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Protein

Myotubularin-related protein 12

Gene

Mtmr12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location.By similarity

GO - Biological processi

  • toxin transport Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 12
Gene namesi
Name:Mtmr12
Synonyms:Kiaa1682
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2443034. Mtmr12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 747747Myotubularin-related protein 12PRO_0000315826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei564 – 5641PhosphoserineBy similarity
Modified residuei601 – 6011PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80TA6.
MaxQBiQ80TA6.
PaxDbiQ80TA6.
PeptideAtlasiQ80TA6.
PRIDEiQ80TA6.

PTM databases

iPTMnetiQ80TA6.
PhosphoSiteiQ80TA6.

Expressioni

Gene expression databases

BgeeiQ80TA6.
CleanExiMM_MTMR12.
ExpressionAtlasiQ80TA6. baseline and differential.
GenevisibleiQ80TA6. MM.

Interactioni

Subunit structurei

Interacts with myotubularin MTM1 and myotubularin-related MTMR2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041227.

Structurei

3D structure databases

ProteinModelPortaliQ80TA6.
SMRiQ80TA6. Positions 224-541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini205 – 643439Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni449 – 558110Interaction with MTM1By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000113684.
HOVERGENiHBG108154.
InParanoidiQ80TA6.
KOiK18085.
OMAiNDITLQC.
OrthoDBiEOG7K0ZBZ.
PhylomeDBiQ80TA6.
TreeFamiTF315197.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80TA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGKGGVGGG GGTKAPKPSF VSYVRPEEIH TDEKEVTEKE VTLHLLPGEQ
60 70 80 90 100
LLCEASTVLK YVQEDSCQRG VYGRLVCTDF KISFLGDEDS ALDNGGEAQF
110 120 130 140 150
KNKIIGVNDV PLHCVDQIYG VFDEKKKPLF GQLKKYPEKL VIHCKDLRVL
160 170 180 190 200
HFCLRYTKEE EVKRIVSGII HHTQSPKLLK RLFLFSYAAA VHGTATDSRN
210 220 230 240 250
CTVMFDTPKD WCWELERTKG SVKYRTVSVN EGYRVSDRLP AYFVVPTPLP
260 270 280 290 300
EDDVRRFQGH GIPIWCWSCH NGSALLKMSA LPKEQDDGAL QVQKSFLDGI
310 320 330 340 350
YKTIHRPPYE MVKTEDLSSN FLSLQEIQSA YCKFKQLFLI DNSSEFWDTD
360 370 380 390 400
IKWFSLLESS SWLDIIRRCL KKAIEITECL EAQNVNVLLL EENASDLCCL
410 420 430 440 450
LSSLVQVMMD AHCRTRTGFQ SLIQKEWVMG GHSFLDRCNH LHQSDKEEVP
460 470 480 490 500
IFLLFLDCVW QLVHQYPPAF EFTETYLTVL SDSLYIPIFS TFFFNSPHQK
510 520 530 540 550
DTNMGRENLD AQSKPLTLLT VWDWSVQFEP KAQTLLRNPL YVEKPKLDRG
560 570 580 590 600
QQKGSRFKHQ RQLSLPLTQS KSSPKRGFFR EETDHLIKNL LGKRISKLIN
610 620 630 640 650
SSDDLQDSSR EFYDSWHSKP TDYHGLLLPH IEGPEIKVWA QRYLRWIPEA
660 670 680 690 700
QILGGGRVAT MGKLLEMMEE VQSLQEKIEA RHHRQEAVHA EAPGLLRNSV
710 720 730 740
RLSSLFPFAL LQRHSAKPVL PTSGWKALGG EDDLAKREDE FVDLGDV
Length:747
Mass (Da):85,516
Last modified:January 15, 2008 - v2
Checksum:iD4D2AE2E8772500E
GO
Isoform 2 (identifier: Q80TA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-357: Missing.

Show »
Length:437
Mass (Da):49,893
Checksum:i463C81470DE9B400
GO

Sequence cautioni

The sequence BAC36227.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC65821.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei48 – 357310Missing in isoform 2. 1 PublicationVSP_030723Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122539 mRNA. Translation: BAC65821.1. Different initiation.
AK030139 mRNA. Translation: BAC26803.1.
AK076161 mRNA. Translation: BAC36227.1. Different initiation.
BC054352 mRNA. Translation: AAH54352.1.
CCDSiCCDS27388.1. [Q80TA6-1]
RefSeqiNP_766546.1. NM_172958.3. [Q80TA6-1]
UniGeneiMm.54460.

Genome annotation databases

EnsembliENSMUST00000038172; ENSMUSP00000041227; ENSMUSG00000039458. [Q80TA6-1]
ENSMUST00000071993; ENSMUSP00000071883; ENSMUSG00000039458. [Q80TA6-2]
GeneIDi268783.
KEGGimmu:268783.
UCSCiuc007vhl.1. mouse. [Q80TA6-1]
uc011zrl.1. mouse. [Q80TA6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122539 mRNA. Translation: BAC65821.1. Different initiation.
AK030139 mRNA. Translation: BAC26803.1.
AK076161 mRNA. Translation: BAC36227.1. Different initiation.
BC054352 mRNA. Translation: AAH54352.1.
CCDSiCCDS27388.1. [Q80TA6-1]
RefSeqiNP_766546.1. NM_172958.3. [Q80TA6-1]
UniGeneiMm.54460.

3D structure databases

ProteinModelPortaliQ80TA6.
SMRiQ80TA6. Positions 224-541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041227.

PTM databases

iPTMnetiQ80TA6.
PhosphoSiteiQ80TA6.

Proteomic databases

EPDiQ80TA6.
MaxQBiQ80TA6.
PaxDbiQ80TA6.
PeptideAtlasiQ80TA6.
PRIDEiQ80TA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038172; ENSMUSP00000041227; ENSMUSG00000039458. [Q80TA6-1]
ENSMUST00000071993; ENSMUSP00000071883; ENSMUSG00000039458. [Q80TA6-2]
GeneIDi268783.
KEGGimmu:268783.
UCSCiuc007vhl.1. mouse. [Q80TA6-1]
uc011zrl.1. mouse. [Q80TA6-2]

Organism-specific databases

CTDi54545.
MGIiMGI:2443034. Mtmr12.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000113684.
HOVERGENiHBG108154.
InParanoidiQ80TA6.
KOiK18085.
OMAiNDITLQC.
OrthoDBiEOG7K0ZBZ.
PhylomeDBiQ80TA6.
TreeFamiTF315197.

Miscellaneous databases

ChiTaRSiMtmr12. mouse.
PROiQ80TA6.
SOURCEiSearch...

Gene expression databases

BgeeiQ80TA6.
CleanExiMM_MTMR12.
ExpressionAtlasiQ80TA6. baseline and differential.
GenevisibleiQ80TA6. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung and Spleen.

Entry informationi

Entry nameiMTMRC_MOUSE
AccessioniPrimary (citable) accession number: Q80TA6
Secondary accession number(s): Q8BVX4, Q8C0P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 6, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks the phosphocysteine intermediate Cys active site in position 391 that is replaced by a Glu residue, preventing the hydrolase activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.