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Q80SZ7

- GBG5_MOUSE

UniProt

Q80SZ7 - GBG5_MOUSE

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Protein
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene
Gng5, Gngt5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Gene namesi
Name:Gng5
Synonyms:Gngt5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:109164. Gng5.

Subcellular locationi

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 6564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
PRO_0000012629Add
BLAST
Propeptidei66 – 683Removed in mature form By similarity
PRO_0000012630

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei2 – 21Phosphoserine By similarity
Modified residuei65 – 651Cysteine methyl ester By similarity
Lipidationi65 – 651S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ80SZ7.
PaxDbiQ80SZ7.
PRIDEiQ80SZ7.

PTM databases

PhosphoSiteiQ80SZ7.

Expressioni

Gene expression databases

ArrayExpressiQ80SZ7.
BgeeiQ80SZ7.
GenevestigatoriQ80SZ7.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

IntActiQ80SZ7. 2 interactions.
MINTiMINT-4095767.
STRINGi10090.ENSMUSP00000114014.

Structurei

3D structure databases

ProteinModelPortaliQ80SZ7.
SMRiQ80SZ7. Positions 6-59.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.

Phylogenomic databases

eggNOGiNOG262845.
GeneTreeiENSGT00740000115214.
HOVERGENiHBG014983.
InParanoidiQ80SZ7.
KOiK04542.
OMAiRFEAGIN.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ80SZ7.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80SZ7-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT   50
GVSSSTNPFR PQKVCSFL 68
Length:68
Mass (Da):7,318
Last modified:September 27, 2004 - v2
Checksum:i9AF7A16558863602
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC002316 mRNA. Translation: AAH02316.3.
BC087872 mRNA. Translation: AAH87872.1.
U38498 mRNA. Translation: AAB01729.1.
CCDSiCCDS17903.1.
RefSeqiNP_034448.2. NM_010318.2.
XP_003945606.1. XM_003945557.2.
XP_006543361.1. XM_006543298.1.
XP_006544124.1. XM_006544061.1.
UniGeneiMm.140804.
Mm.440505.

Genome annotation databases

EnsembliENSMUST00000090031; ENSMUSP00000087485; ENSMUSG00000068523.
ENSMUST00000118280; ENSMUSP00000114014; ENSMUSG00000068523.
GeneIDi100043507.
102641276.
14707.
KEGGimmu:100043507.
mmu:102641276.
mmu:14707.
UCSCiuc008rrk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC002316 mRNA. Translation: AAH02316.3 .
BC087872 mRNA. Translation: AAH87872.1 .
U38498 mRNA. Translation: AAB01729.1 .
CCDSi CCDS17903.1.
RefSeqi NP_034448.2. NM_010318.2.
XP_003945606.1. XM_003945557.2.
XP_006543361.1. XM_006543298.1.
XP_006544124.1. XM_006544061.1.
UniGenei Mm.140804.
Mm.440505.

3D structure databases

ProteinModelPortali Q80SZ7.
SMRi Q80SZ7. Positions 6-59.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80SZ7. 2 interactions.
MINTi MINT-4095767.
STRINGi 10090.ENSMUSP00000114014.

PTM databases

PhosphoSitei Q80SZ7.

Proteomic databases

MaxQBi Q80SZ7.
PaxDbi Q80SZ7.
PRIDEi Q80SZ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090031 ; ENSMUSP00000087485 ; ENSMUSG00000068523 .
ENSMUST00000118280 ; ENSMUSP00000114014 ; ENSMUSG00000068523 .
GeneIDi 100043507.
102641276.
14707.
KEGGi mmu:100043507.
mmu:102641276.
mmu:14707.
UCSCi uc008rrk.1. mouse.

Organism-specific databases

CTDi 2787.
MGIi MGI:109164. Gng5.

Phylogenomic databases

eggNOGi NOG262845.
GeneTreei ENSGT00740000115214.
HOVERGENi HBG014983.
InParanoidi Q80SZ7.
KOi K04542.
OMAi RFEAGIN.
OrthoDBi EOG7H1JP7.
PhylomeDBi Q80SZ7.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

NextBioi 20806541.
PROi Q80SZ7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80SZ7.
Bgeei Q80SZ7.
Genevestigatori Q80SZ7.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Mammary tumor.
  2. "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development."
    Williams C.J., Schultz R.M., Kopf G.S.
    Mol. Reprod. Dev. 44:315-323(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-53.
    Strain: CF-1 / Harlan.

Entry informationi

Entry nameiGBG5_MOUSE
AccessioniPrimary (citable) accession number: Q80SZ7
Secondary accession number(s): P30670, Q5I0W4, Q61015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: September 3, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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