Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q80T14

- FRAS1_MOUSE

UniProt

Q80T14 - FRAS1_MOUSE

Protein

Extracellular matrix protein FRAS1

Gene

Fras1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell communication Source: InterPro
    2. embryonic limb morphogenesis Source: MGI
    3. metanephros morphogenesis Source: MGI
    4. morphogenesis of an epithelium Source: MGI
    5. palate development Source: MGI
    6. protein transport Source: MGI
    7. skin development Source: MGI

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Extracellular matrix protein FRAS1
    Gene namesi
    Name:Fras1
    Synonyms:Kiaa1500
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2385368. Fras1.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: BHF-UCL
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell
    4. sublamina densa Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Fras1 are the cause of blebbed (bl) phenotype, which is characterized by blister formation, syndactyly, eyelid fusion and renal agenesis. Subepidermal blisters are predominantly formed in the head region around the eyes and at the distal part of the limbs. As development proceeds blisters that are initially transparent gradually become hemorrhagic and embryos die between E14.5 and E16.5.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 40103985Extracellular matrix protein FRAS1PRO_0000010121Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei343 – 3431PhosphoserineBy similarity
    Glycosylationi727 – 7271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1094 – 10941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1107 – 11071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1506 – 15061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1779 – 17791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1950 – 19501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1980 – 19801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2565 – 25651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2666 – 26661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2684 – 26841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2910 – 29101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2987 – 29871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3072 – 30721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3220 – 32201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3678 – 36781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3877 – 38771N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ80T14.
    PRIDEiQ80T14.

    PTM databases

    PhosphoSiteiQ80T14.

    Expressioni

    Tissue specificityi

    Found in a linear fashion underlying the epidermis and the basal surface of other epithelia in embryos.1 Publication

    Developmental stagei

    Highly expressed in the apical ectodermal ridge of the limb buds from E10.5-E12.5 and expression was also detected in the interdigital spaces at E14.5. Found in cells just underlying the surface epithelium of the entire embryo and in the linings of the peritoneal cavity and dorsal aorta. At E12 detected in the mesonephric duct and in the lens.1 Publication

    Gene expression databases

    BgeeiQ80T14.
    CleanExiMM_FRAS1.
    GenevestigatoriQ80T14.

    Interactioni

    Protein-protein interaction databases

    BioGridi231125. 1 interaction.
    MINTiMINT-4997571.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80T14.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 39033878ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini3925 – 401086CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3904 – 392421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 8762VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini92 – 15261VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini156 – 21661VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini218 – 27861VWFC 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini282 – 34261VWFC 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini358 – 41659VWFC 6PROSITE-ProRule annotationAdd
    BLAST
    Repeati408 – 45952FU 1Add
    BLAST
    Repeati461 – 50444FU 2Add
    BLAST
    Repeati506 – 55247FU 3Add
    BLAST
    Repeati554 – 59845FU 4Add
    BLAST
    Repeati601 – 64646FU 5Add
    BLAST
    Repeati648 – 70457FU 6Add
    BLAST
    Repeati707 – 75246FU 7Add
    BLAST
    Repeati754 – 79946FU 8Add
    BLAST
    Repeati802 – 85150FU 9Add
    BLAST
    Repeati853 – 89947FU 10Add
    BLAST
    Repeati902 – 94746FU 11Add
    BLAST
    Repeati951 – 99646FU 12Add
    BLAST
    Repeati998 – 104144FU 13Add
    BLAST
    Repeati1045 – 108844FU 14Add
    BLAST
    Repeati1089 – 1200112CSPG 1Add
    BLAST
    Repeati1201 – 1309109CSPG 2Add
    BLAST
    Repeati1310 – 1447138CSPG 3Add
    BLAST
    Repeati1448 – 1576129CSPG 4Add
    BLAST
    Repeati1577 – 1693117CSPG 5Add
    BLAST
    Repeati1694 – 1823130CSPG 6Add
    BLAST
    Repeati1824 – 1941118CSPG 7Add
    BLAST
    Repeati1942 – 2061120CSPG 8Add
    BLAST
    Repeati2062 – 2180119CSPG 9Add
    BLAST
    Repeati2181 – 2295115CSPG 10Add
    BLAST
    Repeati2296 – 2417122CSPG 11Add
    BLAST
    Repeati2420 – 2544125CSPG 12Add
    BLAST
    Domaini2545 – 2648104Calx-beta 1Add
    BLAST
    Domaini2661 – 2772112Calx-beta 2Add
    BLAST
    Domaini2786 – 2892107Calx-beta 3Add
    BLAST
    Domaini2907 – 3009103Calx-beta 4Add
    BLAST
    Domaini3027 – 3131105Calx-beta 5Add
    BLAST

    Domaini

    The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

    Sequence similaritiesi

    Belongs to the FRAS1 family.Curated
    Contains 5 Calx-beta domains.Curated
    Contains 12 CSPG (NG2) repeats.Curated
    Contains 14 FU (furin-like) repeats.Curated
    Contains 6 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00550000074429.
    HOGENOMiHOG000076882.
    HOVERGENiHBG051659.
    InParanoidiQ80T14.
    OMAiFTMEDIN.
    OrthoDBiEOG751NDJ.
    TreeFamiTF316876.

    Family and domain databases

    InterProiIPR003644. Calx_beta.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF03160. Calx-beta. 5 hits.
    PF00093. VWC. 5 hits.
    [Graphical view]
    SMARTiSM00237. Calx_beta. 5 hits.
    SM00261. FU. 14 hits.
    SM00214. VWC. 6 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 5 hits.
    PROSITEiPS01208. VWFC_1. 6 hits.
    PS50184. VWFC_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q80T14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVLKAWLGV ALALAEFAVL PNCEGACLYQ GSFLADATIW KPDSCQNCRC     50
    HGDIVICKPV VCKNPRCAFE KGEVLWIAPN QCCPQCAPRT PGSCHHEGKI 100
    HEHGTEWASA PCTVCSCTHG EVRCSHQQCT PLSCGPQELE FLAEGRCCPI 150
    CVGTGKPCSY DGHVFQDGED WQLSRCAKCV CRNGLTQCFA AQCQPLFCNQ 200
    DEIVVRVPGK CCSQCSARSC STAGQVYEHG EQWKEDACTL CMCDQGQVRC 250
    HKQVCPPLRC AKGQGRARHH GQCCEECATP DRSCSSGGVL RYQDEMWKGS 300
    ACEFCMCDQG QVTCQTGECA KVACALGEEL VHLEGKCCPE CISRNGYCIY 350
    EQKAETMSSS AREIKHVPDG EKWEEGPCKL CECREAQVTC YEPSCPPCPV 400
    ATLALVVKGQ CCPDCTPVHC HPDCLTCSHS PDHCDLCQDP TKLLQNGRCV 450
    HSCGLGFYQA GSLCLACQPQ CSTCTNGLEC SSCLPPLLMQ QGQCVSTCGD 500
    GFYQDHHSCA VCHESCAGCW GPTEKHCMAC RDPLQVLRDS SCENTCGNGF 550
    YNRQGTCVAC DQSCKSCGPS SPRCLSCAEK TILHDGKCIS ECPHGYYADS 600
    TGSCKVCHSS CASCSGPTAA HCIACIHPQT LRQGHCLPSC GEGFYPDHGI 650
    CEACHASCHT CVGPQPSHCT QCKKPEAGLL VEQHSGENVP YGKCVSRCGT 700
    HFYLESTGLC EVCHPSCLTC EGKSPHNCTG CESTHALLAG CCVSQCPETH 750
    FNLEGTCTEC HPSCRQCHGP LESDCVSCHP HLTLTSGHCK TSCKEEQFLN 800
    LVGYCADCHP LCQHCVANLQ DTGSICLKCQ HARHLLLGDH CVPECPPGHY 850
    KERGTCKTCH SSCRSCQNGG PFSCSSCDTG LVLTHIGTCS TACFPGHYLD 900
    DNQVCQPCNR HCRSCDSQGS CTSCRDPSKV LLFGECQYES CTPQYYLDIA 950
    TKTCKECDWS CNACTGPLRT DCLQCMDGYV LQDGVCVEQC SPQHYRDSGS 1000
    CKRCDSHCVE CQGPHECTRC EEPFLLFQAQ CVQECGKGYF ADHAKHRCIA 1050
    CPQGCLRCSH KDRCHLCDHS FFLKSGLCMP TCVPGFSGHS SNENCTDKMY 1100
    TPSLHVNGSL TLGIGSMKPL DFSLLNIQHQ DGRVEDLLFH VVSTPTNGQL 1150
    LLSRNGKEVQ LEKAGHFSWK DVNEKKVRFV HSKEKLRKGY FSLKISDQQF 1200
    FSEPQLINIQ AFSTQAPYVL RNEVLHVSKG ERATITTQLL DIRDDDNPQD 1250
    VVVNVLDPPL HGQLLQMPPA PAASIYQFHL DELSRGLLLY AHDGSDSTSD 1300
    IIVFQANDGH SFQNILFHVK NIPKNDRALR LVTNSMVWVP EGGMLKITNR 1350
    ILKAQAPGVR ADDIIYKITH SRPQFGEVVL LMNLPADSPA GPAEEGHHLP 1400
    DGRMATPIST FTQQDIDDGV VWYRHLGAPT QSDSFRFQVS SATSAQEHLE 1450
    SHMFNIAILP QAPEAPKLSL GTSLHMTARE DGLSVIQPQS LSFVKAESPS 1500
    GKIIYNITVP LHPNQGIIEH RDRPHSPIQY FTQEDINQGQ IMYRPPVAPP 1550
    HLQEIMAFSF AGLPESVKFY FTVSDGQHTS PEMALTIHLL HSDLQPPAFQ 1600
    VKAPLLEVSP GGRTSLGLQL LVRDAQVVPE ELFFQLQKSP QHGMLVKYTA 1650
    KSSVTMAAGD TFTYDEVERN VLQYVHDGSS AWEDSLEISV TDGLTVTTSE 1700
    VKVEVSPSEN RGPRLAPGSS LSMTVASQHT AIITRSHLAY VDDSSSDPEI 1750
    WIRLSSLPLY GVLFRSSGPD MDELSGDSNF TMEDINKKNI RYSAVFETDG 1800
    HSVTDGFHFS VSDMDGNHVD NQVFTITVTP AENPPHIIAF ADLITVDEGG 1850
    RAPLSLHHFF ATEDQDNLQD DAVIKLSALP KYGCIENTGT GDRFGPGANS 1900
    ELEASFPIQD VLENYIYYFQ SVHESIEPTH DVFSFYVSDG SGRSEIHSIN 1950
    ITIERKNDEP PRMTLRPLGV RLSSGVAISN SSLSLQDLDT PDNELIFVLM 2000
    KKPDHGHLLR RSTASDPLEN GTVLDQGSSF TYQDVLAGLV GYLPGDIYMA 2050
    VDEFRFSLTD GLHVDTGRME IYIELPSTNI PHLAINRGLQ LSAGSVARIT 2100
    EQHLKATDTD SEAGQVVYIM KEDPGAGRLL MAKADNLEQI SVRGPIRSFT 2150
    QADVSQGQIE YSHGPGEPGG SFAFKFDVVD GEGNKLADQS FSIGVLEDKS 2200
    PPVVITNRGL VLDENSVEKI TTAQLSATDQ DSKPTELIYR ITTQPQLGHL 2250
    EHVASPGIQI SSFTQADLAS RNVQYVRSSG TGKQSDAFSF VLSDGLHEVT 2300
    QTFPITIHPV DDARPLVQNR GMRVQEGVRK TITEFELKAV DVDTEAESIT 2350
    FTIVQPPRHG TIERTARGQR FHQTSSFTME DIYQNRVSYS HDGSNSLKDR 2400
    FTFTVSDGTN PFFIIEEGGE EIMTAAPQQF HVDILPVDDG TPRIVTNLGL 2450
    QWLEYMDGKA TNLITKKELL TVDPDTEDSQ LIYEVTTGPM HGYLENKLQP 2500
    GRAAATFTQE HVNLGLIRYV LYEEKIQKVM DSFQFLVKDS KPNVVSDNVF 2550
    HIQWSLISFK YTSYNVSEKA GSVSVTVQRT GNLNQYAIVL CRTEQGTASS 2600
    SSHPGQQDYM EYAGQVQFDE GEGTKSCTVI INDDDVFENI ESFTVGLSMP 2650
    AYALLGEFTQ AKVVINDTED EPTLEFDKKT YRVNESAGFL FAPIKRQGDS 2700
    SSTVSAVCYT VPKSAMGSSL YALESGSDFK SRGRSAESRV IFGPGVTVST 2750
    CDVMVIDDSE YEEEEEFEIA LADASNNARI GRQAVAKVLI SGPNDASTVS 2800
    LGNTAFTISE DAGTVKIPVI RHGTDLSTFT SVWCATRPSD PASATPGVDY 2850
    VPSSRKVEFG PGITEQYCTL TILDDTQYPV IEGLETFVVF LSSAQGAELT 2900
    KPSQAVIAIN DTFQDVPSMQ FSKDLLLVKE KEGVLHIPII RSGDLSYESS 2950
    VRCYTQGHSA QVMEDFEERR NADSSRITFL KGQKTKNCTV YIHDDSMFEP 3000
    EEQFRVYLGH PLGNHWSGAR IGKNSVATVT ISNDEDAPTI EFEEAAYQVR 3050
    EPAGPEAIAV LSIKVIRRGD QNRTSKIRCS TRDGSAQSGV DYYPKSRVLK 3100
    FSPGVDHIFF KVEILSNEDR EWHESFSLVL GPDDLVEAVL GDVTTATVTI 3150
    LDQEAAGSLI LPAPPIVVTL ADYDHVEELA KEGVKKAPSP GYPLVCVTPC 3200
    DPRYPRYAVM KERCSEAGIN QTSVQFSWEV AAPTDGNGAR SPFETITDNT 3250
    PFTSVNHKVL DSIYFSRRFH VRCVAKAVDK VGHVGTPLRS NVVTIGTDSA 3300
    ICHTPVVAGT ARGFQAQSFI ATLKYLDVKH KEHPNRIHIS VQIPHQDGML 3350
    PLISTMPLHN LHFLLSESIY RHQHVCSNLV TAQDLRGLAE AGFLNDAGFH 3400
    STALGPGYDR PFQFDSSVRE PKTIQLYRHL NLKSCVWTFD AYYDMTELID 3450
    VCGGSVTADF QVRDSAQSFL TVHVPLYVSY IYVTAPRGWA SLEHHTEMEF 3500
    SFFYDTVLWR TGIQTDSVLS ARLQIIRIYI REDGRLVIEF KTHAKFRGQF 3550
    VIEHHTLPDV KSFILTPDHL GGIQFDLQLL WSAQTFDSPH QLWRATSSYN 3600
    RKDYSGEYTI YLIPCTVQPT QPWVDPGEKA LACTAHAPER FLIPIAFQQT 3650
    NRPVPVVYSL NTEFQLCNNE KVFLMDPNTS DMSLAEMDYK GAFSKGQILY 3700
    GRVLWNPEQN LHSAYKLQLE KVYLCTGKDG YVPFFDPTGT IYNEGPQYGC 3750
    IQPNKHLKHR FLLLDRSQPE VTDKYFHDVP FEAHFASELP DFQVVSSMPG 3800
    VDGFTLKVDA LYKVEAGHQW YLQVIYIIGP DSTSRPRVQR SLTVSLRRHQ 3850
    RDLVDPSGWL SLDDSLIYDN EGDQVKNGTN MKSLNLEMQE PVIAASLSQT 3900
    GASIGSALAA IMLLLLLFLV ACFVTRKCQK QKKKQPPEDT LEEYPLNTKV 3950
    DVAKRNADKV EKNANRQYCT VRNVNILSDN EGYYTFKGAK VKKLNLEVRV 4000
    HNNLQDGTEV 4010
    Length:4,010
    Mass (Da):442,369
    Last modified:July 27, 2011 - v2
    Checksum:i7C1DDED1C8ACEC04
    GO

    Sequence cautioni

    The sequence BAC34788.1 differs from that shown. Reason: Frameshift at position 2788.
    The sequence BAC34788.1 differs from that shown. Reason: Erroneous termination at position 2854. Translated as Ser.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221N → H in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti1026 – 10261L → F in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti1063 – 10631R → Q in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti1466 – 14661P → H in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti2020 – 20201N → H in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti2208 – 22081R → K in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti2310 – 23101V → L in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti2310 – 23101V → L in BAC65800. (PubMed:12693553)Curated
    Sequence conflicti2314 – 23141R → Q in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti2314 – 23141R → Q in BAC65800. (PubMed:12693553)Curated
    Sequence conflicti2623 – 26231G → S in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti2623 – 26231G → S in BAC65800. (PubMed:12693553)Curated
    Sequence conflicti2646 – 26461G → W in BAC34788. (PubMed:16141072)Curated
    Sequence conflicti2664 – 26641V → I in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti2664 – 26641V → I in BAC65800. (PubMed:12693553)Curated
    Sequence conflicti3135 – 31351L → P in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti3135 – 31351L → P in BAC65800. (PubMed:12693553)Curated
    Sequence conflicti3172 – 31721D → G in BAC34788. (PubMed:16141072)Curated
    Sequence conflicti3383 – 33831Q → R in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti3383 – 33831Q → R in BAC65800. (PubMed:12693553)Curated
    Sequence conflicti3383 – 33831Q → R in AAH44881. (PubMed:15489334)Curated
    Sequence conflicti3395 – 33951N → D in CAD33519. (PubMed:12766770)Curated
    Sequence conflicti3395 – 33951N → D in BAC65800. (PubMed:12693553)Curated
    Sequence conflicti3395 – 33951N → D in AAH44881. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ489280 mRNA. Translation: CAD33519.1.
    AC101391 Genomic DNA. No translation available.
    AC121829 Genomic DNA. No translation available.
    AC122007 Genomic DNA. No translation available.
    AC151985 Genomic DNA. No translation available.
    AK122518 mRNA. Translation: BAC65800.1.
    AK051850 mRNA. Translation: BAC34788.1. Sequence problems.
    BC044881 mRNA. Translation: AAH44881.1.
    CCDSiCCDS19450.1.
    RefSeqiNP_780682.3. NM_175473.3.
    UniGeneiMm.291120.

    Genome annotation databases

    EnsembliENSMUST00000036019; ENSMUSP00000043250; ENSMUSG00000034687.
    GeneIDi231470.
    KEGGimmu:231470.
    UCSCiuc008yfk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ489280 mRNA. Translation: CAD33519.1 .
    AC101391 Genomic DNA. No translation available.
    AC121829 Genomic DNA. No translation available.
    AC122007 Genomic DNA. No translation available.
    AC151985 Genomic DNA. No translation available.
    AK122518 mRNA. Translation: BAC65800.1 .
    AK051850 mRNA. Translation: BAC34788.1 . Sequence problems.
    BC044881 mRNA. Translation: AAH44881.1 .
    CCDSi CCDS19450.1.
    RefSeqi NP_780682.3. NM_175473.3.
    UniGenei Mm.291120.

    3D structure databases

    ProteinModelPortali Q80T14.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 231125. 1 interaction.
    MINTi MINT-4997571.

    PTM databases

    PhosphoSitei Q80T14.

    Proteomic databases

    PaxDbi Q80T14.
    PRIDEi Q80T14.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036019 ; ENSMUSP00000043250 ; ENSMUSG00000034687 .
    GeneIDi 231470.
    KEGGi mmu:231470.
    UCSCi uc008yfk.1. mouse.

    Organism-specific databases

    CTDi 80144.
    MGIi MGI:2385368. Fras1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00550000074429.
    HOGENOMi HOG000076882.
    HOVERGENi HBG051659.
    InParanoidi Q80T14.
    OMAi FTMEDIN.
    OrthoDBi EOG751NDJ.
    TreeFami TF316876.

    Miscellaneous databases

    ChiTaRSi FRAS1. mouse.
    NextBioi 380572.
    PROi Q80T14.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80T14.
    CleanExi MM_FRAS1.
    Genevestigatori Q80T14.

    Family and domain databases

    InterProi IPR003644. Calx_beta.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF03160. Calx-beta. 5 hits.
    PF00093. VWC. 5 hits.
    [Graphical view ]
    SMARTi SM00237. Calx_beta. 5 hits.
    SM00261. FU. 14 hits.
    SM00214. VWC. 6 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 5 hits.
    PROSITEi PS01208. VWFC_1. 6 hits.
    PS50184. VWFC_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice."
      Vrontou S., Petrou P., Meyer B.I., Vassilis K., Galanopoulos K., Imai K., Yanagi M., Chowdhury K., Scambler P.J., Chalepakis G.
      Nat. Genet. 34:209-214(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISEASE.
      Strain: NMRI.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2283-4010.
      Tissue: Brain.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2646-4010.
      Strain: C57BL/6J.
      Tissue: Eye.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3228-4010.
      Strain: FVB/N.
      Tissue: Kidney.
    6. Cited for: DEVELOPMENTAL STAGE, DISEASE.

    Entry informationi

    Entry nameiFRAS1_MOUSE
    AccessioniPrimary (citable) accession number: Q80T14
    Secondary accession number(s): E9QPG9
    , Q80TC7, Q811H8, Q8BPZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3