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Protein

ADAMTS-like protein 4

Gene

Adamtsl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
ADAMTS-like protein 4
Short name:
ADAMTSL-4
Alternative name(s):
Thrombospondin repeat-containing protein 1
Gene namesi
Name:Adamtsl4Imported
Synonyms:Tsrc1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2389008. Adamtsl4.

Subcellular locationi

GO - Cellular componenti

  • interstitial matrix Source: MGI
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 10361012ADAMTS-like protein 4Sequence analysisPRO_0000257967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence analysis
Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ80T21.
PaxDbiQ80T21.
PRIDEiQ80T21.

PTM databases

iPTMnetiQ80T21.
PhosphoSiteiQ80T21.

Expressioni

Tissue specificityi

Widely expressed in a range of tissues. Especially prevalent in brain, spinal cord, muscle, lung and heart.1 Publication

Gene expression databases

BgeeiQ80T21.
CleanExiMM_ADAMTSL4.
ExpressionAtlasiQ80T21. baseline and differential.
GenevisibleiQ80T21. MM.

Interactioni

Subunit structurei

Interacts with CTSB. Interacts with FBN1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015994.

Structurei

3D structure databases

ProteinModelPortaliQ80T21.
SMRiQ80T21. Positions 321-515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 9145TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini687 – 74862TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini750 – 80455TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini805 – 87167TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini872 – 93160TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini932 – 98857TSP type-1 6PROSITE-ProRule annotationAdd
BLAST
Domaini991 – 102838PLACPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 350277Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PLAC domain.PROSITE-ProRule annotation
Contains 6 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
KOG4597. Eukaryota.
ENOG41102GD. LUCA.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000034174.
HOVERGENiHBG080879.
InParanoidiQ80T21.
OMAiRCGRGQR.
OrthoDBiEOG73FQKT.
PhylomeDBiQ80T21.
TreeFamiTF316874.

Family and domain databases

InterProiIPR010294. ADAM_spacer1.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
SMARTiSM00209. TSP1. 7 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS50900. PLAC. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80T21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESWLGRLWL CMMLLLPLPQ PCQDQELFGP SHQLPSEEGQ VPEGLWGPWG
60 70 80 90 100
RWASCSQPCG VGVQRRSRTC ELHPALPLPP RPPRHPEAHR PRGQGSRPQT
110 120 130 140 150
PRDPQSLYRP QPRGRGGPLR APASQVGREE TQEPQGAQRF RVRDPIKPGM
160 170 180 190 200
FGYGRVPFAL PLHRSRRHPH RPGQPKNSST GEGMVPSQPP STELASEKHG
210 220 230 240 250
PHMQPPEPRS HSAETPRSGT AQTEVLPRTS SAPSYTGTPA PTSSFGDSRS
260 270 280 290 300
FQGSLGPRMP PSPGSWSSPQ GAERRHPPPF SPVPRSQQSR RHWRPPGPHR
310 320 330 340 350
SPDGWLPLTR DSSPLWSIFA PSIPAPNCSG ESEQMRACSQ EPCPPEQPDP
360 370 380 390 400
RALQCAAFDS QEFMGQLYQW EPFTEVQGSQ RCELNCRPRG FRFYVRHTEK
410 420 430 440 450
VQDGTLCQPG SLDICVAGRC LSPGCDGVLG SGRRPDGCGV CGGDGSTCRL
460 470 480 490 500
VSGNLTDRGG PLGYQKILWI PAGASHLHIS QLRPSSNYLA LRGPGGRSII
510 520 530 540 550
NGNWAVDPPG SYTAIGTVFQ YNRPPREEGK GESLSAEGPT TQPVDVYMIF
560 570 580 590 600
QEDNPGVFYQ YVISSPPAVL ESPSTKPPAL QPQPEMLRGE PLLPSAPRPV
610 620 630 640 650
RAPGTLQRQV RIPQVPPPTR VRTAMGSSAG YWKQVGHSEC SASCGKGVWH
660 670 680 690 700
PIFLCISRES GEELDEQSCA VGARPPASPE PCHGPPCPPY WEAGEWTSCS
710 720 730 740 750
RSCGPGTQHR QLLCRQEFGG GGSSVPPERC GHLPRPNITQ PCQLHLCGHW
760 770 780 790 800
EISSPWSQCS VRCGRGQRSR QVRCVGSNGD EVDKQECASG PPPPPSREAC
810 820 830 840 850
DMGPCTTAWF YSDWSSKCSA ECGTGIQRRA VVCLRSGETL QGDPEAGSTE
860 870 880 890 900
QGCPLRSRPP DMRACSLGPC ERTWRWFTGP WSECSSECGS GTQHRDIICV
910 920 930 940 950
SKLGAEFNVT SPSNCSHLPR PPALQPCQGQ ACEDKWFSTL WSPCSRSCQG
960 970 980 990 1000
GMQTREVQCL SGNQTLSSRC PPHLRPSRKR PCNSQPCNQR PDDQCKDSSP
1010 1020 1030
HCPLVVQARL CVYPYYTTTC CRSCAHVLEQ SQLEPA
Length:1,036
Mass (Da):113,225
Last modified:June 1, 2003 - v1
Checksum:iF018D59E71018714
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931G → R in AAI17926 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158701 mRNA. Translation: AAO17738.1.
BC117925 mRNA. Translation: AAI17926.1.
CCDSiCCDS17618.1.
RefSeqiNP_001288634.1. NM_001301705.1.
NP_659148.2. NM_144899.3.
UniGeneiMm.490574.

Genome annotation databases

EnsembliENSMUST00000015994; ENSMUSP00000015994; ENSMUSG00000015850.
ENSMUST00000117782; ENSMUSP00000113424; ENSMUSG00000015850.
GeneIDi229595.
KEGGimmu:229595.
UCSCiuc008qkm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158701 mRNA. Translation: AAO17738.1.
BC117925 mRNA. Translation: AAI17926.1.
CCDSiCCDS17618.1.
RefSeqiNP_001288634.1. NM_001301705.1.
NP_659148.2. NM_144899.3.
UniGeneiMm.490574.

3D structure databases

ProteinModelPortaliQ80T21.
SMRiQ80T21. Positions 321-515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015994.

PTM databases

iPTMnetiQ80T21.
PhosphoSiteiQ80T21.

Proteomic databases

MaxQBiQ80T21.
PaxDbiQ80T21.
PRIDEiQ80T21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015994; ENSMUSP00000015994; ENSMUSG00000015850.
ENSMUST00000117782; ENSMUSP00000113424; ENSMUSG00000015850.
GeneIDi229595.
KEGGimmu:229595.
UCSCiuc008qkm.2. mouse.

Organism-specific databases

CTDi54507.
MGIiMGI:2389008. Adamtsl4.

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
KOG4597. Eukaryota.
ENOG41102GD. LUCA.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000034174.
HOVERGENiHBG080879.
InParanoidiQ80T21.
OMAiRCGRGQR.
OrthoDBiEOG73FQKT.
PhylomeDBiQ80T21.
TreeFamiTF316874.

Enzyme and pathway databases

ReactomeiR-MMU-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

PROiQ80T21.
SOURCEiSearch...

Gene expression databases

BgeeiQ80T21.
CleanExiMM_ADAMTSL4.
ExpressionAtlasiQ80T21. baseline and differential.
GenevisibleiQ80T21. MM.

Family and domain databases

InterProiIPR010294. ADAM_spacer1.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
SMARTiSM00209. TSP1. 7 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 6 hits.
PROSITEiPS50900. PLAC. 1 hit.
PS50092. TSP1. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TSRC1, a widely expressed gene containing seven thrombospondin type I repeats."
    Buchner D.A., Meisler M.H.
    Gene 307:23-30(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6JImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiATL4_MOUSE
AccessioniPrimary (citable) accession number: Q80T21
Secondary accession number(s): Q148X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although similar to members of the ADAMTS family, it lacks the metalloprotease and disintegrin-like domains which are typical of that family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.