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Protein

Lebercilin

Gene

Lca5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Might be involved in minus end-directed microtubule transport.

GO - Molecular functioni

GO - Biological processi

  • intraciliary transport Source: MGI
  • photoreceptor cell maintenance Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lebercilin
Alternative name(s):
Leber congenital amaurosis 5 protein homolog
Gene namesi
Name:Lca5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1923032. Lca5.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: MGI
  • ciliary basal body Source: MGI
  • cilium Source: MGI
  • cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895471 – 704LebercilinAdd BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei48PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80ST9.
PRIDEiQ80ST9.

PTM databases

iPTMnetiQ80ST9.
PhosphoSitePlusiQ80ST9.

Expressioni

Tissue specificityi

Detected in several tissues.1 Publication

Developmental stagei

Almost ubiquitous, low-level staining at E12.5. At later stages (E14.5, E16.5 and E18.5), staining of the eye, inner ear, kidney, regions of the central and peripheral neural system, the gut and the ciliated epithelium of the nasopharynx, trachea and lungs is more pronounced. Expression in the mouse eye shifted during development from the ganglion cell layer to the photoreceptors. In adult eyes (P90), expression is limited to the photoreceptor cell layer.1 Publication

Gene expression databases

CleanExiMM_LCA5.

Interactioni

Subunit structurei

Interacts with NINL. Interacts with OFD1. Interacts with FAM161A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ80ST9. 1 interactor.
STRINGi10090.ENSMUSP00000034791.

Structurei

3D structure databases

ProteinModelPortaliQ80ST9.
SMRiQ80ST9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili105 – 300Sequence analysisAdd BLAST196
Coiled coili448 – 479Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the LCA5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKE1. Eukaryota.
ENOG4111R6E. LUCA.
HOGENOMiHOG000113290.
HOVERGENiHBG074315.
InParanoidiQ80ST9.
PhylomeDBiQ80ST9.

Family and domain databases

InterProiIPR026684. Lebercilin.
IPR026188. Lebercilin-like.
IPR028933. Lebercilin_dom.
[Graphical view]
PANTHERiPTHR16650. PTHR16650. 1 hit.
PTHR16650:SF10. PTHR16650:SF10. 1 hit.
PfamiPF15619. Lebercilin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80ST9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGERARSPDI EQGKKGGKHP YSHYSSDLGS SPQSSGPSSP VNTTPCASTR
60 70 80 90 100
EKNPKRHLSD NQVHHPTVRK VSPKAVPSKK GIRVGFRSQS LNREPLRKDP
110 120 130 140 150
DIVTKRVLSA RLLKINELQN EVSELQVKLA QLLKENKALK SLQYRQEKAL
160 170 180 190 200
NKFEDAENEI SQLIHRHNNE ITALKERLRK SQEKERATEK RVKETEGELF
210 220 230 240 250
RTKFSLQKLK KISEARHLPE RDDLAKKLVS AELKLDDTER KIKELSKNLE
260 270 280 290 300
LSTNSFQRQL LAERKRAFEA YDENKVLQKE LQRLHHKLKE KEKELDIKNI
310 320 330 340 350
YANRLPKSSP KKEKEIERKH VSCQSDFTDQ CTKGVQTAED FELEDFPFTA
360 370 380 390 400
QTVLCYENRW DEPEYLSSYL EYQDLNKHGS EMLSSVLGQE GKYDEDEDPC
410 420 430 440 450
SAKQEARKPE SEWAREELDK VKGKSALLGR AEKLALEAGR FPTENYQAQS
460 470 480 490 500
VDKFEDEAER LKTEMLLAKL NEINKELQDP QNLGRAPLPL LPNFESKLHS
510 520 530 540 550
PDRSTRPYSF PESLDRSFNG QHLQDLSFLT PRGEGGSPGP IRSPGQIRSP
560 570 580 590 600
APLDEFSFGS YVPSFGKTLG KSNPPSQKSS LLDFQSNSSE SPSKDSLDLM
610 620 630 640 650
SRKEKKATLM EQLFGPSASN TSVSSKSTDP HFPAASRGDM DPLHFLSGDR
660 670 680 690 700
NSRVREPGDE EEDLFLREGR SFNPNRHRLK HASNKPTVTA VDSVDEDIEE

VTLR
Length:704
Mass (Da):80,162
Last modified:June 1, 2003 - v1
Checksum:iC9B5D28C450F8B0E
GO
Isoform 2 (identifier: Q80ST9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     412-419: EWAREELD → GNLLVRIS
     420-704: Missing.

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):48,424
Checksum:i4E380BC8E2D6EB04
GO

Sequence cautioni

The sequence BAB30781 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28L → F in BAB29769 (PubMed:16141072).Curated1
Sequence conflicti110A → V in BAB29769 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014944412 – 419EWAREELD → GNLLVRIS in isoform 2. 1 Publication8
Alternative sequenceiVSP_014945420 – 704Missing in isoform 2. 1 PublicationAdd BLAST285

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015260 mRNA. Translation: BAB29769.1.
AK017509 mRNA. Translation: BAB30781.1. Different initiation.
BC049101 mRNA. Translation: AAH49101.1.
BC052060 mRNA. Translation: AAH52060.1.
CCDSiCCDS23373.1. [Q80ST9-2]
CCDS23374.1. [Q80ST9-1]
RefSeqiNP_081724.1. NM_027448.2.
NP_083710.2. NM_029434.3.
UniGeneiMm.199698.

Genome annotation databases

GeneIDi75782.
KEGGimmu:75782.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015260 mRNA. Translation: BAB29769.1.
AK017509 mRNA. Translation: BAB30781.1. Different initiation.
BC049101 mRNA. Translation: AAH49101.1.
BC052060 mRNA. Translation: AAH52060.1.
CCDSiCCDS23373.1. [Q80ST9-2]
CCDS23374.1. [Q80ST9-1]
RefSeqiNP_081724.1. NM_027448.2.
NP_083710.2. NM_029434.3.
UniGeneiMm.199698.

3D structure databases

ProteinModelPortaliQ80ST9.
SMRiQ80ST9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80ST9. 1 interactor.
STRINGi10090.ENSMUSP00000034791.

PTM databases

iPTMnetiQ80ST9.
PhosphoSitePlusiQ80ST9.

Proteomic databases

PaxDbiQ80ST9.
PRIDEiQ80ST9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi75782.
KEGGimmu:75782.

Organism-specific databases

CTDi167691.
MGIiMGI:1923032. Lca5.

Phylogenomic databases

eggNOGiENOG410IKE1. Eukaryota.
ENOG4111R6E. LUCA.
HOGENOMiHOG000113290.
HOVERGENiHBG074315.
InParanoidiQ80ST9.
PhylomeDBiQ80ST9.

Miscellaneous databases

ChiTaRSiLca5. mouse.
PROiQ80ST9.
SOURCEiSearch...

Gene expression databases

CleanExiMM_LCA5.

Family and domain databases

InterProiIPR026684. Lebercilin.
IPR026188. Lebercilin-like.
IPR028933. Lebercilin_dom.
[Graphical view]
PANTHERiPTHR16650. PTHR16650. 1 hit.
PTHR16650:SF10. PTHR16650:SF10. 1 hit.
PfamiPF15619. Lebercilin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCA5_MOUSE
AccessioniPrimary (citable) accession number: Q80ST9
Secondary accession number(s): Q9CYM9, Q9D5J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.