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Protein

Glia maturation factor gamma

Gene

Gmfg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: InterPro
  • Arp2/3 complex binding Source: InterPro
  • growth factor activity Source: UniProtKB-KW
  • kinase regulator activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor gamma
Short name:
GMF-gamma
Gene namesi
Name:Gmfg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620506. Gmfg.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002149492 – 142Glia maturation factor gammaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ80T18.
PRIDEiQ80T18.

PTM databases

iPTMnetiQ80T18.
PhosphoSitePlusiQ80T18.

Expressioni

Tissue specificityi

Expressed in rat thymus, testis, and spleen. Is present predominantly in proliferative and differentiative organs.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026891.

Structurei

3D structure databases

ProteinModelPortaliQ80T18.
SMRiQ80T18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 139ADF-HPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1736. Eukaryota.
ENOG4111RK6. LUCA.
HOGENOMiHOG000175654.
HOVERGENiHBG003045.
InParanoidiQ80T18.
PhylomeDBiQ80T18.

Family and domain databases

CDDicd11283. ADF_GMF-beta_like. 1 hit.
Gene3Di3.40.20.10. 1 hit.
InterProiView protein in InterPro
IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR011171. GMF.
IPR030076. GMFG.
PANTHERiPTHR11249. PTHR11249. 1 hit.
PTHR11249:SF6. PTHR11249:SF6. 1 hit.
PfamiView protein in Pfam
PF00241. Cofilin_ADF. 1 hit.
PIRSFiPIRSF001788. GMF-beta. 1 hit.
SMARTiView protein in SMART
SM00102. ADF. 1 hit.
PROSITEiView protein in PROSITE
PS51263. ADF_H. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80T18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSLVVCDV DPELKETLRK FRFRKETNNA AIIMKVDKDR QMVVLEDEFQ
60 70 80 90 100
NVSPEELKLE LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ
110 120 130 140
QMMYAGSKNR LVQIAELTKV FEIRTTDDLN ETWLKEKLAF FR
Length:142
Mass (Da):16,779
Last modified:June 1, 2003 - v1
Checksum:iB5468FC5F2EFFA05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007364 mRNA. Translation: BAC76430.1.
RefSeqiNP_851605.1. NM_181091.2.
UniGeneiRn.15333.

Genome annotation databases

GeneIDi113940.
KEGGirno:113940.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGMFG_RAT
AccessioniPrimary (citable) accession number: Q80T18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: May 10, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families