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Q80SU6

- NPT2C_MOUSE

UniProt

Q80SU6 - NPT2C_MOUSE

Protein

Sodium-dependent phosphate transport protein 2C

Gene

Slc34a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.

    GO - Molecular functioni

    1. sodium:phosphate symporter activity Source: Ensembl
    2. sodium-dependent phosphate transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. cellular phosphate ion homeostasis Source: Ensembl
    2. phosphate ion transport Source: MGI

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent phosphate transport protein 2C
    Short name:
    Sodium-phosphate transport protein 2C
    Alternative name(s):
    Na(+)-dependent phosphate cotransporter 2C
    Sodium/phosphate cotransporter 2C
    Short name:
    Na(+)/Pi cotransporter 2C
    Short name:
    NaPi-2c
    Solute carrier family 34 member 3
    Gene namesi
    Name:Slc34a3
    Synonyms:Npt2c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2159410. Slc34a3.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. brush border Source: MGI
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi189 – 1913SGS → AGA: Change of cotransport Na(+):Pi stoichiometry to 3:1; when associated with D-195.
    Mutagenesisi195 – 1951G → D: Change of cotransport Na(+):Pi stoichiometry to 3:1; when associated with 189-AGA-191. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 601601Sodium-dependent phosphate transport protein 2CPRO_0000068618Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi275 ↔ 311By similarity
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ80SU6.
    PRIDEiQ80SU6.

    PTM databases

    PhosphoSiteiQ80SU6.

    Expressioni

    Tissue specificityi

    Observed only in kidney.

    Gene expression databases

    BgeeiQ80SU6.
    GenevestigatoriQ80SU6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000006638.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 11014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 18756CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini209 – 324116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini346 – 36924CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini391 – 44151ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini463 – 48725CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini509 – 5124ExtracellularSequence Analysis
    Topological domaini534 – 60168CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621Helical; Name=M1Sequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121Helical; Name=M2Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=M3Sequence AnalysisAdd
    BLAST
    Transmembranei325 – 34521Helical; Name=M4Sequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021Helical; Name=M5Sequence AnalysisAdd
    BLAST
    Transmembranei442 – 46221Helical; Name=M6Sequence AnalysisAdd
    BLAST
    Transmembranei488 – 50821Helical; Name=M7Sequence AnalysisAdd
    BLAST
    Transmembranei513 – 53321Helical; Name=M8Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi426 – 4294Poly-Thr

    Sequence similaritiesi

    Belongs to the SLC34A transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1283.
    GeneTreeiENSGT00390000005032.
    HOGENOMiHOG000006550.
    HOVERGENiHBG006527.
    InParanoidiQ05AC3.
    KOiK14683.
    OMAiLIKRWCG.
    OrthoDBiEOG72ZCDP.
    TreeFamiTF313981.

    Family and domain databases

    InterProiIPR003841. Na/Pi_transpt.
    [Graphical view]
    PfamiPF02690. Na_Pi_cotrans. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR01013. 2a58. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q80SU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNSLAGGQV PNPTLDAFDL VDRSLRNAGI SGSIPGLEEG GTDPWTFSPL    50
    KNADQLKEVG MASRLRRVVS SFLKACGLLG SLYFFICSLD ILSSAFQLLG 100
    SKMAGDIFKD NVVLSNPVAG LVIGVLVTVL VQSSSTSSSI VVSMVASKLL 150
    TVQVSVPIIM GVNVGTSITS TLVSMAQSGD RDEFQRAFSG SAVHGIFNWL 200
    TVLVLLPLES ATAALERLSE LALGAASLQP GQQAPDILKA LTRPFTHLII 250
    QLDSSVITSG ITSNTTNSSL IKHWCGFRGE TPQGSSEGCG LFSSCTERNS 300
    SASPEEDRLL CHHLFAGSKL TDLAVGFILL AGSLLVLCVC LVLIVKLLNS 350
    VLKGRIAQAV KTVINADFPF PFGWLSGYLA ILVGAGLTFL LQSSSVFTAA 400
    IVPLMGVGVI DLERAYPLFL GSNIGTTTTA LLAALASPAD MLIFAVQVAL 450
    IHFFFNLAGI LLWYLVPVLR LPIPLAKRFG NLTAQYRWVA IVYLLLTFLL 500
    LPLAAFGLSL AGGTVLAAVG GPLVGLVLLI ILVNVLQQHR PSWLPRCLQS 550
    WAWLPLWLHS LEPWDRLVTA CCPCRACSNS PMTSKVAHCY ENPQVIASQQ 600
    L 601
    Length:601
    Mass (Da):63,939
    Last modified:July 27, 2011 - v2
    Checksum:i4B7FE1FBC5877AB6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti353 – 3531K → R in BAB83241. (PubMed:12690469)Curated
    Sequence conflicti353 – 3531K → R in BAC55069. (PubMed:12690469)Curated
    Sequence conflicti361 – 3611K → R in BAB83241. (PubMed:12690469)Curated
    Sequence conflicti361 – 3611K → R in BAC55069. (PubMed:12690469)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB054999 mRNA. Translation: BAB83241.1.
    AB080134 Genomic DNA. Translation: BAC55069.1.
    AL732309 Genomic DNA. Translation: CAM14672.1.
    CH466542 Genomic DNA. Translation: EDL08215.1.
    CH466542 Genomic DNA. Translation: EDL08216.1.
    BC125326 mRNA. Translation: AAI25327.1.
    BC131997 mRNA. Translation: AAI31998.1.
    CCDSiCCDS15754.1.
    RefSeqiNP_543130.2. NM_080854.3.
    XP_006497740.1. XM_006497677.1.
    XP_006497741.1. XM_006497678.1.
    UniGeneiMm.346652.
    Mm.490356.

    Genome annotation databases

    EnsembliENSMUST00000006638; ENSMUSP00000006638; ENSMUSG00000006469.
    GeneIDi142681.
    KEGGimmu:142681.
    UCSCiuc008iqt.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB054999 mRNA. Translation: BAB83241.1 .
    AB080134 Genomic DNA. Translation: BAC55069.1 .
    AL732309 Genomic DNA. Translation: CAM14672.1 .
    CH466542 Genomic DNA. Translation: EDL08215.1 .
    CH466542 Genomic DNA. Translation: EDL08216.1 .
    BC125326 mRNA. Translation: AAI25327.1 .
    BC131997 mRNA. Translation: AAI31998.1 .
    CCDSi CCDS15754.1.
    RefSeqi NP_543130.2. NM_080854.3.
    XP_006497740.1. XM_006497677.1.
    XP_006497741.1. XM_006497678.1.
    UniGenei Mm.346652.
    Mm.490356.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000006638.

    PTM databases

    PhosphoSitei Q80SU6.

    Proteomic databases

    PaxDbi Q80SU6.
    PRIDEi Q80SU6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006638 ; ENSMUSP00000006638 ; ENSMUSG00000006469 .
    GeneIDi 142681.
    KEGGi mmu:142681.
    UCSCi uc008iqt.3. mouse.

    Organism-specific databases

    CTDi 142680.
    MGIi MGI:2159410. Slc34a3.

    Phylogenomic databases

    eggNOGi COG1283.
    GeneTreei ENSGT00390000005032.
    HOGENOMi HOG000006550.
    HOVERGENi HBG006527.
    InParanoidi Q05AC3.
    KOi K14683.
    OMAi LIKRWCG.
    OrthoDBi EOG72ZCDP.
    TreeFami TF313981.

    Miscellaneous databases

    NextBioi 370049.
    PROi Q80SU6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80SU6.
    Genevestigatori Q80SU6.

    Family and domain databases

    InterProi IPR003841. Na/Pi_transpt.
    [Graphical view ]
    Pfami PF02690. Na_Pi_cotrans. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01013. 2a58. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney."
      Ohkido I., Segawa H., Yanagida R., Nakamura M., Miyamoto K.
      Pflugers Arch. 446:106-115(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], CHARACTERIZATION, INDUCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Renouncing electroneutrality is not free of charge: switching on electrogenicity in a Na+-coupled phosphate cotransporter."
      Bacconi A., Virkki L.V., Biber J., Murer H., Forster I.C.
      Proc. Natl. Acad. Sci. U.S.A. 102:12606-12611(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF GLY-195 AND 189-SER--SER-191.

    Entry informationi

    Entry nameiNPT2C_MOUSE
    AccessioniPrimary (citable) accession number: Q80SU6
    Secondary accession number(s): Q05AC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The cotransport has a Na+:Pi stoichiometry of 2:1 and is electroneutral.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3