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Protein

Interferon alpha-13

Gene

Ifna13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits antiviral activity against Theiler's virus, Mengo virus and vesicular stomatitis virus. Interferons alpha stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiR-MMU-909733. Interferon alpha/beta signaling.
R-MMU-912694. Regulation of IFNA signaling.
R-MMU-933541. TRAF6 mediated IRF7 activation.
R-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-13
Short name:
IFN-alpha-13
Gene namesi
Name:Ifna13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2667155. Ifna13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 189166Interferon alpha-13PRO_5000090349Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ80SU4.
PRIDEiQ80SU4.

PTM databases

iPTMnetiQ80SU4.
PhosphoSiteiQ80SU4.

Expressioni

Inductioni

Transcribed constitutively. Not induces by viral infection.1 Publication

Gene expression databases

BgeeiENSMUSG00000063376.
CleanExiMM_IFNA13.
ExpressionAtlasiQ80SU4. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072517.

Structurei

3D structure databases

ProteinModelPortaliQ80SU4.
SMRiQ80SU4. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiQ80SU4.
KOiK05414.
OMAiSLNNRRT.
OrthoDBiEOG091G0MJ6.
PhylomeDBiQ80SU4.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80SU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPCAFLMV LVVLSYWSAC SLGCDLPQTH NLRNKRALTL LEQMRRLSPL
60 70 80 90 100
SCLKDRKDFG FPQEKVDAQQ IKKAQAIPFV HELTQQILTL FTSNDSSAAW
110 120 130 140 150
NATLLDSFCN DLHQQLNDLK ACLMQQVGVQ EFPLTQEDSL LAVRKYFHSI
160 170 180
TVYLREKKHS PCAWEVVRAE VQRTLSSSAN LLARLSKEE
Length:189
Mass (Da):21,567
Last modified:June 1, 2003 - v1
Checksum:iC0CB2AA2813186CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190047 mRNA. Translation: AAO38688.1.
AY220461 Genomic DNA. Translation: AAO64454.1.
BC120724 mRNA. Translation: AAI20725.1.
BC120750 mRNA. Translation: AAI20751.1.
CCDSiCCDS18324.1.
RefSeqiNP_796321.1. NM_177347.2.
UniGeneiMm.246592.

Genome annotation databases

EnsembliENSMUST00000105149; ENSMUSP00000100780; ENSMUSG00000063376.
GeneIDi230396.
KEGGimmu:230396.
UCSCiuc008tng.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190047 mRNA. Translation: AAO38688.1.
AY220461 Genomic DNA. Translation: AAO64454.1.
BC120724 mRNA. Translation: AAI20725.1.
BC120750 mRNA. Translation: AAI20751.1.
CCDSiCCDS18324.1.
RefSeqiNP_796321.1. NM_177347.2.
UniGeneiMm.246592.

3D structure databases

ProteinModelPortaliQ80SU4.
SMRiQ80SU4. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072517.

PTM databases

iPTMnetiQ80SU4.
PhosphoSiteiQ80SU4.

Proteomic databases

PaxDbiQ80SU4.
PRIDEiQ80SU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105149; ENSMUSP00000100780; ENSMUSG00000063376.
GeneIDi230396.
KEGGimmu:230396.
UCSCiuc008tng.1. mouse.

Organism-specific databases

CTDi3447.
MGIiMGI:2667155. Ifna13.

Phylogenomic databases

eggNOGiENOG410J735. Eukaryota.
ENOG410ZH91. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiQ80SU4.
KOiK05414.
OMAiSLNNRRT.
OrthoDBiEOG091G0MJ6.
PhylomeDBiQ80SU4.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiR-MMU-909733. Interferon alpha/beta signaling.
R-MMU-912694. Regulation of IFNA signaling.
R-MMU-933541. TRAF6 mediated IRF7 activation.
R-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiQ80SU4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063376.
CleanExiMM_IFNA13.
ExpressionAtlasiQ80SU4. baseline.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFNAD_MOUSE
AccessioniPrimary (citable) accession number: Q80SU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.