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Protein

RNA polymerase II-associated protein 1

Gene

Rpap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, Transferase
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II-associated protein 1
Gene namesi
Name:Rpap1
Synonyms:Kiaa1403
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916175 Rpap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848421 – 1409RNA polymerase II-associated protein 1Add BLAST1409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei337PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80TE0
PaxDbiQ80TE0
PeptideAtlasiQ80TE0
PRIDEiQ80TE0

PTM databases

iPTMnetiQ80TE0
PhosphoSitePlusiQ80TE0

Expressioni

Gene expression databases

BgeeiENSMUSG00000034032
CleanExiMM_RPAP1
ExpressionAtlasiQ80TE0 baseline and differential
GenevisibleiQ80TE0 MM

Interactioni

Subunit structurei

Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF.By similarity

Protein-protein interaction databases

IntActiQ80TE0, 1 interactor
STRINGi10090.ENSMUSP00000037275

Structurei

3D structure databases

ProteinModelPortaliQ80TE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi843 – 1302Leu-richAdd BLAST460

Sequence similaritiesi

Belongs to the RPAP1 family.Curated

Phylogenomic databases

eggNOGiKOG1894 Eukaryota
ENOG410XNVT LUCA
GeneTreeiENSGT00390000007594
HOVERGENiHBG057248
InParanoidiQ80TE0
KOiK20826
OMAiQWVLVLE
OrthoDBiEOG091G06IW
PhylomeDBiQ80TE0
TreeFamiTF324391

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR013929 RNA_pol_II_AP1_C
IPR013930 RNA_pol_II_AP1_N
PfamiView protein in Pfam
PF08620 RPAP1_C, 1 hit
PF08621 RPAP1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLSRPKPGE SEVDLLRFQS QFLEAGAAPA VQLVKGSRRH GDAPPDRLPP
60 70 80 90 100
QDHRDVVMLD NLPDLPPALL PAPAKRARPS PGHPLPHDED PEERLNRHDQ
110 120 130 140 150
HITAVLSKIV ERDTSSVTVT LPVPSGVAFP PVFHRSQERQ VKPAASGKRS
160 170 180 190 200
IFAQEIAARR VSGNRVTSAE QVVPSLDTPE GAVPCETPSF RDRSNQLPGR
210 220 230 240 250
SHGFHRPNLV TGKGLRSKVA EQEVQTIHEE NVARLQAMDP EEILKEQQQL
260 270 280 290 300
LAQLDPSLVA FLRSHSQVQE QTGTKATKKQ SPKRPSVLVT KEEPVTSTRT
310 320 330 340 350
REPRTGDKLE EKPEATVEDK MEDKLQPRTP ALKLPMTPSK DWLHMDTVEL
360 370 380 390 400
DKLHWTQDLP PLRRQQTQER MQARFSLQGE LLAPDVDLPT HLGLHHHGEE
410 420 430 440 450
AERAGYSLQE LFHLTRSQVS QQRALALQVL SQIVGRAQAG EFGDRLVGSV
460 470 480 490 500
LRLLLDAGFL FLLRFSLDDR VDSVIAAAVR ALRTLLVAPG DEELLDRTFS
510 520 530 540 550
WYHGASVFPL MPSQDDKEDE DEDEELETEK VKRKTPEEGS RPPPDLARHD
560 570 580 590 600
VIKGLLATNL LPRLRYVLEV TCPGPSVILD ILAVLIRLAR HSLESAMRVL
610 620 630 640 650
ECPRLMETIV QEFLPTSWSP IGVGPTPSLY KVPCASAMKL LRVLASAGRN
660 670 680 690 700
IAARLLSGFD VRSRLCRFIA EAPHDLALPP EEAEILTTEA FRLWAVAASY
710 720 730 740 750
GQGGDLYREL YPVLLRALQT LPTELSAHPL QPLAMQRVAA LFTLLTQLTL
760 770 780 790 800
AASSIPPEPA SGPAESCVPA IPSSVTWTQV SGLKPLVEPC LKQTLKFLPR
810 820 830 840 850
PDVWNALGPV PSACLLFLGA YYQAWSRQSH LCPEDWLQDM ERLLDESLLP
860 870 880 890 900
LLSQPPLGSL WDSLRDCSPL CNPLSCASNP EALPSLVSLG CAGGCPPLSV
910 920 930 940 950
AGSASPFPFL TALLSLINTL VQSHKGLCGQ LSAVLTAPGL QNYFLQCVAP
960 970 980 990 1000
APAPQLTPFS AWALHHEYHL QYLVLSFAHK AATLQPEPAA STALHHAVAL
1010 1020 1030 1040 1050
VLLSRLLPGS EYLAQELLLS CVFRLEFLPE SASGGPEAAD FSDGLSLGSS
1060 1070 1080 1090 1100
GDPQCRRGAL LVQACRDLPS IRSCYLAHCS PARASLLSSQ ALYCGELLRV
1110 1120 1130 1140 1150
SSLLLPVPKE PLLATDWPFQ PLIHLYHRAS DTPSGPPAAD TVGVAMRVLQ
1160 1170 1180 1190 1200
WVLVLESWRP EVLWAVPPAA RLARLMCVYL VDSELFRETP IQRLVAALLA
1210 1220 1230 1240 1250
RLCRPQVLPN LKLDCPLPGL TSFPDLYASF LDHFEAVSFG DHLFGALVLL
1260 1270 1280 1290 1300
PLQRRFSVTL RLALFGEHVG VLRALGLPLT QLPVPLECYT EPAEDSLPLL
1310 1320 1330 1340 1350
QLYFRALVTG TLRARWCPIL YTVAVAHVNS FIFCQDPKSS DEVKTARRSM
1360 1370 1380 1390 1400
LQRTWLLTDE GLRQHLLHYK LPNSSLPEGF ELYSQLPRLR QQCLQTLPTE

GLQNGGVKT
Length:1,409
Mass (Da):155,270
Last modified:April 17, 2007 - v2
Checksum:i7E49F6D8A2D31687
GO
Isoform 2 (identifier: Q80TE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1282-1290: LPVPLECYT → VCPTLSRPS
     1291-1409: Missing.

Show »
Length:1,290
Mass (Da):141,601
Checksum:i357BD5B9357A9C8C
GO

Sequence cautioni

The sequence BAC65787 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83H → R in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti83H → R in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti83H → R in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti126G → S in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti126G → S in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti190F → V in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti190F → V in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti190F → V in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti283K → E in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti283K → E in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti283K → E in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti432Q → R in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti527E → T in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti527E → T in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti527E → T in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti560L → Q in BAE39647 (PubMed:16141072).Curated1
Sequence conflicti578I → V in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti578I → V in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti578I → V in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti879N → T in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti879N → T in BAE38647 (PubMed:16141072).Curated1
Sequence conflicti879N → T in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti879N → T in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti880P → Q in BAE39647 (PubMed:16141072).Curated1
Sequence conflicti942N → K in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti942N → K in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti942N → K in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti942N → K in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti977F → L in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti977F → L in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti977F → L in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti977F → L in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti1066R → Q in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti1066R → Q in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti1066R → Q in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1066R → Q in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti1094C → R in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti1094C → R in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti1094C → R in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1094C → R in AAI17975 (PubMed:15489334).Curated1
Sequence conflicti1183S → N in BAE39647 (PubMed:16141072).Curated1
Sequence conflicti1263A → T in BAE38647 (PubMed:16141072).Curated1
Sequence conflicti1305R → W in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in BAC65787 (PubMed:12693553).Curated1
Sequence conflicti1311T → S in AAH12218 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in AAH51680 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in AAI17974 (PubMed:15489334).Curated1
Sequence conflicti1311T → S in AAI17975 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0246821282 – 1290LPVPLECYT → VCPTLSRPS in isoform 2. 1 Publication9
Alternative sequenceiVSP_0246831291 – 1409Missing in isoform 2. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122505 mRNA Translation: BAC65787.1 Different initiation.
AK161487 mRNA Translation: BAE36419.1
AK166232 mRNA Translation: BAE38647.1
AK167589 mRNA Translation: BAE39647.1
AL844536 Genomic DNA No translation available.
BC012218 mRNA Translation: AAH12218.1
BC051680 mRNA Translation: AAH51680.1
BC117973 mRNA Translation: AAI17974.1
BC117974 mRNA Translation: AAI17975.1
CCDSiCCDS16610.1 [Q80TE0-1]
RefSeqiNP_001157173.1, NM_001163701.1 [Q80TE0-1]
NP_796268.3, NM_177294.5 [Q80TE0-1]
XP_006500184.1, XM_006500121.3 [Q80TE0-1]
XP_011238061.1, XM_011239759.2 [Q80TE0-1]
UniGeneiMm.259223
Mm.30496

Genome annotation databases

EnsembliENSMUST00000048493; ENSMUSP00000037275; ENSMUSG00000034032 [Q80TE0-1]
ENSMUST00000099529; ENSMUSP00000097127; ENSMUSG00000034032 [Q80TE0-1]
ENSMUST00000110793; ENSMUSP00000106420; ENSMUSG00000034032 [Q80TE0-1]
GeneIDi68925
KEGGimmu:68925
UCSCiuc008luk.2 mouse [Q80TE0-1]
uc008lun.2 mouse [Q80TE0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRPAP1_MOUSE
AccessioniPrimary (citable) accession number: Q80TE0
Secondary accession number(s): A2AQ24
, Q148U0, Q148U1, Q3TJ48, Q3TLZ5, Q3TTA6, Q80UT8, Q91VM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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