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Protein

Probable G-protein coupled receptor 101

Gene

Gpr101

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 101
Gene namesi
Name:Gpr101
Synonyms:Gm365
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2685211. Gpr101.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence analysisAdd
BLAST
Transmembranei36 – 5621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini57 – 6711CytoplasmicSequence analysisAdd
BLAST
Transmembranei68 – 9023Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 10616ExtracellularSequence analysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini128 – 14922CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 19626ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 398181CytoplasmicSequence analysisAdd
BLAST
Transmembranei399 – 41921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini420 – 43213ExtracellularSequence analysisAdd
BLAST
Transmembranei433 – 45321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini454 – 51158CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Probable G-protein coupled receptor 101PRO_0000069602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ80T62.
PRIDEiQ80T62.

PTM databases

iPTMnetiQ80T62.

Expressioni

Tissue specificityi

Expressed in the brain in hypothalamus.1 Publication

Gene expression databases

BgeeiQ80T62.
CleanExiMM_GPR101.
ExpressionAtlasiQ80T62. baseline and differential.
GenevisibleiQ80T62. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058183.

Structurei

3D structure databases

ProteinModelPortaliQ80T62.
SMRiQ80T62. Positions 36-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000112760.
HOVERGENiHBG051766.
InParanoidiQ80T62.
KOiK08423.
OMAiSHFCTAL.
OrthoDBiEOG7N0C5C.
PhylomeDBiQ80T62.
TreeFamiTF331895.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80T62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPSCTNSTQ ENNGSRVCLP LSKMPISVAH GIIRSVVLLV ILGVAFLGNV
60 70 80 90 100
VLGYVLHRKP NLLQVTNRFI FNLLVTDLLQ VALVAPWVVS TAIPFFWPLN
110 120 130 140 150
IHFCTALVSL THLFAFASVN TIVVVSVDRY LTIIHPLSYP SKMTNRRSYI
160 170 180 190 200
LLYGTWIAAF LQSTPPLYGW GHATFDDRNA FCSMIWGASP AYTVVSVVSF
210 220 230 240 250
LVIPLGVMIA CYSVVFGAAR RQQALLYKAK SHRLEVRVED SVVHENEEGA
260 270 280 290 300
KKRDEFQDKN EFQGQDGGGQ AEAKGSSSME ESPMVAEGSS QKTGKGSLDF
310 320 330 340 350
SAGIMEGKDS DEVSNGSMEG LEVITEFQAS SAKADTGRID ANQCNIDVGE
360 370 380 390 400
DDVEFGMDEI HFNDDVEAMR IPESSPPSRR NSTSDPPLPP CYECKAARVI
410 420 430 440 450
FVIISTYVLS LGPYCFLAVL AVWVDIDTRV PQWVITIIIW LFFLQCCIHP
460 470 480 490 500
YVYGYMHKSI KKEIQEVLKK LICKKSPPVE DSHPDLHETE AGTEGGIEGK
510
AVPSHDSATS P
Length:511
Mass (Da):56,245
Last modified:December 6, 2005 - v2
Checksum:i0E224DE2FA43C7E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138185 mRNA. Translation: BAE23572.1.
AK138370 mRNA. Translation: BAE23636.1.
AY255576 mRNA. Translation: AAO85088.1.
CCDSiCCDS30154.1.
RefSeqiNP_001028532.1. NM_001033360.3.
UniGeneiMm.336070.

Genome annotation databases

EnsembliENSMUST00000057645; ENSMUSP00000058183; ENSMUSG00000036357.
GeneIDi245424.
KEGGimmu:245424.
UCSCiuc009thn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138185 mRNA. Translation: BAE23572.1.
AK138370 mRNA. Translation: BAE23636.1.
AY255576 mRNA. Translation: AAO85088.1.
CCDSiCCDS30154.1.
RefSeqiNP_001028532.1. NM_001033360.3.
UniGeneiMm.336070.

3D structure databases

ProteinModelPortaliQ80T62.
SMRiQ80T62. Positions 36-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058183.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ80T62.

Proteomic databases

PaxDbiQ80T62.
PRIDEiQ80T62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057645; ENSMUSP00000058183; ENSMUSG00000036357.
GeneIDi245424.
KEGGimmu:245424.
UCSCiuc009thn.2. mouse.

Organism-specific databases

CTDi83550.
MGIiMGI:2685211. Gpr101.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000112760.
HOVERGENiHBG051766.
InParanoidiQ80T62.
KOiK08423.
OMAiSHFCTAL.
OrthoDBiEOG7N0C5C.
PhylomeDBiQ80T62.
TreeFamiTF331895.

Miscellaneous databases

PROiQ80T62.
SOURCEiSearch...

Gene expression databases

BgeeiQ80T62.
CleanExiMM_GPR101.
ExpressionAtlasiQ80T62. baseline and differential.
GenevisibleiQ80T62. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-217.
  3. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGP101_MOUSE
AccessioniPrimary (citable) accession number: Q80T62
Secondary accession number(s): Q3UUI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 6, 2005
Last modified: June 8, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.