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Protein

Adenosine deaminase-like protein

Gene

Adal

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23Zinc; catalyticBy similarity1
Metal bindingi25Zinc; catalyticBy similarity1
Binding sitei25SubstrateBy similarity1
Binding sitei180Substrate; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi207Zinc; catalyticBy similarity1
Active sitei210Proton donorBy similarity1
Sitei231Important for catalytic activityBy similarity1
Metal bindingi292Zinc; catalyticBy similarity1
Binding sitei293SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-2161541 Abacavir metabolism
R-MMU-74217 Purine salvage

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminase-like protein (EC:3.5.4.-)
Gene namesi
Name:Adal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923144 Adal

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850911 – 360Adenosine deaminase-like proteinAdd BLAST360

Proteomic databases

PaxDbiQ80SY6
PeptideAtlasiQ80SY6
PRIDEiQ80SY6

Expressioni

Gene expression databases

BgeeiENSMUSG00000027259
CleanExiMM_ADAL
ExpressionAtlasiQ80SY6 baseline and differential
GenevisibleiQ80SY6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067133

Structurei

3D structure databases

ProteinModelPortaliQ80SY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1097 Eukaryota
COG1816 LUCA
GeneTreeiENSGT00730000111081
HOGENOMiHOG000205847
HOVERGENiHBG055638
InParanoidiQ80SY6
OMAiRGWFRFQ
OrthoDBiEOG091G0UAU
PhylomeDBiQ80SY6
TreeFamiTF314270

Family and domain databases

InterProiView protein in InterPro
IPR001365 A/AMP_deaminase_dom
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80SY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAGQQWPGK TDFYLQLPKV ELHAHLNGSI SSSTMKKLIA KKPHLNVHGH
60 70 80 90 100
MTMIDKGKKR TLQECFQMFQ VIHQLTTSAE DILMVTKDVI KEFADDGVKY
110 120 130 140 150
LELRSTPREE NATGMTRKTY VESVLEGIKQ CKQENLDIDV RYLMAIDRRG
160 170 180 190 200
GPTIARETVE LAKEFFLSTE NTVLGLDLSG DPTIGQANDF LEPLLEAKKA
210 220 230 240 250
GLKLALHLAE IPNREKENQM LLSLLPDRIG HGTFLSASEA GALDQVDFVR
260 270 280 290 300
QHQIPLELCL TSNIKSQTVP SYDQHHFGFW YSIAHPSVIC TDDKGVFATY
310 320 330 340 350
LSQEYQLAAE TFNLTPFQVW DLSYESINYI FACDNTRSEL RKRWTHLKQK
360
VLNCNEVNYF
Length:360
Mass (Da):41,001
Last modified:June 1, 2003 - v1
Checksum:i525AEBD0EF7D217D
GO
Isoform 2 (identifier: Q80SY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Show »
Length:293
Mass (Da):33,375
Checksum:i8C321E1E770FEA9D
GO
Isoform 3 (identifier: Q80SY6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-114: TKDVIKEFADDGVKYLELRSTPREENATG → RHRGRLKWRDFPQQCTANLAHVLWLSSTL
     115-360: Missing.

Show »
Length:114
Mass (Da):13,175
Checksum:iADF1223487A426F4
GO
Isoform 4 (identifier: Q80SY6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Show »
Length:217
Mass (Da):24,597
Checksum:iDDB3891B89539BEE
GO

Sequence cautioni

The sequence CAM18206 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q80SY6-3)
Sequence conflicti39I → T in BAC31744 (PubMed:16141072).Curated1
Sequence conflicti103N → H in BAC31744 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0248251 – 143Missing in isoform 4. CuratedAdd BLAST143
Alternative sequenceiVSP_0248221 – 67Missing in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_02482386 – 114TKDVI…ENATG → RHRGRLKWRDFPQQCTANLA HVLWLSSTL in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_024824115 – 360Missing in isoform 3. 1 PublicationAdd BLAST246

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016299 mRNA Translation: BAB30184.1
AK044025 mRNA Translation: BAC31744.1
AK048809 mRNA Translation: BAC33464.1
AK049697 mRNA Translation: BAC33880.1
AL845479 Genomic DNA Translation: CAM18204.1
AL845479 Genomic DNA Translation: CAM18205.1
AL845479 Genomic DNA Translation: CAM18206.1 Sequence problems.
AL845479 Genomic DNA Translation: CAM18207.1
BC050879 mRNA Translation: AAH50879.1
BC052048 mRNA Translation: AAH52048.1
CCDSiCCDS16633.1 [Q80SY6-1]
CCDS71121.1 [Q80SY6-2]
RefSeqiNP_001277740.1, NM_001290811.1 [Q80SY6-2]
NP_001277741.1, NM_001290812.1
NP_083751.1, NM_029475.2 [Q80SY6-1]
XP_006500414.1, XM_006500351.2 [Q80SY6-1]
XP_006500415.1, XM_006500352.2 [Q80SY6-1]
XP_006500416.1, XM_006500353.3 [Q80SY6-1]
XP_006500421.1, XM_006500358.2
XP_006500422.1, XM_006500359.2 [Q80SY6-4]
XP_006500423.1, XM_006500360.2 [Q80SY6-4]
UniGeneiMm.384805

Genome annotation databases

EnsembliENSMUST00000028702; ENSMUSP00000028702; ENSMUSG00000027259 [Q80SY6-2]
ENSMUST00000066155; ENSMUSP00000067133; ENSMUSG00000027259 [Q80SY6-1]
ENSMUST00000110662; ENSMUSP00000106290; ENSMUSG00000027259 [Q80SY6-4]
ENSMUST00000119031; ENSMUSP00000113052; ENSMUSG00000027259 [Q80SY6-1]
GeneIDi75894
KEGGimmu:75894
UCSCiuc008lxo.1 mouse [Q80SY6-3]
uc008lxp.2 mouse [Q80SY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiADAL_MOUSE
AccessioniPrimary (citable) accession number: Q80SY6
Secondary accession number(s): A2ARU3
, A2ARU4, Q8BLN3, Q8BX67, Q9D4Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health