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Q80T03

- MUC6_MOUSE

UniProt

Q80T03 - MUC6_MOUSE

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Protein
Mucin-6
Gene
Muc6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.

Protein family/group databases

MEROPSiI08.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-6
Short name:
MUC-6
Alternative name(s):
Gastric mucin-6
Secreted gel-forming mucin-6
Gene namesi
Name:Muc6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2663233. Muc6.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 28502828Mucin-6
PRO_0000259497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 2848 By similarity
Disulfide bondi67 ↔ 75 By similarity
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi310 – 3101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi528 – 5281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi701 – 7011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1017 – 10171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1221 – 12211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2760 ↔ 2807 By similarity
Disulfide bondi2774 ↔ 2821 By similarity
Disulfide bondi2783 ↔ 2841 By similarity
Disulfide bondi2787 ↔ 2843 By similarity

Post-translational modificationi

O-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ80T03.
PRIDEiQ80T03.

PTM databases

PhosphoSiteiQ80T03.

Expressioni

Tissue specificityi

Expressed in stomach, duodenum and small intestine.2 Publications

Gene expression databases

CleanExiMM_MUC6.
GenevestigatoriQ80T03.

Interactioni

Subunit structurei

Multimer; disulfide-linked By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ80T03.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 288245VWFD 1
Add
BLAST
Domaini344 – 39956TIL 1
Add
BLAST
Domaini438 – 650213VWFD 2
Add
BLAST
Domaini806 – 86964TIL 2
Add
BLAST
Domaini909 – 1117209VWFD 3
Add
BLAST
Repeati1440 – 15551161
Add
BLAST
Repeati1556 – 17121572
Add
BLAST
Repeati1713 – 18851733
Add
BLAST
Repeati1886 – 20541694
Add
BLAST
Repeati2055 – 22271735
Add
BLAST
Repeati2228 – 23961696
Add
BLAST
Repeati2397 – 25631677
Add
BLAST
Repeati2564 – 26711088
Add
BLAST
Domaini2760 – 284990CTCK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1440 – 26711232Approximate repeats By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2291 – 2755465Ser-rich
Add
BLAST

Sequence similaritiesi

Contains 3 VWFD domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000170714.
HOVERGENiHBG081998.
InParanoidiQ80T03.
PhylomeDBiQ80T03.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF01826. TIL. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 3 hits.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS01225. CTCK_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80T03-1 [UniParc]FASTAAdd to Basket

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MLRVRQLLLL LLFRGPLIDA GAWTGDVTDS DTEDNLQSSP EKGWCSTWGA     50
GHFSTFDGHE YNFQGMCNYI FTATCGDDVP ATFSIQLRRD MEGNISRIIM 100
ELGASVVTVN KETISVRDIG VVSLPYTSNG LQITPYGQSV QLVAKQLELE 150
LVITWGPDAH LTEGQGGDEV GTPGTLKQES KGSPAWAGSS LCIPTETNST 200
TPQVQVETKY MGKLCGLCGN FDGKIDNEFL SEDGKLLEAH KYATLQKLDD 250
PNEICAHEAI PSTIILKTRY AQICNQLLTL VSPGCDVPKE TLMLSCQADM 300
AACARPGQPN CSCATLSEYS RRCSMTGQPV RNWRTPALCP MSQCPANQVY 350
QECGEVCIKT CSNPQHSCSS PCTFGCFCPH GTLLDDISGN QSCVPVNQCP 400
CMLNGMVYGP GEITKTACQT CQCTMGRWTC TKQPCPGHCS LEGGSFVTTF 450
DARPYRFHGT CTYTLLQSPQ LPNEGTLMAV YDKSGYSHSE TSLVAIMYLS 500
KKDKIVISED EVITNNGDTK LLPYKTHNIT IFRQTSTHLQ MATTFGLELV 550
FQMQPVFQVY ITVGPQFKGQ TRGLCGNFNG DTTDDFTTSM GIDEGTASLF 600
VDSWRAGNCP AALEREMDPC SMSQLNKVCA ETHCSMLLKK GSVFEKCHSV 650
VNPQPFYKRC VYQACNYEET FPHICSALGA YAHACSARGI LLWGWRNSVD 700
NCTVPCTGNR TFSYDSQACD RTCLSLSDRE TECHVSPVPV DGCNCPEGTY 750
LNHKAECVHK AQCPCLLDDY KFVQADQSTM INGVICHCIN GRLSCPRQAE 800
MFFASCPEPK TFQSCSQSSE DKFGAACAPT CQMLATGIDC VPTKCESGCV 850
CPKGLYENSD GQCVPAEECP CDYAGVSYPG GFELHTDCKT CTCSQGRWTC 900
QLSTQCPSTC VLYGEGHIIT FDGQRFVFDG DCEYMLATDD CGANSSQPTF 950
KVLTENVICG KSGVTCSRAI KISLGGLFIT MADSNYTVSG EEPLVHLKVK 1000
PSPLNLVLDI DIPGRLNLTL VWNKHMSVSI KIRRATQDAL CGLCGNANGN 1050
MKDDFETRSK YVASNELEFV NSWKESPLCG DASYAVDPCS LNTFRRSWAE 1100
RKCNIINSQT FAACHSKVYH LPYYEACVRD ACGCDTGGDC ECLCDAVAAY 1150
AKACLDKGVC VDWRTPDFCP IYCDFYNTHT LVGENEYQYA QESNCTWHYQ 1200
PCLCPGSLGS FPDTNTEGCY NCSQNEYFDH SEGTCVPCAP PTTTLPPTTT 1250
GSQPTTETTI STEFHSSTSA NTPVAPSYLP GLPTPPPSAP SSTEELTVWT 1300
TPKESTVSSG EYPQTTMAAT PPTSPWPPTS IPKSTPTELP VTQATSKPTA 1350
SSLSSSTKTT AELTESTTVT LLTLMPGMST SQEGTPTSKI PVTQTTTHRV 1400
PSRCITNQST TMFQTTTVQE AEITQTLAPS TYTTNDITKT QNLFSTAPHL 1450
SETSAVTAHQ STPTAVSANS IKPTMSSTGT PVVHTTSGTS SSPQTPRTTH 1500
PSTTVAVSGT VHTTGLPSGT SVHTTTNFPT HSGPQSSLST HLPLFSTLSV 1550
TPTTEGLNTQ STPIPAITNS LMTTGGLTGT PPVHTTSGTT SSPQTPRTTH 1600
PFSTVAVSNT KHTTGVSLET SVQTTIASPT PSAPQTSLAT HLPFSSTSSV 1650
TPTSEVIITP TPQHTLSSAS TSTTTGNILP TTIGKTGSPH TSVPVIYTTS 1700
AITQTKTSFS TDRTSTSTSA PHLSETSAVT AHQSTPTAVS ANSIKPTMSS 1750
TGTPVVHTTS GTTSSPQTPR TTHPSTTVAV SGTVHTTGLP SGTSVHTTTN 1800
FPTHSGPQSS LSTHLPLFST LSVTPTTEGL NTPTSPHSLS VASTSMPLMT 1850
VLPTTLEGTR PPHTSVPVTY TTTAATQTKS SFSTDRTSAP HLSQPSTVTP 1900
TQSTPIPATT NSLMTTGGLT GTPPVHTTSG TTSSPQTPRT THPFSTVAVS 1950
NTKHTTGVSL ETSVQTTIAS PTPSAPQTSL ATHLPFSSTS SVTPTSEVII 2000
TPTPQHTLSS ASTSTTTGNI LPTTIGQTGS PHTSVPVIYT TSAITQTKTS 2050
FSTDRTSTST SAPHLSETSA VTAHQSTPTA VSANSIKPTM SSTGTPVVHT 2100
TSGTTSSPQT PRTTHPSTTV AVSGTVHTTG LPSGTSVHTT TNFPTHSGPQ 2150
SSLSTHLPLF STLSVTPTTE GLNTPTSPHS LSAASTSMPL MTVLPTTLEG 2200
TRPPHTSVPV TYTTTAATQT KSSFSTDRTS TPHLSQSSTV TPTQPTPIPA 2250
TTNSPMTTVG LTGTPVVHTP SGTSSIAHTP HTTHSLPTAA SSSTTLSTAP 2300
QFRTSEQSTT TFPTPSAPQT SLVTSLPPFS TSSVSPTDEI HITSTNPHTV 2350
SSVSMSRPVS TILQTTIEVT TPPNTSTPVT HSTSATTEAQ GSFSTERTST 2400
SYLSHPSSTT VHQSTAGPVI TSIKSTMGVT GTPPVHTTSG TTSSPQTPHS 2450
THPISTAAIS RTTGISGTPF RTPMKTTITF PTPSSLQTSM ATLFPPFSTS 2500
VMSSTEIFNT PTNPHSVSSA STSRPLSTSL PTTIKGTGTP QTPVSDINTT 2550
SATTQAHSSF PTTRTSTSHL SLPSSMTSTL TPASRSASTL QYTPTPSSVS 2600
HSPLLTTPTA SPPSSAPTFV SPTAASTVIS SALPTIHMTP TPSSRPTSST 2650
GLLSTSKTTS HVPTFSSFSS KSTTAHLTSL TTQAATSGLL SSTMGMTNLP 2700
SSGSPDINHT TRPPGSSPLP TSAFLSRSTS PTGSSSPSTP VSSSNPDSSV 2750
SSPPSHPGTC SLQEEEHQIT YQGCVANVTL TRCQGFCASS VSFNKDTLQL 2800
ESSCGCCQPL STYKKQLSLP CPDPDAPGQQ LTLTLQVFSS CVCSPLQCKN 2850
Length:2,850
Mass (Da):300,401
Last modified:June 1, 2003 - v1
Checksum:i9CD95F0845C79C9D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1436 – 144611DITKTQNLFST → ILHRRTSTSTS in CAD54411. 1 Publication
Add
BLAST
Sequence conflicti2793 – 27931Missing in CAD54411. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY184388
, AY184385, AY184387, AY184386 Genomic DNA. Translation: AAO47735.1.
AJ511869 Genomic DNA. Translation: CAD54411.1.
RefSeqiNP_859418.1. NM_181729.2.
UniGeneiMm.246621.

Genome annotation databases

GeneIDi353328.
KEGGimmu:353328.
UCSCiuc009klu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY184388
, AY184385 , AY184387 , AY184386 Genomic DNA. Translation: AAO47735.1 .
AJ511869 Genomic DNA. Translation: CAD54411.1 .
RefSeqi NP_859418.1. NM_181729.2.
UniGenei Mm.246621.

3D structure databases

ProteinModelPortali Q80T03.
ModBasei Search...

Protein family/group databases

MEROPSi I08.952.

PTM databases

PhosphoSitei Q80T03.

Proteomic databases

MaxQBi Q80T03.
PRIDEi Q80T03.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 353328.
KEGGi mmu:353328.
UCSCi uc009klu.2. mouse.

Organism-specific databases

CTDi 4588.
MGIi MGI:2663233. Muc6.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000170714.
HOVERGENi HBG081998.
InParanoidi Q80T03.
PhylomeDBi Q80T03.

Miscellaneous databases

NextBioi 400410.
PROi Q80T03.
SOURCEi Search...

Gene expression databases

CleanExi MM_MUC6.
Genevestigatori Q80T03.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF01826. TIL. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view ]
SMARTi SM00832. C8. 3 hits.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS01225. CTCK_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse."
    Desseyn J.-L., Laine A.
    Genomics 81:433-436(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1436-2850, TISSUE SPECIFICITY.
    Strain: C57BL/6J.

Entry informationi

Entry nameiMUC6_MOUSE
AccessioniPrimary (citable) accession number: Q80T03
Secondary accession number(s): Q80Z22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi