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Protein

Ethanolaminephosphotransferase 1

Gene

Ept1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway (By similarity).By similarity

Catalytic activityi

CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine.

Cofactori

Mg2+By similarity, Mn2+By similarity

Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Choline/ethanolamine kinase (Chkb), Ethanolamine kinase 2 (Etnk2), Ethanolamine kinase 1 (Etnk1), Choline kinase alpha (Chka)
  2. Ethanolamine-phosphate cytidylyltransferase (Pcyt2)
  3. Choline/ethanolaminephosphotransferase 1 (Cept1), Ethanolaminephosphotransferase 1 (Ept1)
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1483213. Synthesis of PE.
UniPathwayiUPA00558; UER00743.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolaminephosphotransferase 1 (EC:2.7.8.1)
Alternative name(s):
Selenoprotein I
Short name:
SelI
Gene namesi
Name:Ept1
Synonyms:D5Wsu178e, Kiaa1724, Seli
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107898. Ept1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6923HelicalSequence analysisAdd
BLAST
Transmembranei84 – 10320HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14523HelicalSequence analysisAdd
BLAST
Transmembranei150 – 17223HelicalSequence analysisAdd
BLAST
Transmembranei179 – 20123HelicalSequence analysisAdd
BLAST
Transmembranei221 – 24323HelicalSequence analysisAdd
BLAST
Transmembranei256 – 27823HelicalSequence analysisAdd
BLAST
Transmembranei291 – 31020HelicalSequence analysisAdd
BLAST
Transmembranei319 – 34123HelicalSequence analysisAdd
BLAST
Transmembranei345 – 36723HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 398397Ethanolaminephosphotransferase 1PRO_0000056814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ80TA1.
PaxDbiQ80TA1.
PRIDEiQ80TA1.

Expressioni

Gene expression databases

BgeeiQ80TA1.
ExpressionAtlasiQ80TA1. baseline and differential.
GenevisibleiQ80TA1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000118368.

Structurei

3D structure databases

ProteinModelPortaliQ80TA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2877. Eukaryota.
COG5050. LUCA.
GeneTreeiENSGT00530000063048.
HOGENOMiHOG000008114.
HOVERGENiHBG044519.
InParanoidiQ80TA1.
KOiK00993.
OMAiVPLFSPC.
OrthoDBiEOG7M6D83.
TreeFamiTF313270.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR014472. CHOPT.
[Graphical view]
PANTHERiPTHR10414. PTHR10414. 1 hit.
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF015665. CHOPT. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80TA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGYEYVSPE QLSGFDKYKY SALDTNPLSL YIMHPFWNTI VKVFPTWLAP
60 70 80 90 100
NLITFSGFML LVFNFLLLTY FDPDFYASAP GHKHVPDWVW IVVGILNFAA
110 120 130 140 150
YTLDGVDGKQ ARRTNSSTPL GELFDHGLDS WSCVYFVVTV YSIFGRGPTG
160 170 180 190 200
VSVFVLYLLL WVVLFSFILS HWEKYNTGVL FLPWGYDISQ VTISFVYIVT
210 220 230 240 250
AVVGVEAWYE PFLFNFLYRD LFTAMIIGCA LCVTLPMSLL NFFRSYKSNT
260 270 280 290 300
LKHKSVYEAM VPFFSPCLLF TLCTVWILWS PSDILEIHPR IFYFMVGTAF
310 320 330 340 350
ANITCQLIVC QMSSTRCPTL NWLLLPLLLV VAAVIVGAAT SRLESALLYT
360 370 380 390
LTAAFTLAHI HYGVQVVKQL SRHFQIYPFS LRKPNSDULG MEEQNIGL
Length:398
Mass (Da):45,346
Last modified:February 26, 2008 - v3
Checksum:i9DE0703774583D23
GO

Sequence cautioni

The sequence BAC33214.1 differs from that shown. Reason: Erroneous termination at position 388. Translated as Sec.Curated
The sequence BAC37608.1 differs from that shown. Reason: Erroneous termination at position 388. Translated as Sec.Curated
The sequence BAC65826.1 differs from that shown. Reason: Erroneous termination at position 388. Translated as Sec.Curated

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei388 – 3881SelenocysteineBy similarity

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122544 mRNA. Translation: BAC65826.1. Sequence problems.
AK048011 mRNA. Translation: BAC33214.1. Sequence problems.
AK079325 mRNA. Translation: BAC37608.1. Sequence problems.
BC106097 mRNA. Translation: AAI06098.2.
BC115783 mRNA. Translation: AAI15784.2.
BC117551 mRNA. Translation: AAI17552.2.
CCDSiCCDS51451.1.
RefSeqiNP_081928.2. NM_027652.2.
UniGeneiMm.168854.

Genome annotation databases

EnsembliENSMUST00000145167; ENSMUSP00000118368; ENSMUSG00000075703.
GeneIDi28042.
KEGGimmu:28042.
UCSCiuc008wvh.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122544 mRNA. Translation: BAC65826.1. Sequence problems.
AK048011 mRNA. Translation: BAC33214.1. Sequence problems.
AK079325 mRNA. Translation: BAC37608.1. Sequence problems.
BC106097 mRNA. Translation: AAI06098.2.
BC115783 mRNA. Translation: AAI15784.2.
BC117551 mRNA. Translation: AAI17552.2.
CCDSiCCDS51451.1.
RefSeqiNP_081928.2. NM_027652.2.
UniGeneiMm.168854.

3D structure databases

ProteinModelPortaliQ80TA1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000118368.

Proteomic databases

MaxQBiQ80TA1.
PaxDbiQ80TA1.
PRIDEiQ80TA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000145167; ENSMUSP00000118368; ENSMUSG00000075703.
GeneIDi28042.
KEGGimmu:28042.
UCSCiuc008wvh.1. mouse.

Organism-specific databases

CTDi85465.
MGIiMGI:107898. Ept1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2877. Eukaryota.
COG5050. LUCA.
GeneTreeiENSGT00530000063048.
HOGENOMiHOG000008114.
HOVERGENiHBG044519.
InParanoidiQ80TA1.
KOiK00993.
OMAiVPLFSPC.
OrthoDBiEOG7M6D83.
TreeFamiTF313270.

Enzyme and pathway databases

UniPathwayiUPA00558; UER00743.
ReactomeiR-MMU-1483213. Synthesis of PE.

Miscellaneous databases

NextBioi306568.
PROiQ80TA1.
SOURCEiSearch...

Gene expression databases

BgeeiQ80TA1.
ExpressionAtlasiQ80TA1. baseline and differential.
GenevisibleiQ80TA1. MM.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR014472. CHOPT.
[Graphical view]
PANTHERiPTHR10414. PTHR10414. 1 hit.
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF015665. CHOPT. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiEPT1_MOUSE
AccessioniPrimary (citable) accession number: Q80TA1
Secondary accession number(s): Q3KQQ5, Q8BG08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: February 26, 2008
Last modified: November 11, 2015
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.