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Protein

G-protein coupled bile acid receptor 1

Gene

Gpbar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity).By similarity

GO - Molecular functioni

  • bile acid receptor activity Source: Ensembl
  • G-protein coupled receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-373076. Class A/1 (Rhodopsin-like receptors).
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled bile acid receptor 1
Alternative name(s):
Membrane-type receptor for bile acids
Short name:
M-BAR
Gene namesi
Name:Gpbar1
Synonyms:Tgr5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi631400. Gpbar1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818ExtracellularSequence analysisAdd
BLAST
Transmembranei19 – 3921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini40 – 4910CytoplasmicSequence analysis
Transmembranei50 – 7021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini71 – 8414ExtracellularSequence analysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini106 – 12419CytoplasmicSequence analysisAdd
BLAST
Transmembranei125 – 14521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini146 – 15712ExtracellularSequence analysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini179 – 22951CytoplasmicSequence analysisAdd
BLAST
Transmembranei230 – 25021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini251 – 26010ExtracellularSequence analysis
Transmembranei261 – 28121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini282 – 32948CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329G-protein coupled bile acid receptor 1PRO_0000069503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi84 ↔ 154PROSITE-ProRule annotation
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ80T02.

Interactioni

Chemistry

BindingDBiQ80T02.

Structurei

3D structure databases

ProteinModelPortaliQ80T02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000065748.
HOVERGENiHBG081571.
InParanoidiQ80T02.
KOiK08400.
OMAiDICRLHR.
OrthoDBiEOG091G0MRP.
PhylomeDBiQ80T02.
TreeFamiTF333321.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80T02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSHNTTELS AIPRGVQELS LVLASLIVIA NLLLALGIVL DRHLRSPPAG
60 70 80 90 100
CFFLSLLLAG LLTGLALPTL PGLWNRSHQG YWSCLLLHLA PNFCFLSLLA
110 120 130 140 150
NLLLVHGERY MAVLQPLRPH GSVRLALFLT WISSLLFASL PALGWNHWSP
160 170 180 190 200
GANCSSQAIF PAPYLYLEVY GLLLPAVGAT ALLSVRVLAT AHHQLREIRR
210 220 230 240 250
LERAVCRDAP STLARALTWR QARAQAGATL LFLLCWGPYV ATLLLSVLAY
260 270 280 290 300
ERRPPLGPVT LLSLISLGSA SAAVVPVAMG LGDQRYTAPW RTAAQRWLQV
310 320
LRGRPKRANP GPSTAYHSSS QCSTDLDLN
Length:329
Mass (Da):35,791
Last modified:June 1, 2003 - v1
Checksum:i03ED6F91C5FC7653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086172 mRNA. Translation: BAC65345.1.
AB089310 mRNA. Translation: BAC55238.1.
RefSeqiNP_808797.1. NM_177936.1.
XP_006245297.1. XM_006245235.2.
UniGeneiRn.41687.

Genome annotation databases

EnsembliENSRNOT00000089698; ENSRNOP00000075574; ENSRNOG00000058260.
GeneIDi338443.
KEGGirno:338443.
UCSCiRGD:631400. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB086172 mRNA. Translation: BAC65345.1.
AB089310 mRNA. Translation: BAC55238.1.
RefSeqiNP_808797.1. NM_177936.1.
XP_006245297.1. XM_006245235.2.
UniGeneiRn.41687.

3D structure databases

ProteinModelPortaliQ80T02.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ80T02.
ChEMBLiCHEMBL1075223.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ80T02.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089698; ENSRNOP00000075574; ENSRNOG00000058260.
GeneIDi338443.
KEGGirno:338443.
UCSCiRGD:631400. rat.

Organism-specific databases

CTDi151306.
RGDi631400. Gpbar1.

Phylogenomic databases

HOGENOMiHOG000065748.
HOVERGENiHBG081571.
InParanoidiQ80T02.
KOiK08400.
OMAiDICRLHR.
OrthoDBiEOG091G0MRP.
PhylomeDBiQ80T02.
TreeFamiTF333321.

Enzyme and pathway databases

ReactomeiR-RNO-373076. Class A/1 (Rhodopsin-like receptors).
R-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ80T02.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPBAR_RAT
AccessioniPrimary (citable) accession number: Q80T02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.