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Protein

Sodium-dependent phosphate transport protein 2C

Gene

Slc34a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_314085. Type II Na+/Pi cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 2C
Short name:
Sodium-phosphate transport protein 2C
Alternative name(s):
Na(+)-dependent phosphate cotransporter 2C
Sodium/phosphate cotransporter 2C
Short name:
Na(+)/Pi cotransporter 2C
Short name:
NaPi-2c
Solute carrier family 34 member 3
Gene namesi
Name:Slc34a3
Synonyms:Npt2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2159410. Slc34a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=M1Sequence AnalysisAdd
BLAST
Topological domaini97 – 11014ExtracellularSequence AnalysisAdd
BLAST
Transmembranei111 – 13121Helical; Name=M2Sequence AnalysisAdd
BLAST
Topological domaini132 – 18756CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=M3Sequence AnalysisAdd
BLAST
Topological domaini209 – 324116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei325 – 34521Helical; Name=M4Sequence AnalysisAdd
BLAST
Topological domaini346 – 36924CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei370 – 39021Helical; Name=M5Sequence AnalysisAdd
BLAST
Topological domaini391 – 44151ExtracellularSequence AnalysisAdd
BLAST
Transmembranei442 – 46221Helical; Name=M6Sequence AnalysisAdd
BLAST
Topological domaini463 – 48725CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei488 – 50821Helical; Name=M7Sequence AnalysisAdd
BLAST
Topological domaini509 – 5124ExtracellularSequence Analysis
Transmembranei513 – 53321Helical; Name=M8Sequence AnalysisAdd
BLAST
Topological domaini534 – 60168CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • brush border Source: MGI
  • brush border membrane Source: InterPro
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi189 – 1913SGS → AGA: Change of cotransport Na(+):Pi stoichiometry to 3:1; when associated with D-195. 1 Publication
Mutagenesisi195 – 1951G → D: Change of cotransport Na(+):Pi stoichiometry to 3:1; when associated with 189-AGA-191. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Sodium-dependent phosphate transport protein 2CPRO_0000068618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi275 ↔ 311By similarity
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ80SU6.
PRIDEiQ80SU6.

PTM databases

PhosphoSiteiQ80SU6.

Expressioni

Tissue specificityi

Observed only in kidney.

Gene expression databases

BgeeiQ80SU6.
GenevisibleiQ80SU6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006638.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi426 – 4294Poly-Thr

Sequence similaritiesi

Belongs to the SLC34A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1283.
GeneTreeiENSGT00390000005032.
HOGENOMiHOG000006550.
HOVERGENiHBG006527.
InParanoidiQ80SU6.
KOiK14683.
OMAiQRHRPAW.
OrthoDBiEOG72ZCDP.
TreeFamiTF313981.

Family and domain databases

InterProiIPR003841. Na/Pi_transpt.
IPR029850. Na/Pi_transpt_2C.
[Graphical view]
PANTHERiPTHR10010:SF22. PTHR10010:SF22. 1 hit.
PfamiPF02690. Na_Pi_cotrans. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01013. 2a58. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80SU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNSLAGGQV PNPTLDAFDL VDRSLRNAGI SGSIPGLEEG GTDPWTFSPL
60 70 80 90 100
KNADQLKEVG MASRLRRVVS SFLKACGLLG SLYFFICSLD ILSSAFQLLG
110 120 130 140 150
SKMAGDIFKD NVVLSNPVAG LVIGVLVTVL VQSSSTSSSI VVSMVASKLL
160 170 180 190 200
TVQVSVPIIM GVNVGTSITS TLVSMAQSGD RDEFQRAFSG SAVHGIFNWL
210 220 230 240 250
TVLVLLPLES ATAALERLSE LALGAASLQP GQQAPDILKA LTRPFTHLII
260 270 280 290 300
QLDSSVITSG ITSNTTNSSL IKHWCGFRGE TPQGSSEGCG LFSSCTERNS
310 320 330 340 350
SASPEEDRLL CHHLFAGSKL TDLAVGFILL AGSLLVLCVC LVLIVKLLNS
360 370 380 390 400
VLKGRIAQAV KTVINADFPF PFGWLSGYLA ILVGAGLTFL LQSSSVFTAA
410 420 430 440 450
IVPLMGVGVI DLERAYPLFL GSNIGTTTTA LLAALASPAD MLIFAVQVAL
460 470 480 490 500
IHFFFNLAGI LLWYLVPVLR LPIPLAKRFG NLTAQYRWVA IVYLLLTFLL
510 520 530 540 550
LPLAAFGLSL AGGTVLAAVG GPLVGLVLLI ILVNVLQQHR PSWLPRCLQS
560 570 580 590 600
WAWLPLWLHS LEPWDRLVTA CCPCRACSNS PMTSKVAHCY ENPQVIASQQ

L
Length:601
Mass (Da):63,939
Last modified:July 27, 2011 - v2
Checksum:i4B7FE1FBC5877AB6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti353 – 3531K → R in BAB83241 (PubMed:12690469).Curated
Sequence conflicti353 – 3531K → R in BAC55069 (PubMed:12690469).Curated
Sequence conflicti361 – 3611K → R in BAB83241 (PubMed:12690469).Curated
Sequence conflicti361 – 3611K → R in BAC55069 (PubMed:12690469).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054999 mRNA. Translation: BAB83241.1.
AB080134 Genomic DNA. Translation: BAC55069.1.
AL732309 Genomic DNA. Translation: CAM14672.1.
CH466542 Genomic DNA. Translation: EDL08215.1.
CH466542 Genomic DNA. Translation: EDL08216.1.
BC125326 mRNA. Translation: AAI25327.1.
BC131997 mRNA. Translation: AAI31998.1.
CCDSiCCDS15754.1.
RefSeqiNP_543130.2. NM_080854.3.
XP_006497740.1. XM_006497677.1.
XP_006497741.1. XM_006497678.1.
UniGeneiMm.346652.
Mm.490356.

Genome annotation databases

EnsembliENSMUST00000006638; ENSMUSP00000006638; ENSMUSG00000006469.
GeneIDi142681.
KEGGimmu:142681.
UCSCiuc008iqt.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054999 mRNA. Translation: BAB83241.1.
AB080134 Genomic DNA. Translation: BAC55069.1.
AL732309 Genomic DNA. Translation: CAM14672.1.
CH466542 Genomic DNA. Translation: EDL08215.1.
CH466542 Genomic DNA. Translation: EDL08216.1.
BC125326 mRNA. Translation: AAI25327.1.
BC131997 mRNA. Translation: AAI31998.1.
CCDSiCCDS15754.1.
RefSeqiNP_543130.2. NM_080854.3.
XP_006497740.1. XM_006497677.1.
XP_006497741.1. XM_006497678.1.
UniGeneiMm.346652.
Mm.490356.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006638.

PTM databases

PhosphoSiteiQ80SU6.

Proteomic databases

PaxDbiQ80SU6.
PRIDEiQ80SU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006638; ENSMUSP00000006638; ENSMUSG00000006469.
GeneIDi142681.
KEGGimmu:142681.
UCSCiuc008iqt.3. mouse.

Organism-specific databases

CTDi142680.
MGIiMGI:2159410. Slc34a3.

Phylogenomic databases

eggNOGiCOG1283.
GeneTreeiENSGT00390000005032.
HOGENOMiHOG000006550.
HOVERGENiHBG006527.
InParanoidiQ80SU6.
KOiK14683.
OMAiQRHRPAW.
OrthoDBiEOG72ZCDP.
TreeFamiTF313981.

Enzyme and pathway databases

ReactomeiREACT_314085. Type II Na+/Pi cotransporters.

Miscellaneous databases

NextBioi370049.
PROiQ80SU6.
SOURCEiSearch...

Gene expression databases

BgeeiQ80SU6.
GenevisibleiQ80SU6. MM.

Family and domain databases

InterProiIPR003841. Na/Pi_transpt.
IPR029850. Na/Pi_transpt_2C.
[Graphical view]
PANTHERiPTHR10010:SF22. PTHR10010:SF22. 1 hit.
PfamiPF02690. Na_Pi_cotrans. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01013. 2a58. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney."
    Ohkido I., Segawa H., Yanagida R., Nakamura M., Miyamoto K.
    Pflugers Arch. 446:106-115(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], CHARACTERIZATION, INDUCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Renouncing electroneutrality is not free of charge: switching on electrogenicity in a Na+-coupled phosphate cotransporter."
    Bacconi A., Virkki L.V., Biber J., Murer H., Forster I.C.
    Proc. Natl. Acad. Sci. U.S.A. 102:12606-12611(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF GLY-195 AND 189-SER--SER-191.

Entry informationi

Entry nameiNPT2C_MOUSE
AccessioniPrimary (citable) accession number: Q80SU6
Secondary accession number(s): Q05AC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The cotransport has a Na+:Pi stoichiometry of 2:1 and is electroneutral.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.