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Q80T03

- MUC6_MOUSE

UniProt

Q80T03 - MUC6_MOUSE

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Protein

Mucin-6

Gene

Muc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.

Protein family/group databases

MEROPSiI08.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-6
Short name:
MUC-6
Alternative name(s):
Gastric mucin-6
Secreted gel-forming mucin-6
Gene namesi
Name:Muc6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2663233. Muc6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 28502828Mucin-6PRO_0000259497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 2848By similarity
Disulfide bondi67 ↔ 75By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi701 – 7011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1017 – 10171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1221 – 12211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2760 ↔ 2807By similarity
Disulfide bondi2774 ↔ 2821By similarity
Disulfide bondi2783 ↔ 2841By similarity
Disulfide bondi2787 ↔ 2843By similarity

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80T03.
PRIDEiQ80T03.

PTM databases

PhosphoSiteiQ80T03.

Expressioni

Tissue specificityi

Expressed in stomach, duodenum and small intestine.2 Publications

Gene expression databases

CleanExiMM_MUC6.
GenevestigatoriQ80T03.

Interactioni

Subunit structurei

Multimer; disulfide-linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ80T03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 288245VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini344 – 39956TIL 1Add
BLAST
Domaini438 – 650213VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini806 – 86964TIL 2Add
BLAST
Domaini909 – 1117209VWFD 3PROSITE-ProRule annotationAdd
BLAST
Repeati1440 – 15551161Add
BLAST
Repeati1556 – 17121572Add
BLAST
Repeati1713 – 18851733Add
BLAST
Repeati1886 – 20541694Add
BLAST
Repeati2055 – 22271735Add
BLAST
Repeati2228 – 23961696Add
BLAST
Repeati2397 – 25631677Add
BLAST
Repeati2564 – 26711088Add
BLAST
Domaini2760 – 284990CTCKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1440 – 26711232Approximate repeatsBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2291 – 2755465Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 3 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000170714.
HOVERGENiHBG081998.
InParanoidiQ80T03.
PhylomeDBiQ80T03.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF01826. TIL. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 3 hits.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS01225. CTCK_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80T03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRVRQLLLL LLFRGPLIDA GAWTGDVTDS DTEDNLQSSP EKGWCSTWGA
60 70 80 90 100
GHFSTFDGHE YNFQGMCNYI FTATCGDDVP ATFSIQLRRD MEGNISRIIM
110 120 130 140 150
ELGASVVTVN KETISVRDIG VVSLPYTSNG LQITPYGQSV QLVAKQLELE
160 170 180 190 200
LVITWGPDAH LTEGQGGDEV GTPGTLKQES KGSPAWAGSS LCIPTETNST
210 220 230 240 250
TPQVQVETKY MGKLCGLCGN FDGKIDNEFL SEDGKLLEAH KYATLQKLDD
260 270 280 290 300
PNEICAHEAI PSTIILKTRY AQICNQLLTL VSPGCDVPKE TLMLSCQADM
310 320 330 340 350
AACARPGQPN CSCATLSEYS RRCSMTGQPV RNWRTPALCP MSQCPANQVY
360 370 380 390 400
QECGEVCIKT CSNPQHSCSS PCTFGCFCPH GTLLDDISGN QSCVPVNQCP
410 420 430 440 450
CMLNGMVYGP GEITKTACQT CQCTMGRWTC TKQPCPGHCS LEGGSFVTTF
460 470 480 490 500
DARPYRFHGT CTYTLLQSPQ LPNEGTLMAV YDKSGYSHSE TSLVAIMYLS
510 520 530 540 550
KKDKIVISED EVITNNGDTK LLPYKTHNIT IFRQTSTHLQ MATTFGLELV
560 570 580 590 600
FQMQPVFQVY ITVGPQFKGQ TRGLCGNFNG DTTDDFTTSM GIDEGTASLF
610 620 630 640 650
VDSWRAGNCP AALEREMDPC SMSQLNKVCA ETHCSMLLKK GSVFEKCHSV
660 670 680 690 700
VNPQPFYKRC VYQACNYEET FPHICSALGA YAHACSARGI LLWGWRNSVD
710 720 730 740 750
NCTVPCTGNR TFSYDSQACD RTCLSLSDRE TECHVSPVPV DGCNCPEGTY
760 770 780 790 800
LNHKAECVHK AQCPCLLDDY KFVQADQSTM INGVICHCIN GRLSCPRQAE
810 820 830 840 850
MFFASCPEPK TFQSCSQSSE DKFGAACAPT CQMLATGIDC VPTKCESGCV
860 870 880 890 900
CPKGLYENSD GQCVPAEECP CDYAGVSYPG GFELHTDCKT CTCSQGRWTC
910 920 930 940 950
QLSTQCPSTC VLYGEGHIIT FDGQRFVFDG DCEYMLATDD CGANSSQPTF
960 970 980 990 1000
KVLTENVICG KSGVTCSRAI KISLGGLFIT MADSNYTVSG EEPLVHLKVK
1010 1020 1030 1040 1050
PSPLNLVLDI DIPGRLNLTL VWNKHMSVSI KIRRATQDAL CGLCGNANGN
1060 1070 1080 1090 1100
MKDDFETRSK YVASNELEFV NSWKESPLCG DASYAVDPCS LNTFRRSWAE
1110 1120 1130 1140 1150
RKCNIINSQT FAACHSKVYH LPYYEACVRD ACGCDTGGDC ECLCDAVAAY
1160 1170 1180 1190 1200
AKACLDKGVC VDWRTPDFCP IYCDFYNTHT LVGENEYQYA QESNCTWHYQ
1210 1220 1230 1240 1250
PCLCPGSLGS FPDTNTEGCY NCSQNEYFDH SEGTCVPCAP PTTTLPPTTT
1260 1270 1280 1290 1300
GSQPTTETTI STEFHSSTSA NTPVAPSYLP GLPTPPPSAP SSTEELTVWT
1310 1320 1330 1340 1350
TPKESTVSSG EYPQTTMAAT PPTSPWPPTS IPKSTPTELP VTQATSKPTA
1360 1370 1380 1390 1400
SSLSSSTKTT AELTESTTVT LLTLMPGMST SQEGTPTSKI PVTQTTTHRV
1410 1420 1430 1440 1450
PSRCITNQST TMFQTTTVQE AEITQTLAPS TYTTNDITKT QNLFSTAPHL
1460 1470 1480 1490 1500
SETSAVTAHQ STPTAVSANS IKPTMSSTGT PVVHTTSGTS SSPQTPRTTH
1510 1520 1530 1540 1550
PSTTVAVSGT VHTTGLPSGT SVHTTTNFPT HSGPQSSLST HLPLFSTLSV
1560 1570 1580 1590 1600
TPTTEGLNTQ STPIPAITNS LMTTGGLTGT PPVHTTSGTT SSPQTPRTTH
1610 1620 1630 1640 1650
PFSTVAVSNT KHTTGVSLET SVQTTIASPT PSAPQTSLAT HLPFSSTSSV
1660 1670 1680 1690 1700
TPTSEVIITP TPQHTLSSAS TSTTTGNILP TTIGKTGSPH TSVPVIYTTS
1710 1720 1730 1740 1750
AITQTKTSFS TDRTSTSTSA PHLSETSAVT AHQSTPTAVS ANSIKPTMSS
1760 1770 1780 1790 1800
TGTPVVHTTS GTTSSPQTPR TTHPSTTVAV SGTVHTTGLP SGTSVHTTTN
1810 1820 1830 1840 1850
FPTHSGPQSS LSTHLPLFST LSVTPTTEGL NTPTSPHSLS VASTSMPLMT
1860 1870 1880 1890 1900
VLPTTLEGTR PPHTSVPVTY TTTAATQTKS SFSTDRTSAP HLSQPSTVTP
1910 1920 1930 1940 1950
TQSTPIPATT NSLMTTGGLT GTPPVHTTSG TTSSPQTPRT THPFSTVAVS
1960 1970 1980 1990 2000
NTKHTTGVSL ETSVQTTIAS PTPSAPQTSL ATHLPFSSTS SVTPTSEVII
2010 2020 2030 2040 2050
TPTPQHTLSS ASTSTTTGNI LPTTIGQTGS PHTSVPVIYT TSAITQTKTS
2060 2070 2080 2090 2100
FSTDRTSTST SAPHLSETSA VTAHQSTPTA VSANSIKPTM SSTGTPVVHT
2110 2120 2130 2140 2150
TSGTTSSPQT PRTTHPSTTV AVSGTVHTTG LPSGTSVHTT TNFPTHSGPQ
2160 2170 2180 2190 2200
SSLSTHLPLF STLSVTPTTE GLNTPTSPHS LSAASTSMPL MTVLPTTLEG
2210 2220 2230 2240 2250
TRPPHTSVPV TYTTTAATQT KSSFSTDRTS TPHLSQSSTV TPTQPTPIPA
2260 2270 2280 2290 2300
TTNSPMTTVG LTGTPVVHTP SGTSSIAHTP HTTHSLPTAA SSSTTLSTAP
2310 2320 2330 2340 2350
QFRTSEQSTT TFPTPSAPQT SLVTSLPPFS TSSVSPTDEI HITSTNPHTV
2360 2370 2380 2390 2400
SSVSMSRPVS TILQTTIEVT TPPNTSTPVT HSTSATTEAQ GSFSTERTST
2410 2420 2430 2440 2450
SYLSHPSSTT VHQSTAGPVI TSIKSTMGVT GTPPVHTTSG TTSSPQTPHS
2460 2470 2480 2490 2500
THPISTAAIS RTTGISGTPF RTPMKTTITF PTPSSLQTSM ATLFPPFSTS
2510 2520 2530 2540 2550
VMSSTEIFNT PTNPHSVSSA STSRPLSTSL PTTIKGTGTP QTPVSDINTT
2560 2570 2580 2590 2600
SATTQAHSSF PTTRTSTSHL SLPSSMTSTL TPASRSASTL QYTPTPSSVS
2610 2620 2630 2640 2650
HSPLLTTPTA SPPSSAPTFV SPTAASTVIS SALPTIHMTP TPSSRPTSST
2660 2670 2680 2690 2700
GLLSTSKTTS HVPTFSSFSS KSTTAHLTSL TTQAATSGLL SSTMGMTNLP
2710 2720 2730 2740 2750
SSGSPDINHT TRPPGSSPLP TSAFLSRSTS PTGSSSPSTP VSSSNPDSSV
2760 2770 2780 2790 2800
SSPPSHPGTC SLQEEEHQIT YQGCVANVTL TRCQGFCASS VSFNKDTLQL
2810 2820 2830 2840 2850
ESSCGCCQPL STYKKQLSLP CPDPDAPGQQ LTLTLQVFSS CVCSPLQCKN
Length:2,850
Mass (Da):300,401
Last modified:June 1, 2003 - v1
Checksum:i9CD95F0845C79C9D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1436 – 144611DITKTQNLFST → ILHRRTSTSTS in CAD54411. (PubMed:14984930)CuratedAdd
BLAST
Sequence conflicti2793 – 27931Missing in CAD54411. (PubMed:14984930)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY184388
, AY184385, AY184387, AY184386 Genomic DNA. Translation: AAO47735.1.
AJ511869 Genomic DNA. Translation: CAD54411.1.
RefSeqiNP_859418.1. NM_181729.2.
UniGeneiMm.246621.

Genome annotation databases

GeneIDi353328.
KEGGimmu:353328.
UCSCiuc009klu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY184388
, AY184385 , AY184387 , AY184386 Genomic DNA. Translation: AAO47735.1 .
AJ511869 Genomic DNA. Translation: CAD54411.1 .
RefSeqi NP_859418.1. NM_181729.2.
UniGenei Mm.246621.

3D structure databases

ProteinModelPortali Q80T03.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I08.952.

PTM databases

PhosphoSitei Q80T03.

Proteomic databases

MaxQBi Q80T03.
PRIDEi Q80T03.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 353328.
KEGGi mmu:353328.
UCSCi uc009klu.2. mouse.

Organism-specific databases

CTDi 4588.
MGIi MGI:2663233. Muc6.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000170714.
HOVERGENi HBG081998.
InParanoidi Q80T03.
PhylomeDBi Q80T03.

Miscellaneous databases

NextBioi 400410.
PROi Q80T03.
SOURCEi Search...

Gene expression databases

CleanExi MM_MUC6.
Genevestigatori Q80T03.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF01826. TIL. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view ]
SMARTi SM00832. C8. 3 hits.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS01225. CTCK_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse."
    Desseyn J.-L., Laine A.
    Genomics 81:433-436(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1436-2850, TISSUE SPECIFICITY.
    Strain: C57BL/6J.

Entry informationi

Entry nameiMUC6_MOUSE
AccessioniPrimary (citable) accession number: Q80T03
Secondary accession number(s): Q80Z22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3