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Q80T14 (FRAS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Extracellular matrix protein FRAS1
Gene names
Name:Fras1
Synonyms:Kiaa1500
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length4010 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass type I membrane protein; Extracellular side Potential.

Tissue specificity

Found in a linear fashion underlying the epidermis and the basal surface of other epithelia in embryos. Ref.1

Developmental stage

Highly expressed in the apical ectodermal ridge of the limb buds from E10.5-E12.5 and expression was also detected in the interdigital spaces at E14.5. Found in cells just underlying the surface epithelium of the entire embryo and in the linings of the peritoneal cavity and dorsal aorta. At E12 detected in the mesonephric duct and in the lens. Ref.6

Domain

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding By similarity.

Involvement in disease

Defects in Fras1 are the cause of blebbed (bl) phenotype, which is characterized by blister formation, syndactyly, eyelid fusion and renal agenesis. Subepidermal blisters are predominantly formed in the head region around the eyes and at the distal part of the limbs. As development proceeds blisters that are initially transparent gradually become hemorrhagic and embryos die between E14.5 and E16.5. Ref.1 Ref.6

Sequence similarities

Belongs to the FRAS1 family.

Contains 5 Calx-beta domains.

Contains 12 CSPG (NG2) repeats.

Contains 14 FU (furin-like) repeats.

Contains 6 VWFC domains.

Sequence caution

The sequence BAC34788.1 differs from that shown. Reason: Erroneous termination at position 2854. Translated as Ser.

The sequence BAC34788.1 differs from that shown. Reason: Frameshift at position 2788.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 40103985Extracellular matrix protein FRAS1
PRO_0000010121

Regions

Topological domain26 – 39033878Extracellular Potential
Transmembrane3904 – 392421Helical; Potential
Topological domain3925 – 401086Cytoplasmic Potential
Domain26 – 8762VWFC 1
Domain92 – 15261VWFC 2
Domain156 – 21661VWFC 3
Domain218 – 27861VWFC 4
Domain282 – 34261VWFC 5
Domain358 – 41659VWFC 6
Repeat408 – 45952FU 1
Repeat461 – 50444FU 2
Repeat506 – 55247FU 3
Repeat554 – 59845FU 4
Repeat601 – 64646FU 5
Repeat648 – 70457FU 6
Repeat707 – 75246FU 7
Repeat754 – 79946FU 8
Repeat802 – 85150FU 9
Repeat853 – 89947FU 10
Repeat902 – 94746FU 11
Repeat951 – 99646FU 12
Repeat998 – 104144FU 13
Repeat1045 – 108844FU 14
Repeat1089 – 1200112CSPG 1
Repeat1201 – 1309109CSPG 2
Repeat1310 – 1447138CSPG 3
Repeat1448 – 1576129CSPG 4
Repeat1577 – 1693117CSPG 5
Repeat1694 – 1823130CSPG 6
Repeat1824 – 1941118CSPG 7
Repeat1942 – 2061120CSPG 8
Repeat2062 – 2180119CSPG 9
Repeat2181 – 2295115CSPG 10
Repeat2296 – 2417122CSPG 11
Repeat2420 – 2544125CSPG 12
Domain2545 – 2648104Calx-beta 1
Domain2661 – 2772112Calx-beta 2
Domain2786 – 2892107Calx-beta 3
Domain2907 – 3009103Calx-beta 4
Domain3027 – 3131105Calx-beta 5

Amino acid modifications

Modified residue3431Phosphoserine By similarity
Glycosylation7271N-linked (GlcNAc...) Potential
Glycosylation10941N-linked (GlcNAc...) Potential
Glycosylation11071N-linked (GlcNAc...) Potential
Glycosylation15061N-linked (GlcNAc...) Potential
Glycosylation17791N-linked (GlcNAc...) Potential
Glycosylation19501N-linked (GlcNAc...) Potential
Glycosylation19801N-linked (GlcNAc...) Potential
Glycosylation25651N-linked (GlcNAc...) Potential
Glycosylation26661N-linked (GlcNAc...) Potential
Glycosylation26841N-linked (GlcNAc...) Potential
Glycosylation29101N-linked (GlcNAc...) Potential
Glycosylation29871N-linked (GlcNAc...) Potential
Glycosylation30721N-linked (GlcNAc...) Potential
Glycosylation32201N-linked (GlcNAc...) Potential
Glycosylation36781N-linked (GlcNAc...) Potential
Glycosylation38771N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict221N → H in CAD33519. Ref.1
Sequence conflict10261L → F in CAD33519. Ref.1
Sequence conflict10631R → Q in CAD33519. Ref.1
Sequence conflict14661P → H in CAD33519. Ref.1
Sequence conflict20201N → H in CAD33519. Ref.1
Sequence conflict22081R → K in CAD33519. Ref.1
Sequence conflict23101V → L in CAD33519. Ref.1
Sequence conflict23101V → L in BAC65800. Ref.3
Sequence conflict23141R → Q in CAD33519. Ref.1
Sequence conflict23141R → Q in BAC65800. Ref.3
Sequence conflict26231G → S in CAD33519. Ref.1
Sequence conflict26231G → S in BAC65800. Ref.3
Sequence conflict26461G → W in BAC34788. Ref.4
Sequence conflict26641V → I in CAD33519. Ref.1
Sequence conflict26641V → I in BAC65800. Ref.3
Sequence conflict31351L → P in CAD33519. Ref.1
Sequence conflict31351L → P in BAC65800. Ref.3
Sequence conflict31721D → G in BAC34788. Ref.4
Sequence conflict33831Q → R in CAD33519. Ref.1
Sequence conflict33831Q → R in BAC65800. Ref.3
Sequence conflict33831Q → R in AAH44881. Ref.5
Sequence conflict33951N → D in CAD33519. Ref.1
Sequence conflict33951N → D in BAC65800. Ref.3
Sequence conflict33951N → D in AAH44881. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q80T14 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 7C1DDED1C8ACEC04

FASTA4,010442,369
        10         20         30         40         50         60 
MGVLKAWLGV ALALAEFAVL PNCEGACLYQ GSFLADATIW KPDSCQNCRC HGDIVICKPV 

        70         80         90        100        110        120 
VCKNPRCAFE KGEVLWIAPN QCCPQCAPRT PGSCHHEGKI HEHGTEWASA PCTVCSCTHG 

       130        140        150        160        170        180 
EVRCSHQQCT PLSCGPQELE FLAEGRCCPI CVGTGKPCSY DGHVFQDGED WQLSRCAKCV 

       190        200        210        220        230        240 
CRNGLTQCFA AQCQPLFCNQ DEIVVRVPGK CCSQCSARSC STAGQVYEHG EQWKEDACTL 

       250        260        270        280        290        300 
CMCDQGQVRC HKQVCPPLRC AKGQGRARHH GQCCEECATP DRSCSSGGVL RYQDEMWKGS 

       310        320        330        340        350        360 
ACEFCMCDQG QVTCQTGECA KVACALGEEL VHLEGKCCPE CISRNGYCIY EQKAETMSSS 

       370        380        390        400        410        420 
AREIKHVPDG EKWEEGPCKL CECREAQVTC YEPSCPPCPV ATLALVVKGQ CCPDCTPVHC 

       430        440        450        460        470        480 
HPDCLTCSHS PDHCDLCQDP TKLLQNGRCV HSCGLGFYQA GSLCLACQPQ CSTCTNGLEC 

       490        500        510        520        530        540 
SSCLPPLLMQ QGQCVSTCGD GFYQDHHSCA VCHESCAGCW GPTEKHCMAC RDPLQVLRDS 

       550        560        570        580        590        600 
SCENTCGNGF YNRQGTCVAC DQSCKSCGPS SPRCLSCAEK TILHDGKCIS ECPHGYYADS 

       610        620        630        640        650        660 
TGSCKVCHSS CASCSGPTAA HCIACIHPQT LRQGHCLPSC GEGFYPDHGI CEACHASCHT 

       670        680        690        700        710        720 
CVGPQPSHCT QCKKPEAGLL VEQHSGENVP YGKCVSRCGT HFYLESTGLC EVCHPSCLTC 

       730        740        750        760        770        780 
EGKSPHNCTG CESTHALLAG CCVSQCPETH FNLEGTCTEC HPSCRQCHGP LESDCVSCHP 

       790        800        810        820        830        840 
HLTLTSGHCK TSCKEEQFLN LVGYCADCHP LCQHCVANLQ DTGSICLKCQ HARHLLLGDH 

       850        860        870        880        890        900 
CVPECPPGHY KERGTCKTCH SSCRSCQNGG PFSCSSCDTG LVLTHIGTCS TACFPGHYLD 

       910        920        930        940        950        960 
DNQVCQPCNR HCRSCDSQGS CTSCRDPSKV LLFGECQYES CTPQYYLDIA TKTCKECDWS 

       970        980        990       1000       1010       1020 
CNACTGPLRT DCLQCMDGYV LQDGVCVEQC SPQHYRDSGS CKRCDSHCVE CQGPHECTRC 

      1030       1040       1050       1060       1070       1080 
EEPFLLFQAQ CVQECGKGYF ADHAKHRCIA CPQGCLRCSH KDRCHLCDHS FFLKSGLCMP 

      1090       1100       1110       1120       1130       1140 
TCVPGFSGHS SNENCTDKMY TPSLHVNGSL TLGIGSMKPL DFSLLNIQHQ DGRVEDLLFH 

      1150       1160       1170       1180       1190       1200 
VVSTPTNGQL LLSRNGKEVQ LEKAGHFSWK DVNEKKVRFV HSKEKLRKGY FSLKISDQQF 

      1210       1220       1230       1240       1250       1260 
FSEPQLINIQ AFSTQAPYVL RNEVLHVSKG ERATITTQLL DIRDDDNPQD VVVNVLDPPL 

      1270       1280       1290       1300       1310       1320 
HGQLLQMPPA PAASIYQFHL DELSRGLLLY AHDGSDSTSD IIVFQANDGH SFQNILFHVK 

      1330       1340       1350       1360       1370       1380 
NIPKNDRALR LVTNSMVWVP EGGMLKITNR ILKAQAPGVR ADDIIYKITH SRPQFGEVVL 

      1390       1400       1410       1420       1430       1440 
LMNLPADSPA GPAEEGHHLP DGRMATPIST FTQQDIDDGV VWYRHLGAPT QSDSFRFQVS 

      1450       1460       1470       1480       1490       1500 
SATSAQEHLE SHMFNIAILP QAPEAPKLSL GTSLHMTARE DGLSVIQPQS LSFVKAESPS 

      1510       1520       1530       1540       1550       1560 
GKIIYNITVP LHPNQGIIEH RDRPHSPIQY FTQEDINQGQ IMYRPPVAPP HLQEIMAFSF 

      1570       1580       1590       1600       1610       1620 
AGLPESVKFY FTVSDGQHTS PEMALTIHLL HSDLQPPAFQ VKAPLLEVSP GGRTSLGLQL 

      1630       1640       1650       1660       1670       1680 
LVRDAQVVPE ELFFQLQKSP QHGMLVKYTA KSSVTMAAGD TFTYDEVERN VLQYVHDGSS 

      1690       1700       1710       1720       1730       1740 
AWEDSLEISV TDGLTVTTSE VKVEVSPSEN RGPRLAPGSS LSMTVASQHT AIITRSHLAY 

      1750       1760       1770       1780       1790       1800 
VDDSSSDPEI WIRLSSLPLY GVLFRSSGPD MDELSGDSNF TMEDINKKNI RYSAVFETDG 

      1810       1820       1830       1840       1850       1860 
HSVTDGFHFS VSDMDGNHVD NQVFTITVTP AENPPHIIAF ADLITVDEGG RAPLSLHHFF 

      1870       1880       1890       1900       1910       1920 
ATEDQDNLQD DAVIKLSALP KYGCIENTGT GDRFGPGANS ELEASFPIQD VLENYIYYFQ 

      1930       1940       1950       1960       1970       1980 
SVHESIEPTH DVFSFYVSDG SGRSEIHSIN ITIERKNDEP PRMTLRPLGV RLSSGVAISN 

      1990       2000       2010       2020       2030       2040 
SSLSLQDLDT PDNELIFVLM KKPDHGHLLR RSTASDPLEN GTVLDQGSSF TYQDVLAGLV 

      2050       2060       2070       2080       2090       2100 
GYLPGDIYMA VDEFRFSLTD GLHVDTGRME IYIELPSTNI PHLAINRGLQ LSAGSVARIT 

      2110       2120       2130       2140       2150       2160 
EQHLKATDTD SEAGQVVYIM KEDPGAGRLL MAKADNLEQI SVRGPIRSFT QADVSQGQIE 

      2170       2180       2190       2200       2210       2220 
YSHGPGEPGG SFAFKFDVVD GEGNKLADQS FSIGVLEDKS PPVVITNRGL VLDENSVEKI 

      2230       2240       2250       2260       2270       2280 
TTAQLSATDQ DSKPTELIYR ITTQPQLGHL EHVASPGIQI SSFTQADLAS RNVQYVRSSG 

      2290       2300       2310       2320       2330       2340 
TGKQSDAFSF VLSDGLHEVT QTFPITIHPV DDARPLVQNR GMRVQEGVRK TITEFELKAV 

      2350       2360       2370       2380       2390       2400 
DVDTEAESIT FTIVQPPRHG TIERTARGQR FHQTSSFTME DIYQNRVSYS HDGSNSLKDR 

      2410       2420       2430       2440       2450       2460 
FTFTVSDGTN PFFIIEEGGE EIMTAAPQQF HVDILPVDDG TPRIVTNLGL QWLEYMDGKA 

      2470       2480       2490       2500       2510       2520 
TNLITKKELL TVDPDTEDSQ LIYEVTTGPM HGYLENKLQP GRAAATFTQE HVNLGLIRYV 

      2530       2540       2550       2560       2570       2580 
LYEEKIQKVM DSFQFLVKDS KPNVVSDNVF HIQWSLISFK YTSYNVSEKA GSVSVTVQRT 

      2590       2600       2610       2620       2630       2640 
GNLNQYAIVL CRTEQGTASS SSHPGQQDYM EYAGQVQFDE GEGTKSCTVI INDDDVFENI 

      2650       2660       2670       2680       2690       2700 
ESFTVGLSMP AYALLGEFTQ AKVVINDTED EPTLEFDKKT YRVNESAGFL FAPIKRQGDS 

      2710       2720       2730       2740       2750       2760 
SSTVSAVCYT VPKSAMGSSL YALESGSDFK SRGRSAESRV IFGPGVTVST CDVMVIDDSE 

      2770       2780       2790       2800       2810       2820 
YEEEEEFEIA LADASNNARI GRQAVAKVLI SGPNDASTVS LGNTAFTISE DAGTVKIPVI 

      2830       2840       2850       2860       2870       2880 
RHGTDLSTFT SVWCATRPSD PASATPGVDY VPSSRKVEFG PGITEQYCTL TILDDTQYPV 

      2890       2900       2910       2920       2930       2940 
IEGLETFVVF LSSAQGAELT KPSQAVIAIN DTFQDVPSMQ FSKDLLLVKE KEGVLHIPII 

      2950       2960       2970       2980       2990       3000 
RSGDLSYESS VRCYTQGHSA QVMEDFEERR NADSSRITFL KGQKTKNCTV YIHDDSMFEP 

      3010       3020       3030       3040       3050       3060 
EEQFRVYLGH PLGNHWSGAR IGKNSVATVT ISNDEDAPTI EFEEAAYQVR EPAGPEAIAV 

      3070       3080       3090       3100       3110       3120 
LSIKVIRRGD QNRTSKIRCS TRDGSAQSGV DYYPKSRVLK FSPGVDHIFF KVEILSNEDR 

      3130       3140       3150       3160       3170       3180 
EWHESFSLVL GPDDLVEAVL GDVTTATVTI LDQEAAGSLI LPAPPIVVTL ADYDHVEELA 

      3190       3200       3210       3220       3230       3240 
KEGVKKAPSP GYPLVCVTPC DPRYPRYAVM KERCSEAGIN QTSVQFSWEV AAPTDGNGAR 

      3250       3260       3270       3280       3290       3300 
SPFETITDNT PFTSVNHKVL DSIYFSRRFH VRCVAKAVDK VGHVGTPLRS NVVTIGTDSA 

      3310       3320       3330       3340       3350       3360 
ICHTPVVAGT ARGFQAQSFI ATLKYLDVKH KEHPNRIHIS VQIPHQDGML PLISTMPLHN 

      3370       3380       3390       3400       3410       3420 
LHFLLSESIY RHQHVCSNLV TAQDLRGLAE AGFLNDAGFH STALGPGYDR PFQFDSSVRE 

      3430       3440       3450       3460       3470       3480 
PKTIQLYRHL NLKSCVWTFD AYYDMTELID VCGGSVTADF QVRDSAQSFL TVHVPLYVSY 

      3490       3500       3510       3520       3530       3540 
IYVTAPRGWA SLEHHTEMEF SFFYDTVLWR TGIQTDSVLS ARLQIIRIYI REDGRLVIEF 

      3550       3560       3570       3580       3590       3600 
KTHAKFRGQF VIEHHTLPDV KSFILTPDHL GGIQFDLQLL WSAQTFDSPH QLWRATSSYN 

      3610       3620       3630       3640       3650       3660 
RKDYSGEYTI YLIPCTVQPT QPWVDPGEKA LACTAHAPER FLIPIAFQQT NRPVPVVYSL 

      3670       3680       3690       3700       3710       3720 
NTEFQLCNNE KVFLMDPNTS DMSLAEMDYK GAFSKGQILY GRVLWNPEQN LHSAYKLQLE 

      3730       3740       3750       3760       3770       3780 
KVYLCTGKDG YVPFFDPTGT IYNEGPQYGC IQPNKHLKHR FLLLDRSQPE VTDKYFHDVP 

      3790       3800       3810       3820       3830       3840 
FEAHFASELP DFQVVSSMPG VDGFTLKVDA LYKVEAGHQW YLQVIYIIGP DSTSRPRVQR 

      3850       3860       3870       3880       3890       3900 
SLTVSLRRHQ RDLVDPSGWL SLDDSLIYDN EGDQVKNGTN MKSLNLEMQE PVIAASLSQT 

      3910       3920       3930       3940       3950       3960 
GASIGSALAA IMLLLLLFLV ACFVTRKCQK QKKKQPPEDT LEEYPLNTKV DVAKRNADKV 

      3970       3980       3990       4000       4010 
EKNANRQYCT VRNVNILSDN EGYYTFKGAK VKKLNLEVRV HNNLQDGTEV 

« Hide

References

« Hide 'large scale' references
[1]"Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice."
Vrontou S., Petrou P., Meyer B.I., Vassilis K., Galanopoulos K., Imai K., Yanagi M., Chowdhury K., Scambler P.J., Chalepakis G.
Nat. Genet. 34:209-214(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISEASE.
Strain: NMRI.
Tissue: Brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2283-4010.
Tissue: Brain.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2646-4010.
Strain: C57BL/6J.
Tissue: Eye.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3228-4010.
Strain: FVB/N.
Tissue: Kidney.
[6]"Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein."
McGregor L.K., Makela V., Darling S.M., Vrontou S., Chalepakis G., Roberts C., Smart N., Rutland P., Prescott N., Hopkins J., Bentley E., Shaw A., Roberts E., Mueller R., Jadeja S., Philip N., Nelson J., Francannet C. expand/collapse author list , Perez-Aytes A., Megarbane A., Kerr B., Wainwright B., Woolf A.S., Winter R.M., Scambler P.J.
Nat. Genet. 34:203-208(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE, DISEASE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ489280 mRNA. Translation: CAD33519.1.
AC101391 Genomic DNA. No translation available.
AC121829 Genomic DNA. No translation available.
AC122007 Genomic DNA. No translation available.
AC151985 Genomic DNA. No translation available.
AK122518 mRNA. Translation: BAC65800.1.
AK051850 mRNA. Translation: BAC34788.1. Sequence problems.
BC044881 mRNA. Translation: AAH44881.1.
CCDSCCDS19450.1.
RefSeqNP_780682.3. NM_175473.3.
UniGeneMm.291120.

3D structure databases

ProteinModelPortalQ80T14.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid231125. 1 interaction.
MINTMINT-4997571.

PTM databases

PhosphoSiteQ80T14.

Proteomic databases

PaxDbQ80T14.
PRIDEQ80T14.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036019; ENSMUSP00000043250; ENSMUSG00000034687.
GeneID231470.
KEGGmmu:231470.
UCSCuc008yfk.1. mouse.

Organism-specific databases

CTD80144.
MGIMGI:2385368. Fras1.
RougeSearch...

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00550000074429.
HOGENOMHOG000076882.
HOVERGENHBG051659.
InParanoidQ80T14.
OMAFTMEDIN.
OrthoDBEOG751NDJ.
TreeFamTF316876.

Gene expression databases

BgeeQ80T14.
CleanExMM_FRAS1.
GenevestigatorQ80T14.

Family and domain databases

InterProIPR003644. Calx_beta.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view]
PfamPF03160. Calx-beta. 5 hits.
PF00093. VWC. 5 hits.
[Graphical view]
SMARTSM00237. Calx_beta. 5 hits.
SM00261. FU. 14 hits.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 5 hits.
PROSITEPS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFRAS1. mouse.
NextBio380572.
PROQ80T14.
SOURCESearch...

Entry information

Entry nameFRAS1_MOUSE
AccessionPrimary (citable) accession number: Q80T14
Secondary accession number(s): E9QPG9 expand/collapse secondary AC list , Q80TC7, Q811H8, Q8BPZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot