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Q80SZ7 (GBG5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene names
Name:Gng5
Synonyms:Gngt5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the G protein gamma family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
PRO_0000012629
Propeptide66 – 683Removed in mature form By similarity
PRO_0000012630

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue21Phosphoserine By similarity
Modified residue651Cysteine methyl ester By similarity
Lipidation651S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80SZ7 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: 9AF7A16558863602

FASTA687,318
        10         20         30         40         50         60 
MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT GVSSSTNPFR 


PQKVCSFL 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Brain and Mammary tumor.
[2]"G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
Williams C.J., Schultz R.M., Kopf G.S.
Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-53.
Strain: CF-1 / Harlan.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC002316 mRNA. Translation: AAH02316.3.
BC087872 mRNA. Translation: AAH87872.1.
U38498 mRNA. Translation: AAB01729.1.
CCDSCCDS17903.1.
RefSeqNP_034448.2. NM_010318.2.
XP_003945606.1. XM_003945557.2.
XP_006543361.1. XM_006543298.1.
XP_006544124.1. XM_006544061.1.
UniGeneMm.140804.
Mm.440505.

3D structure databases

ProteinModelPortalQ80SZ7.
SMRQ80SZ7. Positions 6-59.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ80SZ7. 2 interactions.
MINTMINT-4095767.
STRING10090.ENSMUSP00000114014.

PTM databases

PhosphoSiteQ80SZ7.

Proteomic databases

MaxQBQ80SZ7.
PaxDbQ80SZ7.
PRIDEQ80SZ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090031; ENSMUSP00000087485; ENSMUSG00000068523.
ENSMUST00000118280; ENSMUSP00000114014; ENSMUSG00000068523.
GeneID100043507.
102641276.
14707.
KEGGmmu:100043507.
mmu:102641276.
mmu:14707.
UCSCuc008rrk.1. mouse.

Organism-specific databases

CTD2787.
MGIMGI:109164. Gng5.

Phylogenomic databases

eggNOGNOG262845.
GeneTreeENSGT00740000115214.
HOVERGENHBG014983.
InParanoidQ80SZ7.
KOK04542.
OMARFEAGIN.
OrthoDBEOG7H1JP7.
PhylomeDBQ80SZ7.
TreeFamTF319909.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

ArrayExpressQ80SZ7.
BgeeQ80SZ7.
GenevestigatorQ80SZ7.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806541.
PROQ80SZ7.
SOURCESearch...

Entry information

Entry nameGBG5_MOUSE
AccessionPrimary (citable) accession number: Q80SZ7
Secondary accession number(s): P30670, Q5I0W4, Q61015
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot