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Protein

Synaptotagmin-like protein 5

Gene

Sytl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri64 – 106FYVE-typeAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 5
Gene namesi
Name:Sytl5
Synonyms:Slp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2668451. Sytl5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902201 – 753Synaptotagmin-like protein 5Add BLAST753

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80T23.
PRIDEiQ80T23.

PTM databases

iPTMnetiQ80T23.
PhosphoSitePlusiQ80T23.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054453.
CleanExiMM_SYTL5.
ExpressionAtlasiQ80T23. baseline and differential.

Interactioni

Subunit structurei

Binds RAB27A that has been activated by GTP-binding.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231780. 1 interactor.
CORUMiQ80T23.
IntActiQ80T23. 1 interactor.
STRINGi10090.ENSMUSP00000064826.

Structurei

3D structure databases

ProteinModelPortaliQ80T23.
SMRiQ80T23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 123RabBDPROSITE-ProRule annotationAdd BLAST117
Domaini431 – 534C2 1PROSITE-ProRule annotationAdd BLAST104
Domaini597 – 701C2 2PROSITE-ProRule annotationAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi206 – 419Ser-richAdd BLAST214

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri64 – 106FYVE-typeAdd BLAST43

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IT3S. Eukaryota.
ENOG410Y1U8. LUCA.
GeneTreeiENSGT00810000125376.
HOGENOMiHOG000231332.
HOVERGENiHBG054255.
InParanoidiQ80T23.
KOiK17598.
OMAiETGDYGN.
OrthoDBiEOG091G07OO.
PhylomeDBiQ80T23.
TreeFamiTF341184.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR010911. Rab_BD.
IPR028702. Slp5.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR10024:SF13. PTHR10024:SF13. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 2 hits.
SMARTiView protein in SMART
SM00239. C2. 2 hits.
SUPFAMiSSF49562. SSF49562. 3 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80T23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK
60 70 80 90 100
RRSGKTHQEA SRVCVHCHKT LGLIFDRGDP CQACSLRVCS ECRVTGLDGS
110 120 130 140 150
WKCTVCAKVA QLRIISGEWF LEEKAKRFKQ VNVLGTDVVR QSILRRSPGS
160 170 180 190 200
EETQNQEQAQ QCVDKSDTLS SVRQKTTHDG PKKKGFLLSK FRSATRGEIR
210 220 230 240 250
TPKPESGRSY SLDLDSQNLQ SFKSASGSDR GSTTSSDLID QEAGRRTSKS
260 270 280 290 300
SYSNGGIPVT QRSPVPSAHS VTSINSREHG FENSMALATI ENTCEELTKS
310 320 330 340 350
HRRNTSGTPS IAVSGTSLSS ERSRSEVDLS ESFAEDLEDT SSIRSRSVPG
360 370 380 390 400
ALDKDLNSLE DTEDGVDLVS SRFSANTHSL ASGLSTNSQA GSDRKRSYLN
410 420 430 440 450
VPDADSDTTS LNSMMSVYSE TGDYGNVKVT GEILLHISYC YKTGGLYIFV
460 470 480 490 500
KSCRNLATGD EKKQRTDAYV KSYLLPDKSR NNKRKTKIRT GTNPEFNETL
510 520 530 540 550
KYTISHTQLE TRTLQLSVWH YDRFGRNSFL GEVEIAFDSW NFENPCDEWF
560 570 580 590 600
VLQPKVELAP DISLQYKGEL TIVLRYIPPE ENLIFPAGQR QEKKIFKRGK
610 620 630 640 650
KKESSSISGG ILEVFIKKAK NLTAVKSGGT SDSFVKGYLL PDDNKATKHK
660 670 680 690 700
TAVVKKSVNP EWNHTFIFSG LYPQDIKNAC LELTIWDKEA FSSNVFLGGV
710 720 730 740 750
RLNSGSGMSY GKTVDWMDSH GEEQRLWQKM ADNPGTSVEG VLMLRSSMAK

CRL
Length:753
Mass (Da):84,089
Last modified:June 1, 2003 - v1
Checksum:iC1560AB677818B57
GO
Isoform 2 (identifier: Q80T23-2) [UniParc]FASTAAdd to basket
Also known as: Slp5 delta 5S-I

The sequence of this isoform differs from the canonical sequence as follows:
     387-408: Missing.

Show »
Length:731
Mass (Da):81,710
Checksum:i4F0B93823D4BB7EF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007905387 – 408Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098160 mRNA. Translation: BAC57421.1.
AB098161 mRNA. Translation: BAC57422.1.
AL672031 Genomic DNA. Translation: CAM24185.1.
CCDSiCCDS40860.1. [Q80T23-1]
CCDS72342.1. [Q80T23-2]
RefSeqiNP_001277657.1. NM_001290728.1. [Q80T23-2]
NP_808372.1. NM_177704.3. [Q80T23-1]
XP_006527667.1. XM_006527604.3. [Q80T23-1]
XP_006527670.1. XM_006527607.3. [Q80T23-1]
XP_006527671.1. XM_006527608.3. [Q80T23-1]
XP_011245762.1. XM_011247460.2. [Q80T23-1]
XP_011245765.1. XM_011247463.2. [Q80T23-1]
XP_011245766.1. XM_011247464.1. [Q80T23-1]
XP_011245767.1. XM_011247465.1. [Q80T23-1]
XP_011245770.1. XM_011247468.1. [Q80T23-1]
XP_011245771.1. XM_011247469.2. [Q80T23-1]
XP_011245772.1. XM_011247470.2. [Q80T23-1]
XP_011245773.1. XM_011247471.2. [Q80T23-1]
XP_011245775.1. XM_011247473.1. [Q80T23-2]
XP_017173956.1. XM_017318467.1. [Q80T23-1]
UniGeneiMm.246606.

Genome annotation databases

EnsembliENSMUST00000067529; ENSMUSP00000064826; ENSMUSG00000054453. [Q80T23-1]
ENSMUST00000086165; ENSMUSP00000083339; ENSMUSG00000054453. [Q80T23-2]
GeneIDi236643.
KEGGimmu:236643.
UCSCiuc009sqa.2. mouse. [Q80T23-1]
uc009sqb.2. mouse. [Q80T23-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSYTL5_MOUSE
AccessioniPrimary (citable) accession number: Q80T23
Secondary accession number(s): A2AF59, Q812E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot