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Protein

Ectopic P granules protein 5 homolog

Gene

Epg5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity).By similarity

GO - Biological processi

  • autophagosome maturation Source: MGI
  • autophagy Source: MGI
  • endocytic recycling Source: MGI
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Ectopic P granules protein 5 homolog
Gene namesi
Name:Epg5
Synonyms:Kiaa1632
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1918673. Epg5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003062561 – 2572Ectopic P granules protein 5 homologAdd BLAST2572

Proteomic databases

EPDiQ80TA9.
MaxQBiQ80TA9.
PaxDbiQ80TA9.
PeptideAtlasiQ80TA9.
PRIDEiQ80TA9.

PTM databases

iPTMnetiQ80TA9.
PhosphoSitePlusiQ80TA9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039840.
CleanExiMM_5430411K18RIK.
GenevisibleiQ80TA9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038681.

Structurei

3D structure databases

ProteinModelPortaliQ80TA9.
SMRiQ80TA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1600 – 1626Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the EPG5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3622. Eukaryota.
ENOG410XUQ7. LUCA.
GeneTreeiENSGT00390000007354.
HOVERGENiHBG108040.
InParanoidiQ80TA9.
OMAiAVEFFYN.
OrthoDBiEOG091G00HO.
PhylomeDBiQ80TA9.
TreeFamiTF313847.

Family and domain databases

InterProiIPR029651. EPG-5.
[Graphical view]
PANTHERiPTHR31139:SF4. PTHR31139:SF4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80TA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAVKPRRA KAKASRTKGK EKKKHEALQT CDAGPLPETC REQESPCPAS
60 70 80 90 100
ELKGDDLKSS ADPQLHSDVC GWNESEMFDI PLTSLTIGDE GPPVQDTEDL
110 120 130 140 150
KERGEVTAGD GDDEMELKVD PGDNVIAKGE PCKNFPEVED HTLIQCGPPE
160 170 180 190 200
STLQPDFPCT QQAVEGSHAR EHPTRKQDEA ALGCSKVFQN VSLHSSYEAK
210 220 230 240 250
EVSQPPRVKK LYPELPAEIA EVPALVAVKP LLRSERLYPE LPSQPEVTPF
260 270 280 290 300
TKEQLKLLEP GSWLENVASY VEEFDNIAHQ DRHEFYELLL NYSRCRKQLL
310 320 330 340 350
LAEAELLTLM SDCHSAKSRL WHFKDEQMAV QGICADQVKV YGHHHYQRVE
360 370 380 390 400
MNENVLGELK KLFDAKSEHL HQTLTLHSYT SVLSRLQVES YIFTLLNSSA
410 420 430 440 450
ALRSLAVYQA DQVPKLTESI PSDVCQLKEC ISVLFMFTRR VSEDAQFHED
460 470 480 490 500
ILLWLQKLVS VLQRVGCPGD HFFLLNHVLR CPAGIRKWAV PFIQIKVLNN
510 520 530 540 550
PSGVFHFMQS LALLMSPVKN RAEFMCHMKP SEWKPSSSGP ASGNWTLVDE
560 570 580 590 600
AGEEDEDPET SWILLNEDDL VTLLSQFPFQ ELFQHLLGFK AKGDYLPETT
610 620 630 640 650
RPQEMMKIFA FANSLVELLA VGLDTFNRAR YRQFVKRIGY LIRMTLGYVS
660 670 680 690 700
DHWAQYVSHS TGAGLTPQPY SMEKLQVEFD ELFLRAVLHV LKAKRLGIWL
710 720 730 740 750
FMSEMPFGTL SVQMLWKLLY LMHQVESGDL QQLCASLQPA ECKRRLQDPE
760 770 780 790 800
HFASFEKCLS SINSSEEICL LTAFAQMARA RRTNVDEDFI KIIVLEIYEV
810 820 830 840 850
SYVTLSTRET FSKVGRELLG AIAAVHPEII SVLLDRVQET IDQVGMVSLY
860 870 880 890 900
LFKELPLYLW RPSAPEIAVI RDWLLNNNLT AVKNKLACVI LEGLNWGFTE
910 920 930 940 950
QGTLHLDQAL HTEVALLVLE AYQKYLAQKP YTGLISESMK QVSYLASIVR
960 970 980 990 1000
YGETPETSFN QWAWNLILRL KLHKNDFGRQ NFPVIPFCST VPDMTESSMF
1010 1020 1030 1040 1050
HPLLKAVKSG LPIGCYLALA VTAVGHSLEK FCAEGIPLLG VLVQSRHLRA
1060 1070 1080 1090 1100
VVHALDKILP VFYPYQCYLL KNEQFLSNLL LFLQLDSGVP QGVTQQVTHR
1110 1120 1130 1140 1150
VAQHLTGAVH GDNVKLLSSM IQAHICVSTQ PDGVGPVAVL EFWVQALISQ
1160 1170 1180 1190 1200
HLWYREQPIL FLMDHLCKTA FHLMQEDCVQ KLLYQQHKNA LGYHCDRSLL
1210 1220 1230 1240 1250
SSLVNWIVAG NITPSFVEGL STSTQVWFAW TVLNMESIFE EDSQLRRVVE
1260 1270 1280 1290 1300
RELVINAFSP DQALKKAQVQ LKLPIVPSLQ RLLIYRWAHQ ALVTPSDHPL
1310 1320 1330 1340 1350
LPLIWQKFFL LYLHRPGPQY GLPVDGCIGR RFFQSPSHVN LLKDMKRRLT
1360 1370 1380 1390 1400
EVADFHYAAS KALRVPAEGS EGTPEGQAGT PGFLTSPELH RELVRLFNVY
1410 1420 1430 1440 1450
VLWLEDENFQ KGDTYIPSLP KHYDVHRLAK VMQNQQDLWM EYVNMERIQH
1460 1470 1480 1490 1500
EFQETVALWT QAKLESHAAP CSSSAQLDFT DPLLAKARVL SNLEKHEAPH
1510 1520 1530 1540 1550
PPLLLHPVRP PVPLIPSAAL LTQKDSTQLM CTDLNLLQQQ ARSATLRESQ
1560 1570 1580 1590 1600
QVALDGELLE TMPKQYVNRE DQATLHLECR GSSGKKCQGA AVVTVQFEGM
1610 1620 1630 1640 1650
NKNEAVSQQI HVLQKEVRQL QAEAAQPPAL NVVEAAVHAE NLITALVNTY
1660 1670 1680 1690 1700
KLQPTPGVQK LGISLFFTVV DHVSDETQRH PPTRQFFTSC IEILGQVFVS
1710 1720 1730 1740 1750
GTKSECRKLL QTILKNRRLC SLLAPFFTPN AAPAEFIQLY ERVVTCLRED
1760 1770 1780 1790 1800
NSDVIFMLLT KFDIQQWLNS TKPPLSDRTR LLESIHLALT AWGLEPEEDI
1810 1820 1830 1840 1850
LMPFNLFCKH WTHLLLYQFP DQYSDVLRLL VQSSAEQLLS PECWKATLRA
1860 1870 1880 1890 1900
LGCYAPSSQQ GAASVESSGL HSASRVLLSD KQVMETVQWL SDFFYKLRLS
1910 1920 1930 1940 1950
KLDFKSFGLF SKWSPYMADV KTFLGYLVKR LTDLEIASLS QDPTASSKEV
1960 1970 1980 1990 2000
LRSLHAQIIQ LFKPWILVLE DAESSHQRHY PWLESDTAVA SSIVQLFSDC
2010 2020 2030 2040 2050
VGSLHTSFKD RLLPGDEGAL RLHLLHYCET CTAPKMPEFI LYAFHSAYQR
2060 2070 2080 2090 2100
LEWKDLHPDQ RLMEAFFKVE RGSPKSCFLF LGSVLCRVNW VSVLSDAWNP
2110 2120 2130 2140 2150
SPLPETQSMA VCLLFMMVLL AKEAQLVDEP DSPLLSLLGQ TSSLSWHLVD
2160 2170 2180 2190 2200
LVSYQSVLGY FSSHYPPSVV LANDCSSELI VKLLKVSAGL SAHADGRKHV
2210 2220 2230 2240 2250
DIVPKCQAFT HQMVQFLSAL EQTGKITFPA LEREISKLLD DIIIFNPPDM
2260 2270 2280 2290 2300
DSQTRHMALS SFFVEVLMMM NNAAVPTAEF LAVSIRTWIG QRVHGLIVLP
2310 2320 2330 2340 2350
LLTAACQSLA SVRHMAEITE ACIMAYFKES SLDQNLGWGP VLVSLQVPQL
2360 2370 2380 2390 2400
TARDFLEECL ALGSCLTLYV YLLQCLNSEQ TVKNDMKMLL VVSGWLEQVY
2410 2420 2430 2440 2450
PSSAQEEAKL FLWWHQILQL SLIQLEQNDS VLTESVIRIL LMLQSRQSLM
2460 2470 2480 2490 2500
AEERLSSGIL GAIGLGRRSP LSNRFRVAAR SMAAFLLVQV PAEDQIRLKP
2510 2520 2530 2540 2550
SSELHLAPKA QQVLTALESM TLSKQYVEYQ DQILHALQFI RHPGHCLQNG
2560 2570
KSFLALLVNR LYPEVHYLDN IR
Length:2,572
Mass (Da):290,801
Last modified:October 2, 2007 - v2
Checksum:i17637F25ACDB8482
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126553 Genomic DNA. No translation available.
AK122536 mRNA. Translation: BAC65818.1.
CCDSiCCDS57126.1.
RefSeqiNP_001182562.1. NM_001195633.1.
UniGeneiMm.297782.
Mm.491179.

Genome annotation databases

EnsembliENSMUST00000044622; ENSMUSP00000038681; ENSMUSG00000039840.
GeneIDi100502841.
KEGGimmu:100502841.
UCSCiuc008fsa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126553 Genomic DNA. No translation available.
AK122536 mRNA. Translation: BAC65818.1.
CCDSiCCDS57126.1.
RefSeqiNP_001182562.1. NM_001195633.1.
UniGeneiMm.297782.
Mm.491179.

3D structure databases

ProteinModelPortaliQ80TA9.
SMRiQ80TA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038681.

PTM databases

iPTMnetiQ80TA9.
PhosphoSitePlusiQ80TA9.

Proteomic databases

EPDiQ80TA9.
MaxQBiQ80TA9.
PaxDbiQ80TA9.
PeptideAtlasiQ80TA9.
PRIDEiQ80TA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044622; ENSMUSP00000038681; ENSMUSG00000039840.
GeneIDi100502841.
KEGGimmu:100502841.
UCSCiuc008fsa.2. mouse.

Organism-specific databases

CTDi57724.
MGIiMGI:1918673. Epg5.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3622. Eukaryota.
ENOG410XUQ7. LUCA.
GeneTreeiENSGT00390000007354.
HOVERGENiHBG108040.
InParanoidiQ80TA9.
OMAiAVEFFYN.
OrthoDBiEOG091G00HO.
PhylomeDBiQ80TA9.
TreeFamiTF313847.

Miscellaneous databases

PROiQ80TA9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039840.
CleanExiMM_5430411K18RIK.
GenevisibleiQ80TA9. MM.

Family and domain databases

InterProiIPR029651. EPG-5.
[Graphical view]
PANTHERiPTHR31139:SF4. PTHR31139:SF4. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEPG5_MOUSE
AccessioniPrimary (citable) accession number: Q80TA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.