Q80SZ7 (GBG5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene names

Name:	Gng5
Synonyms:	Gngt5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	68 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Acetylation Lipoprotein Methylation Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 65	64	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5		PRO_0000012629
	Propeptide	66 – 68	3	Removed in mature form By similarity		PRO_0000012630
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	2	1	Phosphoserine By similarity
	Modified residue	65	1	Cysteine methyl ester By similarity
	Lipidation	65	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q80SZ7 [UniParc]. Last modified September 27, 2004. Version 2. Checksum: 9AF7A16558863602	FASTA	68	7,318
	10 20 30 40 50 60 MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT GVSSSTNPFR PQKVCSFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Brain and Mammary tumor.
[2]	"G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development." Williams C.J., Schultz R.M., Kopf G.S. Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-53. Strain: CF-1 / Harlan.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC002316 mRNA. Translation: AAH02316.3. BC087872 mRNA. Translation: AAH87872.1. U38498 mRNA. Translation: AAB01729.1.
IPI	IPI00459353.
RefSeq	NP_034448.2. NM_010318.2. XP_003689438.1. XM_003689390.2. XP_003945606.1. XM_003945557.1. XP_003946024.1. XM_003945975.1.
UniGene	Mm.140804. Mm.440505.
3D structure databases
ProteinModelPortal	Q80SZ7.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4095767.
STRING	10090.ENSMUSP00000114014.
PTM databases
PhosphoSite	Q80SZ7.
Proteomic databases
PaxDb	Q80SZ7.
PRIDE	Q80SZ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000090031; ENSMUSP00000087485; ENSMUSG00000068523. ENSMUST00000118280; ENSMUSP00000114014; ENSMUSG00000068523.
GeneID	100043507. 100048410. 14707.
KEGG	mmu:100043507. mmu:100048410. mmu:14707.
UCSC	uc008rrk.1. mouse.
Organism-specific databases
CTD	2787.
MGI	MGI:109164. Gng5.
Phylogenomic databases
eggNOG	NOG262845.
GeneTree	ENSGT00550000074352.
HOVERGEN	HBG014983.
InParanoid	Q80SZ7.
KO	K04542.
OMA	QLRFEAS.
OrthoDB	EOG43FGZM.
Gene expression databases
ArrayExpress	Q80SZ7.
Bgee	Q80SZ7.
Genevestigator	Q80SZ7.
GermOnline	ENSMUSG00000068481. Mus musculus. ENSMUSG00000068523. Mus musculus.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806541.
SOURCE	Search...

Entry information

Entry name

GBG5_MOUSE

Accession

Primary (citable) accession number: Q80SZ7
Secondary accession number(s): P30670, Q5I0W4, Q61015

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	September 27, 2004
Last modified:	May 29, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program