
ENOG410XNVT. LUCA.
GeneTreeiENSGT00390000007594.
HOVERGENiHBG057248.
InParanoidiQ80TE0.
KOiK20826.
OMAiSTFSWYH.
OrthoDBiEOG091G06IW.
PhylomeDBiQ80TE0.
TreeFamiTF324391.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013929. RNA_pol_II_AP1_C.
IPR013930. RNA_pol_II_AP1_N.
[Graphical view]
PfamiPF08620. RPAP1_C. 1 hit.
PF08621. RPAP1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLSRPKPGE SEVDLLRFQS QFLEAGAAPA VQLVKGSRRH GDAPPDRLPP
60 70 80 90 100
QDHRDVVMLD NLPDLPPALL PAPAKRARPS PGHPLPHDED PEERLNRHDQ
110 120 130 140 150
HITAVLSKIV ERDTSSVTVT LPVPSGVAFP PVFHRSQERQ VKPAASGKRS
160 170 180 190 200
IFAQEIAARR VSGNRVTSAE QVVPSLDTPE GAVPCETPSF RDRSNQLPGR
210 220 230 240 250
SHGFHRPNLV TGKGLRSKVA EQEVQTIHEE NVARLQAMDP EEILKEQQQL
260 270 280 290 300
LAQLDPSLVA FLRSHSQVQE QTGTKATKKQ SPKRPSVLVT KEEPVTSTRT
310 320 330 340 350
REPRTGDKLE EKPEATVEDK MEDKLQPRTP ALKLPMTPSK DWLHMDTVEL
360 370 380 390 400
DKLHWTQDLP PLRRQQTQER MQARFSLQGE LLAPDVDLPT HLGLHHHGEE
410 420 430 440 450
AERAGYSLQE LFHLTRSQVS QQRALALQVL SQIVGRAQAG EFGDRLVGSV
460 470 480 490 500
LRLLLDAGFL FLLRFSLDDR VDSVIAAAVR ALRTLLVAPG DEELLDRTFS
510 520 530 540 550
WYHGASVFPL MPSQDDKEDE DEDEELETEK VKRKTPEEGS RPPPDLARHD
560 570 580 590 600
VIKGLLATNL LPRLRYVLEV TCPGPSVILD ILAVLIRLAR HSLESAMRVL
610 620 630 640 650
ECPRLMETIV QEFLPTSWSP IGVGPTPSLY KVPCASAMKL LRVLASAGRN
660 670 680 690 700
IAARLLSGFD VRSRLCRFIA EAPHDLALPP EEAEILTTEA FRLWAVAASY
710 720 730 740 750
GQGGDLYREL YPVLLRALQT LPTELSAHPL QPLAMQRVAA LFTLLTQLTL
760 770 780 790 800
AASSIPPEPA SGPAESCVPA IPSSVTWTQV SGLKPLVEPC LKQTLKFLPR
810 820 830 840 850
PDVWNALGPV PSACLLFLGA YYQAWSRQSH LCPEDWLQDM ERLLDESLLP
860 870 880 890 900
LLSQPPLGSL WDSLRDCSPL CNPLSCASNP EALPSLVSLG CAGGCPPLSV
910 920 930 940 950
AGSASPFPFL TALLSLINTL VQSHKGLCGQ LSAVLTAPGL QNYFLQCVAP
960 970 980 990 1000
APAPQLTPFS AWALHHEYHL QYLVLSFAHK AATLQPEPAA STALHHAVAL
1010 1020 1030 1040 1050
VLLSRLLPGS EYLAQELLLS CVFRLEFLPE SASGGPEAAD FSDGLSLGSS
1060 1070 1080 1090 1100
GDPQCRRGAL LVQACRDLPS IRSCYLAHCS PARASLLSSQ ALYCGELLRV
1110 1120 1130 1140 1150
SSLLLPVPKE PLLATDWPFQ PLIHLYHRAS DTPSGPPAAD TVGVAMRVLQ
1160 1170 1180 1190 1200
WVLVLESWRP EVLWAVPPAA RLARLMCVYL VDSELFRETP IQRLVAALLA
1210 1220 1230 1240 1250
RLCRPQVLPN LKLDCPLPGL TSFPDLYASF LDHFEAVSFG DHLFGALVLL
1260 1270 1280 1290 1300
PLQRRFSVTL RLALFGEHVG VLRALGLPLT QLPVPLECYT EPAEDSLPLL
1310 1320 1330 1340 1350
QLYFRALVTG TLRARWCPIL YTVAVAHVNS FIFCQDPKSS DEVKTARRSM
1360 1370 1380 1390 1400
LQRTWLLTDE GLRQHLLHYK LPNSSLPEGF ELYSQLPRLR QQCLQTLPTE

GLQNGGVKT
Length:1,409
Mass (Da):155,270
Last modified:April 17, 2007 - v2
Checksum:i7E49F6D8A2D31687
GO
Isoform 2 (identifier: Q80TE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1282-1290: LPVPLECYT → VCPTLSRPS
     1291-1409: Missing.

Show »
Length:1,290
Mass (Da):141,601
Checksum:i357BD5B9357A9C8C
GO

Sequence cautioni

The sequence BAC65787 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83H → R in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti83H → R in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti83H → R in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti126G → S in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti126G → S in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti190F → V in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti190F → V in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti190F → V in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti283K → E in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti283K → E in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti283K → E in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti432Q → R in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti527E → T in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti527E → T in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti527E → T in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti560L → Q in BAE39647 (PubMed:16141072).Curated1
Sequence conflicti578I → V in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti578I → V in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti578I → V in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti879N → T in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti879N → T in BAE38647 (PubMed:16141072).Curated1
Sequence conflicti879N → T in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti879N → T in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti880P → Q in BAE39647 (PubMed:16141072).Curated1
Sequence conflicti942N → K in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti942N → K in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti942N → K in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti942N → K in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti977F → L in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti977F → L in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti977F → L in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti977F → L in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti1066R → Q in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti1066R → Q in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti1066R → Q in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1066R → Q in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti1094C → R in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti1094C → R in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti1094C → R in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1094C → R in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti1183S → N in BAE39647 (PubMed:16141072).Curated1
Sequence conflicti1263A → T in BAE38647 (PubMed:16141072).Curated1
Sequence conflicti1305R → W in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti1311T → S in AAH12218 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in AAI17975 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0246821282 – 1290LPVPLECYT → VCPTLSRPS in isoform 2. 1 Publication9
Alternative sequenceiVSP_0246831291 – 1409Missing in isoform 2. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122505 mRNA. Translation: BAC65787.1. Different initiation.
AK161487 mRNA. Translation: BAE36419.1.
AK166232 mRNA. Translation: BAE38647.1.
AK167589 mRNA. Translation: BAE39647.1.
AL844536 Genomic DNA. Translation: CAM18083.1.
BC012218 mRNA. Translation: AAH12218.1.
BC051680 mRNA. Translation: AAH51680.1.
BC117973 mRNA. Translation: AAI17974.1.
BC117974 mRNA. Translation: AAI17975.1.
CCDSiCCDS16610.1. [Q80TE0-1]
RefSeqiNP_001157173.1. NM_001163701.1. [Q80TE0-1]
NP_796268.3. NM_177294.5. [Q80TE0-1]
XP_006500184.1. XM_006500121.3. [Q80TE0-1]
XP_011238061.1. XM_011239759.2. [Q80TE0-1]
UniGeneiMm.259223.
Mm.30496.

Genome annotation databases

EnsembliENSMUST00000048493; ENSMUSP00000037275; ENSMUSG00000034032. [Q80TE0-1]
ENSMUST00000099529; ENSMUSP00000097127; ENSMUSG00000034032. [Q80TE0-1]
ENSMUST00000110793; ENSMUSP00000106420; ENSMUSG00000034032. [Q80TE0-1]
GeneIDi68925.
KEGGimmu:68925.
UCSCiuc008luk.2. mouse. [Q80TE0-1]
uc008lun.2. mouse. [Q80TE0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122505 mRNA. Translation: BAC65787.1. Different initiation.
AK161487 mRNA. Translation: BAE36419.1.
AK166232 mRNA. Translation: BAE38647.1.
AK167589 mRNA. Translation: BAE39647.1.
AL844536 Genomic DNA. Translation: CAM18083.1.
BC012218 mRNA. Translation: AAH12218.1.
BC051680 mRNA. Translation: AAH51680.1.
BC117973 mRNA. Translation: AAI17974.1.
BC117974 mRNA. Translation: AAI17975.1.
CCDSiCCDS16610.1. [Q80TE0-1]
RefSeqiNP_001157173.1. NM_001163701.1. [Q80TE0-1]
NP_796268.3. NM_177294.5. [Q80TE0-1]
XP_006500184.1. XM_006500121.3. [Q80TE0-1]
XP_011238061.1. XM_011239759.2. [Q80TE0-1]
UniGeneiMm.259223.
Mm.30496.

3D structure databases

ProteinModelPortaliQ80TE0.
SMRiQ80TE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80TE0. 1 interactor.
STRINGi10090.ENSMUSP00000037275.

PTM databases

iPTMnetiQ80TE0.
PhosphoSitePlusiQ80TE0.

Proteomic databases

EPDiQ80TE0.
PaxDbiQ80TE0.
PeptideAtlasiQ80TE0.
PRIDEiQ80TE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048493; ENSMUSP00000037275; ENSMUSG00000034032. [Q80TE0-1]
ENSMUST00000099529; ENSMUSP00000097127; ENSMUSG00000034032. [Q80TE0-1]
ENSMUST00000110793; ENSMUSP00000106420; ENSMUSG00000034032. [Q80TE0-1]
GeneIDi68925.
KEGGimmu:68925.
UCSCiuc008luk.2. mouse. [Q80TE0-1]
uc008lun.2. mouse. [Q80TE0-2]

Organism-specific databases

CTDi26015.
MGIiMGI:1916175. Rpap1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1894. Eukaryota.
ENOG410XNVT. LUCA.
GeneTreeiENSGT00390000007594.
HOVERGENiHBG057248.
InParanoidiQ80TE0.
KOiK20826.
OMAiSTFSWYH.
OrthoDBiEOG091G06IW.
PhylomeDBiQ80TE0.
TreeFamiTF324391.

Miscellaneous databases

PROiQ80TE0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034032.
CleanExiMM_RPAP1.
ExpressionAtlasiQ80TE0. baseline and differential.
GenevisibleiQ80TE0. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013929. RNA_pol_II_AP1_C.
IPR013930. RNA_pol_II_AP1_N.
[Graphical view]
PfamiPF08620. RPAP1_C. 1 hit.
PF08621. RPAP1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPAP1_MOUSE
AccessioniPrimary (citable) accession number: Q80TE0
Secondary accession number(s): A2AQ24
, Q148U0, Q148U1, Q3TJ48, Q3TLZ5, Q3TTA6, Q80UT8, Q91VM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.