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Protein

Kelch-like protein 29

Gene

Klhl29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 29
Alternative name(s):
Kelch repeat and BTB domain-containing protein 9
Gene namesi
Name:Klhl29
Synonyms:Kbtbd9, Kiaa1921
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2683857. Klhl29.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Kelch-like protein 29PRO_0000119087Add
BLAST

Proteomic databases

MaxQBiQ80T74.
PaxDbiQ80T74.
PRIDEiQ80T74.

PTM databases

iPTMnetiQ80T74.

Expressioni

Gene expression databases

BgeeiQ80T74.
CleanExiMM_KLHL29.
GenevisibleiQ80T74. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020958.

Structurei

3D structure databases

ProteinModelPortaliQ80T74.
SMRiQ80T74. Positions 305-562, 569-869.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini329 – 40173BTBPROSITE-ProRule annotationAdd
BLAST
Repeati585 – 63551Kelch 1Add
BLAST
Repeati637 – 68347Kelch 2Add
BLAST
Repeati684 – 73047Kelch 3Add
BLAST
Repeati732 – 77847Kelch 4Add
BLAST
Repeati779 – 82143Kelch 5Add
BLAST
Repeati822 – 87049Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000230815.
HOVERGENiHBG096078.
InParanoidiQ80T74.
KOiK10465.
OMAiWIKKDPV.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80T74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRHHSRFER DYRIGWDRRE WSVNGTHGAT SVCSVTSGAG GSTASSLSAR
60 70 80 90 100
PGLLPLPVVP SRLPTPATAP APCTTGSSEA ITSLVVSSAS AATTKAPGIS
110 120 130 140 150
KADNQSQGLT TSIRWGQTPV NQSTPWDTDE PPSKQMRESD NPGTGPWVTT
160 170 180 190 200
VAAGNQPSLI THSYGVTQPP TFSPAVNVQA PVIGVTPSLP PHVGPQLPLI
210 220 230 240 250
PGHYSLPQPP SQPLSSVVVN MPAQALYASP QPLAVSTLPG VGQVSRPGPT
260 270 280 290 300
PVGNGHMAGP LLPPPPPAQP SAALPSSVPA TNGPPTTDSA HGLQMLRTIG
310 320 330 340 350
VGKYEFTDPG HPKEMLKELN QQRRAKAFTD LKIVVEGREF EVHQNVLASC
360 370 380 390 400
SLYFKDLIQR SVQDSSQSSR EKLELVLSNL QADVLELLLE FVYTGSLVID
410 420 430 440 450
SANAKTLLEA ASKFQFHTFC KVCVSFLEKQ LTASNCLGVL AMAEAMQCSE
460 470 480 490 500
LYHMAKAFAL QIFPEVAAQE EILSISKDDF IAYVSNDSLN TKAEELVYET
510 520 530 540 550
VIKWIKKDPA TRAQYAAELL AAVRLPFIHP SYLLNVVDNE ELIKSSEACR
560 570 580 590 600
DLVNEAKRYH MLPHARQEMQ TPRTRPRLSA GVAEVIVLVG GRQMVGMTQR
610 620 630 640 650
SLVAVTCWNP QNNKWYPLAS LPFYDREFFS VVSAGDNIYL SGGMESGVTL
660 670 680 690 700
ADVWCYMSLL DNWNLVSRMT VPRCRHNSLV YDGKIYTLGG LGVAGNVDHV
710 720 730 740 750
ERYDTITNQW EAVAPLPKAV HSAAATVCGG KIYVFGGVNE AGRAAGVLQS
760 770 780 790 800
YVPQTNTWSF IESPMIDNKY APAVTLNGFV FILGGAYARA TTIYDPEKGN
810 820 830 840 850
IKAGPNMNHS RQFCSAVVLD GKIYATGGIV SSEGPALGNM EAYEPTTNTW
860 870
TLLPHMPCPV FRHGCVVIKK YIQSG
Length:875
Mass (Da):94,359
Last modified:May 14, 2014 - v3
Checksum:i3B5AB4A0A30D2968
GO

Sequence cautioni

The sequence AAI38284.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI45749.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC65854.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122572 mRNA. Translation: BAC65854.1. Different initiation.
BC138283 mRNA. Translation: AAI38284.1. Different initiation.
BC145748 mRNA. Translation: AAI45749.1. Different initiation.
CCDSiCCDS49021.1.
RefSeqiNP_001157965.1. NM_001164493.1.
UniGeneiMm.388281.

Genome annotation databases

EnsembliENSMUST00000020958; ENSMUSP00000020958; ENSMUSG00000020627.
GeneIDi208439.
KEGGimmu:208439.
UCSCiuc007myw.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122572 mRNA. Translation: BAC65854.1. Different initiation.
BC138283 mRNA. Translation: AAI38284.1. Different initiation.
BC145748 mRNA. Translation: AAI45749.1. Different initiation.
CCDSiCCDS49021.1.
RefSeqiNP_001157965.1. NM_001164493.1.
UniGeneiMm.388281.

3D structure databases

ProteinModelPortaliQ80T74.
SMRiQ80T74. Positions 305-562, 569-869.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020958.

PTM databases

iPTMnetiQ80T74.

Proteomic databases

MaxQBiQ80T74.
PaxDbiQ80T74.
PRIDEiQ80T74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020958; ENSMUSP00000020958; ENSMUSG00000020627.
GeneIDi208439.
KEGGimmu:208439.
UCSCiuc007myw.3. mouse.

Organism-specific databases

CTDi114818.
MGIiMGI:2683857. Klhl29.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129689.
HOGENOMiHOG000230815.
HOVERGENiHBG096078.
InParanoidiQ80T74.
KOiK10465.
OMAiWIKKDPV.

Miscellaneous databases

ChiTaRSiKlhl29. mouse.
PROiQ80T74.
SOURCEiSearch...

Gene expression databases

BgeeiQ80T74.
CleanExiMM_KLHL29.
GenevisibleiQ80T74. MM.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKLH29_MOUSE
AccessioniPrimary (citable) accession number: Q80T74
Secondary accession number(s): A6H646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 14, 2014
Last modified: July 6, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although the complete sequence is not known with certainty, sequence shown here appears to be the most probable in accordance with human sequence ortholog.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.