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Protein
Submitted name:

NOD2

Gene

Nod2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
NOD2Imported
Submitted name:
Nucleotide-binding oligomerization domain-containing protein 2Imported
Gene namesi
Name:Nod2Imported
Synonyms:Card15Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2429397. Nod2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113773.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282CARDInterPro annotationAdd
BLAST
Domaini107 – 17872CARDInterPro annotationAdd
BLAST
Domaini266 – 402137NACHTInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains NACHT domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129782.
HOVERGENiHBG050792.
KOiK10165.
OrthoDBiEOG7P5T07.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR018228. DNase_TatD-rel_CS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 2 hits.
PS50837. NACHT. 1 hit.
PS01137. TATD_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80SY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSQEEFQAQ RSQLVALLIS GSLEGFESIL DWLLSWDVLS REDYEGLSLP
60 70 80 90 100
GQPLSHSARR LLDTVWNKGV WGCQKLLEAV QEAQANSHTF ELYGSWDTHS
110 120 130 140 150
LHPTRDLQSH RPAIVRRLYN HVEAMLELAR EGGFLSQYEC EEIRLPIFTS
160 170 180 190 200
SQRARRLLDL AAVKANGLAA FLLQHVRELP APLPLPYEAA ECQKFISKLR
210 220 230 240 250
TMVLTQSRFL STYDGSENLC LEDIYTENIL ELQTEVGTAG ALQKSPAILG
260 270 280 290 300
LEDLFDTHGH LNRDADTILV VGEAGSGKST LLQRLHLLWA TGRSFQEFLF
310 320 330 340 350
IFPFSCRQLQ CVAKPLSLRT LLFEHCCWPD VAQDDVFQFL LDHPDRVLLT
360 370 380 390 400
FDGLDEFKFR FTDRERHCSP IDPTSVQTLL FNLLQGNLLK NACKVLTSRP
410 420 430 440 450
DAVSALLRKF VRTELQLKGF SEEGIQLYLR KHHREPGVAD RLIQLIQATS
460 470 480 490 500
ALHGLCHLPV FSWMVSRCHR ELLLQNRGFP TTSTDMYLLI LQHFLLHASP
510 520 530 540 550
PDSSPLGLGP GLLQSRLSTL LHLGHLALRG LAMSCYVFSA QQLQAAQVDS
560 570 580 590 600
DDISLGFLVR AQSSVPGSKA PLEFLHITFQ CFFAAFYLAV SADTSVASLK
610 620 630 640 650
HLFSCGRLGS SLLGRLLPNL CIQGSRVKKG SEAALLQKAE PHNLQITAAF
660 670 680 690 700
LAGLLSQQHR DLLAACQVSE RVLLQRQARA RSCLAHSLRE HFHSIPPAVP
710 720 730 740 750
GETKSMHAMP GFIWLIRSLY EMQEEQLAQE AVRRLDIGHL KLTFCRVGPA
760 770 780 790 800
ECAALAFVLQ HLQRPVALQL DYNSVGDVGV EQLRPCLGVC TALYLRDNNI
810 820 830 840 850
SDRGARTLVE CALRCEQLQK LALFNNKLTD ACACSMAKLL AHKQNFLSLR
860 870 880 890 900
VGNNHITAAG AEVLAQGLKS NTSLKFLGFW GNSVGDKGTQ ALAEVVADHQ
910 920 930 940 950
NLKWLSLVGN NIGSMGAEAL ALMLEKNKSL EELCLEENHI CDEGVYSLAE
960 970 980 990 1000
GLKRNSTLKF LKLSNNGITY RGAEALLQAL SRNSAILEVW LRGNTFSLEE
1010
IQTLSSRDAR LLL
Length:1,013
Mass (Da):112,779
Last modified:June 1, 2003 - v1
Checksum:i459CD3CBE6F66375
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156937 Genomic DNA. No translation available.
AY160220 mRNA. Translation: AAN52477.1.
AY160348
, AY160340, AY160341, AY160342, AY160343, AY160344, AY160345, AY160346, AY160347 Genomic DNA. Translation: AAN57787.1.
AY160368
, AY160360, AY160361, AY160362, AY160363, AY160364, AY160365, AY160366, AY160367 Genomic DNA. Translation: AAN57789.1.
AY160568
, AY160560, AY160561, AY160562, AY160563, AY160564, AY160565, AY160566, AY160567 Genomic DNA. Translation: AAN62470.1.
AY160578
, AY160570, AY160571, AY160572, AY160573, AY160574, AY160575, AY160576, AY160577 Genomic DNA. Translation: AAN62471.1.
AY160608
, AY160600, AY160601, AY160602, AY160603, AY160604, AY160605, AY160606, AY160607 Genomic DNA. Translation: AAN63034.1.
AY160618
, AY160610, AY160611, AY160612, AY160613, AY160614, AY160615, AY160616, AY160617 Genomic DNA. Translation: AAN63035.1.
AY160658
, AY160650, AY160651, AY160652, AY160653, AY160654, AY160655, AY160656, AY160657 Genomic DNA. Translation: AAN63039.1.
RefSeqiNP_665856.2. NM_145857.2.
UniGeneiMm.222633.

Genome annotation databases

EnsembliENSMUST00000118370; ENSMUSP00000113773; ENSMUSG00000055994.
GeneIDi257632.
KEGGimmu:257632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156937 Genomic DNA. No translation available.
AY160220 mRNA. Translation: AAN52477.1.
AY160348
, AY160340, AY160341, AY160342, AY160343, AY160344, AY160345, AY160346, AY160347 Genomic DNA. Translation: AAN57787.1.
AY160368
, AY160360, AY160361, AY160362, AY160363, AY160364, AY160365, AY160366, AY160367 Genomic DNA. Translation: AAN57789.1.
AY160568
, AY160560, AY160561, AY160562, AY160563, AY160564, AY160565, AY160566, AY160567 Genomic DNA. Translation: AAN62470.1.
AY160578
, AY160570, AY160571, AY160572, AY160573, AY160574, AY160575, AY160576, AY160577 Genomic DNA. Translation: AAN62471.1.
AY160608
, AY160600, AY160601, AY160602, AY160603, AY160604, AY160605, AY160606, AY160607 Genomic DNA. Translation: AAN63034.1.
AY160618
, AY160610, AY160611, AY160612, AY160613, AY160614, AY160615, AY160616, AY160617 Genomic DNA. Translation: AAN63035.1.
AY160658
, AY160650, AY160651, AY160652, AY160653, AY160654, AY160655, AY160656, AY160657 Genomic DNA. Translation: AAN63039.1.
RefSeqiNP_665856.2. NM_145857.2.
UniGeneiMm.222633.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113773.

Protocols and materials databases

DNASUi257632.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118370; ENSMUSP00000113773; ENSMUSG00000055994.
GeneIDi257632.
KEGGimmu:257632.

Organism-specific databases

CTDi64127.
MGIiMGI:2429397. Nod2.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00840000129782.
HOVERGENiHBG050792.
KOiK10165.
OrthoDBiEOG7P5T07.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR018228. DNase_TatD-rel_CS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 2 hits.
PS50837. NACHT. 1 hit.
PS01137. TATD_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn's disease."
    Ogura Y., Saab L., Chen F.F., Benito A., Inohara N., Nunez G.
    Genomics 81:369-377(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/JImported, C3H/HeJImported, C57BL/6Imported, C57BL/6JImported, DDY/JclImported, EL/SuzImported, VM/DkImported and YBR/EiImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ80SY9_MOUSE
AccessioniPrimary (citable) accession number: Q80SY9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.