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Q80T14

- FRAS1_MOUSE

UniProt

Q80T14 - FRAS1_MOUSE

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Protein

Extracellular matrix protein FRAS1

Gene

Fras1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell communication Source: InterPro
  2. embryonic limb morphogenesis Source: MGI
  3. metanephros morphogenesis Source: MGI
  4. morphogenesis of an epithelium Source: MGI
  5. palate development Source: MGI
  6. protein transport Source: MGI
  7. skin development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein FRAS1
Gene namesi
Name:Fras1
Synonyms:Kiaa1500
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2385368. Fras1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 39033878ExtracellularSequence AnalysisAdd
BLAST
Transmembranei3904 – 392421HelicalSequence AnalysisAdd
BLAST
Topological domaini3925 – 401086CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basement membrane Source: BHF-UCL
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
  4. sublamina densa Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Fras1 are the cause of blebbed (bl) phenotype, which is characterized by blister formation, syndactyly, eyelid fusion and renal agenesis. Subepidermal blisters are predominantly formed in the head region around the eyes and at the distal part of the limbs. As development proceeds blisters that are initially transparent gradually become hemorrhagic and embryos die between E14.5 and E16.5.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 40103985Extracellular matrix protein FRAS1PRO_0000010121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei343 – 3431PhosphoserineBy similarity
Glycosylationi727 – 7271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1094 – 10941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1107 – 11071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1506 – 15061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1779 – 17791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1950 – 19501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1980 – 19801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2565 – 25651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2666 – 26661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2684 – 26841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2910 – 29101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2987 – 29871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3072 – 30721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3220 – 32201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3678 – 36781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3877 – 38771N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ80T14.
PRIDEiQ80T14.

PTM databases

PhosphoSiteiQ80T14.

Expressioni

Tissue specificityi

Found in a linear fashion underlying the epidermis and the basal surface of other epithelia in embryos.1 Publication

Developmental stagei

Highly expressed in the apical ectodermal ridge of the limb buds from E10.5-E12.5 and expression was also detected in the interdigital spaces at E14.5. Found in cells just underlying the surface epithelium of the entire embryo and in the linings of the peritoneal cavity and dorsal aorta. At E12 detected in the mesonephric duct and in the lens.1 Publication

Gene expression databases

BgeeiQ80T14.
CleanExiMM_FRAS1.
GenevestigatoriQ80T14.

Interactioni

Protein-protein interaction databases

BioGridi231125. 1 interaction.
MINTiMINT-4997571.

Structurei

3D structure databases

ProteinModelPortaliQ80T14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 8762VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini92 – 15261VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini156 – 21661VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini218 – 27861VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini282 – 34261VWFC 5PROSITE-ProRule annotationAdd
BLAST
Domaini358 – 41659VWFC 6PROSITE-ProRule annotationAdd
BLAST
Repeati408 – 45952FU 1Add
BLAST
Repeati461 – 50444FU 2Add
BLAST
Repeati506 – 55247FU 3Add
BLAST
Repeati554 – 59845FU 4Add
BLAST
Repeati601 – 64646FU 5Add
BLAST
Repeati648 – 70457FU 6Add
BLAST
Repeati707 – 75246FU 7Add
BLAST
Repeati754 – 79946FU 8Add
BLAST
Repeati802 – 85150FU 9Add
BLAST
Repeati853 – 89947FU 10Add
BLAST
Repeati902 – 94746FU 11Add
BLAST
Repeati951 – 99646FU 12Add
BLAST
Repeati998 – 104144FU 13Add
BLAST
Repeati1045 – 108844FU 14Add
BLAST
Repeati1089 – 1200112CSPG 1Add
BLAST
Repeati1201 – 1309109CSPG 2Add
BLAST
Repeati1310 – 1447138CSPG 3Add
BLAST
Repeati1448 – 1576129CSPG 4Add
BLAST
Repeati1577 – 1693117CSPG 5Add
BLAST
Repeati1694 – 1823130CSPG 6Add
BLAST
Repeati1824 – 1941118CSPG 7Add
BLAST
Repeati1942 – 2061120CSPG 8Add
BLAST
Repeati2062 – 2180119CSPG 9Add
BLAST
Repeati2181 – 2295115CSPG 10Add
BLAST
Repeati2296 – 2417122CSPG 11Add
BLAST
Repeati2420 – 2544125CSPG 12Add
BLAST
Domaini2545 – 2648104Calx-beta 1Add
BLAST
Domaini2661 – 2772112Calx-beta 2Add
BLAST
Domaini2786 – 2892107Calx-beta 3Add
BLAST
Domaini2907 – 3009103Calx-beta 4Add
BLAST
Domaini3027 – 3131105Calx-beta 5Add
BLAST

Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

Sequence similaritiesi

Belongs to the FRAS1 family.Curated
Contains 5 Calx-beta domains.Curated
Contains 12 CSPG (NG2) repeats.Curated
Contains 14 FU (furin-like) repeats.Curated
Contains 6 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00550000074429.
HOGENOMiHOG000076882.
HOVERGENiHBG051659.
InParanoidiQ80T14.
OMAiFTMEDIN.
OrthoDBiEOG751NDJ.
TreeFamiTF316876.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view]
PfamiPF03160. Calx-beta. 5 hits.
PF00093. VWC. 5 hits.
[Graphical view]
SMARTiSM00237. Calx_beta. 5 hits.
SM00261. FU. 14 hits.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 5 hits.
PROSITEiPS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80T14-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGVLKAWLGV ALALAEFAVL PNCEGACLYQ GSFLADATIW KPDSCQNCRC
60 70 80 90 100
HGDIVICKPV VCKNPRCAFE KGEVLWIAPN QCCPQCAPRT PGSCHHEGKI
110 120 130 140 150
HEHGTEWASA PCTVCSCTHG EVRCSHQQCT PLSCGPQELE FLAEGRCCPI
160 170 180 190 200
CVGTGKPCSY DGHVFQDGED WQLSRCAKCV CRNGLTQCFA AQCQPLFCNQ
210 220 230 240 250
DEIVVRVPGK CCSQCSARSC STAGQVYEHG EQWKEDACTL CMCDQGQVRC
260 270 280 290 300
HKQVCPPLRC AKGQGRARHH GQCCEECATP DRSCSSGGVL RYQDEMWKGS
310 320 330 340 350
ACEFCMCDQG QVTCQTGECA KVACALGEEL VHLEGKCCPE CISRNGYCIY
360 370 380 390 400
EQKAETMSSS AREIKHVPDG EKWEEGPCKL CECREAQVTC YEPSCPPCPV
410 420 430 440 450
ATLALVVKGQ CCPDCTPVHC HPDCLTCSHS PDHCDLCQDP TKLLQNGRCV
460 470 480 490 500
HSCGLGFYQA GSLCLACQPQ CSTCTNGLEC SSCLPPLLMQ QGQCVSTCGD
510 520 530 540 550
GFYQDHHSCA VCHESCAGCW GPTEKHCMAC RDPLQVLRDS SCENTCGNGF
560 570 580 590 600
YNRQGTCVAC DQSCKSCGPS SPRCLSCAEK TILHDGKCIS ECPHGYYADS
610 620 630 640 650
TGSCKVCHSS CASCSGPTAA HCIACIHPQT LRQGHCLPSC GEGFYPDHGI
660 670 680 690 700
CEACHASCHT CVGPQPSHCT QCKKPEAGLL VEQHSGENVP YGKCVSRCGT
710 720 730 740 750
HFYLESTGLC EVCHPSCLTC EGKSPHNCTG CESTHALLAG CCVSQCPETH
760 770 780 790 800
FNLEGTCTEC HPSCRQCHGP LESDCVSCHP HLTLTSGHCK TSCKEEQFLN
810 820 830 840 850
LVGYCADCHP LCQHCVANLQ DTGSICLKCQ HARHLLLGDH CVPECPPGHY
860 870 880 890 900
KERGTCKTCH SSCRSCQNGG PFSCSSCDTG LVLTHIGTCS TACFPGHYLD
910 920 930 940 950
DNQVCQPCNR HCRSCDSQGS CTSCRDPSKV LLFGECQYES CTPQYYLDIA
960 970 980 990 1000
TKTCKECDWS CNACTGPLRT DCLQCMDGYV LQDGVCVEQC SPQHYRDSGS
1010 1020 1030 1040 1050
CKRCDSHCVE CQGPHECTRC EEPFLLFQAQ CVQECGKGYF ADHAKHRCIA
1060 1070 1080 1090 1100
CPQGCLRCSH KDRCHLCDHS FFLKSGLCMP TCVPGFSGHS SNENCTDKMY
1110 1120 1130 1140 1150
TPSLHVNGSL TLGIGSMKPL DFSLLNIQHQ DGRVEDLLFH VVSTPTNGQL
1160 1170 1180 1190 1200
LLSRNGKEVQ LEKAGHFSWK DVNEKKVRFV HSKEKLRKGY FSLKISDQQF
1210 1220 1230 1240 1250
FSEPQLINIQ AFSTQAPYVL RNEVLHVSKG ERATITTQLL DIRDDDNPQD
1260 1270 1280 1290 1300
VVVNVLDPPL HGQLLQMPPA PAASIYQFHL DELSRGLLLY AHDGSDSTSD
1310 1320 1330 1340 1350
IIVFQANDGH SFQNILFHVK NIPKNDRALR LVTNSMVWVP EGGMLKITNR
1360 1370 1380 1390 1400
ILKAQAPGVR ADDIIYKITH SRPQFGEVVL LMNLPADSPA GPAEEGHHLP
1410 1420 1430 1440 1450
DGRMATPIST FTQQDIDDGV VWYRHLGAPT QSDSFRFQVS SATSAQEHLE
1460 1470 1480 1490 1500
SHMFNIAILP QAPEAPKLSL GTSLHMTARE DGLSVIQPQS LSFVKAESPS
1510 1520 1530 1540 1550
GKIIYNITVP LHPNQGIIEH RDRPHSPIQY FTQEDINQGQ IMYRPPVAPP
1560 1570 1580 1590 1600
HLQEIMAFSF AGLPESVKFY FTVSDGQHTS PEMALTIHLL HSDLQPPAFQ
1610 1620 1630 1640 1650
VKAPLLEVSP GGRTSLGLQL LVRDAQVVPE ELFFQLQKSP QHGMLVKYTA
1660 1670 1680 1690 1700
KSSVTMAAGD TFTYDEVERN VLQYVHDGSS AWEDSLEISV TDGLTVTTSE
1710 1720 1730 1740 1750
VKVEVSPSEN RGPRLAPGSS LSMTVASQHT AIITRSHLAY VDDSSSDPEI
1760 1770 1780 1790 1800
WIRLSSLPLY GVLFRSSGPD MDELSGDSNF TMEDINKKNI RYSAVFETDG
1810 1820 1830 1840 1850
HSVTDGFHFS VSDMDGNHVD NQVFTITVTP AENPPHIIAF ADLITVDEGG
1860 1870 1880 1890 1900
RAPLSLHHFF ATEDQDNLQD DAVIKLSALP KYGCIENTGT GDRFGPGANS
1910 1920 1930 1940 1950
ELEASFPIQD VLENYIYYFQ SVHESIEPTH DVFSFYVSDG SGRSEIHSIN
1960 1970 1980 1990 2000
ITIERKNDEP PRMTLRPLGV RLSSGVAISN SSLSLQDLDT PDNELIFVLM
2010 2020 2030 2040 2050
KKPDHGHLLR RSTASDPLEN GTVLDQGSSF TYQDVLAGLV GYLPGDIYMA
2060 2070 2080 2090 2100
VDEFRFSLTD GLHVDTGRME IYIELPSTNI PHLAINRGLQ LSAGSVARIT
2110 2120 2130 2140 2150
EQHLKATDTD SEAGQVVYIM KEDPGAGRLL MAKADNLEQI SVRGPIRSFT
2160 2170 2180 2190 2200
QADVSQGQIE YSHGPGEPGG SFAFKFDVVD GEGNKLADQS FSIGVLEDKS
2210 2220 2230 2240 2250
PPVVITNRGL VLDENSVEKI TTAQLSATDQ DSKPTELIYR ITTQPQLGHL
2260 2270 2280 2290 2300
EHVASPGIQI SSFTQADLAS RNVQYVRSSG TGKQSDAFSF VLSDGLHEVT
2310 2320 2330 2340 2350
QTFPITIHPV DDARPLVQNR GMRVQEGVRK TITEFELKAV DVDTEAESIT
2360 2370 2380 2390 2400
FTIVQPPRHG TIERTARGQR FHQTSSFTME DIYQNRVSYS HDGSNSLKDR
2410 2420 2430 2440 2450
FTFTVSDGTN PFFIIEEGGE EIMTAAPQQF HVDILPVDDG TPRIVTNLGL
2460 2470 2480 2490 2500
QWLEYMDGKA TNLITKKELL TVDPDTEDSQ LIYEVTTGPM HGYLENKLQP
2510 2520 2530 2540 2550
GRAAATFTQE HVNLGLIRYV LYEEKIQKVM DSFQFLVKDS KPNVVSDNVF
2560 2570 2580 2590 2600
HIQWSLISFK YTSYNVSEKA GSVSVTVQRT GNLNQYAIVL CRTEQGTASS
2610 2620 2630 2640 2650
SSHPGQQDYM EYAGQVQFDE GEGTKSCTVI INDDDVFENI ESFTVGLSMP
2660 2670 2680 2690 2700
AYALLGEFTQ AKVVINDTED EPTLEFDKKT YRVNESAGFL FAPIKRQGDS
2710 2720 2730 2740 2750
SSTVSAVCYT VPKSAMGSSL YALESGSDFK SRGRSAESRV IFGPGVTVST
2760 2770 2780 2790 2800
CDVMVIDDSE YEEEEEFEIA LADASNNARI GRQAVAKVLI SGPNDASTVS
2810 2820 2830 2840 2850
LGNTAFTISE DAGTVKIPVI RHGTDLSTFT SVWCATRPSD PASATPGVDY
2860 2870 2880 2890 2900
VPSSRKVEFG PGITEQYCTL TILDDTQYPV IEGLETFVVF LSSAQGAELT
2910 2920 2930 2940 2950
KPSQAVIAIN DTFQDVPSMQ FSKDLLLVKE KEGVLHIPII RSGDLSYESS
2960 2970 2980 2990 3000
VRCYTQGHSA QVMEDFEERR NADSSRITFL KGQKTKNCTV YIHDDSMFEP
3010 3020 3030 3040 3050
EEQFRVYLGH PLGNHWSGAR IGKNSVATVT ISNDEDAPTI EFEEAAYQVR
3060 3070 3080 3090 3100
EPAGPEAIAV LSIKVIRRGD QNRTSKIRCS TRDGSAQSGV DYYPKSRVLK
3110 3120 3130 3140 3150
FSPGVDHIFF KVEILSNEDR EWHESFSLVL GPDDLVEAVL GDVTTATVTI
3160 3170 3180 3190 3200
LDQEAAGSLI LPAPPIVVTL ADYDHVEELA KEGVKKAPSP GYPLVCVTPC
3210 3220 3230 3240 3250
DPRYPRYAVM KERCSEAGIN QTSVQFSWEV AAPTDGNGAR SPFETITDNT
3260 3270 3280 3290 3300
PFTSVNHKVL DSIYFSRRFH VRCVAKAVDK VGHVGTPLRS NVVTIGTDSA
3310 3320 3330 3340 3350
ICHTPVVAGT ARGFQAQSFI ATLKYLDVKH KEHPNRIHIS VQIPHQDGML
3360 3370 3380 3390 3400
PLISTMPLHN LHFLLSESIY RHQHVCSNLV TAQDLRGLAE AGFLNDAGFH
3410 3420 3430 3440 3450
STALGPGYDR PFQFDSSVRE PKTIQLYRHL NLKSCVWTFD AYYDMTELID
3460 3470 3480 3490 3500
VCGGSVTADF QVRDSAQSFL TVHVPLYVSY IYVTAPRGWA SLEHHTEMEF
3510 3520 3530 3540 3550
SFFYDTVLWR TGIQTDSVLS ARLQIIRIYI REDGRLVIEF KTHAKFRGQF
3560 3570 3580 3590 3600
VIEHHTLPDV KSFILTPDHL GGIQFDLQLL WSAQTFDSPH QLWRATSSYN
3610 3620 3630 3640 3650
RKDYSGEYTI YLIPCTVQPT QPWVDPGEKA LACTAHAPER FLIPIAFQQT
3660 3670 3680 3690 3700
NRPVPVVYSL NTEFQLCNNE KVFLMDPNTS DMSLAEMDYK GAFSKGQILY
3710 3720 3730 3740 3750
GRVLWNPEQN LHSAYKLQLE KVYLCTGKDG YVPFFDPTGT IYNEGPQYGC
3760 3770 3780 3790 3800
IQPNKHLKHR FLLLDRSQPE VTDKYFHDVP FEAHFASELP DFQVVSSMPG
3810 3820 3830 3840 3850
VDGFTLKVDA LYKVEAGHQW YLQVIYIIGP DSTSRPRVQR SLTVSLRRHQ
3860 3870 3880 3890 3900
RDLVDPSGWL SLDDSLIYDN EGDQVKNGTN MKSLNLEMQE PVIAASLSQT
3910 3920 3930 3940 3950
GASIGSALAA IMLLLLLFLV ACFVTRKCQK QKKKQPPEDT LEEYPLNTKV
3960 3970 3980 3990 4000
DVAKRNADKV EKNANRQYCT VRNVNILSDN EGYYTFKGAK VKKLNLEVRV
4010
HNNLQDGTEV
Length:4,010
Mass (Da):442,369
Last modified:July 27, 2011 - v2
Checksum:i7C1DDED1C8ACEC04
GO

Sequence cautioni

The sequence BAC34788.1 differs from that shown. Reason: Frameshift at position 2788. Curated
The sequence BAC34788.1 differs from that shown. Reason: Erroneous termination at position 2854. Translated as Ser.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221N → H in CAD33519. (PubMed:12766770)Curated
Sequence conflicti1026 – 10261L → F in CAD33519. (PubMed:12766770)Curated
Sequence conflicti1063 – 10631R → Q in CAD33519. (PubMed:12766770)Curated
Sequence conflicti1466 – 14661P → H in CAD33519. (PubMed:12766770)Curated
Sequence conflicti2020 – 20201N → H in CAD33519. (PubMed:12766770)Curated
Sequence conflicti2208 – 22081R → K in CAD33519. (PubMed:12766770)Curated
Sequence conflicti2310 – 23101V → L in CAD33519. (PubMed:12766770)Curated
Sequence conflicti2310 – 23101V → L in BAC65800. (PubMed:12693553)Curated
Sequence conflicti2314 – 23141R → Q in CAD33519. (PubMed:12766770)Curated
Sequence conflicti2314 – 23141R → Q in BAC65800. (PubMed:12693553)Curated
Sequence conflicti2623 – 26231G → S in CAD33519. (PubMed:12766770)Curated
Sequence conflicti2623 – 26231G → S in BAC65800. (PubMed:12693553)Curated
Sequence conflicti2646 – 26461G → W in BAC34788. (PubMed:16141072)Curated
Sequence conflicti2664 – 26641V → I in CAD33519. (PubMed:12766770)Curated
Sequence conflicti2664 – 26641V → I in BAC65800. (PubMed:12693553)Curated
Sequence conflicti3135 – 31351L → P in CAD33519. (PubMed:12766770)Curated
Sequence conflicti3135 – 31351L → P in BAC65800. (PubMed:12693553)Curated
Sequence conflicti3172 – 31721D → G in BAC34788. (PubMed:16141072)Curated
Sequence conflicti3383 – 33831Q → R in CAD33519. (PubMed:12766770)Curated
Sequence conflicti3383 – 33831Q → R in BAC65800. (PubMed:12693553)Curated
Sequence conflicti3383 – 33831Q → R in AAH44881. (PubMed:15489334)Curated
Sequence conflicti3395 – 33951N → D in CAD33519. (PubMed:12766770)Curated
Sequence conflicti3395 – 33951N → D in BAC65800. (PubMed:12693553)Curated
Sequence conflicti3395 – 33951N → D in AAH44881. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ489280 mRNA. Translation: CAD33519.1.
AC101391 Genomic DNA. No translation available.
AC121829 Genomic DNA. No translation available.
AC122007 Genomic DNA. No translation available.
AC151985 Genomic DNA. No translation available.
AK122518 mRNA. Translation: BAC65800.1.
AK051850 mRNA. Translation: BAC34788.1. Sequence problems.
BC044881 mRNA. Translation: AAH44881.1.
CCDSiCCDS19450.1.
RefSeqiNP_780682.3. NM_175473.3.
UniGeneiMm.291120.

Genome annotation databases

EnsembliENSMUST00000036019; ENSMUSP00000043250; ENSMUSG00000034687.
GeneIDi231470.
KEGGimmu:231470.
UCSCiuc008yfk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ489280 mRNA. Translation: CAD33519.1 .
AC101391 Genomic DNA. No translation available.
AC121829 Genomic DNA. No translation available.
AC122007 Genomic DNA. No translation available.
AC151985 Genomic DNA. No translation available.
AK122518 mRNA. Translation: BAC65800.1 .
AK051850 mRNA. Translation: BAC34788.1 . Sequence problems.
BC044881 mRNA. Translation: AAH44881.1 .
CCDSi CCDS19450.1.
RefSeqi NP_780682.3. NM_175473.3.
UniGenei Mm.291120.

3D structure databases

ProteinModelPortali Q80T14.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231125. 1 interaction.
MINTi MINT-4997571.

PTM databases

PhosphoSitei Q80T14.

Proteomic databases

PaxDbi Q80T14.
PRIDEi Q80T14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036019 ; ENSMUSP00000043250 ; ENSMUSG00000034687 .
GeneIDi 231470.
KEGGi mmu:231470.
UCSCi uc008yfk.1. mouse.

Organism-specific databases

CTDi 80144.
MGIi MGI:2385368. Fras1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00550000074429.
HOGENOMi HOG000076882.
HOVERGENi HBG051659.
InParanoidi Q80T14.
OMAi FTMEDIN.
OrthoDBi EOG751NDJ.
TreeFami TF316876.

Miscellaneous databases

ChiTaRSi Fras1. mouse.
NextBioi 380572.
PROi Q80T14.
SOURCEi Search...

Gene expression databases

Bgeei Q80T14.
CleanExi MM_FRAS1.
Genevestigatori Q80T14.

Family and domain databases

InterProi IPR003644. Calx_beta.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF03160. Calx-beta. 5 hits.
PF00093. VWC. 5 hits.
[Graphical view ]
SMARTi SM00237. Calx_beta. 5 hits.
SM00261. FU. 14 hits.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 5 hits.
PROSITEi PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view ]
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Publicationsi

« Hide 'large scale' publications
  1. "Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice."
    Vrontou S., Petrou P., Meyer B.I., Vassilis K., Galanopoulos K., Imai K., Yanagi M., Chowdhury K., Scambler P.J., Chalepakis G.
    Nat. Genet. 34:209-214(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISEASE.
    Strain: NMRI.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2283-4010.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2646-4010.
    Strain: C57BL/6J.
    Tissue: Eye.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3228-4010.
    Strain: FVB/N.
    Tissue: Kidney.
  6. Cited for: DEVELOPMENTAL STAGE, DISEASE.

Entry informationi

Entry nameiFRAS1_MOUSE
AccessioniPrimary (citable) accession number: Q80T14
Secondary accession number(s): E9QPG9
, Q80TC7, Q811H8, Q8BPZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3