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Q80T03 (MUC6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mucin-6

Short name=MUC-6
Alternative name(s):
Gastric mucin-6
Secreted gel-forming mucin-6
Gene names
Name:Muc6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2850 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.

Subunit structure

Multimer; disulfide-linked By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed in stomach, duodenum and small intestine. Ref.1 Ref.2

Post-translational modification

O-glycosylated By similarity.

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 2 TIL (trypsin inhibitory-like) domains.

Contains 3 VWFD domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 28502828Mucin-6
PRO_0000259497

Regions

Domain44 – 288245VWFD 1
Domain344 – 39956TIL 1
Domain438 – 650213VWFD 2
Domain806 – 86964TIL 2
Domain909 – 1117209VWFD 3
Repeat1440 – 15551161
Repeat1556 – 17121572
Repeat1713 – 18851733
Repeat1886 – 20541694
Repeat2055 – 22271735
Repeat2228 – 23961696
Repeat2397 – 25631677
Repeat2564 – 26711088
Domain2760 – 284990CTCK
Region1440 – 26711232Approximate repeats By similarity
Compositional bias2291 – 2755465Ser-rich

Amino acid modifications

Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation3101N-linked (GlcNAc...) Potential
Glycosylation5281N-linked (GlcNAc...) Potential
Glycosylation7011N-linked (GlcNAc...) Potential
Glycosylation10171N-linked (GlcNAc...) Potential
Glycosylation12211N-linked (GlcNAc...) Potential
Disulfide bond67 ↔ 75 By similarity
Disulfide bond2760 ↔ 2807 By similarity
Disulfide bond2774 ↔ 2821 By similarity
Disulfide bond2783 ↔ 2841 By similarity
Disulfide bond2787 ↔ 2843 By similarity
Disulfide bond? ↔ 2848 By similarity

Experimental info

Sequence conflict1436 – 144611DITKTQNLFST → ILHRRTSTSTS in CAD54411. Ref.2
Sequence conflict27931Missing in CAD54411. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q80T03 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 9CD95F0845C79C9D

FASTA2,850300,401
        10         20         30         40         50         60 
MLRVRQLLLL LLFRGPLIDA GAWTGDVTDS DTEDNLQSSP EKGWCSTWGA GHFSTFDGHE 

        70         80         90        100        110        120 
YNFQGMCNYI FTATCGDDVP ATFSIQLRRD MEGNISRIIM ELGASVVTVN KETISVRDIG 

       130        140        150        160        170        180 
VVSLPYTSNG LQITPYGQSV QLVAKQLELE LVITWGPDAH LTEGQGGDEV GTPGTLKQES 

       190        200        210        220        230        240 
KGSPAWAGSS LCIPTETNST TPQVQVETKY MGKLCGLCGN FDGKIDNEFL SEDGKLLEAH 

       250        260        270        280        290        300 
KYATLQKLDD PNEICAHEAI PSTIILKTRY AQICNQLLTL VSPGCDVPKE TLMLSCQADM 

       310        320        330        340        350        360 
AACARPGQPN CSCATLSEYS RRCSMTGQPV RNWRTPALCP MSQCPANQVY QECGEVCIKT 

       370        380        390        400        410        420 
CSNPQHSCSS PCTFGCFCPH GTLLDDISGN QSCVPVNQCP CMLNGMVYGP GEITKTACQT 

       430        440        450        460        470        480 
CQCTMGRWTC TKQPCPGHCS LEGGSFVTTF DARPYRFHGT CTYTLLQSPQ LPNEGTLMAV 

       490        500        510        520        530        540 
YDKSGYSHSE TSLVAIMYLS KKDKIVISED EVITNNGDTK LLPYKTHNIT IFRQTSTHLQ 

       550        560        570        580        590        600 
MATTFGLELV FQMQPVFQVY ITVGPQFKGQ TRGLCGNFNG DTTDDFTTSM GIDEGTASLF 

       610        620        630        640        650        660 
VDSWRAGNCP AALEREMDPC SMSQLNKVCA ETHCSMLLKK GSVFEKCHSV VNPQPFYKRC 

       670        680        690        700        710        720 
VYQACNYEET FPHICSALGA YAHACSARGI LLWGWRNSVD NCTVPCTGNR TFSYDSQACD 

       730        740        750        760        770        780 
RTCLSLSDRE TECHVSPVPV DGCNCPEGTY LNHKAECVHK AQCPCLLDDY KFVQADQSTM 

       790        800        810        820        830        840 
INGVICHCIN GRLSCPRQAE MFFASCPEPK TFQSCSQSSE DKFGAACAPT CQMLATGIDC 

       850        860        870        880        890        900 
VPTKCESGCV CPKGLYENSD GQCVPAEECP CDYAGVSYPG GFELHTDCKT CTCSQGRWTC 

       910        920        930        940        950        960 
QLSTQCPSTC VLYGEGHIIT FDGQRFVFDG DCEYMLATDD CGANSSQPTF KVLTENVICG 

       970        980        990       1000       1010       1020 
KSGVTCSRAI KISLGGLFIT MADSNYTVSG EEPLVHLKVK PSPLNLVLDI DIPGRLNLTL 

      1030       1040       1050       1060       1070       1080 
VWNKHMSVSI KIRRATQDAL CGLCGNANGN MKDDFETRSK YVASNELEFV NSWKESPLCG 

      1090       1100       1110       1120       1130       1140 
DASYAVDPCS LNTFRRSWAE RKCNIINSQT FAACHSKVYH LPYYEACVRD ACGCDTGGDC 

      1150       1160       1170       1180       1190       1200 
ECLCDAVAAY AKACLDKGVC VDWRTPDFCP IYCDFYNTHT LVGENEYQYA QESNCTWHYQ 

      1210       1220       1230       1240       1250       1260 
PCLCPGSLGS FPDTNTEGCY NCSQNEYFDH SEGTCVPCAP PTTTLPPTTT GSQPTTETTI 

      1270       1280       1290       1300       1310       1320 
STEFHSSTSA NTPVAPSYLP GLPTPPPSAP SSTEELTVWT TPKESTVSSG EYPQTTMAAT 

      1330       1340       1350       1360       1370       1380 
PPTSPWPPTS IPKSTPTELP VTQATSKPTA SSLSSSTKTT AELTESTTVT LLTLMPGMST 

      1390       1400       1410       1420       1430       1440 
SQEGTPTSKI PVTQTTTHRV PSRCITNQST TMFQTTTVQE AEITQTLAPS TYTTNDITKT 

      1450       1460       1470       1480       1490       1500 
QNLFSTAPHL SETSAVTAHQ STPTAVSANS IKPTMSSTGT PVVHTTSGTS SSPQTPRTTH 

      1510       1520       1530       1540       1550       1560 
PSTTVAVSGT VHTTGLPSGT SVHTTTNFPT HSGPQSSLST HLPLFSTLSV TPTTEGLNTQ 

      1570       1580       1590       1600       1610       1620 
STPIPAITNS LMTTGGLTGT PPVHTTSGTT SSPQTPRTTH PFSTVAVSNT KHTTGVSLET 

      1630       1640       1650       1660       1670       1680 
SVQTTIASPT PSAPQTSLAT HLPFSSTSSV TPTSEVIITP TPQHTLSSAS TSTTTGNILP 

      1690       1700       1710       1720       1730       1740 
TTIGKTGSPH TSVPVIYTTS AITQTKTSFS TDRTSTSTSA PHLSETSAVT AHQSTPTAVS 

      1750       1760       1770       1780       1790       1800 
ANSIKPTMSS TGTPVVHTTS GTTSSPQTPR TTHPSTTVAV SGTVHTTGLP SGTSVHTTTN 

      1810       1820       1830       1840       1850       1860 
FPTHSGPQSS LSTHLPLFST LSVTPTTEGL NTPTSPHSLS VASTSMPLMT VLPTTLEGTR 

      1870       1880       1890       1900       1910       1920 
PPHTSVPVTY TTTAATQTKS SFSTDRTSAP HLSQPSTVTP TQSTPIPATT NSLMTTGGLT 

      1930       1940       1950       1960       1970       1980 
GTPPVHTTSG TTSSPQTPRT THPFSTVAVS NTKHTTGVSL ETSVQTTIAS PTPSAPQTSL 

      1990       2000       2010       2020       2030       2040 
ATHLPFSSTS SVTPTSEVII TPTPQHTLSS ASTSTTTGNI LPTTIGQTGS PHTSVPVIYT 

      2050       2060       2070       2080       2090       2100 
TSAITQTKTS FSTDRTSTST SAPHLSETSA VTAHQSTPTA VSANSIKPTM SSTGTPVVHT 

      2110       2120       2130       2140       2150       2160 
TSGTTSSPQT PRTTHPSTTV AVSGTVHTTG LPSGTSVHTT TNFPTHSGPQ SSLSTHLPLF 

      2170       2180       2190       2200       2210       2220 
STLSVTPTTE GLNTPTSPHS LSAASTSMPL MTVLPTTLEG TRPPHTSVPV TYTTTAATQT 

      2230       2240       2250       2260       2270       2280 
KSSFSTDRTS TPHLSQSSTV TPTQPTPIPA TTNSPMTTVG LTGTPVVHTP SGTSSIAHTP 

      2290       2300       2310       2320       2330       2340 
HTTHSLPTAA SSSTTLSTAP QFRTSEQSTT TFPTPSAPQT SLVTSLPPFS TSSVSPTDEI 

      2350       2360       2370       2380       2390       2400 
HITSTNPHTV SSVSMSRPVS TILQTTIEVT TPPNTSTPVT HSTSATTEAQ GSFSTERTST 

      2410       2420       2430       2440       2450       2460 
SYLSHPSSTT VHQSTAGPVI TSIKSTMGVT GTPPVHTTSG TTSSPQTPHS THPISTAAIS 

      2470       2480       2490       2500       2510       2520 
RTTGISGTPF RTPMKTTITF PTPSSLQTSM ATLFPPFSTS VMSSTEIFNT PTNPHSVSSA 

      2530       2540       2550       2560       2570       2580 
STSRPLSTSL PTTIKGTGTP QTPVSDINTT SATTQAHSSF PTTRTSTSHL SLPSSMTSTL 

      2590       2600       2610       2620       2630       2640 
TPASRSASTL QYTPTPSSVS HSPLLTTPTA SPPSSAPTFV SPTAASTVIS SALPTIHMTP 

      2650       2660       2670       2680       2690       2700 
TPSSRPTSST GLLSTSKTTS HVPTFSSFSS KSTTAHLTSL TTQAATSGLL SSTMGMTNLP 

      2710       2720       2730       2740       2750       2760 
SSGSPDINHT TRPPGSSPLP TSAFLSRSTS PTGSSSPSTP VSSSNPDSSV SSPPSHPGTC 

      2770       2780       2790       2800       2810       2820 
SLQEEEHQIT YQGCVANVTL TRCQGFCASS VSFNKDTLQL ESSCGCCQPL STYKKQLSLP 

      2830       2840       2850 
CPDPDAPGQQ LTLTLQVFSS CVCSPLQCKN 

« Hide

References

[1]"Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse."
Desseyn J.-L., Laine A.
Genomics 81:433-436(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
Strain: C57BL/6J.
[2]"The mouse secreted gel-forming mucin gene cluster."
Escande F., Porchet N., Bernigaud A., Petitprez D., Aubert J.-P., Buisine M.-P.
Biochim. Biophys. Acta 1676:240-250(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1436-2850, TISSUE SPECIFICITY.
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY184388 expand/collapse EMBL AC list , AY184385, AY184387, AY184386 Genomic DNA. Translation: AAO47735.1.
AJ511869 Genomic DNA. Translation: CAD54411.1.
RefSeqNP_859418.1. NM_181729.2.
UniGeneMm.246621.

3D structure databases

ProteinModelPortalQ80T03.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI08.952.

PTM databases

PhosphoSiteQ80T03.

Proteomic databases

MaxQBQ80T03.
PRIDEQ80T03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID353328.
KEGGmmu:353328.
UCSCuc009klu.2. mouse.

Organism-specific databases

CTD4588.
MGIMGI:2663233. Muc6.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000170714.
HOVERGENHBG081998.
InParanoidQ80T03.
PhylomeDBQ80T03.

Gene expression databases

CleanExMM_MUC6.
GenevestigatorQ80T03.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001846. VWF_type-D.
[Graphical view]
PfamPF08742. C8. 3 hits.
PF01826. TIL. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTSM00832. C8. 3 hits.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMSSF57567. SSF57567. 3 hits.
PROSITEPS01225. CTCK_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio400410.
PROQ80T03.
SOURCESearch...

Entry information

Entry nameMUC6_MOUSE
AccessionPrimary (citable) accession number: Q80T03
Secondary accession number(s): Q80Z22
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot