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Protein

Adhesion G-protein coupled receptor D1

Gene

Adgrd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Signals via G(s)-alpha family of G-proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Protein family/group databases

MEROPSiP02.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor D1
Alternative name(s):
G-protein coupled receptor 133
G-protein coupled receptor PGR25
Gene namesi
Name:Adgrd1
Synonyms:Gpr133, Pgr25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:3041203. Adgrd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 599ExtracellularCuratedAdd BLAST573
Transmembranei600 – 620Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini621 – 632CytoplasmicCuratedAdd BLAST12
Transmembranei633 – 653Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini654 – 662ExtracellularCurated9
Transmembranei663 – 683Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini684 – 701CytoplasmicCuratedAdd BLAST18
Transmembranei702 – 722Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini723 – 740ExtracellularCuratedAdd BLAST18
Transmembranei741 – 761Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini762 – 789CytoplasmicCuratedAdd BLAST28
Transmembranei790 – 810Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini811 – 813ExtracellularCurated3
Transmembranei814 – 834Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini835 – 903CytoplasmicCuratedAdd BLAST69

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000030711327 – 903Adhesion G-protein coupled receptor D1Add BLAST877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1
Glycosylationi331N-linked (GlcNAc...)Sequence analysis1
Glycosylationi338N-linked (GlcNAc...)Sequence analysis1
Glycosylationi348N-linked (GlcNAc...)Sequence analysis1
Glycosylationi505N-linked (GlcNAc...)Sequence analysis1
Glycosylationi530N-linked (GlcNAc...)Sequence analysis1
Glycosylationi543N-linked (GlcNAc...)Sequence analysis1
Glycosylationi562N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ80T32.
PRIDEiQ80T32.

PTM databases

PhosphoSitePlusiQ80T32.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044017.
CleanExiMM_GPR133.
ExpressionAtlasiQ80T32. baseline and differential.
GenevisibleiQ80T32. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060307.

Structurei

3D structure databases

ProteinModelPortaliQ80T32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini536 – 585GPSPROSITE-ProRule annotationAdd BLAST50

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000056451.
HOVERGENiHBG051779.
InParanoidiQ80T32.
KOiK08465.
OMAiYCAFLDY.
OrthoDBiEOG091G00GJ.
PhylomeDBiQ80T32.
TreeFamiTF351999.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80T32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDLPAFPCS WVWLLWSFCS VQVCSTQPRA QEHPGFAVLA SASHYWPLEN
60 70 80 90 100
VDGILELQDT TGALRTLNLT VPLSHNATFV FTNDSAYSNL SATVDIMEGK
110 120 130 140 150
VNKGIYLKEE KGVTFLYYGT YKSSCISNPA QCGPEGVTFS FFWKTQGDQT
160 170 180 190 200
RPAPYAYGGQ VVSDGFKVCS SGGKGSVELY TRDNSMTWKA TFNPPGPYWT
210 220 230 240 250
HVLFTWKSKE GLKVYVNGTL STSDPSGKVS HTYGDPHVNL VIGSEQDQTK
260 270 280 290 300
RYENGAFDEF IIWERALTPD EIKMYFTAAI GKHALLSSTP PAMPTAHTVI
310 320 330 340 350
PTDAYHPIIT NLTEERKRFQ RPGTVLRYLQ NVSLRLPNKS LSEETALNLT
360 370 380 390 400
ETFLRTVGEV LLLPSWTHES EDNAMTLGLV DTIDTVMGHI SSNLQSREPH
410 420 430 440 450
VTLTGSSSTA EFTVAKVLPP ALSAPHYRFP AHGHSYIEIP REALHSQAWT
460 470 480 490 500
TIVGLLYHTM HYYLKNIHPT STEIPEAVNC RDCLLSVASH LISLEVSPPP
510 520 530 540 550
TLSQNLSGSP LITVHLRHKL TQKQYSDATN ESNRLFLYCA FLNFSSGEGV
560 570 580 590 600
WSSQGCALTE GNLTYSVCHC THLTNFAILM QVVPLKLTHG HQVALSSISY
610 620 630 640 650
VGCSLSVLCL AATLVTFAVL SSVSTIRNQR YHIHANLSFA VLVAQVLLLI
660 670 680 690 700
SFSMEPGTVP CQVLAVLLHY FFLTAFAWML VEGLHLYSMV IKVFGSEDSK
710 720 730 740 750
HLYYYGIGWG CPLLICIISI SSSMDSYGTS DSCWLALGSG AIWAFVGPAL
760 770 780 790 800
LVIVVNIVIL VAVTRVISHI STDSYKIHGD PSAFKLTAKA VAVLLPILGT
810 820 830 840 850
SWVFGVLAVS DRALVFQYMF AILNSLQGLF IFLFHCLLNS EVRAAFKHKT
860 870 880 890 900
KVWSLTSSSA RTANTKPFSS DTVNGTRPGT ASTKLSPWDK SSHSAHRVDL

SAV
Length:903
Mass (Da):99,277
Last modified:October 2, 2007 - v2
Checksum:iFBF67ECFB3B5781B
GO

Sequence cautioni

The sequence BAC35624 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115899 Genomic DNA. No translation available.
AC158913 Genomic DNA. No translation available.
BC151161 mRNA. Translation: AAI51162.1.
AY255618 mRNA. Translation: AAO85130.1.
AK054021 mRNA. Translation: BAC35624.1. Different initiation.
CCDSiCCDS39289.1.
RefSeqiNP_001074811.1. NM_001081342.1.
UniGeneiMm.440501.

Genome annotation databases

EnsembliENSMUST00000056617; ENSMUSP00000060307; ENSMUSG00000044017.
GeneIDi243277.
KEGGimmu:243277.
UCSCiuc008zst.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115899 Genomic DNA. No translation available.
AC158913 Genomic DNA. No translation available.
BC151161 mRNA. Translation: AAI51162.1.
AY255618 mRNA. Translation: AAO85130.1.
AK054021 mRNA. Translation: BAC35624.1. Different initiation.
CCDSiCCDS39289.1.
RefSeqiNP_001074811.1. NM_001081342.1.
UniGeneiMm.440501.

3D structure databases

ProteinModelPortaliQ80T32.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060307.

Protein family/group databases

MEROPSiP02.021.
GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ80T32.

Proteomic databases

PaxDbiQ80T32.
PRIDEiQ80T32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056617; ENSMUSP00000060307; ENSMUSG00000044017.
GeneIDi243277.
KEGGimmu:243277.
UCSCiuc008zst.1. mouse.

Organism-specific databases

CTDi283383.
MGIiMGI:3041203. Adgrd1.

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000056451.
HOVERGENiHBG051779.
InParanoidiQ80T32.
KOiK08465.
OMAiYCAFLDY.
OrthoDBiEOG091G00GJ.
PhylomeDBiQ80T32.
TreeFamiTF351999.

Miscellaneous databases

ChiTaRSiGpr133. mouse.
PROiQ80T32.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044017.
CleanExiMM_GPR133.
ExpressionAtlasiQ80T32. baseline and differential.
GenevisibleiQ80T32. MM.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRD1_MOUSE
AccessioniPrimary (citable) accession number: Q80T32
Secondary accession number(s): B2RXC3, Q8BW80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The N-terminal domain and autocatalytic activity of ADGRD1 at the GPCR proteolysis site (GPS) are not required for G-protein coupling activity.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.