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Protein

Zinc finger SWIM domain-containing protein 6

Gene

Zswim6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri238 – 275SWIM-typePROSITE-ProRule annotationAdd BLAST38

GO - Molecular functioni

GO - Biological processi

  • neuron projection morphogenesis Source: MGI
  • regulation of neuron migration Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 6
Gene namesi
Name:Zswim6
Synonyms:Kiaa1577
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914513. Zswim6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002231061 – 1207Zinc finger SWIM domain-containing protein 6Add BLAST1207

Proteomic databases

PaxDbiQ80TB7.
PRIDEiQ80TB7.

PTM databases

PhosphoSitePlusiQ80TB7.

Expressioni

Tissue specificityi

Mouse embryos and newborn mice shown expression in the central nervous system (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000032846.
CleanExiMM_ZSWIM6.
GenevisibleiQ80TB7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100724.

Structurei

3D structure databases

ProteinModelPortaliQ80TB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri238 – 275SWIM-typePROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3615. Eukaryota.
ENOG410XPZG. LUCA.
GeneTreeiENSGT00390000012572.
HOGENOMiHOG000231419.
HOVERGENiHBG058098.
InParanoidiQ80TB7.
OMAiRETFMMA.
OrthoDBiEOG091G05BK.
TreeFamiTF324881.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAERGQQPPP AKRLCCRPGG GGGGGGGGGG SSGGGAGGGY SSACRPGPRA
60 70 80 90 100
GGAAAAAACG GGAALGLLPP GKTQSPESLL DIAARRVAEK WPFQRVEERF
110 120 130 140 150
ERIPEPVQRR IVYWSFPRSE REICMYSSFN TGGGSAGGPG DDSGGGGGRQ
160 170 180 190 200
HGRGAAAGGS SSSPAATSAA AAAVAAGTGT PSVGAASAAD GGDETRLPFR
210 220 230 240 250
RGIALLESGC VDNVLQVGFH LSGTVTEPAI QPEPETVCNV AISFDRCKIT
260 270 280 290 300
SVTCSCGNKD IFYCAHVVAL SLYRIRKPEQ VKLHLPISET LFQMNRDQLQ
310 320 330 340 350
KFVQYLITVH HTEVLPTAQK LADEILSQNS EINQVHGAPD PTAGASIDDE
360 370 380 390 400
NCWHLDEEQV QEQVKVFLSQ GGYHGSGKQL NMLFAKVREM LKMRDSNGAR
410 420 430 440 450
MLTLITEQFM ADPRLSLWRQ QGTAMTDKYR QLWDELGALW MCIVLNPHCK
460 470 480 490 500
LEQKASWLKQ LKKWNSVDVC PWEDGNHGSE LPNLTNALPQ GANANQDSSN
510 520 530 540 550
RPHRTVFTRA IEACDLHWQD SHLQHIISSD LYTNYCYHDD TENSLFDSRG
560 570 580 590 600
WPLWHEHVPT ACARVDALRS HGYPREALRL AIAIVNTLRR QQQKQLEMFR
610 620 630 640 650
TQKKELPHKS ITSITNLEGW VGHPLDPVGT LFSSLMEACH TDGDAFSGFS
660 670 680 690 700
DCTDNMGQCK SLEYHHLPAH KFLEEGESYV TLAVEVALIG LGQQRIMPDG
710 720 730 740 750
LYTQEKVCRN EEQLISKLQE IELDDTLVKI FRKQAVFLLE AGPYSGLGEI
760 770 780 790 800
IHRESVPMHT FAKYLFTSLL PHDAELAYKI ALRAMRLLVL ESTAPTGDLS
810 820 830 840 850
RPHHIASVVP NRYPRWFTLS HIESQQCELA STMLTAAKGD VRRLETVLES
860 870 880 890 900
IQKNIHSSSH IFKLAQDAFK IATLMDSLPD ITLLKVSLEL GLQVMRMTLS
910 920 930 940 950
TLNWRRREMV RWLVTCATEV GVYALDSIMQ SWFTLFTPTE ATSIVATTVM
960 970 980 990 1000
SNSTIVRLHL DCHQQEKLAS SARTLALQCA MKDPQNCALS ALTLCEKDHI
1010 1020 1030 1040 1050
AFETAYQIVL DAATTGMSYT QLFTIARYME HRGYPMRAYK LATLAMTHLN
1060 1070 1080 1090 1100
LSYNQDTHPA INDVLWACAL SHSLGKNELA AIIPLVVKSV KCATVLSDIL
1110 1120 1130 1140 1150
RRCTLTTPGM VGLHGRRNSG KLMSLDKAPL RQLLDATIGA YINTTHSRLT
1160 1170 1180 1190 1200
HISPRHYSEF IEFLSKARET FLMAHDGHIQ FTQFIDNLKQ IYKGKKKLMM

LVRERFG
Length:1,207
Mass (Da):133,109
Last modified:October 29, 2014 - v3
Checksum:i223C935EE2C5EF44
GO
Isoform 2 (identifier: Q80TB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-605: Missing.
     1061-1066: INDVLW → FVPFLT
     1067-1207: Missing.

Show »
Length:1,017
Mass (Da):111,531
Checksum:i6CB2EF2AF491395D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009238557 – 605Missing in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_0092391061 – 1066INDVLW → FVPFLT in isoform 2. 1 Publication6
Alternative sequenceiVSP_0092401067 – 1207Missing in isoform 2. 1 PublicationAdd BLAST141

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122528 mRNA. Translation: BAC65810.1.
AK037945 mRNA. Translation: BAC29905.1.
AC154503 Genomic DNA. No translation available.
AC165250 Genomic DNA. No translation available.
CT572986 Genomic DNA. No translation available.
RefSeqiNP_663431.2. NM_145456.2. [Q80TB7-1]
UniGeneiMm.490418.

Genome annotation databases

EnsembliENSMUST00000105097; ENSMUSP00000100724; ENSMUSG00000032846. [Q80TB7-1]
GeneIDi67263.
KEGGimmu:67263.
UCSCiuc007rup.2. mouse. [Q80TB7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122528 mRNA. Translation: BAC65810.1.
AK037945 mRNA. Translation: BAC29905.1.
AC154503 Genomic DNA. No translation available.
AC165250 Genomic DNA. No translation available.
CT572986 Genomic DNA. No translation available.
RefSeqiNP_663431.2. NM_145456.2. [Q80TB7-1]
UniGeneiMm.490418.

3D structure databases

ProteinModelPortaliQ80TB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100724.

PTM databases

PhosphoSitePlusiQ80TB7.

Proteomic databases

PaxDbiQ80TB7.
PRIDEiQ80TB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105097; ENSMUSP00000100724; ENSMUSG00000032846. [Q80TB7-1]
GeneIDi67263.
KEGGimmu:67263.
UCSCiuc007rup.2. mouse. [Q80TB7-1]

Organism-specific databases

CTDi57688.
MGIiMGI:1914513. Zswim6.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3615. Eukaryota.
ENOG410XPZG. LUCA.
GeneTreeiENSGT00390000012572.
HOGENOMiHOG000231419.
HOVERGENiHBG058098.
InParanoidiQ80TB7.
OMAiRETFMMA.
OrthoDBiEOG091G05BK.
TreeFamiTF324881.

Miscellaneous databases

ChiTaRSiZswim6. mouse.
PROiQ80TB7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032846.
CleanExiMM_ZSWIM6.
GenevisibleiQ80TB7. MM.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSWM6_MOUSE
AccessioniPrimary (citable) accession number: Q80TB7
Secondary accession number(s): E9PX41, Q8CAS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 29, 2014
Last modified: November 30, 2016
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.