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Q80TA1 (EPT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ethanolaminephosphotransferase 1
EC=2.7.8.1
Alternative name(s):
Selenoprotein I
Short name=SelI
Gene names
Name:Ept1
Synonyms:D5Wsu178e, Kiaa1724, Seli
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway By similarity.

Catalytic activity

CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.

Cofactor

Magnesium or manganese By similarity.

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Sequence caution

The sequence BAC33214.1 differs from that shown. Reason: Erroneous termination at position 388. Translated as Sec.

The sequence BAC37608.1 differs from that shown. Reason: Erroneous termination at position 388. Translated as Sec.

The sequence BAC65826.1 differs from that shown. Reason: Erroneous termination at position 388. Translated as Sec.

Ontologies

Keywords
   Biological processLipid biosynthesis
Lipid metabolism
Phospholipid biosynthesis
Phospholipid metabolism
   Cellular componentMembrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionethanolaminephosphotransferase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Ethanolaminephosphotransferase 1
PRO_0000056814

Regions

Transmembrane47 – 6923Helical; Potential
Transmembrane84 – 10320Helical; Potential
Transmembrane123 – 14523Helical; Potential
Transmembrane150 – 17223Helical; Potential
Transmembrane179 – 20123Helical; Potential
Transmembrane221 – 24323Helical; Potential
Transmembrane256 – 27823Helical; Potential
Transmembrane291 – 31020Helical; Potential
Transmembrane319 – 34123Helical; Potential
Transmembrane345 – 36723Helical; Potential

Amino acid modifications

Non-standard residue3881Selenocysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80TA1 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: 9DE0703774583D23

FASTA39845,346
        10         20         30         40         50         60 
MAGYEYVSPE QLSGFDKYKY SALDTNPLSL YIMHPFWNTI VKVFPTWLAP NLITFSGFML 

        70         80         90        100        110        120 
LVFNFLLLTY FDPDFYASAP GHKHVPDWVW IVVGILNFAA YTLDGVDGKQ ARRTNSSTPL 

       130        140        150        160        170        180 
GELFDHGLDS WSCVYFVVTV YSIFGRGPTG VSVFVLYLLL WVVLFSFILS HWEKYNTGVL 

       190        200        210        220        230        240 
FLPWGYDISQ VTISFVYIVT AVVGVEAWYE PFLFNFLYRD LFTAMIIGCA LCVTLPMSLL 

       250        260        270        280        290        300 
NFFRSYKSNT LKHKSVYEAM VPFFSPCLLF TLCTVWILWS PSDILEIHPR IFYFMVGTAF 

       310        320        330        340        350        360 
ANITCQLIVC QMSSTRCPTL NWLLLPLLLV VAAVIVGAAT SRLESALLYT LTAAFTLAHI 

       370        380        390 
HYGVQVVKQL SRHFQIYPFS LRKPNSDULG MEEQNIGL

« Hide

References

[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum and Head.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK122544 mRNA. Translation: BAC65826.1. Sequence problems.
AK048011 mRNA. Translation: BAC33214.1. Sequence problems.
AK079325 mRNA. Translation: BAC37608.1. Sequence problems.
BC106097 mRNA. Translation: AAI06098.2.
BC115783 mRNA. Translation: AAI15784.2.
BC117551 mRNA. Translation: AAI17552.2.
IPIIPI00753965.
RefSeqNP_081928.2. NM_027652.2.
UniGeneMm.168854.

3D structure databases

ModBaseSearch...

Proteomic databases

PaxDbQ80TA1.
PRIDEQ80TA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000145167; ENSMUSP00000118368; ENSMUSG00000075703.
GeneID28042.
KEGGmmu:28042.
UCSCuc008wvh.1. mouse.

Organism-specific databases

CTD85465.
MGIMGI:107898. Ept1.
RougeSearch...

Phylogenomic databases

eggNOGCOG5050.
GeneTreeENSGT00530000063048.
HOGENOMHOG000008114.
HOVERGENHBG044519.
InParanoidQ80TA1.
KOK00993.
OMATCQLIVC.

Enzyme and pathway databases

UniPathwayUPA00558; UER00743.

Gene expression databases

ArrayExpressQ80TA1.
BgeeQ80TA1.
GenevestigatorQ80TA1.
GermOnlineENSMUSG00000075703. Mus musculus.

Family and domain databases

InterProIPR000462. CDP-OH_P_trans.
IPR014472. CHOPT.
[Graphical view]
PfamPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFPIRSF015665. CHOPT. 1 hit.
PROSITEPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio306568.
SOURCESearch...

Entry information

Entry nameEPT1_MOUSE
AccessionPrimary (citable) accession number: Q80TA1
Secondary accession number(s): Q3KQQ5, Q8BG08
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: February 26, 2008
Last modified: April 3, 2013
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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