ID GBG5_MOUSE Reviewed; 68 AA. AC Q80SZ7; P30670; Q5I0W4; Q61015; DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot. DT 27-SEP-2004, sequence version 2. DT 27-MAR-2024, entry version 164. DE RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; DE Flags: Precursor; GN Name=Gng5; Synonyms=Gngt5; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Brain, and Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-53. RC STRAIN=CF-1 / Harlan; RX PubMed=8858601; RX DOI=10.1002/(sici)1098-2795(199607)44:3<315::aid-mrd5>3.0.co;2-p; RA Williams C.J., Schultz R.M., Kopf G.S.; RT "G protein gene expression during mouse oocyte growth and maturation, and RT preimplantation embryo development."; RL Mol. Reprod. Dev. 44:315-323(1996). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Kidney, Lung, and Spleen; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved CC as a modulator or transducer in various transmembrane signaling CC systems. The beta and gamma chains are required for the GTPase CC activity, for replacement of GDP by GTP, and for G protein-effector CC interaction. CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}. CC -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC002316; AAH02316.3; -; mRNA. DR EMBL; BC087872; AAH87872.1; -; mRNA. DR EMBL; U38498; AAB01729.1; -; mRNA. DR CCDS; CCDS17903.1; -. DR RefSeq; NP_034448.2; NM_010318.2. DR RefSeq; XP_003945606.1; XM_003945557.2. DR AlphaFoldDB; Q80SZ7; -. DR SMR; Q80SZ7; -. DR BioGRID; 199991; 4. DR IntAct; Q80SZ7; 1. DR STRING; 10090.ENSMUSP00000114014; -. DR iPTMnet; Q80SZ7; -. DR PhosphoSitePlus; Q80SZ7; -. DR EPD; Q80SZ7; -. DR jPOST; Q80SZ7; -. DR MaxQB; Q80SZ7; -. DR PaxDb; 10090-ENSMUSP00000087485; -. DR ProteomicsDB; 266777; -. DR Pumba; Q80SZ7; -. DR DNASU; 14707; -. DR Ensembl; ENSMUST00000090031.12; ENSMUSP00000087485.6; ENSMUSG00000068523.13. DR Ensembl; ENSMUST00000118280.2; ENSMUSP00000114014.2; ENSMUSG00000068523.13. DR GeneID; 14707; -. DR KEGG; mmu:14707; -. DR UCSC; uc008rrk.1; mouse. DR AGR; MGI:109164; -. DR CTD; 2787; -. DR MGI; MGI:109164; Gng5. DR VEuPathDB; HostDB:ENSMUSG00000068523; -. DR eggNOG; KOG4119; Eukaryota. DR GeneTree; ENSGT01100000263525; -. DR HOGENOM; CLU_168377_3_0_1; -. DR InParanoid; Q80SZ7; -. DR OMA; QNALHDP; -. DR OrthoDB; 2872810at2759; -. DR PhylomeDB; Q80SZ7; -. DR TreeFam; TF319909; -. DR Reactome; R-MMU-1296041; Activation of G protein gated Potassium channels. DR Reactome; R-MMU-202040; G-protein activation. DR Reactome; R-MMU-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion. DR Reactome; R-MMU-392170; ADP signalling through P2Y purinoceptor 12. DR Reactome; R-MMU-392451; G beta:gamma signalling through PI3Kgamma. DR Reactome; R-MMU-392851; Prostacyclin signalling through prostacyclin receptor. DR Reactome; R-MMU-400042; Adrenaline,noradrenaline inhibits insulin secretion. DR Reactome; R-MMU-4086398; Ca2+ pathway. DR Reactome; R-MMU-416476; G alpha (q) signalling events. DR Reactome; R-MMU-416482; G alpha (12/13) signalling events. DR Reactome; R-MMU-418217; G beta:gamma signalling through PLC beta. DR Reactome; R-MMU-418555; G alpha (s) signalling events. DR Reactome; R-MMU-418592; ADP signalling through P2Y purinoceptor 1. DR Reactome; R-MMU-418594; G alpha (i) signalling events. DR Reactome; R-MMU-418597; G alpha (z) signalling events. DR Reactome; R-MMU-420092; Glucagon-type ligand receptors. DR Reactome; R-MMU-428930; Thromboxane signalling through TP receptor. DR Reactome; R-MMU-432040; Vasopressin regulates renal water homeostasis via Aquaporins. DR Reactome; R-MMU-456926; Thrombin signalling through proteinase activated receptors (PARs). DR Reactome; R-MMU-500657; Presynaptic function of Kainate receptors. DR Reactome; R-MMU-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding. DR Reactome; R-MMU-8964315; G beta:gamma signalling through BTK. DR Reactome; R-MMU-8964616; G beta:gamma signalling through CDC42. DR Reactome; R-MMU-9009391; Extra-nuclear estrogen signaling. DR Reactome; R-MMU-9634597; GPER1 signaling. DR Reactome; R-MMU-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits. DR BioGRID-ORCS; 14707; 10 hits in 72 CRISPR screens. DR ChiTaRS; Gng5; mouse. DR PRO; PR:Q80SZ7; -. DR Proteomes; UP000000589; Chromosome 3. DR RNAct; Q80SZ7; Protein. DR Bgee; ENSMUSG00000068523; Expressed in right kidney and 120 other cell types or tissues. DR ExpressionAtlas; Q80SZ7; baseline and differential. DR GO; GO:0031680; C:G-protein beta/gamma-subunit complex; ISO:MGI. DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central. DR GO; GO:0005739; C:mitochondrion; HDA:MGI. DR GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central. DR GO; GO:0030165; F:PDZ domain binding; ISO:MGI. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; IMP:MGI. DR GO; GO:0072513; P:positive regulation of secondary heart field cardioblast proliferation; IMP:MGI. DR CDD; cd00068; GGL; 1. DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1. DR InterPro; IPR015898; G-protein_gamma-like_dom. DR InterPro; IPR036284; GGL_sf. DR InterPro; IPR001770; Gprotein-gamma. DR PANTHER; PTHR13809:SF5; GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-5-RELATED; 1. DR PANTHER; PTHR13809; GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT; 1. DR Pfam; PF00631; G-gamma; 1. DR PRINTS; PR00321; GPROTEING. DR SMART; SM01224; G_gamma; 1. DR SMART; SM00224; GGL; 1. DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1. DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1. DR Genevisible; Q80SZ7; MM. PE 1: Evidence at protein level; KW Acetylation; Cell membrane; Lipoprotein; Membrane; Methylation; KW Phosphoprotein; Prenylation; Reference proteome; Transducer. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000250|UniProtKB:P63218" FT CHAIN 2..65 FT /note="Guanine nucleotide-binding protein G(I)/G(S)/G(O) FT subunit gamma-5" FT /id="PRO_0000012629" FT PROPEP 66..68 FT /note="Removed in mature form" FT /evidence="ECO:0000250" FT /id="PRO_0000012630" FT MOD_RES 2 FT /note="N-acetylserine" FT /evidence="ECO:0000250|UniProtKB:P63218" FT MOD_RES 2 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P63218" FT MOD_RES 65 FT /note="Cysteine methyl ester" FT /evidence="ECO:0000250" FT LIPID 65 FT /note="S-geranylgeranyl cysteine" FT /evidence="ECO:0000250" SQ SEQUENCE 68 AA; 7318 MW; 9AF7A16558863602 CRC64; MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT GVSSSTNPFR PQKVCSFL //