Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q80SZ7

- GBG5_MOUSE

UniProt

Q80SZ7 - GBG5_MOUSE

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Gene

Gng5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
    Gene namesi
    Name:Gng5
    Synonyms:Gngt5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:109164. Gng5.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5PRO_0000012629Add
    BLAST
    Propeptidei66 – 683Removed in mature formBy similarityPRO_0000012630

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei2 – 21PhosphoserineBy similarity
    Modified residuei65 – 651Cysteine methyl esterBy similarity
    Lipidationi65 – 651S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    MaxQBiQ80SZ7.
    PaxDbiQ80SZ7.
    PRIDEiQ80SZ7.

    PTM databases

    PhosphoSiteiQ80SZ7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80SZ7.
    BgeeiQ80SZ7.
    GenevestigatoriQ80SZ7.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    IntActiQ80SZ7. 2 interactions.
    MINTiMINT-4095767.
    STRINGi10090.ENSMUSP00000114014.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80SZ7.
    SMRiQ80SZ7. Positions 6-59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG262845.
    GeneTreeiENSGT00740000115214.
    HOVERGENiHBG014983.
    InParanoidiQ80SZ7.
    KOiK04542.
    OMAiRFEAGIN.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiQ80SZ7.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q80SZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT   50
    GVSSSTNPFR PQKVCSFL 68
    Length:68
    Mass (Da):7,318
    Last modified:September 27, 2004 - v2
    Checksum:i9AF7A16558863602
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC002316 mRNA. Translation: AAH02316.3.
    BC087872 mRNA. Translation: AAH87872.1.
    U38498 mRNA. Translation: AAB01729.1.
    CCDSiCCDS17903.1.
    RefSeqiNP_034448.2. NM_010318.2.
    XP_003945606.1. XM_003945557.2.
    XP_006543361.1. XM_006543298.1.
    XP_006544124.1. XM_006544061.1.
    UniGeneiMm.140804.
    Mm.440505.

    Genome annotation databases

    EnsembliENSMUST00000090031; ENSMUSP00000087485; ENSMUSG00000068523.
    ENSMUST00000118280; ENSMUSP00000114014; ENSMUSG00000068523.
    GeneIDi100043507.
    102641276.
    14707.
    KEGGimmu:100043507.
    mmu:102641276.
    mmu:14707.
    UCSCiuc008rrk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC002316 mRNA. Translation: AAH02316.3 .
    BC087872 mRNA. Translation: AAH87872.1 .
    U38498 mRNA. Translation: AAB01729.1 .
    CCDSi CCDS17903.1.
    RefSeqi NP_034448.2. NM_010318.2.
    XP_003945606.1. XM_003945557.2.
    XP_006543361.1. XM_006543298.1.
    XP_006544124.1. XM_006544061.1.
    UniGenei Mm.140804.
    Mm.440505.

    3D structure databases

    ProteinModelPortali Q80SZ7.
    SMRi Q80SZ7. Positions 6-59.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q80SZ7. 2 interactions.
    MINTi MINT-4095767.
    STRINGi 10090.ENSMUSP00000114014.

    PTM databases

    PhosphoSitei Q80SZ7.

    Proteomic databases

    MaxQBi Q80SZ7.
    PaxDbi Q80SZ7.
    PRIDEi Q80SZ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090031 ; ENSMUSP00000087485 ; ENSMUSG00000068523 .
    ENSMUST00000118280 ; ENSMUSP00000114014 ; ENSMUSG00000068523 .
    GeneIDi 100043507.
    102641276.
    14707.
    KEGGi mmu:100043507.
    mmu:102641276.
    mmu:14707.
    UCSCi uc008rrk.1. mouse.

    Organism-specific databases

    CTDi 2787.
    MGIi MGI:109164. Gng5.

    Phylogenomic databases

    eggNOGi NOG262845.
    GeneTreei ENSGT00740000115214.
    HOVERGENi HBG014983.
    InParanoidi Q80SZ7.
    KOi K04542.
    OMAi RFEAGIN.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi Q80SZ7.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_208837. Activation of G protein gated Potassium channels.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Miscellaneous databases

    NextBioi 20806541.
    PROi Q80SZ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80SZ7.
    Bgeei Q80SZ7.
    Genevestigatori Q80SZ7.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Brain and Mammary tumor.
    2. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
      Williams C.J., Schultz R.M., Kopf G.S.
      Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-53.
      Strain: CF-1 / Harlan.

    Entry informationi

    Entry nameiGBG5_MOUSE
    AccessioniPrimary (citable) accession number: Q80SZ7
    Secondary accession number(s): P30670, Q5I0W4, Q61015
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3