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Q80T03

- MUC6_MOUSE

UniProt

Q80T03 - MUC6_MOUSE

Protein

Mucin-6

Gene

Muc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.

    Protein family/group databases

    MEROPSiI08.952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucin-6
    Short name:
    MUC-6
    Alternative name(s):
    Gastric mucin-6
    Secreted gel-forming mucin-6
    Gene namesi
    Name:Muc6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2663233. Muc6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 28502828Mucin-6PRO_0000259497Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 2848By similarity
    Disulfide bondi67 ↔ 75By similarity
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi701 – 7011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1017 – 10171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1221 – 12211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2760 ↔ 2807By similarity
    Disulfide bondi2774 ↔ 2821By similarity
    Disulfide bondi2783 ↔ 2841By similarity
    Disulfide bondi2787 ↔ 2843By similarity

    Post-translational modificationi

    O-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ80T03.
    PRIDEiQ80T03.

    PTM databases

    PhosphoSiteiQ80T03.

    Expressioni

    Tissue specificityi

    Expressed in stomach, duodenum and small intestine.2 Publications

    Gene expression databases

    CleanExiMM_MUC6.
    GenevestigatoriQ80T03.

    Interactioni

    Subunit structurei

    Multimer; disulfide-linked.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ80T03.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 288245VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini344 – 39956TIL 1Add
    BLAST
    Domaini438 – 650213VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini806 – 86964TIL 2Add
    BLAST
    Domaini909 – 1117209VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Repeati1440 – 15551161Add
    BLAST
    Repeati1556 – 17121572Add
    BLAST
    Repeati1713 – 18851733Add
    BLAST
    Repeati1886 – 20541694Add
    BLAST
    Repeati2055 – 22271735Add
    BLAST
    Repeati2228 – 23961696Add
    BLAST
    Repeati2397 – 25631677Add
    BLAST
    Repeati2564 – 26711088Add
    BLAST
    Domaini2760 – 284990CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1440 – 26711232Approximate repeatsBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2291 – 2755465Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 3 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000170714.
    HOVERGENiHBG081998.
    InParanoidiQ80T03.
    PhylomeDBiQ80T03.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF08742. C8. 3 hits.
    PF01826. TIL. 2 hits.
    PF00094. VWD. 4 hits.
    [Graphical view]
    SMARTiSM00832. C8. 3 hits.
    SM00216. VWD. 3 hits.
    [Graphical view]
    SUPFAMiSSF57567. SSF57567. 3 hits.
    PROSITEiPS01225. CTCK_2. 1 hit.
    PS51233. VWFD. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q80T03-1 [UniParc]FASTAAdd to Basket

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    MLRVRQLLLL LLFRGPLIDA GAWTGDVTDS DTEDNLQSSP EKGWCSTWGA     50
    GHFSTFDGHE YNFQGMCNYI FTATCGDDVP ATFSIQLRRD MEGNISRIIM 100
    ELGASVVTVN KETISVRDIG VVSLPYTSNG LQITPYGQSV QLVAKQLELE 150
    LVITWGPDAH LTEGQGGDEV GTPGTLKQES KGSPAWAGSS LCIPTETNST 200
    TPQVQVETKY MGKLCGLCGN FDGKIDNEFL SEDGKLLEAH KYATLQKLDD 250
    PNEICAHEAI PSTIILKTRY AQICNQLLTL VSPGCDVPKE TLMLSCQADM 300
    AACARPGQPN CSCATLSEYS RRCSMTGQPV RNWRTPALCP MSQCPANQVY 350
    QECGEVCIKT CSNPQHSCSS PCTFGCFCPH GTLLDDISGN QSCVPVNQCP 400
    CMLNGMVYGP GEITKTACQT CQCTMGRWTC TKQPCPGHCS LEGGSFVTTF 450
    DARPYRFHGT CTYTLLQSPQ LPNEGTLMAV YDKSGYSHSE TSLVAIMYLS 500
    KKDKIVISED EVITNNGDTK LLPYKTHNIT IFRQTSTHLQ MATTFGLELV 550
    FQMQPVFQVY ITVGPQFKGQ TRGLCGNFNG DTTDDFTTSM GIDEGTASLF 600
    VDSWRAGNCP AALEREMDPC SMSQLNKVCA ETHCSMLLKK GSVFEKCHSV 650
    VNPQPFYKRC VYQACNYEET FPHICSALGA YAHACSARGI LLWGWRNSVD 700
    NCTVPCTGNR TFSYDSQACD RTCLSLSDRE TECHVSPVPV DGCNCPEGTY 750
    LNHKAECVHK AQCPCLLDDY KFVQADQSTM INGVICHCIN GRLSCPRQAE 800
    MFFASCPEPK TFQSCSQSSE DKFGAACAPT CQMLATGIDC VPTKCESGCV 850
    CPKGLYENSD GQCVPAEECP CDYAGVSYPG GFELHTDCKT CTCSQGRWTC 900
    QLSTQCPSTC VLYGEGHIIT FDGQRFVFDG DCEYMLATDD CGANSSQPTF 950
    KVLTENVICG KSGVTCSRAI KISLGGLFIT MADSNYTVSG EEPLVHLKVK 1000
    PSPLNLVLDI DIPGRLNLTL VWNKHMSVSI KIRRATQDAL CGLCGNANGN 1050
    MKDDFETRSK YVASNELEFV NSWKESPLCG DASYAVDPCS LNTFRRSWAE 1100
    RKCNIINSQT FAACHSKVYH LPYYEACVRD ACGCDTGGDC ECLCDAVAAY 1150
    AKACLDKGVC VDWRTPDFCP IYCDFYNTHT LVGENEYQYA QESNCTWHYQ 1200
    PCLCPGSLGS FPDTNTEGCY NCSQNEYFDH SEGTCVPCAP PTTTLPPTTT 1250
    GSQPTTETTI STEFHSSTSA NTPVAPSYLP GLPTPPPSAP SSTEELTVWT 1300
    TPKESTVSSG EYPQTTMAAT PPTSPWPPTS IPKSTPTELP VTQATSKPTA 1350
    SSLSSSTKTT AELTESTTVT LLTLMPGMST SQEGTPTSKI PVTQTTTHRV 1400
    PSRCITNQST TMFQTTTVQE AEITQTLAPS TYTTNDITKT QNLFSTAPHL 1450
    SETSAVTAHQ STPTAVSANS IKPTMSSTGT PVVHTTSGTS SSPQTPRTTH 1500
    PSTTVAVSGT VHTTGLPSGT SVHTTTNFPT HSGPQSSLST HLPLFSTLSV 1550
    TPTTEGLNTQ STPIPAITNS LMTTGGLTGT PPVHTTSGTT SSPQTPRTTH 1600
    PFSTVAVSNT KHTTGVSLET SVQTTIASPT PSAPQTSLAT HLPFSSTSSV 1650
    TPTSEVIITP TPQHTLSSAS TSTTTGNILP TTIGKTGSPH TSVPVIYTTS 1700
    AITQTKTSFS TDRTSTSTSA PHLSETSAVT AHQSTPTAVS ANSIKPTMSS 1750
    TGTPVVHTTS GTTSSPQTPR TTHPSTTVAV SGTVHTTGLP SGTSVHTTTN 1800
    FPTHSGPQSS LSTHLPLFST LSVTPTTEGL NTPTSPHSLS VASTSMPLMT 1850
    VLPTTLEGTR PPHTSVPVTY TTTAATQTKS SFSTDRTSAP HLSQPSTVTP 1900
    TQSTPIPATT NSLMTTGGLT GTPPVHTTSG TTSSPQTPRT THPFSTVAVS 1950
    NTKHTTGVSL ETSVQTTIAS PTPSAPQTSL ATHLPFSSTS SVTPTSEVII 2000
    TPTPQHTLSS ASTSTTTGNI LPTTIGQTGS PHTSVPVIYT TSAITQTKTS 2050
    FSTDRTSTST SAPHLSETSA VTAHQSTPTA VSANSIKPTM SSTGTPVVHT 2100
    TSGTTSSPQT PRTTHPSTTV AVSGTVHTTG LPSGTSVHTT TNFPTHSGPQ 2150
    SSLSTHLPLF STLSVTPTTE GLNTPTSPHS LSAASTSMPL MTVLPTTLEG 2200
    TRPPHTSVPV TYTTTAATQT KSSFSTDRTS TPHLSQSSTV TPTQPTPIPA 2250
    TTNSPMTTVG LTGTPVVHTP SGTSSIAHTP HTTHSLPTAA SSSTTLSTAP 2300
    QFRTSEQSTT TFPTPSAPQT SLVTSLPPFS TSSVSPTDEI HITSTNPHTV 2350
    SSVSMSRPVS TILQTTIEVT TPPNTSTPVT HSTSATTEAQ GSFSTERTST 2400
    SYLSHPSSTT VHQSTAGPVI TSIKSTMGVT GTPPVHTTSG TTSSPQTPHS 2450
    THPISTAAIS RTTGISGTPF RTPMKTTITF PTPSSLQTSM ATLFPPFSTS 2500
    VMSSTEIFNT PTNPHSVSSA STSRPLSTSL PTTIKGTGTP QTPVSDINTT 2550
    SATTQAHSSF PTTRTSTSHL SLPSSMTSTL TPASRSASTL QYTPTPSSVS 2600
    HSPLLTTPTA SPPSSAPTFV SPTAASTVIS SALPTIHMTP TPSSRPTSST 2650
    GLLSTSKTTS HVPTFSSFSS KSTTAHLTSL TTQAATSGLL SSTMGMTNLP 2700
    SSGSPDINHT TRPPGSSPLP TSAFLSRSTS PTGSSSPSTP VSSSNPDSSV 2750
    SSPPSHPGTC SLQEEEHQIT YQGCVANVTL TRCQGFCASS VSFNKDTLQL 2800
    ESSCGCCQPL STYKKQLSLP CPDPDAPGQQ LTLTLQVFSS CVCSPLQCKN 2850
    Length:2,850
    Mass (Da):300,401
    Last modified:June 1, 2003 - v1
    Checksum:i9CD95F0845C79C9D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1436 – 144611DITKTQNLFST → ILHRRTSTSTS in CAD54411. (PubMed:14984930)CuratedAdd
    BLAST
    Sequence conflicti2793 – 27931Missing in CAD54411. (PubMed:14984930)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY184388
    , AY184385, AY184387, AY184386 Genomic DNA. Translation: AAO47735.1.
    AJ511869 Genomic DNA. Translation: CAD54411.1.
    RefSeqiNP_859418.1. NM_181729.2.
    UniGeneiMm.246621.

    Genome annotation databases

    GeneIDi353328.
    KEGGimmu:353328.
    UCSCiuc009klu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY184388
    , AY184385 , AY184387 , AY184386 Genomic DNA. Translation: AAO47735.1 .
    AJ511869 Genomic DNA. Translation: CAD54411.1 .
    RefSeqi NP_859418.1. NM_181729.2.
    UniGenei Mm.246621.

    3D structure databases

    ProteinModelPortali Q80T03.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I08.952.

    PTM databases

    PhosphoSitei Q80T03.

    Proteomic databases

    MaxQBi Q80T03.
    PRIDEi Q80T03.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 353328.
    KEGGi mmu:353328.
    UCSCi uc009klu.2. mouse.

    Organism-specific databases

    CTDi 4588.
    MGIi MGI:2663233. Muc6.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000170714.
    HOVERGENi HBG081998.
    InParanoidi Q80T03.
    PhylomeDBi Q80T03.

    Miscellaneous databases

    NextBioi 400410.
    PROi Q80T03.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_MUC6.
    Genevestigatori Q80T03.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF08742. C8. 3 hits.
    PF01826. TIL. 2 hits.
    PF00094. VWD. 4 hits.
    [Graphical view ]
    SMARTi SM00832. C8. 3 hits.
    SM00216. VWD. 3 hits.
    [Graphical view ]
    SUPFAMi SSF57567. SSF57567. 3 hits.
    PROSITEi PS01225. CTCK_2. 1 hit.
    PS51233. VWFD. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse."
      Desseyn J.-L., Laine A.
      Genomics 81:433-436(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: C57BL/6J.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1436-2850, TISSUE SPECIFICITY.
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiMUC6_MOUSE
    AccessioniPrimary (citable) accession number: Q80T03
    Secondary accession number(s): Q80Z22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3