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Protein

Sodium-dependent phosphate transport protein 2C

Gene

Slc34a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-427589. Type II Na+/Pi cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 2C
Short name:
Sodium-phosphate transport protein 2C
Alternative name(s):
Na(+)-dependent phosphate cotransporter 2C
Sodium/phosphate cotransporter 2C
Short name:
Na(+)/Pi cotransporter 2C
Short name:
NaPi-2c
Solute carrier family 34 member 3
Gene namesi
Name:Slc34a3
Synonyms:Npt2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2159410. Slc34a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75CytoplasmicSequence analysisAdd BLAST75
Transmembranei76 – 96Helical; Name=M1Sequence analysisAdd BLAST21
Topological domaini97 – 110ExtracellularSequence analysisAdd BLAST14
Transmembranei111 – 131Helical; Name=M2Sequence analysisAdd BLAST21
Topological domaini132 – 187CytoplasmicSequence analysisAdd BLAST56
Transmembranei188 – 208Helical; Name=M3Sequence analysisAdd BLAST21
Topological domaini209 – 324ExtracellularSequence analysisAdd BLAST116
Transmembranei325 – 345Helical; Name=M4Sequence analysisAdd BLAST21
Topological domaini346 – 369CytoplasmicSequence analysisAdd BLAST24
Transmembranei370 – 390Helical; Name=M5Sequence analysisAdd BLAST21
Topological domaini391 – 441ExtracellularSequence analysisAdd BLAST51
Transmembranei442 – 462Helical; Name=M6Sequence analysisAdd BLAST21
Topological domaini463 – 487CytoplasmicSequence analysisAdd BLAST25
Transmembranei488 – 508Helical; Name=M7Sequence analysisAdd BLAST21
Topological domaini509 – 512ExtracellularSequence analysis4
Transmembranei513 – 533Helical; Name=M8Sequence analysisAdd BLAST21
Topological domaini534 – 601CytoplasmicSequence analysisAdd BLAST68

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • brush border Source: MGI
  • brush border membrane Source: InterPro
  • cytoplasm Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
  • vesicle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi189 – 191SGS → AGA: Change of cotransport Na(+):Pi stoichiometry to 3:1; when associated with D-195. 1 Publication3
Mutagenesisi195G → D: Change of cotransport Na(+):Pi stoichiometry to 3:1; when associated with 189-AGA-191. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686181 – 601Sodium-dependent phosphate transport protein 2CAdd BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Glycosylationi264N-linked (GlcNAc...)Sequence analysis1
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi275 ↔ 311By similarity
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ80SU6.
PRIDEiQ80SU6.

PTM databases

iPTMnetiQ80SU6.
PhosphoSitePlusiQ80SU6.

Expressioni

Tissue specificityi

Observed only in kidney.

Gene expression databases

BgeeiENSMUSG00000006469.
GenevisibleiQ80SU6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006638.

Structurei

3D structure databases

ProteinModelPortaliQ80SU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi426 – 429Poly-Thr4

Sequence similaritiesi

Belongs to the SLC34A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8P. Eukaryota.
COG1283. LUCA.
GeneTreeiENSGT00390000005032.
HOGENOMiHOG000006550.
HOVERGENiHBG006527.
InParanoidiQ80SU6.
KOiK14683.
OMAiMDPWALP.
OrthoDBiEOG091G0DR5.
TreeFamiTF313981.

Family and domain databases

InterProiIPR003841. Na/Pi_transpt.
IPR029850. Na/Pi_transpt_2C.
[Graphical view]
PANTHERiPTHR10010:SF35. PTHR10010:SF35. 2 hits.
PfamiPF02690. Na_Pi_cotrans. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01013. 2a58. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80SU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNSLAGGQV PNPTLDAFDL VDRSLRNAGI SGSIPGLEEG GTDPWTFSPL
60 70 80 90 100
KNADQLKEVG MASRLRRVVS SFLKACGLLG SLYFFICSLD ILSSAFQLLG
110 120 130 140 150
SKMAGDIFKD NVVLSNPVAG LVIGVLVTVL VQSSSTSSSI VVSMVASKLL
160 170 180 190 200
TVQVSVPIIM GVNVGTSITS TLVSMAQSGD RDEFQRAFSG SAVHGIFNWL
210 220 230 240 250
TVLVLLPLES ATAALERLSE LALGAASLQP GQQAPDILKA LTRPFTHLII
260 270 280 290 300
QLDSSVITSG ITSNTTNSSL IKHWCGFRGE TPQGSSEGCG LFSSCTERNS
310 320 330 340 350
SASPEEDRLL CHHLFAGSKL TDLAVGFILL AGSLLVLCVC LVLIVKLLNS
360 370 380 390 400
VLKGRIAQAV KTVINADFPF PFGWLSGYLA ILVGAGLTFL LQSSSVFTAA
410 420 430 440 450
IVPLMGVGVI DLERAYPLFL GSNIGTTTTA LLAALASPAD MLIFAVQVAL
460 470 480 490 500
IHFFFNLAGI LLWYLVPVLR LPIPLAKRFG NLTAQYRWVA IVYLLLTFLL
510 520 530 540 550
LPLAAFGLSL AGGTVLAAVG GPLVGLVLLI ILVNVLQQHR PSWLPRCLQS
560 570 580 590 600
WAWLPLWLHS LEPWDRLVTA CCPCRACSNS PMTSKVAHCY ENPQVIASQQ

L
Length:601
Mass (Da):63,939
Last modified:July 27, 2011 - v2
Checksum:i4B7FE1FBC5877AB6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353K → R in BAB83241 (PubMed:12690469).Curated1
Sequence conflicti353K → R in BAC55069 (PubMed:12690469).Curated1
Sequence conflicti361K → R in BAB83241 (PubMed:12690469).Curated1
Sequence conflicti361K → R in BAC55069 (PubMed:12690469).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054999 mRNA. Translation: BAB83241.1.
AB080134 Genomic DNA. Translation: BAC55069.1.
AL732309 Genomic DNA. Translation: CAM14672.1.
CH466542 Genomic DNA. Translation: EDL08215.1.
CH466542 Genomic DNA. Translation: EDL08216.1.
BC125326 mRNA. Translation: AAI25327.1.
BC131997 mRNA. Translation: AAI31998.1.
CCDSiCCDS15754.1.
RefSeqiNP_543130.2. NM_080854.3.
XP_006497740.1. XM_006497677.1.
XP_006497741.1. XM_006497678.1.
UniGeneiMm.346652.
Mm.490356.

Genome annotation databases

EnsembliENSMUST00000006638; ENSMUSP00000006638; ENSMUSG00000006469.
GeneIDi142681.
KEGGimmu:142681.
UCSCiuc008iqt.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054999 mRNA. Translation: BAB83241.1.
AB080134 Genomic DNA. Translation: BAC55069.1.
AL732309 Genomic DNA. Translation: CAM14672.1.
CH466542 Genomic DNA. Translation: EDL08215.1.
CH466542 Genomic DNA. Translation: EDL08216.1.
BC125326 mRNA. Translation: AAI25327.1.
BC131997 mRNA. Translation: AAI31998.1.
CCDSiCCDS15754.1.
RefSeqiNP_543130.2. NM_080854.3.
XP_006497740.1. XM_006497677.1.
XP_006497741.1. XM_006497678.1.
UniGeneiMm.346652.
Mm.490356.

3D structure databases

ProteinModelPortaliQ80SU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006638.

PTM databases

iPTMnetiQ80SU6.
PhosphoSitePlusiQ80SU6.

Proteomic databases

PaxDbiQ80SU6.
PRIDEiQ80SU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006638; ENSMUSP00000006638; ENSMUSG00000006469.
GeneIDi142681.
KEGGimmu:142681.
UCSCiuc008iqt.3. mouse.

Organism-specific databases

CTDi142680.
MGIiMGI:2159410. Slc34a3.

Phylogenomic databases

eggNOGiENOG410IE8P. Eukaryota.
COG1283. LUCA.
GeneTreeiENSGT00390000005032.
HOGENOMiHOG000006550.
HOVERGENiHBG006527.
InParanoidiQ80SU6.
KOiK14683.
OMAiMDPWALP.
OrthoDBiEOG091G0DR5.
TreeFamiTF313981.

Enzyme and pathway databases

ReactomeiR-MMU-427589. Type II Na+/Pi cotransporters.

Miscellaneous databases

PROiQ80SU6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006469.
GenevisibleiQ80SU6. MM.

Family and domain databases

InterProiIPR003841. Na/Pi_transpt.
IPR029850. Na/Pi_transpt_2C.
[Graphical view]
PANTHERiPTHR10010:SF35. PTHR10010:SF35. 2 hits.
PfamiPF02690. Na_Pi_cotrans. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01013. 2a58. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNPT2C_MOUSE
AccessioniPrimary (citable) accession number: Q80SU6
Secondary accession number(s): Q05AC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The cotransport has a Na+:Pi stoichiometry of 2:1 and is electroneutral.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.