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Q80T14

- FRAS1_MOUSE

UniProt

Q80T14 - FRAS1_MOUSE

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Protein

Extracellular matrix protein FRAS1

Gene
Fras1, Kiaa1500
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell communication Source: InterPro
  2. embryonic limb morphogenesis Source: MGI
  3. metanephros morphogenesis Source: MGI
  4. morphogenesis of an epithelium Source: MGI
  5. palate development Source: MGI
  6. protein transport Source: MGI
  7. skin development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein FRAS1
Gene namesi
Name:Fras1
Synonyms:Kiaa1500
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2385368. Fras1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 39033878Extracellular Reviewed predictionAdd
BLAST
Transmembranei3904 – 392421Helical; Reviewed predictionAdd
BLAST
Topological domaini3925 – 401086Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basement membrane Source: BHF-UCL
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
  4. sublamina densa Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Fras1 are the cause of blebbed (bl) phenotype, which is characterized by blister formation, syndactyly, eyelid fusion and renal agenesis. Subepidermal blisters are predominantly formed in the head region around the eyes and at the distal part of the limbs. As development proceeds blisters that are initially transparent gradually become hemorrhagic and embryos die between E14.5 and E16.5.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 40103985Extracellular matrix protein FRAS1PRO_0000010121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei343 – 3431Phosphoserine By similarity
Glycosylationi727 – 7271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1094 – 10941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1107 – 11071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1506 – 15061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1779 – 17791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1950 – 19501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1980 – 19801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2565 – 25651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2666 – 26661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2684 – 26841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2910 – 29101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2987 – 29871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3072 – 30721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3220 – 32201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3678 – 36781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3877 – 38771N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ80T14.
PRIDEiQ80T14.

PTM databases

PhosphoSiteiQ80T14.

Expressioni

Tissue specificityi

Found in a linear fashion underlying the epidermis and the basal surface of other epithelia in embryos.1 Publication

Developmental stagei

Highly expressed in the apical ectodermal ridge of the limb buds from E10.5-E12.5 and expression was also detected in the interdigital spaces at E14.5. Found in cells just underlying the surface epithelium of the entire embryo and in the linings of the peritoneal cavity and dorsal aorta. At E12 detected in the mesonephric duct and in the lens.1 Publication

Gene expression databases

BgeeiQ80T14.
CleanExiMM_FRAS1.
GenevestigatoriQ80T14.

Interactioni

Protein-protein interaction databases

BioGridi231125. 1 interaction.
MINTiMINT-4997571.

Structurei

3D structure databases

ProteinModelPortaliQ80T14.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 8762VWFC 1Add
BLAST
Domaini92 – 15261VWFC 2Add
BLAST
Domaini156 – 21661VWFC 3Add
BLAST
Domaini218 – 27861VWFC 4Add
BLAST
Domaini282 – 34261VWFC 5Add
BLAST
Domaini358 – 41659VWFC 6Add
BLAST
Repeati408 – 45952FU 1Add
BLAST
Repeati461 – 50444FU 2Add
BLAST
Repeati506 – 55247FU 3Add
BLAST
Repeati554 – 59845FU 4Add
BLAST
Repeati601 – 64646FU 5Add
BLAST
Repeati648 – 70457FU 6Add
BLAST
Repeati707 – 75246FU 7Add
BLAST
Repeati754 – 79946FU 8Add
BLAST
Repeati802 – 85150FU 9Add
BLAST
Repeati853 – 89947FU 10Add
BLAST
Repeati902 – 94746FU 11Add
BLAST
Repeati951 – 99646FU 12Add
BLAST
Repeati998 – 104144FU 13Add
BLAST
Repeati1045 – 108844FU 14Add
BLAST
Repeati1089 – 1200112CSPG 1Add
BLAST
Repeati1201 – 1309109CSPG 2Add
BLAST
Repeati1310 – 1447138CSPG 3Add
BLAST
Repeati1448 – 1576129CSPG 4Add
BLAST
Repeati1577 – 1693117CSPG 5Add
BLAST
Repeati1694 – 1823130CSPG 6Add
BLAST
Repeati1824 – 1941118CSPG 7Add
BLAST
Repeati1942 – 2061120CSPG 8Add
BLAST
Repeati2062 – 2180119CSPG 9Add
BLAST
Repeati2181 – 2295115CSPG 10Add
BLAST
Repeati2296 – 2417122CSPG 11Add
BLAST
Repeati2420 – 2544125CSPG 12Add
BLAST
Domaini2545 – 2648104Calx-beta 1Add
BLAST
Domaini2661 – 2772112Calx-beta 2Add
BLAST
Domaini2786 – 2892107Calx-beta 3Add
BLAST
Domaini2907 – 3009103Calx-beta 4Add
BLAST
Domaini3027 – 3131105Calx-beta 5Add
BLAST

Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding By similarity.

Sequence similaritiesi

Belongs to the FRAS1 family.
Contains 5 Calx-beta domains.
Contains 12 CSPG (NG2) repeats.
Contains 6 VWFC domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00550000074429.
HOGENOMiHOG000076882.
HOVERGENiHBG051659.
InParanoidiQ80T14.
OMAiFTMEDIN.
OrthoDBiEOG751NDJ.
TreeFamiTF316876.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view]
PfamiPF03160. Calx-beta. 5 hits.
PF00093. VWC. 5 hits.
[Graphical view]
SMARTiSM00237. Calx_beta. 5 hits.
SM00261. FU. 14 hits.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 5 hits.
PROSITEiPS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80T14-1 [UniParc]FASTAAdd to Basket

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MGVLKAWLGV ALALAEFAVL PNCEGACLYQ GSFLADATIW KPDSCQNCRC     50
HGDIVICKPV VCKNPRCAFE KGEVLWIAPN QCCPQCAPRT PGSCHHEGKI 100
HEHGTEWASA PCTVCSCTHG EVRCSHQQCT PLSCGPQELE FLAEGRCCPI 150
CVGTGKPCSY DGHVFQDGED WQLSRCAKCV CRNGLTQCFA AQCQPLFCNQ 200
DEIVVRVPGK CCSQCSARSC STAGQVYEHG EQWKEDACTL CMCDQGQVRC 250
HKQVCPPLRC AKGQGRARHH GQCCEECATP DRSCSSGGVL RYQDEMWKGS 300
ACEFCMCDQG QVTCQTGECA KVACALGEEL VHLEGKCCPE CISRNGYCIY 350
EQKAETMSSS AREIKHVPDG EKWEEGPCKL CECREAQVTC YEPSCPPCPV 400
ATLALVVKGQ CCPDCTPVHC HPDCLTCSHS PDHCDLCQDP TKLLQNGRCV 450
HSCGLGFYQA GSLCLACQPQ CSTCTNGLEC SSCLPPLLMQ QGQCVSTCGD 500
GFYQDHHSCA VCHESCAGCW GPTEKHCMAC RDPLQVLRDS SCENTCGNGF 550
YNRQGTCVAC DQSCKSCGPS SPRCLSCAEK TILHDGKCIS ECPHGYYADS 600
TGSCKVCHSS CASCSGPTAA HCIACIHPQT LRQGHCLPSC GEGFYPDHGI 650
CEACHASCHT CVGPQPSHCT QCKKPEAGLL VEQHSGENVP YGKCVSRCGT 700
HFYLESTGLC EVCHPSCLTC EGKSPHNCTG CESTHALLAG CCVSQCPETH 750
FNLEGTCTEC HPSCRQCHGP LESDCVSCHP HLTLTSGHCK TSCKEEQFLN 800
LVGYCADCHP LCQHCVANLQ DTGSICLKCQ HARHLLLGDH CVPECPPGHY 850
KERGTCKTCH SSCRSCQNGG PFSCSSCDTG LVLTHIGTCS TACFPGHYLD 900
DNQVCQPCNR HCRSCDSQGS CTSCRDPSKV LLFGECQYES CTPQYYLDIA 950
TKTCKECDWS CNACTGPLRT DCLQCMDGYV LQDGVCVEQC SPQHYRDSGS 1000
CKRCDSHCVE CQGPHECTRC EEPFLLFQAQ CVQECGKGYF ADHAKHRCIA 1050
CPQGCLRCSH KDRCHLCDHS FFLKSGLCMP TCVPGFSGHS SNENCTDKMY 1100
TPSLHVNGSL TLGIGSMKPL DFSLLNIQHQ DGRVEDLLFH VVSTPTNGQL 1150
LLSRNGKEVQ LEKAGHFSWK DVNEKKVRFV HSKEKLRKGY FSLKISDQQF 1200
FSEPQLINIQ AFSTQAPYVL RNEVLHVSKG ERATITTQLL DIRDDDNPQD 1250
VVVNVLDPPL HGQLLQMPPA PAASIYQFHL DELSRGLLLY AHDGSDSTSD 1300
IIVFQANDGH SFQNILFHVK NIPKNDRALR LVTNSMVWVP EGGMLKITNR 1350
ILKAQAPGVR ADDIIYKITH SRPQFGEVVL LMNLPADSPA GPAEEGHHLP 1400
DGRMATPIST FTQQDIDDGV VWYRHLGAPT QSDSFRFQVS SATSAQEHLE 1450
SHMFNIAILP QAPEAPKLSL GTSLHMTARE DGLSVIQPQS LSFVKAESPS 1500
GKIIYNITVP LHPNQGIIEH RDRPHSPIQY FTQEDINQGQ IMYRPPVAPP 1550
HLQEIMAFSF AGLPESVKFY FTVSDGQHTS PEMALTIHLL HSDLQPPAFQ 1600
VKAPLLEVSP GGRTSLGLQL LVRDAQVVPE ELFFQLQKSP QHGMLVKYTA 1650
KSSVTMAAGD TFTYDEVERN VLQYVHDGSS AWEDSLEISV TDGLTVTTSE 1700
VKVEVSPSEN RGPRLAPGSS LSMTVASQHT AIITRSHLAY VDDSSSDPEI 1750
WIRLSSLPLY GVLFRSSGPD MDELSGDSNF TMEDINKKNI RYSAVFETDG 1800
HSVTDGFHFS VSDMDGNHVD NQVFTITVTP AENPPHIIAF ADLITVDEGG 1850
RAPLSLHHFF ATEDQDNLQD DAVIKLSALP KYGCIENTGT GDRFGPGANS 1900
ELEASFPIQD VLENYIYYFQ SVHESIEPTH DVFSFYVSDG SGRSEIHSIN 1950
ITIERKNDEP PRMTLRPLGV RLSSGVAISN SSLSLQDLDT PDNELIFVLM 2000
KKPDHGHLLR RSTASDPLEN GTVLDQGSSF TYQDVLAGLV GYLPGDIYMA 2050
VDEFRFSLTD GLHVDTGRME IYIELPSTNI PHLAINRGLQ LSAGSVARIT 2100
EQHLKATDTD SEAGQVVYIM KEDPGAGRLL MAKADNLEQI SVRGPIRSFT 2150
QADVSQGQIE YSHGPGEPGG SFAFKFDVVD GEGNKLADQS FSIGVLEDKS 2200
PPVVITNRGL VLDENSVEKI TTAQLSATDQ DSKPTELIYR ITTQPQLGHL 2250
EHVASPGIQI SSFTQADLAS RNVQYVRSSG TGKQSDAFSF VLSDGLHEVT 2300
QTFPITIHPV DDARPLVQNR GMRVQEGVRK TITEFELKAV DVDTEAESIT 2350
FTIVQPPRHG TIERTARGQR FHQTSSFTME DIYQNRVSYS HDGSNSLKDR 2400
FTFTVSDGTN PFFIIEEGGE EIMTAAPQQF HVDILPVDDG TPRIVTNLGL 2450
QWLEYMDGKA TNLITKKELL TVDPDTEDSQ LIYEVTTGPM HGYLENKLQP 2500
GRAAATFTQE HVNLGLIRYV LYEEKIQKVM DSFQFLVKDS KPNVVSDNVF 2550
HIQWSLISFK YTSYNVSEKA GSVSVTVQRT GNLNQYAIVL CRTEQGTASS 2600
SSHPGQQDYM EYAGQVQFDE GEGTKSCTVI INDDDVFENI ESFTVGLSMP 2650
AYALLGEFTQ AKVVINDTED EPTLEFDKKT YRVNESAGFL FAPIKRQGDS 2700
SSTVSAVCYT VPKSAMGSSL YALESGSDFK SRGRSAESRV IFGPGVTVST 2750
CDVMVIDDSE YEEEEEFEIA LADASNNARI GRQAVAKVLI SGPNDASTVS 2800
LGNTAFTISE DAGTVKIPVI RHGTDLSTFT SVWCATRPSD PASATPGVDY 2850
VPSSRKVEFG PGITEQYCTL TILDDTQYPV IEGLETFVVF LSSAQGAELT 2900
KPSQAVIAIN DTFQDVPSMQ FSKDLLLVKE KEGVLHIPII RSGDLSYESS 2950
VRCYTQGHSA QVMEDFEERR NADSSRITFL KGQKTKNCTV YIHDDSMFEP 3000
EEQFRVYLGH PLGNHWSGAR IGKNSVATVT ISNDEDAPTI EFEEAAYQVR 3050
EPAGPEAIAV LSIKVIRRGD QNRTSKIRCS TRDGSAQSGV DYYPKSRVLK 3100
FSPGVDHIFF KVEILSNEDR EWHESFSLVL GPDDLVEAVL GDVTTATVTI 3150
LDQEAAGSLI LPAPPIVVTL ADYDHVEELA KEGVKKAPSP GYPLVCVTPC 3200
DPRYPRYAVM KERCSEAGIN QTSVQFSWEV AAPTDGNGAR SPFETITDNT 3250
PFTSVNHKVL DSIYFSRRFH VRCVAKAVDK VGHVGTPLRS NVVTIGTDSA 3300
ICHTPVVAGT ARGFQAQSFI ATLKYLDVKH KEHPNRIHIS VQIPHQDGML 3350
PLISTMPLHN LHFLLSESIY RHQHVCSNLV TAQDLRGLAE AGFLNDAGFH 3400
STALGPGYDR PFQFDSSVRE PKTIQLYRHL NLKSCVWTFD AYYDMTELID 3450
VCGGSVTADF QVRDSAQSFL TVHVPLYVSY IYVTAPRGWA SLEHHTEMEF 3500
SFFYDTVLWR TGIQTDSVLS ARLQIIRIYI REDGRLVIEF KTHAKFRGQF 3550
VIEHHTLPDV KSFILTPDHL GGIQFDLQLL WSAQTFDSPH QLWRATSSYN 3600
RKDYSGEYTI YLIPCTVQPT QPWVDPGEKA LACTAHAPER FLIPIAFQQT 3650
NRPVPVVYSL NTEFQLCNNE KVFLMDPNTS DMSLAEMDYK GAFSKGQILY 3700
GRVLWNPEQN LHSAYKLQLE KVYLCTGKDG YVPFFDPTGT IYNEGPQYGC 3750
IQPNKHLKHR FLLLDRSQPE VTDKYFHDVP FEAHFASELP DFQVVSSMPG 3800
VDGFTLKVDA LYKVEAGHQW YLQVIYIIGP DSTSRPRVQR SLTVSLRRHQ 3850
RDLVDPSGWL SLDDSLIYDN EGDQVKNGTN MKSLNLEMQE PVIAASLSQT 3900
GASIGSALAA IMLLLLLFLV ACFVTRKCQK QKKKQPPEDT LEEYPLNTKV 3950
DVAKRNADKV EKNANRQYCT VRNVNILSDN EGYYTFKGAK VKKLNLEVRV 4000
HNNLQDGTEV 4010
Length:4,010
Mass (Da):442,369
Last modified:July 27, 2011 - v2
Checksum:i7C1DDED1C8ACEC04
GO

Sequence cautioni

The sequence BAC34788.1 differs from that shown. Reason: Frameshift at position 2788.
The sequence BAC34788.1 differs from that shown. Reason: Erroneous termination at position 2854. Translated as Ser.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221N → H in CAD33519. 1 Publication
Sequence conflicti1026 – 10261L → F in CAD33519. 1 Publication
Sequence conflicti1063 – 10631R → Q in CAD33519. 1 Publication
Sequence conflicti1466 – 14661P → H in CAD33519. 1 Publication
Sequence conflicti2020 – 20201N → H in CAD33519. 1 Publication
Sequence conflicti2208 – 22081R → K in CAD33519. 1 Publication
Sequence conflicti2310 – 23101V → L in CAD33519. 1 Publication
Sequence conflicti2310 – 23101V → L in BAC65800. 1 Publication
Sequence conflicti2314 – 23141R → Q in CAD33519. 1 Publication
Sequence conflicti2314 – 23141R → Q in BAC65800. 1 Publication
Sequence conflicti2623 – 26231G → S in CAD33519. 1 Publication
Sequence conflicti2623 – 26231G → S in BAC65800. 1 Publication
Sequence conflicti2646 – 26461G → W in BAC34788. 1 Publication
Sequence conflicti2664 – 26641V → I in CAD33519. 1 Publication
Sequence conflicti2664 – 26641V → I in BAC65800. 1 Publication
Sequence conflicti3135 – 31351L → P in CAD33519. 1 Publication
Sequence conflicti3135 – 31351L → P in BAC65800. 1 Publication
Sequence conflicti3172 – 31721D → G in BAC34788. 1 Publication
Sequence conflicti3383 – 33831Q → R in CAD33519. 1 Publication
Sequence conflicti3383 – 33831Q → R in BAC65800. 1 Publication
Sequence conflicti3383 – 33831Q → R in AAH44881. 1 Publication
Sequence conflicti3395 – 33951N → D in CAD33519. 1 Publication
Sequence conflicti3395 – 33951N → D in BAC65800. 1 Publication
Sequence conflicti3395 – 33951N → D in AAH44881. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ489280 mRNA. Translation: CAD33519.1.
AC101391 Genomic DNA. No translation available.
AC121829 Genomic DNA. No translation available.
AC122007 Genomic DNA. No translation available.
AC151985 Genomic DNA. No translation available.
AK122518 mRNA. Translation: BAC65800.1.
AK051850 mRNA. Translation: BAC34788.1. Sequence problems.
BC044881 mRNA. Translation: AAH44881.1.
CCDSiCCDS19450.1.
RefSeqiNP_780682.3. NM_175473.3.
UniGeneiMm.291120.

Genome annotation databases

EnsembliENSMUST00000036019; ENSMUSP00000043250; ENSMUSG00000034687.
GeneIDi231470.
KEGGimmu:231470.
UCSCiuc008yfk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ489280 mRNA. Translation: CAD33519.1 .
AC101391 Genomic DNA. No translation available.
AC121829 Genomic DNA. No translation available.
AC122007 Genomic DNA. No translation available.
AC151985 Genomic DNA. No translation available.
AK122518 mRNA. Translation: BAC65800.1 .
AK051850 mRNA. Translation: BAC34788.1 . Sequence problems.
BC044881 mRNA. Translation: AAH44881.1 .
CCDSi CCDS19450.1.
RefSeqi NP_780682.3. NM_175473.3.
UniGenei Mm.291120.

3D structure databases

ProteinModelPortali Q80T14.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231125. 1 interaction.
MINTi MINT-4997571.

PTM databases

PhosphoSitei Q80T14.

Proteomic databases

PaxDbi Q80T14.
PRIDEi Q80T14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036019 ; ENSMUSP00000043250 ; ENSMUSG00000034687 .
GeneIDi 231470.
KEGGi mmu:231470.
UCSCi uc008yfk.1. mouse.

Organism-specific databases

CTDi 80144.
MGIi MGI:2385368. Fras1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00550000074429.
HOGENOMi HOG000076882.
HOVERGENi HBG051659.
InParanoidi Q80T14.
OMAi FTMEDIN.
OrthoDBi EOG751NDJ.
TreeFami TF316876.

Miscellaneous databases

ChiTaRSi FRAS1. mouse.
NextBioi 380572.
PROi Q80T14.
SOURCEi Search...

Gene expression databases

Bgeei Q80T14.
CleanExi MM_FRAS1.
Genevestigatori Q80T14.

Family and domain databases

InterProi IPR003644. Calx_beta.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF03160. Calx-beta. 5 hits.
PF00093. VWC. 5 hits.
[Graphical view ]
SMARTi SM00237. Calx_beta. 5 hits.
SM00261. FU. 14 hits.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 5 hits.
PROSITEi PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice."
    Vrontou S., Petrou P., Meyer B.I., Vassilis K., Galanopoulos K., Imai K., Yanagi M., Chowdhury K., Scambler P.J., Chalepakis G.
    Nat. Genet. 34:209-214(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISEASE.
    Strain: NMRI.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2283-4010.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2646-4010.
    Strain: C57BL/6J.
    Tissue: Eye.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3228-4010.
    Strain: FVB/N.
    Tissue: Kidney.
  6. Cited for: DEVELOPMENTAL STAGE, DISEASE.

Entry informationi

Entry nameiFRAS1_MOUSE
AccessioniPrimary (citable) accession number: Q80T14
Secondary accession number(s): E9QPG9
, Q80TC7, Q811H8, Q8BPZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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