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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene

Gng5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_272374. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_286837. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_297430. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_308732. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_339334. Activation of G protein gated Potassium channels.
REACT_339920. Glucagon-type ligand receptors.
REACT_345203. Glucagon signaling in metabolic regulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene namesi
Name:Gng5
Synonyms:Gngt5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:109164. Gng5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5PRO_0000012629Add
BLAST
Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012630

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei65 – 651Cysteine methyl esterBy similarity
Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ80SZ7.
PaxDbiQ80SZ7.
PRIDEiQ80SZ7.

PTM databases

PhosphoSiteiQ80SZ7.

Expressioni

Gene expression databases

BgeeiQ80SZ7.
ExpressionAtlasiQ80SZ7. baseline and differential.
GenevisibleiQ80SZ7. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

IntActiQ80SZ7. 2 interactions.
MINTiMINT-4095767.
STRINGi10090.ENSMUSP00000087485.

Structurei

3D structure databases

ProteinModelPortaliQ80SZ7.
SMRiQ80SZ7. Positions 6-59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG262845.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiQ80SZ7.
KOiK04542.
OMAiADLQQFC.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ80SZ7.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80SZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT
60
GVSSSTNPFR PQKVCSFL
Length:68
Mass (Da):7,318
Last modified:September 27, 2004 - v2
Checksum:i9AF7A16558863602
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002316 mRNA. Translation: AAH02316.3.
BC087872 mRNA. Translation: AAH87872.1.
U38498 mRNA. Translation: AAB01729.1.
CCDSiCCDS17903.1.
RefSeqiNP_034448.2. NM_010318.2.
XP_003945606.1. XM_003945557.2.
XP_006543361.1. XM_006543298.1.
XP_006544124.1. XM_006544061.1.
UniGeneiMm.140804.
Mm.440505.

Genome annotation databases

EnsembliENSMUST00000090031; ENSMUSP00000087485; ENSMUSG00000068523.
ENSMUST00000118280; ENSMUSP00000114014; ENSMUSG00000068523.
GeneIDi100043507.
102641276.
14707.
KEGGimmu:100043507.
mmu:102641276.
mmu:14707.
UCSCiuc008rrk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002316 mRNA. Translation: AAH02316.3.
BC087872 mRNA. Translation: AAH87872.1.
U38498 mRNA. Translation: AAB01729.1.
CCDSiCCDS17903.1.
RefSeqiNP_034448.2. NM_010318.2.
XP_003945606.1. XM_003945557.2.
XP_006543361.1. XM_006543298.1.
XP_006544124.1. XM_006544061.1.
UniGeneiMm.140804.
Mm.440505.

3D structure databases

ProteinModelPortaliQ80SZ7.
SMRiQ80SZ7. Positions 6-59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80SZ7. 2 interactions.
MINTiMINT-4095767.
STRINGi10090.ENSMUSP00000087485.

PTM databases

PhosphoSiteiQ80SZ7.

Proteomic databases

MaxQBiQ80SZ7.
PaxDbiQ80SZ7.
PRIDEiQ80SZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090031; ENSMUSP00000087485; ENSMUSG00000068523.
ENSMUST00000118280; ENSMUSP00000114014; ENSMUSG00000068523.
GeneIDi100043507.
102641276.
14707.
KEGGimmu:100043507.
mmu:102641276.
mmu:14707.
UCSCiuc008rrk.1. mouse.

Organism-specific databases

CTDi2787.
MGIiMGI:109164. Gng5.

Phylogenomic databases

eggNOGiNOG262845.
GeneTreeiENSGT00760000119218.
HOVERGENiHBG014983.
InParanoidiQ80SZ7.
KOiK04542.
OMAiADLQQFC.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ80SZ7.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_272374. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_286837. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_297430. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_308732. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_339334. Activation of G protein gated Potassium channels.
REACT_339920. Glucagon-type ligand receptors.
REACT_345203. Glucagon signaling in metabolic regulation.

Miscellaneous databases

NextBioi20806541.
PROiQ80SZ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ80SZ7.
ExpressionAtlasiQ80SZ7. baseline and differential.
GenevisibleiQ80SZ7. MM.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Mammary tumor.
  2. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
    Williams C.J., Schultz R.M., Kopf G.S.
    Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-53.
    Strain: CF-1 / Harlan.

Entry informationi

Entry nameiGBG5_MOUSE
AccessioniPrimary (citable) accession number: Q80SZ7
Secondary accession number(s): P30670, Q5I0W4, Q61015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: June 24, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.